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Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 06/2014, Volume 277, Issue 2, pp. 210 - 220
The anti-fibrotic effect of morin was examined in LX-2 cells (culture-activated human hepatic stellate cells) and in diethylnitrosamine induced rat model of... 
β-Catenin | Liver fibrosis | G1 cell cycle arrest | Morin | Diethylnitrosamine | LX-2 cells | OXIDATIVE STRESS | LIPID-PEROXIDATION | CANONICAL WNT | HEPATIC-FIBROSIS | RAT MODEL | PATHWAY | MOUSE MODEL | beta-Catenin | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | CYCLE PROGRESSION | PULMONARY-FIBROSIS | Cyclin D1 - metabolism | Liver - pathology | Rats, Wistar | Humans | Hepatic Stellate Cells - metabolism | Glycogen Synthase Kinase 3 beta | Male | Dose-Response Relationship, Drug | Liver Cirrhosis, Experimental - prevention & control | Liver - drug effects | Time Factors | Lipid Peroxidation - drug effects | Liver Cirrhosis, Experimental - pathology | Flavonoids - pharmacology | Hepatic Stellate Cells - pathology | Cytoprotection | Hepatic Stellate Cells - drug effects | Cell Line | Cell Survival - drug effects | Liver - metabolism | Rats | Glycogen Synthase Kinase 3 - metabolism | beta Catenin - metabolism | Animals | Wnt Signaling Pathway - drug effects | Liver Cirrhosis, Experimental - chemically induced | Cell Proliferation - drug effects | Oxidative Stress - drug effects | G1 Phase Cell Cycle Checkpoints - drug effects | Liver Cirrhosis, Experimental - metabolism | Index Medicus | FIBROSIS | HUMAN POPULATIONS | CELL CULTURES | RATS | CELL PROLIFERATION | IN VIVO | 60 APPLIED LIFE SCIENCES | CONCENTRATION RATIO | MOLECULES | PEROXIDES | ENZYMES | IN VITRO | LIVER | MORIN | CELL CYCLE | LIPIDS
Journal Article
Gastroenterology, ISSN 0016-5085, 2014, Volume 146, Issue 5, pp. 1339 - 1350.e1
Background & Aims Vascular endothelial growth factor (VEGF)−induced angiogenesis is implicated in fibrogenesis and portal hypertension. However, the function... 
Gastroenterology and Hepatology | Extracellular Matrix | Sinusoidal Endothelial Cell | Liver Damage | Hepatic Sinusoid | Keywords | FACTOR VEGF | ANGIOGENESIS | MACROPHAGES | LIVER FIBROSIS | FIBROGENESIS | PATHOGENESIS | MATRIX METALLOPROTEINASES | HEPATIC STELLATE CELLS | INFLAMMATION | NEOVASCULARIZATION | GASTROENTEROLOGY & HEPATOLOGY | Antibodies, Neutralizing - administration & dosage | Liver - pathology | Capillary Permeability | Human Umbilical Vein Endothelial Cells - metabolism | Carbon Tetrachloride | Coculture Techniques | Humans | Monocytes - metabolism | Monocytes - immunology | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Vascular Endothelial Growth Factor A - genetics | fas Receptor - metabolism | Liver Cirrhosis, Experimental - prevention & control | Liver - immunology | Ligation | Cholecystostomy | Adenoviridae - genetics | Liver Cirrhosis, Experimental - pathology | Macrophages - immunology | Tacrolimus Binding Protein 1A - genetics | Gene Transfer Techniques | Promoter Regions, Genetic | Liver Regeneration | Liver Cirrhosis, Experimental - immunology | Jejunostomy | Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Receptor, Macrophage Colony-Stimulating Factor - genetics | Mice, Transgenic | Vascular Endothelial Growth Factor A - immunology | Bile Ducts - surgery | Liver Cirrhosis, Experimental - genetics | Remission Induction | Matrix Metalloproteinase 13 - metabolism | Injections | Macrophages - metabolism | Animals | Chemokine CXCL9 - metabolism | Liver Cirrhosis, Experimental - chemically induced | Tacrolimus Binding Protein 1A - metabolism | Mice | Genetic Vectors | Liver Cirrhosis, Experimental - metabolism | Apoptosis | Hypertension | Medical colleges | Vascular endothelial growth factor | Health aspects | Fibrosis | Index Medicus | Abridged Index Medicus
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 12/2015, Volume 289, Issue 2, pp. 163 - 176
SIRT1 (silent information regulator 1), a conserved NAD +-dependent histone deacetylase, is closely related with various biological processes. Moreover, the... 
Reversion | MALAT1 | Liver fibrosis | SIRT1 | Apoptosis | RESVERATROL | METASTASIS | MECHANISMS | CANCER | HEPATIC-FIBROSIS | RENAL FIBROSIS | LONG NONCODING RNA | MALAT-1 | PHARMACOLOGY & PHARMACY | TOXICOLOGY | EXPRESSION | PULMONARY-FIBROSIS | Sirtuin 1 - metabolism | Liver - pathology | Liver - enzymology | Apoptosis - drug effects | Carbon Tetrachloride | Humans | Actins - metabolism | Myofibroblasts - enzymology | Male | RNA, Messenger - metabolism | Xanthines - pharmacology | Sirtuin 1 - genetics | Actins - genetics | Dose-Response Relationship, Drug | Liver Cirrhosis, Experimental - prevention & control | Liver Cirrhosis, Experimental - enzymology | Collagen Type I - genetics | Dexamethasone - pharmacology | Transfection | Liver - drug effects | RNA Interference | Time Factors | Liver Cirrhosis, Experimental - pathology | Female | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - enzymology | Chemical and Drug Induced Liver Injury - etiology | Hepatic Stellate Cells - pathology | Transforming Growth Factor beta1 - pharmacology | Hepatic Stellate Cells - drug effects | Cell Line | Chemical and Drug Induced Liver Injury - prevention & control | Insulin - pharmacology | Myofibroblasts - pathology | Collagen Type I - metabolism | Signal Transduction | Mice, Inbred C57BL | Gene Expression Regulation | Hepatic Stellate Cells - enzymology | Chemical and Drug Induced Liver Injury - genetics | Liver Cirrhosis, Experimental - genetics | Phenotype | Animals | Liver Cirrhosis, Experimental - chemically induced | RNA, Long Noncoding - metabolism | Corticosteroids | Liver | Analysis | Fibrosis | Bone morphogenetic proteins | Transforming growth factors | Liver cirrhosis | Index Medicus | APOPTOSIS | DEXAMETHASONE | COLLAGEN | RNA | LUNGS | METASTASES | 60 APPLIED LIFE SCIENCES | HISTONES | MICE | VIRUSES | FIBROSIS | ONCOGENES | TRANSCRIPTION FACTORS | ACTIN | MATERIALS RECOVERY | STEROLS | TRANSCRIPTION | PHENOTYPE | INSULIN | NAD | GROWTH FACTORS | CARBON TETRACHLORIDE | LIVER | CARCINOMAS | RECEPTORS | MUSCLES
Journal Article
Gastroenterology, ISSN 0016-5085, 2012, Volume 142, Issue 4, pp. 938 - 946
Background & Aims The pathogenesis of liver fibrosis involves activation of hepatic stellate cells, which is associated with depletion of intracellular lipid... 
Gastroenterology and Hepatology | Inflammation | Myofibroblasts | Energy Depletion | Mouse Model | RAT-LIVER | FIBROSIS | PATHWAY | DISEASE | MECHANISMS | RETINOL | GASTROENTEROLOGY & HEPATOLOGY | Liver - pathology | Kidney - pathology | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Carbon Tetrachloride | Humans | Hepatic Stellate Cells - metabolism | Autophagy - drug effects | Idiopathic Pulmonary Fibrosis - metabolism | Kidney - metabolism | Epoxy Compounds - pharmacology | Liver - drug effects | RNA Interference | Adenosine Triphosphate - metabolism | Liver Cirrhosis, Experimental - pathology | Lung - metabolism | Autophagy - genetics | Microtubule-Associated Proteins - deficiency | Hepatic Stellate Cells - pathology | Fibroblasts - metabolism | Hepatic Stellate Cells - drug effects | Cell Line | Lung - pathology | Oleic Acid - metabolism | Adenine - analogs & derivatives | Liver - metabolism | Mice, Inbred C57BL | Adenine - pharmacology | Liver Cirrhosis, Experimental - genetics | Fibroblasts - pathology | Mice, Knockout | Thioacetamide | Autophagy-Related Protein 7 | Animals | Autophagy-Related Protein 5 | Energy Metabolism | Fibroblasts - drug effects | Liver Cirrhosis, Experimental - chemically induced | Lipid Metabolism - drug effects | Idiopathic Pulmonary Fibrosis - pathology | Mice | Liver Cirrhosis, Experimental - metabolism | Phosphates | Medical colleges | Neurosciences | Platelet-derived growth factor | Liver diseases | Albumin | Lipids | Muscle proteins | Fatty acids | Cells | Monosaccharides | Unsaturated fatty acids | Monounsaturated fatty acids | Actin | Analysis | Intermediate filament proteins | Sugars | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 2, pp. e16789 - e16789
Background: Human amniotic membrane-derived mesenchymal stem cells (hAMCs) have the potential to reduce heart and lung fibrosis, but whether could reduce liver... 
ACTIVATION | HEPATOCYTE GROWTH-FACTOR | CLINICAL-TRIALS | BIOLOGY | SENESCENCE | MICE | DIFFERENTIATION | CARDIOMYOCYTES | CYTOTOXICITY | ASSOCIATION | HEPATIC-FIBROSIS | Liver Cirrhosis, Experimental - therapy | Amnion - cytology | Carbon Tetrachloride | Humans | Mice, Inbred C57BL | Cells, Cultured | Hepatocytes - pathology | Carbon Tetrachloride Poisoning - pathology | Liver Regeneration - physiology | Mesenchymal Stromal Cells - cytology | Animals | Carbon Tetrachloride Poisoning - therapy | Liver Cirrhosis, Experimental - chemically induced | Liver Cirrhosis, Experimental - pathology | Female | Mice | Hepatocytes - physiology | Mesenchymal Stem Cell Transplantation | Mesenchymal Stromal Cells - physiology | Medical examination | Analysis | Carbon tetrachloride | Stem cells | Albumin | Aspartate | Transplantation | Gene therapy | Liver cirrhosis | Blood | Heart | Cell proliferation | Senescence | Mesenchyme | Syngeneic grafts | Liver | Body weight | Lung | Stem cell transplantation | Cytotoxicity | Infusion | Hepatitis | Allografts | Rodents | Penicillin | Fibroblasts | Bone marrow | Growth factors | Spleen | Stellate cells | Enzymes | Alanine | Liver diseases | Free radicals | Medical treatment | Polymerase chain reaction | Amniotic membrane | Cirrhosis | Regeneration | Placenta | Fibrosis | Alanine transaminase | Aspartate aminotransferase | Laboratory animals | Immunofluorescence | Apoptosis | Index Medicus
Journal Article
Phytotherapy Research, ISSN 0951-418X, 12/2018, Volume 32, Issue 12, pp. 2568 - 2576
Stevia has been shown to prevent oxidative stress and inflammation in carbon tetrachloride‐induced cirrhosis models. This study aimed to investigate the... 
anti‐inflammatory | antioxidant |