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Journal Article
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2012, Volume 58, Issue 1, pp. 98 - 103
Background & Aims Statins improve hepatic endothelial function and liver fibrosis in experimental models of cirrhosis, thus they have been proposed as... 
Gastroenterology and Hepatology | Kruppel-like factor 2 | Cirrhosis | Simvastatin | Liver | Portal hypertension | Endothelium | ACTIVATION | ANGIOGENESIS | PHENOTYPE | CIRRHOTIC RAT LIVERS | PRESSURE | RESISTANCE | KRUPPEL-LIKE FACTOR-2 | DYSFUNCTION | GASTROENTEROLOGY & HEPATOLOGY | PORTAL-HYPERTENSION | Gene Expression - drug effects | Lovastatin - pharmacology | Rats, Wistar | Hepatic Stellate Cells - metabolism | Stress, Mechanical | Cell Communication - physiology | Male | Lovastatin - analogs & derivatives | Liver Cirrhosis, Experimental - drug therapy | Simvastatin - pharmacology | Hepatic Stellate Cells - cytology | Paracrine Communication - physiology | Kruppel-Like Transcription Factors - metabolism | Liver Circulation - drug effects | Gene Expression - physiology | Liver Cirrhosis, Experimental - pathology | Heptanoic Acids - pharmacology | Disease Models, Animal | Liver Circulation - physiology | Endothelial Cells - metabolism | Hypertension, Portal - pathology | Liver - metabolism | Rats | Hypertension, Portal - drug therapy | Atorvastatin Calcium | Pyrroles - pharmacology | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Endothelial Cells - cytology | Hypertension, Portal - metabolism | Paracrine Communication - drug effects | Cell Communication - drug effects | Liver - cytology | Kruppel-Like Transcription Factors - genetics | Liver Cirrhosis, Experimental - metabolism | Hypertension | Actin | Analysis | Nitric oxide | Carbon tetrachloride | Muscle proteins | Vascular endothelial growth factor | Liver cirrhosis | Antilipemic agents | Index Medicus
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2013, Volume 58, Issue 5, pp. 904 - 910
Background & Aims Resveratrol, a polyphenol found in a variety of fruits, exerts a wide range of beneficial effects on the endothelium, regulates multiple... 
Gastroenterology and Hepatology | Endothelial dysfunction | Oxidative stress | Thromboxane | Nitric oxide | CELLS | ACTIVATION | LIVER FIBROSIS | VASCULAR-TONE | CCL4 | NITRIC-OXIDE | RESISTANCE | RED WINE | HYPERTENSION | GASTROENTEROLOGY & HEPATOLOGY | Liver - pathology | Hypertension, Portal - physiopathology | Rats, Wistar | Stilbenes - therapeutic use | Endothelium, Vascular - drug effects | Male | Stilbenes - pharmacology | Liver Cirrhosis, Experimental - drug therapy | Liver Cirrhosis, Experimental - physiopathology | Hypertension, Portal - prevention & control | Dose-Response Relationship, Drug | Portal Pressure - drug effects | Liver - drug effects | Liver Cirrhosis - metabolism | Nitric Oxide Synthase Type III - metabolism | Disease Models, Animal | Liver Cirrhosis - prevention & control | Portal Pressure - physiology | Carbon Tetrachloride - adverse effects | Endothelium, Vascular - physiopathology | Rats | Antioxidants - pharmacology | Thromboxane A2 - metabolism | Antioxidants - therapeutic use | Liver - blood supply | Animals | Endothelium, Vascular - metabolism | Hypertension, Portal - metabolism | Liver Cirrhosis, Experimental - chemically induced | Liver Cirrhosis - physiopathology | Hypertension | COX-2 inhibitors | Carbon tetrachloride | Resveratrol | Fibrosis | Acetylcholine | Superoxide | Liver cirrhosis | Endothelium | Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2013, Volume 288, Issue 52, pp. 37082 - 37093
Sustained activation of hepatic stellate cells (HSCs) leads to hepatic fibrosis, which is characterized by excessive collagen production, and for which there... 
ACTIVATION | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIVER FIBROSIS | STELLATE CELLS | AP-1 | Liver Injury | MicroRNA | Hepatic Stellate Cells | Fibrosis | IN-VIVO | Transforming Growth Factor (TGF) | PDCD4 | MIR-21 | MICRORNA EXPRESSION | UP-REGULATION | Carbon Tetrachloride Poisoning - drug therapy | RNA-Binding Proteins - genetics | MicroRNAs - antagonists & inhibitors | Transcription Factor AP-1 - genetics | Humans | Middle Aged | Hepatic Stellate Cells - metabolism | Male | MicroRNAs - metabolism | Liver Cirrhosis, Experimental - drug therapy | Transcription Factor AP-1 - metabolism | Carbon Tetrachloride Poisoning - metabolism | Apoptosis Regulatory Proteins - genetics | Liver Cirrhosis, Experimental - pathology | Adult | Female | Hepatic Stellate Cells - pathology | Signal Transduction | Liver Cirrhosis, Experimental - genetics | Carbon Tetrachloride - toxicity | Carbon Tetrachloride Poisoning - pathology | Mice, Inbred ICR | Apoptosis Regulatory Proteins - metabolism | Animals | Thioacetamide - toxicity | Transforming Growth Factor beta - genetics | Liver Cirrhosis, Experimental - chemically induced | Carbon Tetrachloride Poisoning - genetics | Aged | Mice | MicroRNAs - genetics | Transforming Growth Factor beta - metabolism | Liver Cirrhosis, Experimental - metabolism | RNA-Binding Proteins - metabolism | Index Medicus | Molecular Bases of Disease | Transforming Growth Factor β (TGFβ)
Journal Article
International Immunopharmacology, ISSN 1567-5769, 04/2015, Volume 25, Issue 2, pp. 340 - 352
Alcoholic liver fibrosis (ALF) is characterized by hyperplasia of extracellular matrix under long-term alcohol stimulation. Hepatic stellate cell (HSC)... 
Alcoholic liver fibrosis | CREB | Hepatic stellate cell | cAMP | PKA | Caffeine | OXIDATIVE-STRESS | COFFEE | RECEPTOR | PROLIFERATION | IMMUNOLOGY | HYALURONIC-ACID | PATHOGENESIS | ETHANOL | PHARMACOLOGY & PHARMACY | SERUM MARKERS | EXPRESSION | CONSUMPTION | Liver - pathology | Actins - metabolism | Hepatic Stellate Cells - metabolism | Male | Alanine Transaminase - blood | Liver Cirrhosis, Experimental - drug therapy | Liver - drug effects | Caffeine - therapeutic use | Peptide Fragments - blood | Caffeine - pharmacology | Liver Cirrhosis, Experimental - pathology | Laminin - blood | Liver Cirrhosis, Alcoholic - blood | Hyaluronic Acid - blood | Cyclic AMP - metabolism | Hepatic Stellate Cells - drug effects | Cyclic AMP-Dependent Protein Kinases - metabolism | Liver Cirrhosis, Alcoholic - drug therapy | Ethanol | Liver Cirrhosis, Alcoholic - pathology | Liver - metabolism | Cells, Cultured | Procollagen - blood | Rats, Sprague-Dawley | Liver Cirrhosis, Experimental - blood | Collagen - metabolism | Animals | Aspartate Aminotransferases - blood | Signal Transduction - drug effects | Cyclic AMP Response Element-Binding Protein - metabolism | Liver Cirrhosis, Alcoholic - metabolism | Liver Cirrhosis, Experimental - metabolism | Immunohistochemistry | Liver diseases | Collagen | Liver | Fibrosis | Aspartate | Colchicine | Hyaluronic acid | Index Medicus
Journal Article