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Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 09/2012, Volume 143, Issue 3, pp. 765 - 776.e3
Background & Aims Interleukin (IL)-17 signaling has been implicated in lung and skin fibrosis. We examined the role of IL-17 signaling in the pathogenesis of... 
Gastroenterology and Hepatology | Immune Response | Myofibroblast | Bone Marrow-Derived Macrophages | Mouse Model | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Kupffer Cells - pathology | Liver - pathology | Carbon Tetrachloride | Humans | Transforming Growth Factor beta1 - metabolism | Hepatic Stellate Cells - metabolism | Receptors, Interleukin-17 - genetics | Interleukin-23 - genetics | Receptors, Interleukin-17 - deficiency | Interleukins - genetics | Liver Cirrhosis, Experimental - prevention & control | Liver - immunology | Time Factors | Bone Marrow Transplantation | Liver Cirrhosis, Alcoholic - immunology | Interleukin-6 - metabolism | STAT3 Transcription Factor - genetics | Interleukin-17 - administration & dosage | Liver Cirrhosis, Experimental - immunology | Signal Transduction | Liver Cirrhosis, Alcoholic - pathology | Liver - metabolism | Interleukin-17 - genetics | Genotype | Bile Ducts - surgery | Disease Progression | Mice, Knockout | Interleukin-17 - metabolism | Phenotype | Interleukins - deficiency | Mice | Liver Cirrhosis, Experimental - metabolism | Tumor Necrosis Factor-alpha - metabolism | Inflammation Mediators - administration & dosage | Liver Cirrhosis, Experimental - etiology | Interleukin-23 - deficiency | Ligation | Hepatic Stellate Cells - immunology | Inflammation Mediators - metabolism | STAT3 Transcription Factor - deficiency | Liver Cirrhosis, Experimental - pathology | Kupffer Cells - metabolism | Hepatic Stellate Cells - pathology | Cell Line | Interleukin-1 - metabolism | Collagen Type I - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Interleukin-17 - deficiency | Liver Cirrhosis, Experimental - genetics | Animals | Interleukins - administration & dosage | Kupffer Cells - immunology | Medical colleges | Liver diseases | Liver | Carbon tetrachloride | Transforming growth factors | Muscle proteins | Macrophages | Endothelium | Messenger RNA | Interleukins | Actin | Analysis | Collagen | Fibrosis | Liver cirrhosis | Index Medicus | Abridged Index Medicus
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 11/2012, Volume 143, Issue 5, pp. 1244 - 1252.e12
...) infection in genome-wide association (GWA) studies. Only a fraction of patients with chronic HCV infection develop liver fibrosis, a process that might also be affected by genetic factors... 
Gastroenterology and Hepatology | Cirrhosis | Genetic Analysis | Liver Disease | Risk Factors | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Humans | Hepatitis C, Chronic - virology | Apoptosis - genetics | Male | Hepatitis C, Chronic - complications | Young Adult | c-Mer Tyrosine Kinase | Adult | Female | Eye Proteins - genetics | Liver Cirrhosis - genetics | Genome-Wide Association Study | Membrane Proteins - genetics | Proportional Hazards Models | Genotype | Logistic Models | Proto-Oncogene Proteins - genetics | Disease Progression | Phenotype | Liver Cirrhosis - virology | Receptor Protein-Tyrosine Kinases - genetics | Polymorphism, Single Nucleotide | Ubiquitin-Protein Ligases - genetics | Hepacivirus | Lipase - genetics | Antiviral agents | Medical research | Medical colleges | Liver | Genomics | Immunodeficiency | Development and progression | Genomes | HIV (Viruses) | Risk factors | Analysis | Fibrosis | Medical genetics | Medicine, Experimental | Hepatitis C virus | Hepatitis C | Health aspects | Liver diseases | Genetic research | Index Medicus | Abridged Index Medicus | Life Sciences | Human health and pathology | Genetics | Hépatology and Gastroenterology | Infectious diseases | Human genetics | risk factors | genetic analysis | liver disease | cirrhosis
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 08/2012, Volume 122, Issue 8, pp. 2884 - 2897
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 05/2014, Volume 146, Issue 5, pp. 1339 - 1350.e1
Background & Aims Vascular endothelial growth factor (VEGF)−induced angiogenesis is implicated in fibrogenesis and portal hypertension. However, the function... 
Gastroenterology and Hepatology | Extracellular Matrix | Sinusoidal Endothelial Cell | Liver Damage | Hepatic Sinusoid | Keywords | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Antibodies, Neutralizing - administration & dosage | Liver - pathology | Capillary Permeability | Human Umbilical Vein Endothelial Cells - metabolism | Carbon Tetrachloride | Coculture Techniques | Humans | Monocytes - metabolism | Monocytes - immunology | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Vascular Endothelial Growth Factor A - genetics | fas Receptor - metabolism | Liver Cirrhosis, Experimental - prevention & control | Liver - immunology | Ligation | Cholecystostomy | Adenoviridae - genetics | Liver Cirrhosis, Experimental - pathology | Macrophages - immunology | Tacrolimus Binding Protein 1A - genetics | Gene Transfer Techniques | Promoter Regions, Genetic | Liver Regeneration | Liver Cirrhosis, Experimental - immunology | Jejunostomy | Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Receptor, Macrophage Colony-Stimulating Factor - genetics | Mice, Transgenic | Vascular Endothelial Growth Factor A - immunology | Bile Ducts - surgery | Liver Cirrhosis, Experimental - genetics | Remission Induction | Matrix Metalloproteinase 13 - metabolism | Injections | Macrophages - metabolism | Animals | Chemokine CXCL9 - metabolism | Liver Cirrhosis, Experimental - chemically induced | Tacrolimus Binding Protein 1A - metabolism | Mice | Genetic Vectors | Liver Cirrhosis, Experimental - metabolism | Apoptosis | Hypertension | Medical colleges | Vascular endothelial growth factor | Health aspects | Fibrosis | Index Medicus | Abridged Index Medicus
Journal Article
Gut, ISSN 0017-5749, 03/2017, Volume 66, Issue 3, pp. 507 - 518
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 04/2015, Volume 125, Issue 4, pp. 1533 - 1544
...Introduction Cirrhosis of the liver, the final pathway for liver injury from multiple types of insults, is a process that is difficult to manage... 
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Liver Cirrhosis, Experimental - therapy | Liver Failure - etiology | Dependovirus - genetics | Genetic Therapy | Hepatocyte Nuclear Factor 1-alpha - genetics | Hepatocyte Nuclear Factor 3-beta - genetics | Rats, Inbred Lew | Transcriptome | Hepatocyte Nuclear Factor 1-alpha - biosynthesis | Liver Failure - pathology | Hepatocytes - pathology | Male | Gene Expression Profiling | Genetic Vectors - therapeutic use | Hepatocytes - metabolism | Gene Regulatory Networks | Hepatocyte Nuclear Factor 4 - physiology | Recombinant Fusion Proteins - metabolism | CCAAT-Enhancer-Binding Protein-alpha - biosynthesis | Hepatocyte Nuclear Factor 4 - biosynthesis | Liver Cirrhosis, Experimental - pathology | Liver Cirrhosis, Experimental - complications | Hepatocyte Nuclear Factor 3-beta - biosynthesis | Transcription Factors - physiology | Transduction, Genetic | PPAR alpha - biosynthesis | Down-Regulation | Cells, Cultured | Gene Expression Regulation | Rats | PPAR alpha - genetics | Hepatocyte Nuclear Factor 4 - genetics | Liver Cirrhosis, Experimental - genetics | Liver Failure - genetics | Disease Progression | Animals | Carbon Tetrachloride Poisoning - therapy | Liver Failure - therapy | CCAAT-Enhancer-Binding Protein-alpha - genetics | Carbon Tetrachloride Poisoning - genetics | Cell Dedifferentiation - genetics | Transcription factors | Liver diseases | Genetic research | Development and progression | Genetic aspects | Genetic transcription | Research | Properties | Hypertension | Cytochrome | Transplants & implants | Rodents | Stem cells | Metabolism | Laboratory animals | Liver cirrhosis | Index Medicus | Abridged Index Medicus | Hepatology | Gastroenterology
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 05/2006, Volume 203, Issue 5, pp. 1209 - 1219
Primary biliary cirrhosis (PBC) is an autoimmune disease with a strong genetic component characterized by biliary ductular inflammation with eventual liver cirrhosis... 
Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Inflammation - pathology | CD8-Positive T-Lymphocytes - pathology | Quantitative Trait Loci - immunology | Dihydrolipoyllysine-Residue Acetyltransferase - immunology | Humans | Cholangitis - immunology | Mitochondrial Proteins - genetics | Adoptive Transfer | CD4-Positive T-Lymphocytes - pathology | Autoimmune Diseases - genetics | CD4-Positive T-Lymphocytes - immunology | Liver Cirrhosis, Biliary - immunology | Dihydrolipoyllysine-Residue Acetyltransferase - genetics | Liver Cirrhosis, Experimental - pathology | Autoimmune Diseases - pathology | Cholangitis - pathology | Disease Models, Animal | Granuloma - genetics | Liver Cirrhosis, Experimental - immunology | Cholangitis - genetics | Autoimmune Diseases - immunology | Mice, Transgenic | Chromosome Mapping | Inflammation - immunology | Protein Structure, Tertiary - genetics | Liver Cirrhosis, Biliary - pathology | Liver Cirrhosis, Experimental - genetics | Liver Cirrhosis, Biliary - genetics | Mice, SCID | Granuloma - pathology | Autoantibodies - immunology | Animals | CD4-Positive T-Lymphocytes - transplantation | CD3 Complex - immunology | Inflammation - genetics | Granuloma - immunology | Mice, Inbred NOD | Mice | Mice, Congenic | CD8-Positive T-Lymphocytes - immunology | Mitochondrial Proteins - immunology | Quantitative Trait Loci - genetics | Index Medicus
Journal Article