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Gastroenterology, ISSN 0016-5085, 2012, Volume 143, Issue 3, pp. 765 - 776.e3
Background & Aims Interleukin (IL)-17 signaling has been implicated in lung and skin fibrosis. We examined the role of IL-17 signaling in the pathogenesis of... 
Gastroenterology and Hepatology | Immune Response | Myofibroblast | Mouse Model | Bone Marrow-Derived Macrophages | RAT-LIVER | TARGET | IL-17 RECEPTOR | HEPATOCYTES | FAMILY-MEMBERS | STAT3 | TRANSDUCTION | PATHWAY | DISEASE | GENE-EXPRESSION | GASTROENTEROLOGY & HEPATOLOGY | Kupffer Cells - pathology | Liver - pathology | Carbon Tetrachloride | Humans | Transforming Growth Factor beta1 - metabolism | Hepatic Stellate Cells - metabolism | Receptors, Interleukin-17 - genetics | Interleukin-23 - genetics | Receptors, Interleukin-17 - deficiency | Interleukins - genetics | Liver Cirrhosis, Experimental - prevention & control | Liver - immunology | Time Factors | Bone Marrow Transplantation | Liver Cirrhosis, Alcoholic - immunology | Interleukin-6 - metabolism | STAT3 Transcription Factor - genetics | Interleukin-17 - administration & dosage | Liver Cirrhosis, Experimental - immunology | Signal Transduction | Liver Cirrhosis, Alcoholic - pathology | Liver - metabolism | Interleukin-17 - genetics | Genotype | Bile Ducts - surgery | Disease Progression | Mice, Knockout | Interleukin-17 - metabolism | Phenotype | Interleukins - deficiency | Mice | Liver Cirrhosis, Experimental - metabolism | Tumor Necrosis Factor-alpha - metabolism | Inflammation Mediators - administration & dosage | Liver Cirrhosis, Experimental - etiology | Interleukin-23 - deficiency | Ligation | Hepatic Stellate Cells - immunology | Inflammation Mediators - metabolism | STAT3 Transcription Factor - deficiency | Liver Cirrhosis, Experimental - pathology | Kupffer Cells - metabolism | Hepatic Stellate Cells - pathology | Cell Line | Interleukin-1 - metabolism | Collagen Type I - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Interleukin-17 - deficiency | Liver Cirrhosis, Experimental - genetics | Animals | Interleukins - administration & dosage | Kupffer Cells - immunology | Medical colleges | Liver diseases | Liver | Carbon tetrachloride | Transforming growth factors | Muscle proteins | Macrophages | Endothelium | Messenger RNA | Interleukins | Actin | Analysis | Collagen | Fibrosis | Liver cirrhosis | Index Medicus | Abridged Index Medicus
Journal Article
Gastroenterology, ISSN 0016-5085, 2014, Volume 146, Issue 5, pp. 1339 - 1350.e1
Background & Aims Vascular endothelial growth factor (VEGF)−induced angiogenesis is implicated in fibrogenesis and portal hypertension. However, the function... 
Gastroenterology and Hepatology | Extracellular Matrix | Sinusoidal Endothelial Cell | Liver Damage | Hepatic Sinusoid | Keywords | FACTOR VEGF | ANGIOGENESIS | MACROPHAGES | LIVER FIBROSIS | FIBROGENESIS | PATHOGENESIS | MATRIX METALLOPROTEINASES | HEPATIC STELLATE CELLS | INFLAMMATION | NEOVASCULARIZATION | GASTROENTEROLOGY & HEPATOLOGY | Antibodies, Neutralizing - administration & dosage | Liver - pathology | Capillary Permeability | Human Umbilical Vein Endothelial Cells - metabolism | Carbon Tetrachloride | Coculture Techniques | Humans | Monocytes - metabolism | Monocytes - immunology | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Vascular Endothelial Growth Factor A - genetics | fas Receptor - metabolism | Liver Cirrhosis, Experimental - prevention & control | Liver - immunology | Ligation | Cholecystostomy | Adenoviridae - genetics | Liver Cirrhosis, Experimental - pathology | Macrophages - immunology | Tacrolimus Binding Protein 1A - genetics | Gene Transfer Techniques | Promoter Regions, Genetic | Liver Regeneration | Liver Cirrhosis, Experimental - immunology | Jejunostomy | Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Receptor, Macrophage Colony-Stimulating Factor - genetics | Mice, Transgenic | Vascular Endothelial Growth Factor A - immunology | Bile Ducts - surgery | Liver Cirrhosis, Experimental - genetics | Remission Induction | Matrix Metalloproteinase 13 - metabolism | Injections | Macrophages - metabolism | Animals | Chemokine CXCL9 - metabolism | Liver Cirrhosis, Experimental - chemically induced | Tacrolimus Binding Protein 1A - metabolism | Mice | Genetic Vectors | Liver Cirrhosis, Experimental - metabolism | Apoptosis | Hypertension | Medical colleges | Vascular endothelial growth factor | Health aspects | Fibrosis | Index Medicus | Abridged Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 11/2007, Volume 13, Issue 11, pp. 1324 - 1332
Journal Article
Cell Metabolism, ISSN 1550-4131, 07/2012, Volume 16, Issue 1, pp. 44 - 54
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 05/2006, Volume 203, Issue 5, pp. 1209 - 1219
Primary biliary cirrhosis (PBC) is an autoimmune disease with a strong genetic component characterized by biliary ductular inflammation with eventual liver... 
ANTIBODIES | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNIZATION | T-CELL RESPONSES | NOD MOUSE | GENETIC-CONTROL | LIVER | MITOCHONDRIAL AUTO-ANTIGEN | IMMUNOLOGY | IDENTIFICATION | DIHYDROLIPOAMIDE ACETYLTRANSFERASE | INFILTRATION | Inflammation - pathology | CD8-Positive T-Lymphocytes - pathology | Quantitative Trait Loci - immunology | Dihydrolipoyllysine-Residue Acetyltransferase - immunology | Humans | Cholangitis - immunology | Mitochondrial Proteins - genetics | Adoptive Transfer | CD4-Positive T-Lymphocytes - pathology | Autoimmune Diseases - genetics | CD4-Positive T-Lymphocytes - immunology | Liver Cirrhosis, Biliary - immunology | Dihydrolipoyllysine-Residue Acetyltransferase - genetics | Liver Cirrhosis, Experimental - pathology | Autoimmune Diseases - pathology | Cholangitis - pathology | Disease Models, Animal | Granuloma - genetics | Liver Cirrhosis, Experimental - immunology | Cholangitis - genetics | Autoimmune Diseases - immunology | Mice, Transgenic | Chromosome Mapping | Inflammation - immunology | Protein Structure, Tertiary - genetics | Liver Cirrhosis, Biliary - pathology | Liver Cirrhosis, Experimental - genetics | Liver Cirrhosis, Biliary - genetics | Mice, SCID | Granuloma - pathology | Autoantibodies - immunology | Animals | CD4-Positive T-Lymphocytes - transplantation | CD3 Complex - immunology | Inflammation - genetics | Granuloma - immunology | Mice, Inbred NOD | Mice | Mice, Congenic | CD8-Positive T-Lymphocytes - immunology | Mitochondrial Proteins - immunology | Quantitative Trait Loci - genetics | Index Medicus
Journal Article
Gut, ISSN 0017-5749, 03/2017, Volume 66, Issue 3, pp. 507 - 518
ObjectivePatients with liver cirrhosis suffer from increased susceptibility to life-threatening bacterial infections that cause substantial... 
Hepatic fibrosis | liver immunology | bacterial infection | immune response | liver cirrhosis | LISTERIA-MONOCYTOGENES | IMMUNITY | REACTIVE OXYGEN | COMMENSAL BACTERIA | I INTERFERONS | INTERLEUKIN-10 | INDUCTION | GASTROENTEROLOGY & HEPATOLOGY | MACROPHAGE ACTIVATION | HEPATIC-FIBROSIS | T-CELLS | Toll-Like Receptor 2 - genetics | Carbon Tetrachloride | Immunity, Innate - genetics | Toll-Like Receptor 9 - genetics | Receptor, Interferon alpha-beta - antagonists & inhibitors | Myeloid Cells - immunology | Listeriosis - immunology | Interferon Type I - metabolism | Receptor, Interferon alpha-beta - genetics | Toll-Like Receptor 7 - genetics | Liver Cirrhosis, Experimental - complications | Listeriosis - metabolism | Liver Cirrhosis, Experimental - immunology | Signal Transduction | Listeriosis - complications | Mice, Inbred C57BL | Toll-Like Receptor 4 - genetics | Mice, Transgenic | Bacterial Translocation | Membrane Glycoproteins - genetics | Mice, Knockout | Animals | Myeloid Cells - metabolism | Receptors, Interleukin-10 - antagonists & inhibitors | Receptors, Pattern Recognition - genetics | Interleukin-10 - biosynthesis | Mice | Myxovirus Resistance Proteins - genetics | Liver Cirrhosis, Experimental - metabolism | Myeloid Cells - microbiology | Bacterial infections | Microbiota (Symbiotic organisms) | Myelocytic leukemia | Genetic aspects | Nonlymphoid leukemia | Research | Liver cirrhosis | Index Medicus | Abridged Index Medicus
Journal Article
世界胃肠病学杂志:英文版, ISSN 1007-9327, 2015, Volume 21, Issue 5, pp. 1531 - 1545
AIM:To investigate the effect of interleukin(IL)-22 onhepatic fibrosis in mice and the possible mechanism involved.METHODS:Liver fibrosis was induced in male... 
helper | cells;T | cel | Hepatic fibrosis | FIBROSIS | T helper 1 cells | HEPATOCYTES | Interleukin-22 | MECHANISMS | IL-22 | PLAYS | DISEASE | MICE | T helper 17 cells | DIFFERENTIATION | GASTROENTEROLOGY & HEPATOLOGY | TH17 | T-CELLS | T helper 22 cells | Liver - pathology | Carbon Tetrachloride | Hepatic Stellate Cells - metabolism | Male | RNA, Messenger - metabolism | Th1 Cells - immunology | Th1 Cells - metabolism | Liver Cirrhosis, Experimental - prevention & control | Liver - immunology | Th17 Cells - drug effects | Hepatic Stellate Cells - immunology | Liver - drug effects | Th17 Cells - metabolism | Time Factors | Inflammation Mediators - metabolism | Liver Cirrhosis, Experimental - pathology | Interleukins - pharmacology | Cytokines - genetics | Hepatic Stellate Cells - pathology | Cytokines - immunology | Hepatic Stellate Cells - drug effects | Inflammation Mediators - immunology | Severity of Illness Index | Th1 Cells - drug effects | Liver Cirrhosis, Experimental - immunology | Cytokines - metabolism | Anti-Inflammatory Agents - pharmacology | Liver - metabolism | Liver Cirrhosis, Experimental - genetics | Recombinant Proteins - pharmacology | Animals | Signal Transduction - drug effects | Liver Cirrhosis, Experimental - chemically induced | Th17 Cells - immunology | Mice, Inbred BALB C | Liver Cirrhosis, Experimental - metabolism | Index Medicus | Basic Study
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 03/2011, Volume 300, Issue 3, pp. 433 - 441
Toll-like receptor 4 (TLR4) and its coreceptor, myeloid differentiation factor-2 (MD-2), are key in recognition of lipopolysaccharide (LPS) and activation of... 
α-smooth muscle actin | Inflammation | Fatty liver | Endotoxin | Nictoinamide adenine dinucleotide phosphate | alpha-smooth muscle actin | PHYSIOLOGY | PROTEIN | FATTY LIVER-DISEASE | fatty liver | nictoinamide adenine dinucleotide phosphate | PATHOGENESIS | LIPID-ACCUMULATION | DANGER SIGNALS | HEPATIC STELLATE CELLS | inflammation | LIPOPOLYSACCHARIDE | MD-2 | GASTROENTEROLOGY & HEPATOLOGY | TLR4 | endotoxin | Oxidative Stress | Tumor Necrosis Factor-alpha - blood | NADPH Oxidases - metabolism | Choline Deficiency - complications | Alanine Transaminase - blood | RNA, Messenger - metabolism | Actins - genetics | Lymphocyte Antigen 96 - genetics | Liver Cirrhosis, Experimental - prevention & control | Liver - immunology | Toll-Like Receptor 4 - deficiency | Non-alcoholic Fatty Liver Disease | NADPH Oxidases - genetics | Female | Collagen - genetics | Lymphocyte Antigen 96 - deficiency | Methionine - deficiency | Fatty Liver - genetics | Fatty Liver - metabolism | Liver Cirrhosis, Experimental - immunology | Liver - metabolism | Mice, Inbred C57BL | Fatty Liver - prevention & control | Toll-Like Receptor 4 - genetics | Genotype | Thiobarbituric Acid Reactive Substances - metabolism | Transforming Growth Factor beta1 - genetics | Liver Cirrhosis, Experimental - genetics | Mice, Knockout | Triglycerides - metabolism | Matrix Metalloproteinase 2 - genetics | Tissue Inhibitor of Metalloproteinase-1 - genetics | Phenotype | Animals | Fatty Liver - immunology | Mice | Lipid Peroxidation | Liver Cirrhosis, Experimental - metabolism | Fibrosis | Physiological aspects | Toll-like receptors | Development and progression | Research | Muscle proteins | Hypothesis testing | Carbohydrates | Disease | Liver | Rodents | Bone marrow | Cell division | Index Medicus | Liver and Biliary Tract
Journal Article
World Journal of Gastroenterology, ISSN 1007-9327, 11/2018, Volume 24, Issue 42, pp. 4759 - 4772
Journal Article
Journal Article