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Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 09/2012, Volume 143, Issue 3, pp. 765 - 776.e3
Background & Aims Interleukin (IL)-17 signaling has been implicated in lung and skin fibrosis. We examined the role of IL-17 signaling in the pathogenesis of... 
Gastroenterology and Hepatology | Immune Response | Myofibroblast | Bone Marrow-Derived Macrophages | Mouse Model | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Kupffer Cells - pathology | Liver - pathology | Carbon Tetrachloride | Humans | Transforming Growth Factor beta1 - metabolism | Hepatic Stellate Cells - metabolism | Receptors, Interleukin-17 - genetics | Interleukin-23 - genetics | Receptors, Interleukin-17 - deficiency | Interleukins - genetics | Liver Cirrhosis, Experimental - prevention & control | Liver - immunology | Time Factors | Bone Marrow Transplantation | Liver Cirrhosis, Alcoholic - immunology | Interleukin-6 - metabolism | STAT3 Transcription Factor - genetics | Interleukin-17 - administration & dosage | Liver Cirrhosis, Experimental - immunology | Signal Transduction | Liver Cirrhosis, Alcoholic - pathology | Liver - metabolism | Interleukin-17 - genetics | Genotype | Bile Ducts - surgery | Disease Progression | Mice, Knockout | Interleukin-17 - metabolism | Phenotype | Interleukins - deficiency | Mice | Liver Cirrhosis, Experimental - metabolism | Tumor Necrosis Factor-alpha - metabolism | Inflammation Mediators - administration & dosage | Liver Cirrhosis, Experimental - etiology | Interleukin-23 - deficiency | Ligation | Hepatic Stellate Cells - immunology | Inflammation Mediators - metabolism | STAT3 Transcription Factor - deficiency | Liver Cirrhosis, Experimental - pathology | Kupffer Cells - metabolism | Hepatic Stellate Cells - pathology | Cell Line | Interleukin-1 - metabolism | Collagen Type I - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Interleukin-17 - deficiency | Liver Cirrhosis, Experimental - genetics | Animals | Interleukins - administration & dosage | Kupffer Cells - immunology | Medical colleges | Liver diseases | Liver | Carbon tetrachloride | Transforming growth factors | Muscle proteins | Macrophages | Endothelium | Messenger RNA | Interleukins | Actin | Analysis | Collagen | Fibrosis | Liver cirrhosis | Index Medicus | Abridged Index Medicus
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 05/2014, Volume 146, Issue 5, pp. 1339 - 1350.e1
Background & Aims Vascular endothelial growth factor (VEGF)−induced angiogenesis is implicated in fibrogenesis and portal hypertension. However, the function... 
Gastroenterology and Hepatology | Extracellular Matrix | Sinusoidal Endothelial Cell | Liver Damage | Hepatic Sinusoid | Keywords | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Antibodies, Neutralizing - administration & dosage | Liver - pathology | Capillary Permeability | Human Umbilical Vein Endothelial Cells - metabolism | Carbon Tetrachloride | Coculture Techniques | Humans | Monocytes - metabolism | Monocytes - immunology | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Vascular Endothelial Growth Factor A - genetics | fas Receptor - metabolism | Liver Cirrhosis, Experimental - prevention & control | Liver - immunology | Ligation | Cholecystostomy | Adenoviridae - genetics | Liver Cirrhosis, Experimental - pathology | Macrophages - immunology | Tacrolimus Binding Protein 1A - genetics | Gene Transfer Techniques | Promoter Regions, Genetic | Liver Regeneration | Liver Cirrhosis, Experimental - immunology | Jejunostomy | Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Receptor, Macrophage Colony-Stimulating Factor - genetics | Mice, Transgenic | Vascular Endothelial Growth Factor A - immunology | Bile Ducts - surgery | Liver Cirrhosis, Experimental - genetics | Remission Induction | Matrix Metalloproteinase 13 - metabolism | Injections | Macrophages - metabolism | Animals | Chemokine CXCL9 - metabolism | Liver Cirrhosis, Experimental - chemically induced | Tacrolimus Binding Protein 1A - metabolism | Mice | Genetic Vectors | Liver Cirrhosis, Experimental - metabolism | Apoptosis | Hypertension | Medical colleges | Vascular endothelial growth factor | Health aspects | Fibrosis | Index Medicus | Abridged Index Medicus
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 08/2012, Volume 122, Issue 8, pp. 2884 - 2897
Journal Article
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 04/2012, Volume 142, Issue 4, pp. 938 - 946
Background & Aims The pathogenesis of liver fibrosis involves activation of hepatic stellate cells, which is associated with depletion of intracellular lipid... 
Gastroenterology and Hepatology | Inflammation | Myofibroblasts | Energy Depletion | Mouse Model | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Liver - pathology | Kidney - pathology | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Carbon Tetrachloride | Humans | Hepatic Stellate Cells - metabolism | Autophagy - drug effects | Idiopathic Pulmonary Fibrosis - metabolism | Kidney - metabolism | Epoxy Compounds - pharmacology | Liver - drug effects | RNA Interference | Adenosine Triphosphate - metabolism | Liver Cirrhosis, Experimental - pathology | Lung - metabolism | Autophagy - genetics | Microtubule-Associated Proteins - deficiency | Hepatic Stellate Cells - pathology | Fibroblasts - metabolism | Hepatic Stellate Cells - drug effects | Cell Line | Lung - pathology | Oleic Acid - metabolism | Adenine - analogs & derivatives | Liver - metabolism | Mice, Inbred C57BL | Adenine - pharmacology | Liver Cirrhosis, Experimental - genetics | Fibroblasts - pathology | Mice, Knockout | Thioacetamide | Autophagy-Related Protein 7 | Animals | Autophagy-Related Protein 5 | Energy Metabolism | Fibroblasts - drug effects | Liver Cirrhosis, Experimental - chemically induced | Lipid Metabolism - drug effects | Idiopathic Pulmonary Fibrosis - pathology | Mice | Liver Cirrhosis, Experimental - metabolism | Phosphates | Medical colleges | Neurosciences | Platelet-derived growth factor | Liver diseases | Albumin | Lipids | Muscle proteins | Fatty acids | Cells | Monosaccharides | Unsaturated fatty acids | Monounsaturated fatty acids | Actin | Analysis | Intermediate filament proteins | Sugars | Index Medicus | Abridged Index Medicus
Journal Article
Hepatology (Baltimore, Md.), ISSN 0270-9139, 12/2012, Volume 56, Issue 6, pp. 2255 - 2267
Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC). However, the mechanism underlying the progression from cirrhosis to HCC remains unclear... 
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Rats, Wistar | TOR Serine-Threonine Kinases - metabolism | Humans | Glycoproteins - metabolism | Liver Neoplasms, Experimental - chemically induced | Male | MicroRNAs - metabolism | Proto-Oncogene Proteins c-akt - genetics | Antigens, CD - metabolism | Epithelial Cell Adhesion Molecule | Pluripotent Stem Cells - pathology | Liver Neoplasms, Experimental - metabolism | Peptides - metabolism | Neoplastic Stem Cells - metabolism | Diethylnitrosamine | Liver Cirrhosis - metabolism | Antigens, Neoplasm - metabolism | Biomarkers, Tumor - metabolism | Antigens, Differentiation - metabolism | Liver Neoplasms, Experimental - pathology | Proto-Oncogene Proteins c-akt - metabolism | STAT3 Transcription Factor - metabolism | Liver - metabolism | Mice, Inbred C57BL | PTEN Phosphohydrolase - metabolism | Rats | Mice, SCID | AC133 Antigen | Cell Adhesion Molecules - metabolism | Cell Transformation, Neoplastic - metabolism | Pluripotent Stem Cells - metabolism | Thy-1 Antigens - metabolism | Transforming Growth Factor beta - pharmacology | Animals | Pluripotent Stem Cells - drug effects | Liver Cirrhosis - pathology | Mice, Inbred NOD | Mice | Cell Transformation, Neoplastic - pathology | Transforming Growth Factor beta - metabolism | Proteins | Liver cancer | Liver cirrhosis | Hepatology | Index Medicus
Journal Article
Cell metabolism, ISSN 1550-4131, 07/2012, Volume 16, Issue 1, pp. 44 - 54
Journal Article
European journal of pharmacology, ISSN 0014-2999, 2008, Volume 595, Issue 1, pp. 69 - 77
Three important features must be considered when proposing therapeutic strategies in liver cirrhosis... 
Gastrointestinal and urogenital pharmacology | Pirfenidone | Experimental liver | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Proto-Oncogene Proteins c-met - metabolism | Liver - pathology | Superoxide Dismutase - genetics | Liver - enzymology | Rats, Wistar | Carbon Tetrachloride | Liver Cirrhosis, Experimental - etiology | Nitrites - metabolism | NF-kappa B - metabolism | Alanine Transaminase - blood | Liver Cirrhosis, Experimental - prevention & control | Liver Cirrhosis, Experimental - enzymology | Collagen Type I - genetics | Ligation | Liver - drug effects | Hepatocyte Growth Factor - genetics | Liver Cirrhosis, Experimental - pathology | Common Bile Duct - surgery | Superoxide Dismutase - metabolism | Malondialdehyde - metabolism | Collagen Type I - metabolism | Catalase - genetics | Rats | Antioxidants - pharmacology | Onium Compounds - pharmacology | Hepatocyte Growth Factor - metabolism | Proto-Oncogene Proteins c-met - genetics | Catalase - metabolism | Bilirubin - blood | Animals | Transforming Growth Factor beta - genetics | Aspartate Aminotransferases - blood | Nitric Oxide Synthase Type II - genetics | Oxidative Stress - drug effects | Transforming Growth Factor beta - metabolism | Pyridones - pharmacology | Nitric Oxide Synthase Type II - metabolism | Antioxidants | Analysis | Carbon tetrachloride | Superoxide dismutase | Transforming growth factors | Gene expression | Liver cirrhosis | Index Medicus
Journal Article
Gastroenterology, ISSN 0016-5085, 2012, Volume 142, Issue 3, pp. 612 - 621.e5
...). Methods We analyzed liver samples from patients with hepatitis C–associated cirrhosis and healthy individuals (controls... 
Gastroenterology and Hepatology | Liver Disease | Intercellular Communication | Mouse Model | Fibers | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Liver - virology | Up-Regulation | Liver - pathology | Cell Proliferation | Carbon Tetrachloride | Coculture Techniques | Humans | Hepatic Stellate Cells - metabolism | Male | RNA, Messenger - metabolism | Liver - drug effects | Time Factors | Hepatitis C - complications | Hepatic Stellate Cells - drug effects | Endothelial Cells - metabolism | Extracellular Matrix Proteins - genetics | Liver - metabolism | Proteoglycans - metabolism | Rats | Liver Cirrhosis, Biliary - pathology | Mice, Knockout | Chemical and Drug Induced Liver Injury - metabolism | Liver Cirrhosis - pathology | Mice | Oxidative Stress - drug effects | Endothelial Cells - pathology | Liver Cirrhosis, Experimental - metabolism | Proteoglycans - genetics | Cell Movement | Extracellular Matrix Proteins - deficiency | Actins - metabolism | Hepatocytes - pathology | Hepatocytes - metabolism | Case-Control Studies | Proteoglycans - deficiency | Transfection | Liver Cirrhosis - metabolism | Liver Cirrhosis, Experimental - pathology | Hepatic Stellate Cells - virology | Chemical and Drug Induced Liver Injury - pathology | Liver Cirrhosis - genetics | Chemical and Drug Induced Liver Injury - etiology | Extracellular Matrix Proteins - metabolism | Hepatic Stellate Cells - pathology | Fibromodulin | Collagen Type I - metabolism | Mice, Inbred C57BL | Antioxidants - pharmacology | Hep G2 Cells | Thioacetamide | Liver - blood supply | Animals | Liver Cirrhosis - virology | Liver Cirrhosis, Experimental - chemically induced | Liver Cirrhosis, Biliary - metabolism | Immunohistochemistry | Liver diseases | Actin | Analysis | Liver | Collagen | Muscle proteins | Index Medicus | Abridged Index Medicus
Journal Article