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Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 09/2012, Volume 143, Issue 3, pp. 765 - 776.e3
Background & Aims Interleukin (IL)-17 signaling has been implicated in lung and skin fibrosis. We examined the role of IL-17 signaling in the pathogenesis of... 
Gastroenterology and Hepatology | Immune Response | Myofibroblast | Bone Marrow-Derived Macrophages | Mouse Model | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Kupffer Cells - pathology | Liver - pathology | Carbon Tetrachloride | Humans | Transforming Growth Factor beta1 - metabolism | Hepatic Stellate Cells - metabolism | Receptors, Interleukin-17 - genetics | Interleukin-23 - genetics | Receptors, Interleukin-17 - deficiency | Interleukins - genetics | Liver Cirrhosis, Experimental - prevention & control | Liver - immunology | Time Factors | Bone Marrow Transplantation | Liver Cirrhosis, Alcoholic - immunology | Interleukin-6 - metabolism | STAT3 Transcription Factor - genetics | Interleukin-17 - administration & dosage | Liver Cirrhosis, Experimental - immunology | Signal Transduction | Liver Cirrhosis, Alcoholic - pathology | Liver - metabolism | Interleukin-17 - genetics | Genotype | Bile Ducts - surgery | Disease Progression | Mice, Knockout | Interleukin-17 - metabolism | Phenotype | Interleukins - deficiency | Mice | Liver Cirrhosis, Experimental - metabolism | Tumor Necrosis Factor-alpha - metabolism | Inflammation Mediators - administration & dosage | Liver Cirrhosis, Experimental - etiology | Interleukin-23 - deficiency | Ligation | Hepatic Stellate Cells - immunology | Inflammation Mediators - metabolism | STAT3 Transcription Factor - deficiency | Liver Cirrhosis, Experimental - pathology | Kupffer Cells - metabolism | Hepatic Stellate Cells - pathology | Cell Line | Interleukin-1 - metabolism | Collagen Type I - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Interleukin-17 - deficiency | Liver Cirrhosis, Experimental - genetics | Animals | Interleukins - administration & dosage | Kupffer Cells - immunology | Medical colleges | Liver diseases | Liver | Carbon tetrachloride | Transforming growth factors | Muscle proteins | Macrophages | Endothelium | Messenger RNA | Interleukins | Actin | Analysis | Collagen | Fibrosis | Liver cirrhosis | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 09/2012, Volume 143, Issue 3, pp. 646 - 654
Journal Article
American journal of physiology: Gastrointestinal and liver physiology, ISSN 1522-1547, 12/2009, Volume 297, Issue 6, pp. G1093 - G1106
Myofibroblastic hepatic stellate cells (MF-HSC) are derived from quiescent hepatic stellate cells (Q-HSC). Q-HSC express certain epithelial cell markers and... 
Regeneration | Proliferation | Bone morphogenetic protein-7 | Cyclopamine | Fibrosis | Gastroenterology & Hepatology | Physiology | Life Sciences & Biomedicine | Science & Technology | Liver - pathology | Cell Proliferation | Epithelial Cells - metabolism | Carbon Tetrachloride | Epithelial Cells - drug effects | Humans | Hedgehog Proteins - metabolism | Hepatic Stellate Cells - metabolism | Male | Cell Transdifferentiation - genetics | RNA, Messenger - metabolism | Hedgehog Proteins - genetics | Liver - drug effects | Time Factors | Cell Transdifferentiation - drug effects | Veratrum Alkaloids - pharmacology | Liver Cirrhosis, Experimental - pathology | Hepatic Stellate Cells - pathology | Fibroblasts - metabolism | Hepatic Stellate Cells - drug effects | Liver Regeneration | Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Rats | Epithelial Cells - pathology | Signal Transduction - genetics | Hedgehog Proteins - antagonists & inhibitors | Liver Cirrhosis, Experimental - genetics | Fibroblasts - pathology | Rats, Sprague-Dawley | Animals | Signal Transduction - drug effects | Fibroblasts - drug effects | Liver Cirrhosis, Experimental - chemically induced | Mice | Liver Cirrhosis, Experimental - metabolism | Physiological aspects | Development and progression | Genetic aspects | Cellular signal transduction | Research | Liver cirrhosis | Liver cells | Proteins | Molecules | Transitions | Rodents | Liver | Ribonucleic acid--RNA | Cells | Index Medicus | fibrosis | bone morphogenetic protein-7 | proliferation | regeneration | Liver and Biliary Tract | cyclopamine
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 04/2012, Volume 142, Issue 4, pp. 938 - 946
Background & Aims The pathogenesis of liver fibrosis involves activation of hepatic stellate cells, which is associated with depletion of intracellular lipid... 
Gastroenterology and Hepatology | Inflammation | Myofibroblasts | Energy Depletion | Mouse Model | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Liver - pathology | Kidney - pathology | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Carbon Tetrachloride | Humans | Hepatic Stellate Cells - metabolism | Autophagy - drug effects | Idiopathic Pulmonary Fibrosis - metabolism | Kidney - metabolism | Epoxy Compounds - pharmacology | Liver - drug effects | RNA Interference | Adenosine Triphosphate - metabolism | Liver Cirrhosis, Experimental - pathology | Lung - metabolism | Autophagy - genetics | Microtubule-Associated Proteins - deficiency | Hepatic Stellate Cells - pathology | Fibroblasts - metabolism | Hepatic Stellate Cells - drug effects | Cell Line | Lung - pathology | Oleic Acid - metabolism | Adenine - analogs & derivatives | Liver - metabolism | Mice, Inbred C57BL | Adenine - pharmacology | Liver Cirrhosis, Experimental - genetics | Fibroblasts - pathology | Mice, Knockout | Thioacetamide | Autophagy-Related Protein 7 | Animals | Autophagy-Related Protein 5 | Energy Metabolism | Fibroblasts - drug effects | Liver Cirrhosis, Experimental - chemically induced | Lipid Metabolism - drug effects | Idiopathic Pulmonary Fibrosis - pathology | Mice | Liver Cirrhosis, Experimental - metabolism | Phosphates | Medical colleges | Neurosciences | Platelet-derived growth factor | Liver diseases | Albumin | Lipids | Muscle proteins | Fatty acids | Cells | Monosaccharides | Unsaturated fatty acids | Monounsaturated fatty acids | Actin | Analysis | Intermediate filament proteins | Sugars | Index Medicus | Abridged Index Medicus
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 05/2006, Volume 203, Issue 5, pp. 1209 - 1219
Primary biliary cirrhosis (PBC) is an autoimmune disease with a strong genetic component characterized by biliary ductular inflammation with eventual liver cirrhosis... 
Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Inflammation - pathology | CD8-Positive T-Lymphocytes - pathology | Quantitative Trait Loci - immunology | Dihydrolipoyllysine-Residue Acetyltransferase - immunology | Humans | Cholangitis - immunology | Mitochondrial Proteins - genetics | Adoptive Transfer | CD4-Positive T-Lymphocytes - pathology | Autoimmune Diseases - genetics | CD4-Positive T-Lymphocytes - immunology | Liver Cirrhosis, Biliary - immunology | Dihydrolipoyllysine-Residue Acetyltransferase - genetics | Liver Cirrhosis, Experimental - pathology | Autoimmune Diseases - pathology | Cholangitis - pathology | Disease Models, Animal | Granuloma - genetics | Liver Cirrhosis, Experimental - immunology | Cholangitis - genetics | Autoimmune Diseases - immunology | Mice, Transgenic | Chromosome Mapping | Inflammation - immunology | Protein Structure, Tertiary - genetics | Liver Cirrhosis, Biliary - pathology | Liver Cirrhosis, Experimental - genetics | Liver Cirrhosis, Biliary - genetics | Mice, SCID | Granuloma - pathology | Autoantibodies - immunology | Animals | CD4-Positive T-Lymphocytes - transplantation | CD3 Complex - immunology | Inflammation - genetics | Granuloma - immunology | Mice, Inbred NOD | Mice | Mice, Congenic | CD8-Positive T-Lymphocytes - immunology | Mitochondrial Proteins - immunology | Quantitative Trait Loci - genetics | Index Medicus
Journal Article
Gastroenterology, ISSN 0016-5085, 2012, Volume 142, Issue 3, pp. 612 - 621.e5
...). Methods We analyzed liver samples from patients with hepatitis C–associated cirrhosis and healthy individuals (controls... 
Gastroenterology and Hepatology | Liver Disease | Intercellular Communication | Mouse Model | Fibers | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Liver - virology | Up-Regulation | Liver - pathology | Cell Proliferation | Carbon Tetrachloride | Coculture Techniques | Humans | Hepatic Stellate Cells - metabolism | Male | RNA, Messenger - metabolism | Liver - drug effects | Time Factors | Hepatitis C - complications | Hepatic Stellate Cells - drug effects | Endothelial Cells - metabolism | Extracellular Matrix Proteins - genetics | Liver - metabolism | Proteoglycans - metabolism | Rats | Liver Cirrhosis, Biliary - pathology | Mice, Knockout | Chemical and Drug Induced Liver Injury - metabolism | Liver Cirrhosis - pathology | Mice | Oxidative Stress - drug effects | Endothelial Cells - pathology | Liver Cirrhosis, Experimental - metabolism | Proteoglycans - genetics | Cell Movement | Extracellular Matrix Proteins - deficiency | Actins - metabolism | Hepatocytes - pathology | Hepatocytes - metabolism | Case-Control Studies | Proteoglycans - deficiency | Transfection | Liver Cirrhosis - metabolism | Liver Cirrhosis, Experimental - pathology | Hepatic Stellate Cells - virology | Chemical and Drug Induced Liver Injury - pathology | Liver Cirrhosis - genetics | Chemical and Drug Induced Liver Injury - etiology | Extracellular Matrix Proteins - metabolism | Hepatic Stellate Cells - pathology | Fibromodulin | Collagen Type I - metabolism | Mice, Inbred C57BL | Antioxidants - pharmacology | Hep G2 Cells | Thioacetamide | Liver - blood supply | Animals | Liver Cirrhosis - virology | Liver Cirrhosis, Experimental - chemically induced | Liver Cirrhosis, Biliary - metabolism | Immunohistochemistry | Liver diseases | Actin | Analysis | Liver | Collagen | Muscle proteins | Index Medicus | Abridged Index Medicus
Journal Article
American journal of physiology: Gastrointestinal and liver physiology, ISSN 1522-1547, 03/2010, Volume 298, Issue 3, pp. G323 - G334
Studies have suggested the reversibility of liver fibrosis, but the mechanisms of fibrosis reversal are poorly understood. We investigated the possible... 
Animal model | Collagenase | Gelatinase | Matrix metalloproteinase | Bile duct | Cirrhosis | Kupffer cell | Integrin αvβ6 | Collagen | PDGF | Transforming growth factor-β | Extracellular matrix | Zymography | Tissue inhibitor of matrix metalloproteinases | Hepatic stellate cell | Liver fibrosis resolution | Repair | Urokinase plasminogen activator receptor-1 | Phagocyte | Gastroenterology & Hepatology | Physiology | Life Sciences & Biomedicine | Science & Technology | Bile Ducts, Extrahepatic - surgery | Liver - pathology | Gene Expression - genetics | Male | Liver Cirrhosis, Biliary - surgery | Cell Movement - physiology | Collagen Type I - genetics | Ligation | Gelatinases - metabolism | Liver Cirrhosis, Experimental - surgery | Liver Cirrhosis, Experimental - pathology | Plasminogen Activator Inhibitor 1 - genetics | Macrophages - physiology | Cell Line | Bile Ducts, Intrahepatic - pathology | Anastomosis, Roux-en-Y | Macrophages - pathology | Liver - metabolism | Cells, Cultured | Phagocytosis - physiology | Rats | Liver Cirrhosis, Biliary - pathology | Rats, Sprague-Dawley | Down-Regulation - genetics | Macrophages - enzymology | Collagen - metabolism | Tissue Inhibitor of Metalloproteinase-1 - genetics | Animals | Transforming Growth Factor beta - genetics | Models, Biological | Mice | Apoptosis - physiology | Integrin beta Chains - genetics | Matrix Metalloproteinases - metabolism | Collagenases - metabolism | Liver Cirrhosis, Biliary - metabolism | Liver Cirrhosis, Experimental - metabolism | Physiological aspects | Research | Macrophages | Risk factors | Phagocytosis | Fibrosis | Leucocytes | Peptides | Rodents | Gene expression | Cells | Apoptosis | Bile | Index Medicus | repair | urokinase plasminogen activator receptor-1 | liver fibrosis resolution | collagen | Liver and Biliary Tract | phagocyte | zymography | collagenase | integrin αvβ6 | tissue inhibitor of matrix metalloproteinases | transforming growth factor-β | bile duct | gelatinase | matrix metalloproteinase | hepatic stellate cell | animal model | cirrhosis | extracellular matrix
Journal Article