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Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 2009, Volume 85, Issue 3, pp. 401 - 407
Acute liver failure in infancy accompanied by lactic acidemia was previously shown to result from mtDNA depletion. We report on 13 unrelated infants who... 
MITOCHONDRIAL-DNA DEPLETION | PROTEIN | CULTURED HUMAN-CELLS | GENETICS & HEREDITY | 1ST YEAR | TRANSFER-RNA | BINDING | LIFE | Chromosome mapping | Usage | Liver failure | Gene mutations | Human genome | RNA | Analysis | Causes of | Genetic aspects | Research | Report
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2010, Volume 107, Issue 19, pp. 8766 - 8771
Hepatitis B virus (HBV)-associated acute liver failure (ALF) is a dramatic clinical syndrome due to a sudden loss of hepatic cells leading to multiorgan... 
T lymphocytes | Hepatocytes | B lymphocytes | Hepatitis antigens | Liver | Kupffer cells | Plasma cells | Antibodies | Hepatitis B virus | Hepatitis B | Fulminant hepatitis B | Phage display fab library | B cell immunity | Gene expression profiling | Pathogenesis | ACTIVATION | PROTEIN | phage display Fab library | FULMINANT VIRAL-HEPATITIS | MEMBRANE | MULTIDISCIPLINARY SCIENCES | NEGATIVE REGULATOR | FAMILY | pathogenesis | fulminant hepatitis B | REJECTION | DISEASE | INFECTION | gene expression profiling | T-CELLS | Immunohistochemistry | Liver - virology | Liver - pathology | Humans | Hepatitis B - virology | Liver Failure, Acute - virology | Complement System Proteins - immunology | Gene Expression Profiling | Hepatitis B - blood | Necrosis - pathology | Necrosis - virology | T-Lymphocytes - virology | Necrosis - immunology | Young Adult | Hepatitis B - immunology | Liver - immunology | Immunoglobulin G - biosynthesis | Liver Failure, Acute - genetics | B-Lymphocytes - virology | Hepatitis B virus - immunology | Disease Progression | Hepatitis B Core Antigens - immunology | Cell Lineage | B-Lymphocytes - immunology | Liver Failure, Acute - immunology | T-Lymphocytes - immunology | Hepatitis B Antibodies - biosynthesis | Cluster Analysis | Immunoglobulin M - biosynthesis | Liver Failure, Acute - blood | Antigens | Care and treatment | Liver failure | Immunoglobulin G | Physiological aspects | Development and progression | Genetic aspects | B cells | Properties | Gene expression | Biological Sciences
Journal Article
Journal of Inherited Metabolic Disease, ISSN 0141-8955, 1/2016, Volume 39, Issue 1, pp. 3 - 16
Journal Article
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 01/2014, Volume 20, Issue 2, pp. 24 - 216
Journal Article
Gastroenterology, ISSN 0016-5085, 2010, Volume 139, Issue 3, pp. 828 - 835.e3
Journal Article
Apoptosis, ISSN 1360-8185, 7/2012, Volume 17, Issue 7, pp. 702 - 716
Acute liver failure (ALF) still has an unacceptable high mortality rate, despite substantial improvements with multidisciplinary care. The precise underlying... 
Biochemistry, general | Acute liver failure | miR-16 | Biomedicine | miRNAs | BCL2 | Oncology | Cancer Research | miR-15b | Cell Biology | Virology | Apoptosis | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INJURY | NECROSIS-FACTOR-ALPHA | MECHANISMS | MICRORNAS | GENE ONTOLOGY | CELL BIOLOGY | TARGETING BCL2 | STELLATE CELL | FULMINANT HEPATIC-FAILURE | GALACTOSAMINE-SENSITIZED MICE | Immunohistochemistry | Tumor Necrosis Factor-alpha - metabolism | Liver - pathology | Oligonucleotide Array Sequence Analysis | 3' Untranslated Regions - genetics | Molecular Sequence Data | Apoptosis - genetics | Hepatocytes - pathology | Male | MicroRNAs - metabolism | Gene Expression Profiling | Hepatocytes - metabolism | RNA, Messenger - metabolism | Gene Knockdown Techniques | Proto-Oncogene Proteins c-bcl-2 - metabolism | Flow Cytometry | Liver Failure, Acute - genetics | Base Sequence | Inflammation Mediators - metabolism | Liver - metabolism | RNA, Messenger - genetics | Computational Biology | Up-Regulation - genetics | Down-Regulation - genetics | Animals | Liver Failure, Acute - pathology | Mice | Mice, Inbred BALB C | MicroRNAs - genetics | Proto-Oncogene Proteins c-bcl-2 - genetics | Tumor Necrosis Factor-alpha - biosynthesis | Liver failure | MicroRNA | Liver diseases | Tumor necrosis factor | Analysis | Genes | Cross infection | Nosocomial infections | Histochemistry
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2016, Volume 11, Issue 8, p. e0156738
Background & Aims The etiology of acute liver failure (ALF) remains elusive in almost half of affected children. We hypothesized that inherited mitochondrial... 
DIAGNOSIS | MITOCHONDRIAL-DNA DEPLETION | RIBONUCLEOTIDE REDUCTASE SUBUNIT | MULTIDISCIPLINARY SCIENCES | DISEASE | ACAD9 | CHOLESTASIS | COMPLEX I DEFICIENCY | MOLECULAR CHARACTERISTICS | MUTATIONS | P53R2 | Liver - pathology | Humans | Liver - metabolism | Child, Preschool | Infant | Male | Liver Failure, Acute - metabolism | Mitochondria - metabolism | Mitochondria - pathology | Genetic Variation | DNA, Mitochondrial - genetics | Energy Metabolism | Mitochondria - genetics | Liver Failure, Acute - genetics | Liver Failure, Acute - pathology | Adolescent | Female | High-Throughput Nucleotide Sequencing | Retrospective Studies | Mutation | Child | Infant, Newborn | Energy metabolism | Liver failure | Care and treatment | Bioenergetics | Patient outcomes | Mitochondrial diseases | Research | Risk factors | Pediatrics | Phosphorylation | Dehydrogenases | Disease | Liver | Genes | Insertion | Pyruvic acid | Mitochondrial DNA | Gene sequencing | Mitochondria | Ribonucleotide reductase | Metabolites | Etiology | Hepatology | Gastroenterology | Genetics | Oxidation | Children | Lactic acidosis | Deoxyribonucleic acid--DNA | Liver diseases | Biochemical analysis | Nutrition | Metabolism | Electron microscopy | Patients | Fatty acids | Steatosis | Genetic variance | Pathology | Hospitals | Hepatocytes | Nitric oxide | Lactic acid | Electron transport | Acidosis | Deoxyribonucleic acid | DNA
Journal Article
Liver International, ISSN 1478-3223, 07/2015, Volume 35, Issue 7, pp. 1877 - 1885
Background & Aims Acute liver failure (ALF) is a condition with high mortality and morbidity. Fibrosis in chronic liver disease was extensively researched,... 
high mobility group box 1 | fibrosis | hepatic stellate cell | autophagy | acute liver failure | hepatitis B virus | High mobility group box 1 | Acute liver failure | Hepatic stellate cell | Hepatitis B virus | Autophagy | Fibrosis | ACTIVATION | REGENERATION | INJURY | FIBROGENESIS | HMGB1 | HEPATIC STELLATE CELLS | DISEASES | MOBILITY GROUP BOX-1 | GASTROENTEROLOGY & HEPATOLOGY | Liver - virology | Predictive Value of Tests | Liver - pathology | Prospective Studies | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Actins - metabolism | Liver Failure, Acute - virology | Hepatic Stellate Cells - metabolism | Actins - genetics | Hepatitis B - complications | Collagen Type I - genetics | Liver Failure, Acute - genetics | Hepatic Stellate Cells - virology | Liver Cirrhosis - genetics | Hepatic Stellate Cells - pathology | Liver Cirrhosis - diagnosis | Collagen Type I - metabolism | Signal Transduction | Liver - metabolism | Cells, Cultured | Liver Failure, Acute - diagnosis | Rats | Liver Cirrhosis - blood | Biomarkers - blood | Disease Progression | Hepatitis B - diagnosis | Animals | Liver Cirrhosis - virology | Biopsy | Liver Failure, Acute - pathology | Liver Cirrhosis - pathology | Elasticity Imaging Techniques | HMGB1 Protein - blood | Liver Failure, Acute - blood | Hepatitis | Liver failure | RNA | Collagen | Analysis | Mortality | Health aspects | Liver Fibrosis
Journal Article