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Science Translational Medicine, ISSN 1946-6234, 03/2011, Volume 3, Issue 73, pp. 73ra21 - 73ra21
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2012, Volume 122, Issue 8, pp. 2871 - 2883
miR-122, an abundant liver-specific microRNA (miRNA), regulates cholesterol metabolism and promotes hepatitis C virus (HCV) replication. Reduced miR-122... 
MICRORNA BINDING | MEDICINE, RESEARCH & EXPERIMENTAL | HEPATOCELLULAR-CARCINOMA | LIPID-METABOLISM | IN-VIVO | GENE-EXPRESSION | MICE | STEATOHEPATITIS | DIFFERENTIATION | HEPATIC STEATOSIS | CANCER | MicroRNAs - therapeutic use | Liver - pathology | Cell Proliferation | MicroRNAs - antagonists & inhibitors | Fatty Liver - pathology | Humans | Cell Survival - genetics | MicroRNAs - metabolism | Liver Neoplasms - therapy | Monocytes - immunology | Genes, myc | Mice, 129 Strain | RNA, Neoplasm - metabolism | Liver Neoplasms, Experimental - metabolism | Liver - immunology | Base Sequence | Carcinoma, Hepatocellular - genetics | Lipids - blood | Monocytes - pathology | Lipid Metabolism - genetics | Liver Neoplasms, Experimental - genetics | 3' Untranslated Regions | Genes, Tumor Suppressor | Neutrophils - pathology | Fatty Liver - genetics | Gene Expression | Fatty Liver - metabolism | Liver Neoplasms - genetics | Liver - metabolism | Neutrophils - immunology | Liver Neoplasms, Experimental - etiology | Mice, Knockout | Animals | Liver Neoplasms - metabolism | RNA, Neoplasm - genetics | Carcinoma, Hepatocellular - therapy | Mice | MicroRNAs - genetics | Cytokines - biosynthesis | Carcinoma, Hepatocellular - metabolism | Fatty Liver - etiology | Liver diseases | MicroRNA | Anti-inflammatory drugs | Tumor necrosis factor | Physiological aspects | Hepatitis C virus | Cholesterol | Tumors | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2012, Volume 122, Issue 8, pp. 2884 - 2897
Journal Article
by Fu, X and Meng, Z and Liang, W and Tian, Y and Wang, X and Han, W and Lou, G and Wang, X and Lou, F and Yen, Y and Yu, H and Jove, R and Huang, W
Oncogene, ISSN 0950-9232, 08/2014, Volume 33, Issue 34, pp. 4296 - 4306
Human cancers often exhibit attenuated microRNA (miRNA) biogenesis and global underexpression of miRNAs; thus, targeting the miRNA biogenesis pathway... 
Zcchc11 | miR-26a | miRNA biogenesis | tumorigenesis | let-7 | metastasis | TRANSFORMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | HMGA2 | PROLIFERATION | MATURATION | CELL BIOLOGY | REGULATOR | ONCOLOGY | GENETICS & HEREDITY | ABSENCE | BLOCKADE | MICRORNA EXPRESSION | Neoplasm Transplantation | Prostatic Neoplasms - metabolism | RNA-Binding Proteins - genetics | Colorectal Neoplasms - genetics | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Male | Melanoma, Experimental - metabolism | DNA-Binding Proteins - metabolism | Liver Neoplasms, Experimental - metabolism | Prostatic Neoplasms - genetics | Lung Neoplasms - secondary | RNA Interference | Female | Liver Neoplasms, Experimental - genetics | Liver Neoplasms, Experimental - pathology | Colorectal Neoplasms - metabolism | Lung Neoplasms - genetics | Prostatic Neoplasms - pathology | Melanoma, Experimental - pathology | MicroRNAs - biosynthesis | Tumor Burden | DNA-Binding Proteins - genetics | Mice, SCID | Animals | Melanoma, Experimental - genetics | Cell Line, Tumor | Mice, Inbred NOD | Mice | MicroRNAs - genetics | MicroRNAs - physiology | RNA-Binding Proteins - metabolism | Apoptosis | MicroRNA | Melanoma | Physiological aspects | Genetic aspects | Biosynthesis | Research | Metastasis | Biology | Ribonucleic acid--RNA | Genes | Tumors | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2012, Volume 122, Issue 8, pp. 2911 - 2915
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 09/2014, Volume 20, Issue 10, pp. 1138 - 1146
In solid tumors, resistance to therapy inevitably develops upon treatment with cytotoxic drugs or molecularly targeted therapies. Here, we describe a system... 
PATHWAYS | MEDICINE, RESEARCH & EXPERIMENTAL | HEPATOCELLULAR-CARCINOMA | INTEGRATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENES | SENSITIVITY | KINASE INHIBITORS | MAP KINASES | JAK/STAT | STRATEGIES | CELL BIOLOGY | Niacinamide - analogs & derivatives | RNA, Small Interfering - genetics | Mitogen-Activated Protein Kinase 14 - antagonists & inhibitors | Humans | Male | Liver Neoplasms, Experimental - metabolism | Carcinoma, Hepatocellular - drug therapy | Mitogen-Activated Protein Kinase 14 - metabolism | RNA Interference | Carcinoma, Hepatocellular - genetics | Female | Antineoplastic Agents - pharmacology | Liver Neoplasms, Experimental - genetics | Liver Neoplasms - genetics | Signal Transduction | Mice, Inbred C57BL | Liver Neoplasms - drug therapy | Mitogen-Activated Protein Kinase 14 - genetics | Activating Transcription Factor 2 - metabolism | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | MAP Kinase Signaling System - drug effects | Liver Neoplasms, Experimental - drug therapy | Liver Neoplasms - metabolism | Mice | Phenylurea Compounds - pharmacology | Protein Kinase Inhibitors - pharmacology | Niacinamide - pharmacology | Carcinoma, Hepatocellular - metabolism | Liver cancer | Research | Drug therapy | Drug resistance | Analysis | Biomarkers | Signal transduction | Protein expression | Pharmacology | Ribonucleic acid--RNA | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2013, Volume 123, Issue 7, pp. 2907 - 2920
Metabolic reprogramming is an important driver of tumor progression; however, the metabolic regulators of tumor cell motility and metastasis are not... 
MEDICINE, RESEARCH & EXPERIMENTAL | HSP90 | HOMEOSTASIS | ACTIVATED PROTEIN-KINASE | PHOSPHORYLATION | GROWTH | FIP200 | AMPK | AUTOPHAGY | DIFFERENTIATION | LKB1 | Liver Neoplasms, Experimental - secondary | NIH 3T3 Cells | Neoplasm Transplantation | RNA, Small Interfering - genetics | Phosphorylation | Lung Neoplasms - mortality | Humans | Lung Neoplasms - metabolism | Stress, Physiological | Bone Neoplasms - secondary | Guanidines - pharmacology | Lung Neoplasms - pathology | Intracellular Signaling Peptides and Proteins - metabolism | Autophagy-Related Protein-1 Homolog | Bone Neoplasms - metabolism | Gene Knockdown Techniques | Liver Neoplasms, Experimental - metabolism | Carcinoma, Non-Small-Cell Lung - secondary | Adenylate Kinase - metabolism | Female | Antineoplastic Agents - pharmacology | HSP90 Heat-Shock Proteins - genetics | Mitochondrial Membranes - enzymology | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Carcinoma, Non-Small-Cell Lung - metabolism | Kaplan-Meier Estimate | Protein-Serine-Threonine Kinases - genetics | Mitochondria - metabolism | Lactams, Macrocyclic - pharmacology | Mice, SCID | Carcinoma, Non-Small-Cell Lung - mortality | Animals | Cell Line, Tumor | Cytoskeleton - metabolism | HSP90 Heat-Shock Proteins - metabolism | Mice | Protein Processing, Post-Translational | Hexokinase - metabolism | Cell Movement | Cancer cells | Physiological aspects | Cytoskeleton | Stress (Physiology) | Metastasis | Research | Health aspects | Motility | Kinases | Experiments | Patients | Cell adhesion & migration | Cell growth | Mitochondria | Microscopy | Protein folding | Laboratory animals | Tumors | Cancer | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2013, Volume 123, Issue 2, pp. 630 - 645
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2009, Volume 51, Issue 4, pp. 725 - 733
Background/Aims The success of sorafenib in the treatment of advanced hepatocellular carcinoma (HCC) has focused interest on the role of Ras signaling in this... 
Gastroenterology and Hepatology | Molecular therapies | mTOR | Liver cancer | HCV | Signaling pathway | Ras | PROMOTER HYPERMETHYLATION | SUPPRESSOR | SIGNALING PATHWAYS | RASSF1A | ABERRANT METHYLATION | INACTIVATION | MOLECULAR CLASSIFICATION | GENE | HIGH-FREQUENCY | GASTROENTEROLOGY & HEPATOLOGY | NORE1A | Niacinamide - analogs & derivatives | Neoplasm Transplantation | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Humans | ras Proteins - metabolism | Transplantation, Heterologous | Phenylurea Compounds | Benzenesulfonates - administration & dosage | Promoter Regions, Genetic - drug effects | RNA, Messenger - metabolism | RNA, Neoplasm - metabolism | Liver Neoplasms, Experimental - metabolism | Gene Dosage - drug effects | Carcinoma, Hepatocellular - drug therapy | Carcinoma, Hepatocellular - genetics | Female | Liver Neoplasms - pathology | Genes, ras - drug effects | Liver Neoplasms, Experimental - genetics | Liver Neoplasms, Experimental - pathology | Protein Kinases - drug effects | Pyridines - administration & dosage | Liver Neoplasms - genetics | RNA, Messenger - genetics | Liver Neoplasms - drug therapy | Drug Synergism | Sirolimus - administration & dosage | Animals | Liver Neoplasms, Experimental - drug therapy | Signal Transduction - drug effects | Mice, Nude | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | RNA, Neoplasm - genetics | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | DNA Methylation - drug effects | Carcinoma, Hepatocellular - metabolism | Antimitotic agents | Oncology, Experimental | Analysis | Genetic research | Transplantation of organs, tissues, etc | Hepatoma | Research | Hepatitis C | Antineoplastic agents | Cancer | Index Medicus
Journal Article