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Journal of Clinical Investigation, ISSN 0021-9738, 12/2008, Volume 118, Issue 12, pp. 3943 - 3953
Journal Article
Gut, ISSN 0017-5749, 12/2012, Volume 61, Issue 12, pp. 1733 - 1743
Background Hepatocellular carcinoma (HCC) is a typical inflammation-associated cancer, but may also provoke antitumour immune responses whose significance and... 
FIBROSIS | HEPATOCELLULAR-CARCINOMA PATIENTS | GENE-EXPRESSION | INNATE | MONOCYTES | RECEPTOR | GASTROENTEROLOGY & HEPATOLOGY | NF-KAPPA-B | T-CELLS | MOUSE MODELS | HEPATOCARCINOGENESIS | Carcinoma, Hepatocellular - chemically induced | Carcinoma, Hepatocellular - mortality | Oligonucleotide Array Sequence Analysis | Humans | Liver Neoplasms, Experimental - chemically induced | Liver Neoplasms - chemically induced | Male | Liver Neoplasms - mortality | Liver Neoplasms, Experimental - immunology | Carcinogens | Diethylnitrosamine | Liver Neoplasms - pathology | Precancerous Conditions - pathology | Carcinoma, Hepatocellular - immunology | Chemokine CCL2 - metabolism | Chemokine CCL5 - metabolism | Liver Neoplasms, Experimental - pathology | B-Lymphocytes - metabolism | Adaptive Immunity | Biomarkers - metabolism | Mice, Inbred C57BL | Liver Neoplasms - immunology | Disease Progression | Mice, Knockout | Macrophages - metabolism | Animals | Precancerous Conditions - immunology | T-Lymphocytes, Cytotoxic - metabolism | Chemokine CXCL9 - metabolism | Carcinoma, Hepatocellular - pathology | Survival Analysis | Mice | Precancerous Conditions - chemically induced | Leukocytes - metabolism | Liver cancer | Development and progression | Prognosis | Immune response | Research | Genes | Mortality | Cytotoxicity | T cell receptors | Inflammation | Hepatitis | Lymphocytes | Rodents | Medical prognosis | Bone marrow | Regulation | Mutation | Chemokines | Immune system | Tumors | Index Medicus | Abridged Index Medicus
Journal Article
The EMBO Journal, ISSN 0261-4189, 05/2012, Volume 31, Issue 9, pp. 2076 - 2089
Journal Article
Hepatology, ISSN 0270-9139, 01/2012, Volume 55, Issue 1, pp. 108 - 120
Hepatitis B virus X (HBx) protein is implicated in hepatitis B virus (HBV)‐associated liver carcinogenesis. However, it remains unclear whether HBx‐expressing... 
LIVER-CANCER | HEPATOCELLULAR-CARCINOMA CELLS | PROTEIN | RAT | DISEASE | CATENIN | STEM/PROGENITOR CELLS | MOUSE-LIVER | OVAL CELLS | GASTROENTEROLOGY & HEPATOLOGY | CANCER STEM-CELLS | Bile Duct Neoplasms - chemically induced | Carcinoma, Hepatocellular - chemically induced | Cholangiocarcinoma - chemically induced | Humans | Middle Aged | Liver Neoplasms, Experimental - chemically induced | Male | Cell Transformation, Neoplastic - chemically induced | Cholangiocarcinoma - virology | Bile Duct Neoplasms - physiopathology | Liver Neoplasms, Experimental - physiopathology | Trans-Activators - genetics | Bile Ducts, Intrahepatic | Female | Gene Expression Regulation, Neoplastic - drug effects | Gene Expression Regulation, Neoplastic - physiology | Disease Models, Animal | Stem Cells - virology | Bile Duct Neoplasms - virology | Carcinoma, Hepatocellular - physiopathology | Cholangiocarcinoma - physiopathology | Liver Neoplasms, Experimental - virology | Mice, Inbred C57BL | Mice, Transgenic | Carcinoma, Hepatocellular - virology | Mice, SCID | Animals | Pyridines - toxicity | Signal Transduction - drug effects | Stem Cells - drug effects | Mice, Inbred NOD | Signal Transduction - physiology | Stem Cells - physiology | Trans-Activators - metabolism | Mice | Hepatitis | Liver cancer | Transgenic animals | Rodents | Tumors | Index Medicus
Journal Article
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 06/2015, Volume 93, pp. 27 - 36
At present, the treatment of hepatocellular carcinoma (HCC) is an international problem. The delivery of a chemotherapeutic agent and chemosensitizer using... 
Co-delivery lipid nanoparticles | Multidrug resistance | Tumor growth inhibition | Hepatocellular carcinoma | Curcumin | Synergistic effect | Doxorubicin | MOLECULAR-MECHANISM | CANCER-CELLS | THERAPEUTICS | APOPTOSIS | OVERCOME MULTIDRUG-RESISTANCE | DRUG-RESISTANCE | HYPOXIA | CHEMOTHERAPY | HEPATOCARCINOGENESIS | PHARMACOLOGY & PHARMACY | CHEMORESISTANCE | Carcinoma, Hepatocellular - chemically induced | Apoptosis - drug effects | Curcumin - chemistry | Humans | Gene Expression Regulation, Neoplastic | Liver Neoplasms, Experimental - chemically induced | Neovascularization, Pathologic | Drug Resistance, Neoplasm | Male | Doxorubicin - chemistry | Curcumin - administration & dosage | Drug Carriers | Dose-Response Relationship, Drug | Nanoparticles | Liver Neoplasms, Experimental - metabolism | Antineoplastic Agents, Phytogenic - administration & dosage | Lipids - chemistry | Carcinoma, Hepatocellular - drug therapy | Antibiotics, Antineoplastic - chemistry | Time Factors | Carcinoma, Hepatocellular - genetics | Diethylnitrosamine | Biomarkers, Tumor - metabolism | Liver Neoplasms, Experimental - genetics | Liver Neoplasms, Experimental - pathology | Nanomedicine | Doxorubicin - administration & dosage | Solubility | Antineoplastic Agents, Phytogenic - chemistry | Technology, Pharmaceutical - methods | Chemistry, Pharmaceutical | Antibiotics, Antineoplastic - administration & dosage | Drug Synergism | Particle Size | Animals | Liver Neoplasms, Experimental - drug therapy | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Biomarkers, Tumor - genetics | Cell Proliferation - drug effects | Mice | Delayed-Action Preparations | Drug Combinations | Carcinoma, Hepatocellular - metabolism | Anthracyclines | Index Medicus
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2012, Volume 57, Issue 4, pp. 803 - 812
Background & Aims Due to its anatomic connection, the liver is constantly exposed to gut-derived bacterial products or metabolites. Disruption of gut... 
Gastroenterology and Hepatology | Probiotics | Hepatocellular carcinoma | Gut homeostasis | Endotoxin | CHRONIC LIVER-DISEASE | INTESTINAL FLORA | BARRIER FUNCTION | IL-6 PRODUCTION | HUMAN FECES | BACTERIAL TRANSLOCATION | REAL-TIME PCR | GROUP-SPECIFIC PRIMERS | GASTROENTEROLOGY & HEPATOLOGY | PREDOMINANT BACTERIA | Diethylnitrosamine - pharmacology | Diethylnitrosamine - toxicity | Endotoxins - blood | Alkylating Agents - pharmacology | Humans | Liver Neoplasms, Experimental - chemically induced | Male | Gastroenteritis - drug therapy | Lactobacillus - drug effects | HMGB1 Protein - metabolism | Carcinoma, Hepatocellular - etiology | Carcinoma, Hepatocellular - blood | Homeostasis - drug effects | Liver Neoplasms, Experimental - microbiology | Liver Neoplasms, Experimental - pathology | Penicillins - pharmacology | Dextran Sulfate - pharmacology | Endotoxins - metabolism | Liver Cirrhosis - complications | Gastrointestinal Tract - physiopathology | Gastrointestinal Tract - microbiology | Rats | Liver Cirrhosis - blood | Probiotics - pharmacology | Rats, Sprague-Dawley | Disease Progression | Bifidobacterium - drug effects | Animals | Carcinoma, Hepatocellular - pathology | Gastroenteritis - chemically induced | Gastroenteritis - metabolism | Probiotics - therapeutic use | Anti-Bacterial Agents - pharmacology | Enterococcus - drug effects | Cytokines - biosynthesis | Dextran | Liver cancer | International cooperation | Chromosomal proteins | Metabolites | Genes | Homeostasis | Transplantation of organs, tissues, etc | Sulfates | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2015, Volume 125, Issue 6, pp. 2445 - 2457
Journal Article
Cancer Research, ISSN 0008-5472, 11/2014, Volume 74, Issue 21, pp. 6184 - 6193
Journal Article
Cancer Research, ISSN 0008-5472, 11/2011, Volume 71, Issue 21, pp. 6888 - 6898
Despite the role of aerobic glycolysis in cancer, recent studies highlight the importance of the mitochondria and biosynthetic pathways as well. PPAR gamma... 
BREAST-CANCER | ESTROGEN-RELATED RECEPTOR | OXIDATIVE-PHOSPHORYLATION | FATTY-ACID SYNTHESIS | ONCOLOGY | ERR-ALPHA | NUCLEAR RECEPTORS | PGC-1 | PPAR-GAMMA | CELL-GROWTH | ENERGY-METABOLISM | Neoplasm Transplantation | Colonic Neoplasms - genetics | Colonic Neoplasms - prevention & control | Humans | Liver Neoplasms, Experimental - chemically induced | Colonic Neoplasms - chemically induced | Cell Line, Tumor - transplantation | Liver Neoplasms, Experimental - prevention & control | Acetyl-CoA Carboxylase - genetics | Trans-Activators - physiology | Fatty Acid Synthases - biosynthesis | Organic Anion Transporters - genetics | Lipogenesis - genetics | Cell Transformation, Neoplastic - genetics | Carcinoma, Hepatocellular - genetics | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Trans-Activators - genetics | Liver Neoplasms - pathology | Cell Line, Tumor - metabolism | Fatty Acid Synthases - genetics | Fatty Acids - metabolism | Gene Expression Regulation, Neoplastic - genetics | Liver Neoplasms - genetics | Oxidative Phosphorylation | Mitochondria - metabolism | Mice, SCID | Mice, Knockout | Citric Acid Cycle - genetics | Animals | Trans-Activators - deficiency | Colonic Neoplasms - pathology | Carcinoma, Hepatocellular - pathology | Acetyl-CoA Carboxylase - biosynthesis | Mice | Transcription Factors | Organic Anion Transporters - biosynthesis | Index Medicus | oxidative metabolism | Warburg Effect | lipogenesis | Cancer metabolism | transcriptional regulation
Journal Article
Cell, ISSN 0092-8674, 2007, Volume 130, Issue 6, pp. 1120 - 1133
Coordination of cell proliferation and cell death is essential to attain proper organ size during development and for maintaining tissue homeostasis throughout... 
DEVBIO | SIGNALING | YES-ASSOCIATED PROTEIN | APOPTOSIS | DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | TUMOR-SUPPRESSOR | YAP | MICE | CELL | CANCER | CELL BIOLOGY | Protein Kinases - metabolism | Phosphorylation | Cell Proliferation | Large Neutral Amino Acid-Transporter 1 - metabolism | Humans | Liver Neoplasms, Experimental - chemically induced | Homeostasis | Cytoplasm - metabolism | Drosophila Proteins - metabolism | Doxorubicin | Drosophila - enzymology | Liver Neoplasms, Experimental - metabolism | Cell Nucleus - metabolism | Transfection | Trans-Activators - genetics | Active Transport, Cell Nucleus | Liver Neoplasms, Experimental - pathology | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Drosophila - genetics | Cell Line | Mammals - metabolism | Mammals - growth & development | Signal Transduction | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Intracellular Signaling Peptides and Proteins | Organ Size | Drosophila - cytology | Mice, Transgenic | Nuclear Proteins - metabolism | Transcription Factors - genetics | Serine - metabolism | Transcription Factors - metabolism | Animals | Liver Neoplasms, Experimental - enzymology | Trans-Activators - metabolism | Drosophila - growth & development | Mice | Drosophila - metabolism | Drosophila Proteins - genetics | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Apoptosis | Drosophila | Knowledge-based systems | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2018, Volume 13, Issue 10, pp. e0204909 - e0204909
RAP1, a component of the telomere-protective shelterin complex, has been shown to have both telomeric and non-telomeric roles. In the liver, RAP1 is involved... 
PPAR-ALPHA | METABOLIC SYNDROME | CARCINOGENESIS | TELOMERE DYSFUNCTION | MAMMALIAN TELOMERES | MULTIDISCIPLINARY SCIENCES | LIVER | GENE-EXPRESSION | PROLIFERATOR-ACTIVATED RECEPTOR |