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Journal of Clinical Investigation, ISSN 0021-9738, 07/2013, Volume 123, Issue 7, pp. 2907 - 2920
Metabolic reprogramming is an important driver of tumor progression; however, the metabolic regulators of tumor cell motility and metastasis are not... 
CROSS-TALK | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | HOMEOSTASIS | PROTEIN | PHOSPHORYLATION | KINASE | GROWTH | AMPK | AUTOPHAGY | LKB1 | Liver Neoplasms, Experimental - secondary | NIH 3T3 Cells | Neoplasm Transplantation | RNA, Small Interfering - genetics | Phosphorylation | Lung Neoplasms - mortality | Humans | Lung Neoplasms - metabolism | Stress, Physiological | Bone Neoplasms - secondary | Guanidines - pharmacology | Lung Neoplasms - pathology | Intracellular Signaling Peptides and Proteins - metabolism | Autophagy-Related Protein-1 Homolog | Bone Neoplasms - metabolism | Gene Knockdown Techniques | Liver Neoplasms, Experimental - metabolism | Carcinoma, Non-Small-Cell Lung - secondary | Adenylate Kinase - metabolism | Female | Antineoplastic Agents - pharmacology | HSP90 Heat-Shock Proteins - genetics | Mitochondrial Membranes - enzymology | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Carcinoma, Non-Small-Cell Lung - metabolism | Kaplan-Meier Estimate | Protein-Serine-Threonine Kinases - genetics | Mitochondria - metabolism | Lactams, Macrocyclic - pharmacology | Mice, SCID | Carcinoma, Non-Small-Cell Lung - mortality | Animals | Cell Line, Tumor | Cytoskeleton - metabolism | HSP90 Heat-Shock Proteins - metabolism | Mice | Protein Processing, Post-Translational | Hexokinase - metabolism | Cell Movement | Cancer cells | Physiological aspects | Cytoskeleton | Stress (Physiology) | Metastasis | Research | Health aspects | Motility | Kinases | Experiments | Patients | Cell adhesion & migration | Cell growth | Mitochondria | Microscopy | Protein folding | Laboratory animals | Tumors | Cancer
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 04/2013, Volume 73, Issue 7, pp. 2322 - 2332
Journal Article
Science Translational Medicine, ISSN 1946-6234, 06/2014, Volume 6, Issue 242, pp. 242ra84 - 242ra84
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2013, Volume 59, Issue 3, pp. 518 - 527
Journal Article
Cancer Cell, ISSN 1535-6108, 2010, Volume 18, Issue 1, pp. 23 - 38
Neuroendocrine (NE) phenotype, seen in >30% of prostate adenocarcinomas (PCa), and NE prostate tumors are implicated in aggressive prostate cancer. Formation... 
CELLCYCLE | TRANSCRIPTION FACTORS | HYPOXIA-INDUCIBLE FACTOR | STEM-CELLS | TRANSGENIC ADENOCARCINOMA | ONCOLOGY | MOUSE | CELL-PROLIFERATION | DIFFERENTIATION | MODEL | SIAH UBIQUITIN LIGASE | CANCER | Neurosecretory Systems - pathology | Liver Neoplasms, Experimental - secondary | Prostatic Neoplasms - metabolism | Adenocarcinoma - pathology | Hepatocyte Nuclear Factor 3-beta - genetics | Humans | Lung Neoplasms - metabolism | Transcriptional Activation | Gene Expression Regulation, Neoplastic | Male | Ubiquitin-Protein Ligases - physiology | Prostate - metabolism | Liver Neoplasms, Experimental - metabolism | Prostate - pathology | Adenocarcinoma - metabolism | Prostatic Neoplasms - genetics | Lung Neoplasms - secondary | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Neurosecretory Systems - metabolism | Female | Adenocarcinoma - genetics | Liver Neoplasms, Experimental - genetics | Hepatocyte Nuclear Factor 3-beta - metabolism | Lung Neoplasms - genetics | Neuroendocrine Tumors - pathology | Prostatic Neoplasms - pathology | Signal Transduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Neuroendocrine Tumors - metabolism | Mice, Inbred C57BL | Mice, Transgenic | Lymphatic Metastasis | Mice, Knockout | Neuroendocrine Tumors - genetics | Phenotype | Animals | Cell Line, Tumor | Mice | Tumors
Journal Article
Journal Article
International Journal of Cancer, ISSN 0020-7136, 09/2014, Volume 135, Issue 6, pp. 1487 - 1496
Regorafenib, a novel multikinase inhibitor, has recently demonstrated overall survival benefits in metastatic colorectal cancer (CRC) patients. Our study aimed... 
regorafenib | CRC | multikinase inhibitor | antimetastasis | antitumorigenesis | MULTICENTER | METASTASIS | BEVACIZUMAB | RECEPTOR | COLON | CHEMOTHERAPY | PHASE-II TRIAL | ONCOLOGY | IRINOTECAN | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | Liver Neoplasms, Experimental - secondary | Humans | Drug Resistance, Neoplasm | Male | Organoplatinum Compounds - pharmacology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Liver Neoplasms, Experimental - metabolism | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Neoplasm Metastasis | Colorectal Neoplasms - drug therapy | Camptothecin - administration & dosage | Female | Colorectal Neoplasms - metabolism | Camptothecin - analogs & derivatives | Pyridines - administration & dosage | Cell Growth Processes - drug effects | Mice, Inbred C57BL | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Random Allocation | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Xenograft Model Antitumor Assays | Animals | Liver Neoplasms, Experimental - drug therapy | Phenylurea Compounds - administration & dosage | Mice, Nude | Cell Line, Tumor | Mice | Phenylurea Compounds - pharmacology | Pyridines - pharmacology | Colorectal Neoplasms - pathology | Vascular Endothelial Growth Factor Receptor-3 - antagonists & inhibitors | Immunohistochemistry | Models | Vascular endothelial growth factor | Analysis | Colorectal cancer | Cancer therapies | Metastasis | Cancer Therapy
Journal Article
Journal Article
Science, ISSN 0036-8075, 2018, Volume 360, Issue 6394, pp. 1202 - 1202
The majority of patients with pancreatic ductal adenocarcinoma (PDA) develop metastatic disease after resection of their primary tumor. We found that livers... 
MHC CLASS-I | UNFOLDED PROTEIN RESPONSE | MICROMETASTATIC CARCINOMA-CELLS | INHIBITION | DUCTAL ADENOCARCINOMA | IMMUNOTHERAPY | MULTIDISCIPLINARY SCIENCES | TUMOR-CELLS | DORMANCY | EXPRESSION | T-CELLS | Carcinoma, Pancreatic Ductal - secondary | Endoribonucleases - genetics | Tumor Escape | Neoplasms, Experimental - secondary | Humans | Lymphocyte Depletion | Endoplasmic Reticulum Stress - immunology | Neoplasms, Experimental - immunology | Neoplasms, Experimental - genetics | Liver Neoplasms - secondary | Carcinoma, Pancreatic Ductal - immunology | Protein-Serine-Threonine Kinases - metabolism | Endoribonucleases - metabolism | Mice, Inbred C57BL | Pancreatic Neoplasms - pathology | Protein-Serine-Threonine Kinases - genetics | Liver Neoplasms - immunology | Animals | Genetic Engineering | X-Box Binding Protein 1 - metabolism | Pancreatic Neoplasms - immunology | T-Lymphocytes - immunology | Genes, MHC Class I | Mice | Keratin-19 - metabolism | X-Box Binding Protein 1 - genetics | Adenocarcinoma | Bone grafts | Cytokeratin | CD8 antigen | Liver | Metastasis | Immunity | Gene sequencing | Metastases | Proteins | Genotype & phenotype | Surgery | Stress response | Stresses | Enzymes | Inositol | Injection | Patients | Survival | Molecular chains | Latency | Organic chemistry | Major histocompatibility complex | Immunogenicity | Pancreatic cancer | Endoplasmic reticulum | Histocompatibility | Cell proliferation | Animal models | Lymphocytes T | Activation | Kinases | Cell surface | Lymphocytes | Protein folding | Lesions | Immune system | Phenotypes | Immune response | Pharmacology | Ribonucleic acid--RNA | Stress | Depletion | Protein kinase | Cell death | Genetic engineering | Cancer | Tumors
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2011, Volume 121, Issue 11, pp. 4526 - 4536
Colorectal cancer is the second leading cause of death from cancer in the United States. Metastases in the liver, the most common metastatic site for... 
COLON-CANCER | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | FAMILY-MEMBERS | ADENOCARCINOMA | S100P | 3G APOBEC3G | MICRORNA EXPRESSION | TUMORS | CD133 | Liver | Colorectal cancer | Cancer cells | Development and progression | Genetic aspects | Metastasis | Research | Gene expression
Journal Article
Gastroenterology, ISSN 0016-5085, 2008, Volume 135, Issue 3, pp. 956 - 968
Journal Article