Biomaterials, ISSN 0142-9612, 2016, Volume 105, pp. 195 - 205
Abstract Extracellular vesicles (EV), including exosomes and microvesicles, are nano-sized intercellular communication vehicles that participate in a multitude...
Advanced Basic Science | Dentistry | Dextran sulfate | Scavenger receptor | Drug delivery | Reticuloendothelial system | Exosomes | Biodistribution | CLASS-A | CLEARANCE | ACTIVATION | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | IL-15 | B16BL6-DERIVED EXOSOMES | INJECTION | INTERLEUKIN-15 | IL-15R-ALPHA | Neoplasms, Experimental - ultrastructure | Extracellular Vesicles - ultrastructure | Humans | Cell Fractionation - methods | Cells, Cultured | Equipment Design | Tissue Engineering - instrumentation | Macrophages - metabolism | Bioreactors | HEK293 Cells | Extracellular Vesicles - physiology | Batch Cell Culture Techniques - instrumentation | Batch Cell Culture Techniques - methods | Cell Fractionation - instrumentation | Dextran | Chemotherapy | Interleukins | Liver | Research institutes | Molecular biology | Sulfates | Health aspects | Cancer | Blood proteins | Drugs | Medical research | Drug delivery systems | Vehicles | Medicine, Experimental | Receptors | Vesicles | Cytokines | Clearances | Macrophages | Culture | Tumors
Advanced Basic Science | Dentistry | Dextran sulfate | Scavenger receptor | Drug delivery | Reticuloendothelial system | Exosomes | Biodistribution | CLASS-A | CLEARANCE | ACTIVATION | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | IL-15 | B16BL6-DERIVED EXOSOMES | INJECTION | INTERLEUKIN-15 | IL-15R-ALPHA | Neoplasms, Experimental - ultrastructure | Extracellular Vesicles - ultrastructure | Humans | Cell Fractionation - methods | Cells, Cultured | Equipment Design | Tissue Engineering - instrumentation | Macrophages - metabolism | Bioreactors | HEK293 Cells | Extracellular Vesicles - physiology | Batch Cell Culture Techniques - instrumentation | Batch Cell Culture Techniques - methods | Cell Fractionation - instrumentation | Dextran | Chemotherapy | Interleukins | Liver | Research institutes | Molecular biology | Sulfates | Health aspects | Cancer | Blood proteins | Drugs | Medical research | Drug delivery systems | Vehicles | Medicine, Experimental | Receptors | Vesicles | Cytokines | Clearances | Macrophages | Culture | Tumors
Journal Article
WORLD JOURNAL OF GASTROENTEROLOGY, ISSN 1007-9327, 01/2016, Volume 22, Issue 1, pp. 300 - 325
The multifactorial and multistage pathogenesis of hepatocellular carcinoma (HCC) has fascinated a wide spectrum of scientists for decades. While a number of...
LARGE ENVELOPE POLYPEPTIDE | SURFACE-ANTIGEN GENE | BREAKAGE SYNDROME GENE | Hepatocellular carcinoma | NONALCOHOLIC STEATOHEPATITIS | T-CELL TOLERANCE | Haploinsufficiency | S-ADENOSYLMETHIONINE | GROWTH-FACTOR-BETA | Mouse models | X PROTEIN TARGETS | Tumor suppressor genes | MOLECULAR PATHOGENESIS | Hepatitis B virus | GASTROENTEROLOGY & HEPATOLOGY | NF-KAPPA-B | Liver Neoplasms - virology | Liver Neoplasms - genetics | Hepatitis B virus - pathogenicity | Humans | Liver Neoplasms, Experimental - virology | Risk Factors | Mice, Transgenic | Carcinoma, Hepatocellular - virology | Signal Transduction - genetics | Liver Neoplasms, Experimental - ultrastructure | Cocarcinogenesis | Animals | Carcinoma, Hepatocellular - genetics | Hepatitis B virus - genetics | Liver Neoplasms, Experimental - genetics | Mice | Carcinoma, Hepatocellular - ultrastructure | Genes, Tumor Suppressor | Topic Highlight
LARGE ENVELOPE POLYPEPTIDE | SURFACE-ANTIGEN GENE | BREAKAGE SYNDROME GENE | Hepatocellular carcinoma | NONALCOHOLIC STEATOHEPATITIS | T-CELL TOLERANCE | Haploinsufficiency | S-ADENOSYLMETHIONINE | GROWTH-FACTOR-BETA | Mouse models | X PROTEIN TARGETS | Tumor suppressor genes | MOLECULAR PATHOGENESIS | Hepatitis B virus | GASTROENTEROLOGY & HEPATOLOGY | NF-KAPPA-B | Liver Neoplasms - virology | Liver Neoplasms - genetics | Hepatitis B virus - pathogenicity | Humans | Liver Neoplasms, Experimental - virology | Risk Factors | Mice, Transgenic | Carcinoma, Hepatocellular - virology | Signal Transduction - genetics | Liver Neoplasms, Experimental - ultrastructure | Cocarcinogenesis | Animals | Carcinoma, Hepatocellular - genetics | Hepatitis B virus - genetics | Liver Neoplasms, Experimental - genetics | Mice | Carcinoma, Hepatocellular - ultrastructure | Genes, Tumor Suppressor | Topic Highlight
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 08/2016, Volume 190, pp. 1 - 12
Shen-Ling-Bai-Zhu Powder (SLBZP) is a classic traditional Chinese medical formula that has been used for several decades in the treatment of patients with...
H22 hepatocellular carcinoma | Chemotherapy | Platelet-derived growth factor | Bcl-2, Bcl-XL | Caspase-9 | Shen-Ling-Bai-Zhu powder | Survivin | Akt | Caspase-3 | Apoptosis | Nuclear factor kappa B | H | Platelet-derivedgrowthfactor | NuclearfactorkappaB | hepatocellular carcinoma | Angiogenic Proteins - genetics | Apoptosis - drug effects | Gene Expression Regulation, Neoplastic | Drugs, Chinese Herbal - pharmacology | Male | Liver Neoplasms, Experimental - ultrastructure | RNA, Messenger - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Liver Neoplasms, Experimental - metabolism | Carcinoma, Hepatocellular - drug therapy | Time Factors | Carcinoma, Hepatocellular - genetics | Apoptosis Regulatory Proteins - genetics | Biomarkers, Tumor - metabolism | Female | Liver Neoplasms, Experimental - genetics | Carcinoma, Hepatocellular - ultrastructure | RNA, Messenger - genetics | Cisplatin - pharmacology | Apoptosis Regulatory Proteins - metabolism | Animals | Liver Neoplasms, Experimental - drug therapy | Signal Transduction - drug effects | Tumor Burden - drug effects | Cell Line, Tumor | Biomarkers, Tumor - genetics | Mice | Antineoplastic Agents, Phytogenic - pharmacology | Angiogenic Proteins - metabolism | Carcinoma, Hepatocellular - metabolism
H22 hepatocellular carcinoma | Chemotherapy | Platelet-derived growth factor | Bcl-2, Bcl-XL | Caspase-9 | Shen-Ling-Bai-Zhu powder | Survivin | Akt | Caspase-3 | Apoptosis | Nuclear factor kappa B | H | Platelet-derivedgrowthfactor | NuclearfactorkappaB | hepatocellular carcinoma | Angiogenic Proteins - genetics | Apoptosis - drug effects | Gene Expression Regulation, Neoplastic | Drugs, Chinese Herbal - pharmacology | Male | Liver Neoplasms, Experimental - ultrastructure | RNA, Messenger - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Liver Neoplasms, Experimental - metabolism | Carcinoma, Hepatocellular - drug therapy | Time Factors | Carcinoma, Hepatocellular - genetics | Apoptosis Regulatory Proteins - genetics | Biomarkers, Tumor - metabolism | Female | Liver Neoplasms, Experimental - genetics | Carcinoma, Hepatocellular - ultrastructure | RNA, Messenger - genetics | Cisplatin - pharmacology | Apoptosis Regulatory Proteins - metabolism | Animals | Liver Neoplasms, Experimental - drug therapy | Signal Transduction - drug effects | Tumor Burden - drug effects | Cell Line, Tumor | Biomarkers, Tumor - genetics | Mice | Antineoplastic Agents, Phytogenic - pharmacology | Angiogenic Proteins - metabolism | Carcinoma, Hepatocellular - metabolism
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 09/2010, Volume 27, Issue 9, pp. 1939 - 1948
Purpose Hepatocellular carcinoma (HCC) is a prevalent solid malignancy. Critically needed discovery of new therapeutics has been hindered by lack of an in...
chitosan | scaffolds | drug resistance | tumor microenvironment | hepatocellular carcinoma in vitro model | ANGIOGENESIS | PROTECTION | EFFICACY | DOXORUBICIN | CANCER | TUMORS | CHEMISTRY, MULTIDISCIPLINARY | LESIONS | GLYPICAN-3 EXPRESSION | GROWTH | PHARMACOLOGY & PHARMACY | CELL | Biocompatible Materials - chemistry | Humans | Drug Resistance, Neoplasm | Male | Liver Neoplasms, Experimental - ultrastructure | Cell Culture Techniques - methods | Neovascularization, Pathologic - pathology | Tissue Scaffolds - chemistry | Liver Neoplasms, Experimental - metabolism | Antineoplastic Agents - pharmacology | Glucuronic Acid - chemistry | Cell Survival - drug effects | Microscopy, Electron, Scanning | Liver Neoplasms, Experimental - blood supply | Hexuronic Acids - chemistry | Xenograft Model Antitumor Assays - methods | Animals | Chitosan - chemistry | Liver Neoplasms, Experimental - drug therapy | Mice, Nude | Neovascularization, Pathologic - drug therapy | Alginates - chemistry | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Neovascularization, Pathologic - metabolism | Doxorubicin - pharmacology | Liver cancer | Anthracyclines | Care and treatment | Analysis | Neovascularization | Hepatoma | Drug resistance | Cancer | Cell culture | Pharmacology | Models | Liver diseases
chitosan | scaffolds | drug resistance | tumor microenvironment | hepatocellular carcinoma in vitro model | ANGIOGENESIS | PROTECTION | EFFICACY | DOXORUBICIN | CANCER | TUMORS | CHEMISTRY, MULTIDISCIPLINARY | LESIONS | GLYPICAN-3 EXPRESSION | GROWTH | PHARMACOLOGY & PHARMACY | CELL | Biocompatible Materials - chemistry | Humans | Drug Resistance, Neoplasm | Male | Liver Neoplasms, Experimental - ultrastructure | Cell Culture Techniques - methods | Neovascularization, Pathologic - pathology | Tissue Scaffolds - chemistry | Liver Neoplasms, Experimental - metabolism | Antineoplastic Agents - pharmacology | Glucuronic Acid - chemistry | Cell Survival - drug effects | Microscopy, Electron, Scanning | Liver Neoplasms, Experimental - blood supply | Hexuronic Acids - chemistry | Xenograft Model Antitumor Assays - methods | Animals | Chitosan - chemistry | Liver Neoplasms, Experimental - drug therapy | Mice, Nude | Neovascularization, Pathologic - drug therapy | Alginates - chemistry | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Neovascularization, Pathologic - metabolism | Doxorubicin - pharmacology | Liver cancer | Anthracyclines | Care and treatment | Analysis | Neovascularization | Hepatoma | Drug resistance | Cancer | Cell culture | Pharmacology | Models | Liver diseases
Journal Article
Bulletin of Experimental Biology and Medicine, ISSN 0007-4888, 7/2018, Volume 165, Issue 3, pp. 390 - 393
Structural changes in the liver of CBA mice were studied during the development of experimental hepatocarcinoma-29 inoculated into the hip. A decrease in the...
Biomedicine, general | Pathology | Biomedicine | Internal Medicine | Laboratory Medicine | impaired structure of hepatocytes | distant tumor growth | Cell Biology | non-selective autophagy | MEDICINE, RESEARCH & EXPERIMENTAL | PHYSIOLOGY | LIVER | THERAPEUTIC TARGETS | MECHANISMS | CANCER | Hepatocytes - pathology | Male | Liver Neoplasms, Experimental - ultrastructure | Autophagy | Mitochondria - ultrastructure | Endoplasmic Reticulum - ultrastructure | Endoplasmic Reticulum - pathology | Lipid Droplets - ultrastructure | Mice, Inbred CBA | Lysosomes - pathology | Carcinoma, Hepatocellular - ultrastructure | Liver Neoplasms, Experimental - pathology | Lipid Droplets - pathology | Injections, Intramuscular | Mitochondria - pathology | Microscopy, Electron | Autophagosomes - pathology | Autophagosomes - ultrastructure | Lysosomes - ultrastructure | Animals | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Hepatocytes - ultrastructure | Mice | Muscle, Skeletal | Glycogen | Tumors | Liver | Ribosomes | Homeostasis | Phagosomes | Lysosomes | Electron microscopy | Hip | Mitochondria | Hepatocytes | Intracellular | Endoplasmic reticulum | Cytoplasm | Phagocytosis
Biomedicine, general | Pathology | Biomedicine | Internal Medicine | Laboratory Medicine | impaired structure of hepatocytes | distant tumor growth | Cell Biology | non-selective autophagy | MEDICINE, RESEARCH & EXPERIMENTAL | PHYSIOLOGY | LIVER | THERAPEUTIC TARGETS | MECHANISMS | CANCER | Hepatocytes - pathology | Male | Liver Neoplasms, Experimental - ultrastructure | Autophagy | Mitochondria - ultrastructure | Endoplasmic Reticulum - ultrastructure | Endoplasmic Reticulum - pathology | Lipid Droplets - ultrastructure | Mice, Inbred CBA | Lysosomes - pathology | Carcinoma, Hepatocellular - ultrastructure | Liver Neoplasms, Experimental - pathology | Lipid Droplets - pathology | Injections, Intramuscular | Mitochondria - pathology | Microscopy, Electron | Autophagosomes - pathology | Autophagosomes - ultrastructure | Lysosomes - ultrastructure | Animals | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Hepatocytes - ultrastructure | Mice | Muscle, Skeletal | Glycogen | Tumors | Liver | Ribosomes | Homeostasis | Phagosomes | Lysosomes | Electron microscopy | Hip | Mitochondria | Hepatocytes | Intracellular | Endoplasmic reticulum | Cytoplasm | Phagocytosis
Journal Article
World Journal of Gastroenterology, ISSN 1007-9327, 06/2007, Volume 13, Issue 24, pp. 3374 - 3379
AIM: To investigate anti-tumor activities and apoptosis-regulated mechanisms of bufalin in the orthotopic transplantation tumor model of human hepatocellular...
Orthotopic transplantation | Treatment | Nude mice | Model | Hepatocellular carcinoma | Bufalin | Apoptosis | PATHWAYS | treatment | ACTIVATION | LEUKEMIA U937 CELLS | apoptosis | orthotopic transplantation | CULTURE | BCL-2 | bufalin | PROSTATE-CANCER CELLS | nude mice | BAX | model | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | hepatocellular carcinoma | In Situ Nick-End Labeling | Neoplasm Transplantation | Apoptosis - drug effects | Humans | Body Weight - drug effects | Male | Transplantation, Heterologous | bcl-2-Associated X Protein - analysis | Antineoplastic Agents - therapeutic use | Liver Neoplasms, Experimental - ultrastructure | Reverse Transcriptase Polymerase Chain Reaction | Necrosis | Bufanolides - therapeutic use | Animals | Liver Neoplasms, Experimental - drug therapy | Mice, Nude | Proto-Oncogene Proteins c-bcl-2 - analysis | Mice | Mice, Inbred BALB C | Liver Neoplasms, Experimental - pathology | Proto-Oncogene Proteins c-bcl-2 - genetics | bcl-2-Associated X Protein - genetics | Rapid Communication
Orthotopic transplantation | Treatment | Nude mice | Model | Hepatocellular carcinoma | Bufalin | Apoptosis | PATHWAYS | treatment | ACTIVATION | LEUKEMIA U937 CELLS | apoptosis | orthotopic transplantation | CULTURE | BCL-2 | bufalin | PROSTATE-CANCER CELLS | nude mice | BAX | model | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | hepatocellular carcinoma | In Situ Nick-End Labeling | Neoplasm Transplantation | Apoptosis - drug effects | Humans | Body Weight - drug effects | Male | Transplantation, Heterologous | bcl-2-Associated X Protein - analysis | Antineoplastic Agents - therapeutic use | Liver Neoplasms, Experimental - ultrastructure | Reverse Transcriptase Polymerase Chain Reaction | Necrosis | Bufanolides - therapeutic use | Animals | Liver Neoplasms, Experimental - drug therapy | Mice, Nude | Proto-Oncogene Proteins c-bcl-2 - analysis | Mice | Mice, Inbred BALB C | Liver Neoplasms, Experimental - pathology | Proto-Oncogene Proteins c-bcl-2 - genetics | bcl-2-Associated X Protein - genetics | Rapid Communication
Journal Article
Hepatology International, ISSN 1936-0533, 1/2015, Volume 9, Issue 1, pp. 93 - 104
Functional disturbances of the endoplasmic reticulum (ER) lead to activation of the unfolded protein response (UPR), which is involved in the consecutive steps...
Liver neoplasm | Medicine & Public Health | Colorectal Surgery | PERK kinase | Hepatology | Surgery | HepG2 cells | Inositol-requiring enzyme-1 | Endoplasmic reticulum | Stress | ACTIVATION | KINASE | FATE | CANCER | PROTEOSTASIS | GROWTH | INHIBITOR | GASTROENTEROLOGY & HEPATOLOGY | ATF6 | Transcription Factor CHOP - genetics | Oxidative Stress | eIF-2 Kinase - metabolism | Humans | Adaptation, Physiological - drug effects | RNA, Messenger - analysis | Male | Endoplasmic Reticulum | Liver Neoplasms, Experimental - ultrastructure | Activating Transcription Factor 6 - genetics | Heat-Shock Proteins - genetics | Liver Neoplasms, Experimental - metabolism | Carcinoma, Hepatocellular - drug therapy | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Carcinoma, Hepatocellular - chemistry | Carcinoma, Hepatocellular - ultrastructure | Phosphorylation - drug effects | Cell Survival - drug effects | Unfolded Protein Response - drug effects | HSP40 Heat-Shock Proteins - genetics | Signal Transduction | Membrane Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Transcription Factor CHOP - analysis | Cell Transformation, Neoplastic - metabolism | eIF-2 Kinase - antagonists & inhibitors | Hep G2 Cells | Membrane Glycoproteins - genetics | Liver Neoplasms, Experimental - chemistry | Animals | Liver Neoplasms, Experimental - drug therapy | Membrane Proteins - antagonists & inhibitors | Protein Kinase Inhibitors - therapeutic use | Tunicamycin - pharmacology | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Carcinoma, Hepatocellular - metabolism | Physiological aspects | Development and progression | Hepatoma | Research | Protein kinases
Liver neoplasm | Medicine & Public Health | Colorectal Surgery | PERK kinase | Hepatology | Surgery | HepG2 cells | Inositol-requiring enzyme-1 | Endoplasmic reticulum | Stress | ACTIVATION | KINASE | FATE | CANCER | PROTEOSTASIS | GROWTH | INHIBITOR | GASTROENTEROLOGY & HEPATOLOGY | ATF6 | Transcription Factor CHOP - genetics | Oxidative Stress | eIF-2 Kinase - metabolism | Humans | Adaptation, Physiological - drug effects | RNA, Messenger - analysis | Male | Endoplasmic Reticulum | Liver Neoplasms, Experimental - ultrastructure | Activating Transcription Factor 6 - genetics | Heat-Shock Proteins - genetics | Liver Neoplasms, Experimental - metabolism | Carcinoma, Hepatocellular - drug therapy | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Carcinoma, Hepatocellular - chemistry | Carcinoma, Hepatocellular - ultrastructure | Phosphorylation - drug effects | Cell Survival - drug effects | Unfolded Protein Response - drug effects | HSP40 Heat-Shock Proteins - genetics | Signal Transduction | Membrane Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Transcription Factor CHOP - analysis | Cell Transformation, Neoplastic - metabolism | eIF-2 Kinase - antagonists & inhibitors | Hep G2 Cells | Membrane Glycoproteins - genetics | Liver Neoplasms, Experimental - chemistry | Animals | Liver Neoplasms, Experimental - drug therapy | Membrane Proteins - antagonists & inhibitors | Protein Kinase Inhibitors - therapeutic use | Tunicamycin - pharmacology | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Carcinoma, Hepatocellular - metabolism | Physiological aspects | Development and progression | Hepatoma | Research | Protein kinases
Journal Article
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, ISSN 1672-7347, 07/2015, Volume 40, Issue 7, p. 715
To observe the micromorphological changes of ultrastructure, apoptosis-related proteins expression and tumor cell apoptosis after ablation with the...
Neoplasms, Experimental - pathology | Neoplasms, Experimental - ultrastructure | Rabbits | Animals | Caspase 3 - metabolism | Liver Neoplasms - pathology | NF-kappa B - metabolism | Vascular Endothelial Growth Factor A - metabolism | High-Intensity Focused Ultrasound Ablation | Liver Neoplasms - ultrastructure | Apoptosis
Neoplasms, Experimental - pathology | Neoplasms, Experimental - ultrastructure | Rabbits | Animals | Caspase 3 - metabolism | Liver Neoplasms - pathology | NF-kappa B - metabolism | Vascular Endothelial Growth Factor A - metabolism | High-Intensity Focused Ultrasound Ablation | Liver Neoplasms - ultrastructure | Apoptosis
Journal Article
Toxicology Mechanisms and Methods, ISSN 1537-6516, 11/2012, Volume 22, Issue 9, pp. 679 - 686
Astaxanthin (AST), a xanthophylls carotenoid, possesses significant anticancer effects. However, to date, the molecular mechanism of anticancer remains...
cell ultra-structure | JAK1/STAT3 signaling pathway | Astaxanthin | Cell ultra-structure | COMPLEX | DOMAIN | METASTASIS | CANCER CELLS | RAT | INITIATION | DBL-1 | HEPATOCELLULAR-CARCINOMA | NM23-H1 | MICE | TOXICOLOGY | In Situ Nick-End Labeling | Microscopy, Electron, Transmission | Microscopy, Electron, Scanning | Apoptosis - drug effects | Rats | Janus Kinase 1 - antagonists & inhibitors | Liver Neoplasms, Experimental - ultrastructure | Reverse Transcriptase Polymerase Chain Reaction | Animals | Flow Cytometry | Signal Transduction - drug effects | Fluorescent Antibody Technique | Cell Line, Tumor | Liver Neoplasms, Experimental - enzymology | Xanthophylls - pharmacology | Antineoplastic Agents - pharmacology | STAT3 Transcription Factor - antagonists & inhibitors | Microscopy, Fluorescence
cell ultra-structure | JAK1/STAT3 signaling pathway | Astaxanthin | Cell ultra-structure | COMPLEX | DOMAIN | METASTASIS | CANCER CELLS | RAT | INITIATION | DBL-1 | HEPATOCELLULAR-CARCINOMA | NM23-H1 | MICE | TOXICOLOGY | In Situ Nick-End Labeling | Microscopy, Electron, Transmission | Microscopy, Electron, Scanning | Apoptosis - drug effects | Rats | Janus Kinase 1 - antagonists & inhibitors | Liver Neoplasms, Experimental - ultrastructure | Reverse Transcriptase Polymerase Chain Reaction | Animals | Flow Cytometry | Signal Transduction - drug effects | Fluorescent Antibody Technique | Cell Line, Tumor | Liver Neoplasms, Experimental - enzymology | Xanthophylls - pharmacology | Antineoplastic Agents - pharmacology | STAT3 Transcription Factor - antagonists & inhibitors | Microscopy, Fluorescence
Journal Article
Toxicology in Vitro, ISSN 0887-2333, 2005, Volume 19, Issue 4, pp. 481 - 489
Cadmium is a toxic metal and no uniform mechanism of toxicity has so far been proposed. The aim of this study was to investigate the biochemical effects of...
Lysosomes | Cadmium | Reactive oxygen species | DNA damage | AQUATIC ORGANISMS | APOPTOSIS | METALLOTHIONEIN | C-FOS | RATS | INDUCTION | STRAND BREAKS | GENOTOXICITY | EPITHELIAL-CELLS | reactive oxygen species | cadmium | lysosomes | TOXICOLOGY | EXPOSURE | Cadmium Chloride - toxicity | DNA Damage - drug effects | L-Lactate Dehydrogenase - metabolism | Lysosomes - drug effects | Reactive Oxygen Species | Glutathione - metabolism | Rats | Liver Neoplasms, Experimental - ultrastructure | Neoplasm Proteins - metabolism | Comet Assay | DNA, Neoplasm - drug effects | Lysosomes - ultrastructure | Liver Neoplasms, Experimental - metabolism | Animals | Adenosine Triphosphate - metabolism | Cadmium Poisoning - pathology | Cell Line, Tumor | Neutral Red | Cadmium Poisoning - metabolism | Cell research | Genetic research | Fluorescence | Stains and staining (Microscopy) | Lactate dehydrogenase | Mitochondrial DNA | Hepatoma | Glutathione
Lysosomes | Cadmium | Reactive oxygen species | DNA damage | AQUATIC ORGANISMS | APOPTOSIS | METALLOTHIONEIN | C-FOS | RATS | INDUCTION | STRAND BREAKS | GENOTOXICITY | EPITHELIAL-CELLS | reactive oxygen species | cadmium | lysosomes | TOXICOLOGY | EXPOSURE | Cadmium Chloride - toxicity | DNA Damage - drug effects | L-Lactate Dehydrogenase - metabolism | Lysosomes - drug effects | Reactive Oxygen Species | Glutathione - metabolism | Rats | Liver Neoplasms, Experimental - ultrastructure | Neoplasm Proteins - metabolism | Comet Assay | DNA, Neoplasm - drug effects | Lysosomes - ultrastructure | Liver Neoplasms, Experimental - metabolism | Animals | Adenosine Triphosphate - metabolism | Cadmium Poisoning - pathology | Cell Line, Tumor | Neutral Red | Cadmium Poisoning - metabolism | Cell research | Genetic research | Fluorescence | Stains and staining (Microscopy) | Lactate dehydrogenase | Mitochondrial DNA | Hepatoma | Glutathione
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 02/2005, Volume 16, Issue 2, pp. 984 - 996
The majority of hepatic intracellular triacylglycerol (TG) is mobilized by lipolysis followed by reesterification to reassemble TG before incorporation into a...
MEMBRANE-FRACTION | RAT HEPATOCYTES | B-CONTAINING LIPOPROTEINS | HEPG2 CELLS | LOW-DENSITY LIPOPROTEIN | INTRACELLULAR DEGRADATION | APOLIPOPROTEIN-B | LIVER CARBOXYLESTERASES | SECRETORY PATHWAY | ACTIVE SYNTHESIS | CELL BIOLOGY | Cercopithecus aethiops | Substrate Specificity | Liver Neoplasms, Experimental - ultrastructure | Endoplasmic Reticulum - ultrastructure | Lipoproteins, VLDL - ultrastructure | Transfection | Tritium - metabolism | Gene Deletion | Lipase - analysis | Lipoproteins - metabolism | Liver Neoplasms, Experimental - pathology | Endoplasmic Reticulum - enzymology | Hydrazines | Centrifugation, Density Gradient | Oleic Acid - metabolism | Rats | Lipase - metabolism | Protein Sorting Signals | Hydrolysis | Oligopeptides - biosynthesis | Xanthenes | Microscopy, Confocal | Animals | Lipoproteins, VLDL - metabolism | Fluorescein | Cell Line, Tumor | Lipase - ultrastructure | COS Cells | Fluorescent Dyes | Lipase - genetics
MEMBRANE-FRACTION | RAT HEPATOCYTES | B-CONTAINING LIPOPROTEINS | HEPG2 CELLS | LOW-DENSITY LIPOPROTEIN | INTRACELLULAR DEGRADATION | APOLIPOPROTEIN-B | LIVER CARBOXYLESTERASES | SECRETORY PATHWAY | ACTIVE SYNTHESIS | CELL BIOLOGY | Cercopithecus aethiops | Substrate Specificity | Liver Neoplasms, Experimental - ultrastructure | Endoplasmic Reticulum - ultrastructure | Lipoproteins, VLDL - ultrastructure | Transfection | Tritium - metabolism | Gene Deletion | Lipase - analysis | Lipoproteins - metabolism | Liver Neoplasms, Experimental - pathology | Endoplasmic Reticulum - enzymology | Hydrazines | Centrifugation, Density Gradient | Oleic Acid - metabolism | Rats | Lipase - metabolism | Protein Sorting Signals | Hydrolysis | Oligopeptides - biosynthesis | Xanthenes | Microscopy, Confocal | Animals | Lipoproteins, VLDL - metabolism | Fluorescein | Cell Line, Tumor | Lipase - ultrastructure | COS Cells | Fluorescent Dyes | Lipase - genetics
Journal Article
中华医学杂志:英文版, ISSN 0366-6999, 2009, Volume 122, Issue 24, pp. 3043 - 3047
Background It is generally accepted that spleen plays a complex role in the tumor immunity, which would change in the different periods of cancer. In this...
亚硝胺 | 脾脏 | 巨噬细胞 | SD大鼠 | 透射电子显微镜 | 肿瘤坏死因子-α | 二乙基 | 肝癌 | Spleen | Liver cancer | Cell function | Ultrastructure | Macrophage | cell function | PHAGOCYTOSIS | spleen | RESECTION | macrophage | SPLENECTOMY | ultrastructure | ANTITUMOR | PATHOGENESIS | SUPPRESS | MEDICINE, GENERAL & INTERNAL | HEPATOCELLULAR-CARCINOMA | IN-VITRO | COLORECTAL-CANCER | liver cancer | Diethylnitrosamine - toxicity | Liver Cirrhosis - immunology | Macrophages - ultrastructure | Microscopy, Electron, Transmission | Macrophages - pathology | Cells, Cultured | Liver Neoplasms, Experimental - chemically induced | Rats | Male | Liver Neoplasms, Experimental - immunology | Liver Neoplasms, Experimental - ultrastructure | Spleen - ultrastructure | Rats, Sprague-Dawley | Lung Neoplasms - immunology | Animals | Lung Neoplasms - secondary | Liver Neoplasms, Experimental - complications | Lung Neoplasms - ultrastructure | Liver Cirrhosis - pathology | Spleen - pathology | Disease Models, Animal
亚硝胺 | 脾脏 | 巨噬细胞 | SD大鼠 | 透射电子显微镜 | 肿瘤坏死因子-α | 二乙基 | 肝癌 | Spleen | Liver cancer | Cell function | Ultrastructure | Macrophage | cell function | PHAGOCYTOSIS | spleen | RESECTION | macrophage | SPLENECTOMY | ultrastructure | ANTITUMOR | PATHOGENESIS | SUPPRESS | MEDICINE, GENERAL & INTERNAL | HEPATOCELLULAR-CARCINOMA | IN-VITRO | COLORECTAL-CANCER | liver cancer | Diethylnitrosamine - toxicity | Liver Cirrhosis - immunology | Macrophages - ultrastructure | Microscopy, Electron, Transmission | Macrophages - pathology | Cells, Cultured | Liver Neoplasms, Experimental - chemically induced | Rats | Male | Liver Neoplasms, Experimental - immunology | Liver Neoplasms, Experimental - ultrastructure | Spleen - ultrastructure | Rats, Sprague-Dawley | Lung Neoplasms - immunology | Animals | Lung Neoplasms - secondary | Liver Neoplasms, Experimental - complications | Lung Neoplasms - ultrastructure | Liver Cirrhosis - pathology | Spleen - pathology | Disease Models, Animal
Journal Article
Stem Cells and Development, ISSN 1547-3287, 11/2009, Volume 18, Issue 9, pp. 1293 - 1298
Hepatic oval cells are thought to represent facultative hepatic epithelial stem cells in liver in which damage inhibits hepatocyte proliferation and liver...
MEDICINE, RESEARCH & EXPERIMENTAL | REGULATORS SNAIL | E-CADHERIN EXPRESSION | BONE-MARROW | TRANSCRIPTION FACTOR SNAIL | CANCER | CELL & TISSUE ENGINEERING | TRANSPLANTATION | NEURAL STEM-CELLS | IN-VIVO | GENE-EXPRESSION | DIFFERENTIATION | HEMATOLOGY | CARCINOMA | Mesenchymoma - ultrastructure | Cadherins - metabolism | Vimentin - metabolism | Male | Transplantation, Heterologous | Neoplasms, Experimental - pathology | Cell Transdifferentiation | Female | Snail Family Transcription Factors | Neoplasms, Experimental - ultrastructure | Mesenchymoma - metabolism | Microscopy, Electron, Transmission | Epithelium - pathology | Mesenchymoma - pathology | Cells, Cultured | Rats | In Situ Hybridization, Fluorescence | Rats, Sprague-Dawley | Blotting, Western | Transcription Factors - metabolism | Animals | Mice, Nude | Liver - cytology | Mice | Mice, Inbred BALB C | Neoplasms, Experimental - metabolism | Mesoderm - pathology | Cell Transplantation - methods | Physiological aspects | Research | Cell differentiation | Liver cells | Stem cells | Original Research Reports
MEDICINE, RESEARCH & EXPERIMENTAL | REGULATORS SNAIL | E-CADHERIN EXPRESSION | BONE-MARROW | TRANSCRIPTION FACTOR SNAIL | CANCER | CELL & TISSUE ENGINEERING | TRANSPLANTATION | NEURAL STEM-CELLS | IN-VIVO | GENE-EXPRESSION | DIFFERENTIATION | HEMATOLOGY | CARCINOMA | Mesenchymoma - ultrastructure | Cadherins - metabolism | Vimentin - metabolism | Male | Transplantation, Heterologous | Neoplasms, Experimental - pathology | Cell Transdifferentiation | Female | Snail Family Transcription Factors | Neoplasms, Experimental - ultrastructure | Mesenchymoma - metabolism | Microscopy, Electron, Transmission | Epithelium - pathology | Mesenchymoma - pathology | Cells, Cultured | Rats | In Situ Hybridization, Fluorescence | Rats, Sprague-Dawley | Blotting, Western | Transcription Factors - metabolism | Animals | Mice, Nude | Liver - cytology | Mice | Mice, Inbred BALB C | Neoplasms, Experimental - metabolism | Mesoderm - pathology | Cell Transplantation - methods | Physiological aspects | Research | Cell differentiation | Liver cells | Stem cells | Original Research Reports
Journal Article
Clinical and Experimental Metastasis, ISSN 0262-0898, 10/2000, Volume 18, Issue 6, pp. 481 - 492
The process of extravasation of the high metastatic Lewis lung carcinoma line was examined in different organs. Four of the five organs (liver, lungs, brain...
endothelium | extravasation | Lewis lung carcinoma | basement membrane | Medicine & Public Health | Hematology | Cancer Research | Oncology | ultrastructure | Surgical Oncology | Ultrastructure | Extravasation | Basement membrane | Endothelium | Liver Neoplasms, Experimental - secondary | Kidney Neoplasms - ultrastructure | Mice, Inbred C57BL | Lung Neoplasms - pathology | Brain Neoplasms - blood supply | Liver Neoplasms, Experimental - blood supply | Liver Neoplasms, Experimental - ultrastructure | Organ Specificity | Carcinoma, Lewis Lung - blood supply | Adrenal Gland Neoplasms - ultrastructure | Brain Neoplasms - secondary | Neoplasm Metastasis | Animals | Adrenal Gland Neoplasms - blood supply | Lung Neoplasms - ultrastructure | Carcinoma, Lewis Lung - pathology | Adrenal Gland Neoplasms - secondary | Mice | Brain Neoplasms - ultrastructure | Carcinoma, Lewis Lung - ultrastructure | Kidney Neoplasms - secondary | Kidney Neoplasms - blood supply | Lung Neoplasms - blood supply
endothelium | extravasation | Lewis lung carcinoma | basement membrane | Medicine & Public Health | Hematology | Cancer Research | Oncology | ultrastructure | Surgical Oncology | Ultrastructure | Extravasation | Basement membrane | Endothelium | Liver Neoplasms, Experimental - secondary | Kidney Neoplasms - ultrastructure | Mice, Inbred C57BL | Lung Neoplasms - pathology | Brain Neoplasms - blood supply | Liver Neoplasms, Experimental - blood supply | Liver Neoplasms, Experimental - ultrastructure | Organ Specificity | Carcinoma, Lewis Lung - blood supply | Adrenal Gland Neoplasms - ultrastructure | Brain Neoplasms - secondary | Neoplasm Metastasis | Animals | Adrenal Gland Neoplasms - blood supply | Lung Neoplasms - ultrastructure | Carcinoma, Lewis Lung - pathology | Adrenal Gland Neoplasms - secondary | Mice | Brain Neoplasms - ultrastructure | Carcinoma, Lewis Lung - ultrastructure | Kidney Neoplasms - secondary | Kidney Neoplasms - blood supply | Lung Neoplasms - blood supply
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 1999, Volume 10, Issue 5, pp. 1477 - 1494
Myosin Is, which constitute a ubiquitous monomeric subclass of myosins with actin-based motor properties, are associated with plasma membrane and intracellular...
ORGANIZATION | LOCALIZATION | TRANSPORT | ACTIN | NERVE GROWTH CONES | VESICLES | BIOCHEMISTRY & MOLECULAR BIOLOGY | UNCONVENTIONAL MYOSIN | MEMBRANE-PROTEINS | IDENTIFICATION | PLASMA-MEMBRANE | CELL BIOLOGY
ORGANIZATION | LOCALIZATION | TRANSPORT | ACTIN | NERVE GROWTH CONES | VESICLES | BIOCHEMISTRY & MOLECULAR BIOLOGY | UNCONVENTIONAL MYOSIN | MEMBRANE-PROTEINS | IDENTIFICATION | PLASMA-MEMBRANE | CELL BIOLOGY
Journal Article