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Journal Article
Pharmacological Reports, ISSN 1734-1140, 02/2018, Volume 70, Issue 1, pp. 172 - 177
Journal Article
Steroids, ISSN 0039-128X, 04/2012, Volume 77, Issue 5, pp. 484 - 495
► Structural elucidation of polyhydroxylated steroids from the marine sponge . ► Discovery of potent agonists of PXR and antagonists of FXR. ► The putative... 
Marine sponge | Nuclear receptors | Theonella swinhoei | Pregnane-X-receptor | Farnesoid-X-receptor | BILE-ACID | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | STEROLS | CHOLESTATIC LIVER-DISEASE | PXR | URSODEOXYCHOLIC ACID | PRIMARY BILIARY-CIRRHOSIS | ENDOCRINOLOGY & METABOLISM | METABOLIC-DISORDERS | T-Lymphocytes, Regulatory - metabolism | Liver - pathology | Gene Expression - drug effects | Humans | Theonella - chemistry | Monocytes - metabolism | Gene Expression Profiling | Receptors, Steroid - agonists | Isomerism | Cholesterol - chemistry | Liver - drug effects | Receptors, Cytoplasmic and Nuclear - chemistry | Molecular Structure | Binding Sites | Cytokines - genetics | Protein Structure, Tertiary | Sterols - pharmacology | Cholesterol - analogs & derivatives | Cytokines - metabolism | Sterols - chemistry | Cholesterol - isolation & purification | Liver - metabolism | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Models, Molecular | Receptors, Cytoplasmic and Nuclear - genetics | Reverse Transcriptase Polymerase Chain Reaction | Hep G2 Cells | Mice, Knockout | Receptors, Steroid - chemistry | Monocytes - drug effects | Sterols - isolation & purification | T-Lymphocytes, Regulatory - drug effects | Animals | Receptors, Steroid - genetics | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Cholesterol - pharmacology | Protein Binding | Mice | CD4-Positive T-Lymphocytes - drug effects | Index Medicus
Journal Article
Journal Article
Chemical and Pharmaceutical Bulletin, ISSN 0009-2363, 2015
Fourteen novel compounds were prepared and their antagonistic activities against liver X receptors (LXR) α/β were tested in vitro. Compound 26 had an IC50... 
liver X receptor β | Liver X receptor α | antagonistic activity
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2014, Volume 723, Issue 1, pp. 108 - 115
Journal Article