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1. Full Text Liver X receptors in lipid metabolism: Opportunities for drug discovery
by Hong, Cynthia and Tontonoz, Peter
Nature Reviews Drug Discovery, ISSN 1474-1776, 2014, Volume 13, Issue 6, pp. 433 - 444
The liver X receptors (LXRs) are pivotal regulators of lipid homeostasis in mammals. These transcription factors control the expression of a battery of genes... 
BINDING CASSETTE TRANSPORTER | BILIARY STEROL SECRETION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | REVERSE CHOLESTEROL TRANSPORT | ALZHEIMERS-DISEASE | LOW-DENSITY-LIPOPROTEIN | PROLIFERATOR-ACTIVATED RECEPTOR | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | EXPRESSION IN-VITRO | ATHEROSCLEROSIS SUSCEPTIBILITY | LXR-ALPHA | Intestines - drug effects | Drugs, Investigational - pharmacology | Humans | Drugs, Investigational - therapeutic use | Intestines - metabolism | Orphan Nuclear Receptors - metabolism | Brain - metabolism | Drugs, Investigational - chemistry | Protein Isoforms - metabolism | Liver - drug effects | Alzheimer Disease - prevention & control | Liver X Receptors | Drug Design | Neurons - metabolism | Hypolipidemic Agents - chemistry | Drug Evaluation, Preclinical | Neurons - drug effects | Hypolipidemic Agents - adverse effects | Nerve Tissue Proteins - antagonists & inhibitors | Molecular Targeted Therapy - adverse effects | Atherosclerosis - drug therapy | Liver - metabolism | Alzheimer Disease - drug therapy | Nootropic Agents - therapeutic use | Clinical Trials as Topic | Hypolipidemic Agents - pharmacology | Nootropic Agents - adverse effects | Nootropic Agents - chemistry | Drug Discovery | Atherosclerosis - metabolism | Brain - drug effects | Nerve Tissue Proteins - metabolism | Orphan Nuclear Receptors - antagonists & inhibitors | Animals | Signal Transduction - drug effects | Alzheimer Disease - metabolism | Lipid Metabolism - drug effects | Hypolipidemic Agents - therapeutic use | Atherosclerosis - prevention & control | Nootropic Agents - pharmacology | Protein Isoforms - antagonists & inhibitors | Care and treatment | Research | Drug discovery | Patient outcomes | Risk factors | Atherosclerosis
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2. Full Text International union of pharmacology. LXII. The NR1H and NR1I receptors: Constitutive androstane receptor, pregnene X receptor, farnesoid X receptor α, farnesoid X receptor β, liver X receptor α, liver X receptor β, and vitamin D receptor
by Moore, David D and Kato, Shigeaki and Xie, Wen and Mangelsdorf, David J and Schmidt, Daniel R and Xiao, Rui and Kliewer, Steven A
Pharmacological Reviews, ISSN 0031-6997, 12/2006, Volume 58, Issue 4, pp. 742 - 759
The nuclear receptors of the NR1H and NR1I subgroups include the constitutive androstane receptor, pregnane X receptor, farnesoid X receptors, liver X... 
SOLUTE TRANSPORTER-ALPHA | NATURALLY-OCCURRING VARIANTS | SALT EXPORT PUMP | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | BILE-ACID-BINDING | LIGAND-BINDING DOMAIN | HETERODIMER PARTNER INTERACTS | PHOSPHOLIPID TRANSFER PROTEIN | XENOBIOTIC RECEPTOR | ORPHAN NUCLEAR RECEPTOR | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Humans | Receptors, Calcitriol - physiology | Terminology as Topic | Receptors, Cytoplasmic and Nuclear - physiology | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Receptors, Calcitriol - genetics | Receptors, Cytoplasmic and Nuclear - classification | Animals | Receptors, Steroid - genetics | Receptors, Steroid - physiology | Liver X Receptors | Mutation | Orphan Nuclear Receptors
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3. Full Text Liver X Receptors in Atherosclerosis and Inflammation
by Im, Seung-Soon and Osborne, Timothy F
Circulation Research, ISSN 0009-7330, 04/2011, Volume 108, Issue 8, pp. 996 - 1001
Liver X receptors (LXRs) are cholesterol-sensing nuclear receptors that are not only key regulators of lipid metabolism and transport but also suppress... 
atherosclerosis | Inflammation | liver X receptor | innate immune response | LXR | SIGNALING PATHWAYS | CARDIAC & CARDIOVASCULAR SYSTEMS | CHOLESTEROL | NUCLEAR RECEPTORS | ELEMENT-BINDING PROTEIN-1C | LOW-DENSITY-LIPOPROTEIN | AGONISTS | LXR-ALPHA | MICE LACKING | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | CELL | Inflammation - pathology | Atherosclerosis - pathology | Inflammation - metabolism | Animals | Humans | Liver X Receptors | Orphan Nuclear Receptors - physiology | Signal Transduction - physiology | Immunity, Innate | Orphan Nuclear Receptors - metabolism | Atherosclerosis - metabolism | Innate immune response | liver-X-receptor, LXR
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4. Full Text Targeting liver X receptors in cancer therapeutics
by Lin, Chin-Yo and Gustafsson, Jan-Åke
Nature Reviews Cancer, ISSN 1474-175X, 04/2015, Volume 15, Issue 4, pp. 216 - 224
Members of the nuclear receptor superfamily of ligand-dependent transcription factors carry out vital cellular functions and are highly druggable therapeutic... 
LXR-BETA | GLUCOCORTICOID-RECEPTOR | ONCOLOGY | PROSTATE-CANCER | RETINOID-X | CELL-PROLIFERATION | HUMAN BREAST-CANCER | BINDING-SITES | DISEASE PATHOLOGY | ESTROGEN-RECEPTOR | NUCLEAR RECEPTOR | Orphan Nuclear Receptors - antagonists & inhibitors | Animals | Humans | Liver X Receptors | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Neoplasms - drug therapy | Physiological aspects | Liver cancer | Care and treatment | Transcription factors | Genetic aspects | Research
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5. Full Text Microbiota-induced obesity requires farnesoid X receptor
by Parséus, Ava and Sommer, Nina and Sommer, Felix and Caesar, Robert and Molinaro, Antonio and Ståhlman, Marcus and Greiner, Thomas U and Perkins, Rosie and Bäckhed, Fredrik and Wallenberg Laboratory and Institute of Medicine, Department of Molecular and Clinical Medicine and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy and Sahlgrenska akademin and Wallenberglaboratoriet and Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Gut, ISSN 0017-5749, 03/2017, Volume 66, Issue 3, pp. 429 - 437
ObjectiveThe gut microbiota has been implicated as an environmental factor that modulates obesity, and recent evidence suggests that microbiota-mediated... 
Bile acid | obesity | FXR | BILE-ACID METABOLISM | EXTRACTION | FATTY LIVER-DISEASE | INSULIN-RESISTANCE | MOUSE | GUT MICROBIOTA | DIET-INDUCED OBESITY | GASTROENTEROLOGY & HEPATOLOGY | NUCLEAR RECEPTOR | VLDL RECEPTOR | Male | Cecum - microbiology | Macrophages | Obesity - microbiology | Feces - microbiology | Dietary Fats - administration & dosage | Weight Gain | Gene Expression | Fatty Liver - metabolism | Obesity - complications | Mice, Inbred C57BL | Adipose Tissue - pathology | Bile Acids and Salts - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Gastrointestinal Microbiome - genetics | Inflammation - etiology | Fecal Microbiota Transplantation | Mice, Knockout | Obesity - metabolism | Phenotype | Animals | Germ-Free Life | Glucose - metabolism | Mice | Insulin-Secreting Cells - pathology | Fatty Liver - etiology | Receptors, Cytoplasmic and Nuclear - metabolism | Obesity | Research | Microbiota (Symbiotic organisms) | Bile acid metabolism | OBESITY | 1506 | Gut Microbiota | BILE ACID | microbiota | dtvedt t | gut | p1341 | Kardiologi | mouse | p497 | 1974 | Endokrinologi och diabetes | vldl receptor | 1957 | Endocrinology and Diabetes | bile-acid metabolism | fxr | american journal of clinical nutrition | fatty liver-disease | extraction | diet-induced obesity | journal of biological chemistry | Gastroenterology & Hepatology | Cardiac and Cardiovascular Systems | insulin-resistance | v226 | nuclear receptor | v27 | lch j
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6. Full Text Liver X receptors as integrators of metabolic and inflammatory signaling
by Zelcer, Noam and Tontonoz, Peter
Journal of Clinical Investigation, ISSN 0021-9738, 03/2006, Volume 116, Issue 3, pp. 607 - 614
The liver X receptors (LXRs) are nuclear receptors that play central roles in the transcriptional control of lipid metabolism. LXRs function as nuclear... 
MEDICINE, RESEARCH & EXPERIMENTAL | TANGIER-DISEASE | LIPID-METABOLISM | CASSETTE TRANSPORTER 1 | HUMAN MACROPHAGES | CELLULAR CHOLESTEROL EFFLUX | HUMAN ABCG1 GENE | LXR-ALPHA | HIGH-DENSITY-LIPOPROTEIN | NUCLEAR RECEPTOR | STEROL 27-HYDROXYLASE | Inflammation - pathology | DNA-Binding Proteins - physiology | Inflammation - metabolism | Animals | Humans | Liver X Receptors | Receptors, Cytoplasmic and Nuclear - physiology | Signal Transduction - physiology | Orphan Nuclear Receptors | Cholesterol - metabolism | Review Series
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7. Full Text Liver X receptor in cholesterol metabolism
by Chunyan Zhao and Karin Dahlman-Wright
Journal of Endocrinology, ISSN 0022-0795, 03/2010, Volume 204, Issue 3, pp. 233 - 240
The liver X receptors (LXRs) are nuclear receptors that are activated by endogenous oxysterols, oxidized derivatives of cholesterol. There are two isoforms of... 
OXYSTEROL RECEPTOR | DIETARY-CHOLESTEROL | ENDOCRINOLOGY & METABOLISM | HUMAN ABCG1 GENE | BILE-ACID BIOSYNTHESIS | DEFICIENT MICE | TRANSFER PROTEIN GENE | LXR TARGET GENE | HIGH-DENSITY-LIPOPROTEIN | APOLIPOPROTEIN-E | NUCLEAR RECEPTOR | Animals | Protein Isoforms - metabolism | Humans | Liver X Receptors | Intestines - metabolism | Cholesterol - metabolism | Orphan Nuclear Receptors - metabolism | Orphan Nuclear Receptors - genetics | Retinoid X Receptors - genetics | Retinoid X Receptors - metabolism | Protein Isoforms - genetics
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8. Full Text BIOLOGICAL ROLE OF LIVER X RECEPTORS
by Baranowski, M
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, ISSN 0867-5910, 12/2008, Volume 59, Issue 4, pp. 31 - 55
Liver X receptors (LXRs) are ligand-activated transcription factors of the nuclear receptor superfamily. There are two LXR isoforms termed a and 6 which upon... 
atherosclerosis | lipids | PHYSIOLOGY | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | ESTER TRANSFER PROTEIN | ELEMENT-BINDING PROTEIN-1C | LXR RESPONSE ELEMENTS | lipogenesis | HEPATIC GENE-EXPRESSION | HIGH-DENSITY-LIPOPROTEIN | nuclear receptors | REVERSE CHOLESTEROL TRANSPORT | FATTY-ACID | liver X receptors | cholesterol | PANCREATIC BETA-CELLS | PHOSPHOLIPID TRANSFER PROTEIN | diabetes
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9. Full Text Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
by Jiang, Changtao and Xie, Cen and Li, Fei and Zhang, Limin and Nichols, Robert G and Krausz, Kristopher W and Cai, Jingwei and Qi, Yunpeng and Fang, Zhong-Ze and Takahashi, Shogo and Tanaka, Naoki and Desai, Dhimant and Amin, Shantu G and Albert, Istvan and Patterson, Andrew D and Gonzalez, Frank J
Journal of Clinical Investigation, ISSN 0021-9738, 01/2015, Volume 125, Issue 1, pp. 386 - 402
Nonalcoholic fatty liver disease (NAFLD) is a major worldwide health problem. Recent studies suggest that the gut microbiota influences NAFLD pathogenesis.... 
MEDICINE, RESEARCH & EXPERIMENTAL | BILE-ACID | FXR | ACTIVATION | HUMAN GUT MICROBIOTA | CHOLESTEROL 7-ALPHA-HYDROXYLASE | DIET-INDUCED OBESITY | CERAMIDE | HEPATIC STEATOSIS | EXPRESSION | INDUCED INSULIN-RESISTANCE | Mitochondrial Dynamics | Gene Expression | Ileum - pathology | Liver - pathology | Microbiota - physiology | Humans | Liver - metabolism | Mice, Inbred C57BL | Non-alcoholic Fatty Liver Disease - microbiology | Gene Expression Regulation | Diet, High-Fat - adverse effects | Ileum - metabolism | Non-alcoholic Fatty Liver Disease - etiology | Bile Acids and Salts - metabolism | Lipid Metabolism | Male | Mice, Transgenic | Non-alcoholic Fatty Liver Disease - metabolism | Non-alcoholic Fatty Liver Disease - drug therapy | Animals | Metabolic Networks and Pathways | Cecum - metabolism | Anti-Bacterial Agents - pharmacology | Receptors, Cytoplasmic and Nuclear - metabolism | Physiological aspects | Cell receptors | Cellular signal transduction | Fatty liver | Research | Risk factors | Studies | Medical research | Lipids | Metabolites | Rodents | Bile
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10. Full Text Liver X Receptor Signaling Pathways and Atherosclerosis
by Calkin, Anna C and Tontonoz, Peter
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 08/2010, Volume 30, Issue 8, pp. 1513 - 1518
First discovered as orphan receptors, liver X receptors (LXRs) were subsequently identified as the nuclear receptor target of the cholesterol metabolites,... 
atherosclerosis | macrophages | ATP-binding cassette transporter | lipoproteins | LIPID-METABOLISM | DEFICIENT MICE | LXR-ALPHA | LDL-RECEPTOR | AGONIST T0901317 | CHOLESTEROL EFFLUX | BINDING CASSETTE TRANSPORTER-1 | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | VASCULAR ENDOTHELIAL-CELLS | HEMATOLOGY | UP-REGULATION | Atherosclerosis - immunology | Muscle, Smooth, Vascular - metabolism | Endothelial Cells - metabolism | Humans | Orphan Nuclear Receptors - agonists | Cholesterol - metabolism | Orphan Nuclear Receptors - metabolism | Atherosclerosis - metabolism | Cardiovascular Agents - pharmacology | Macrophages - metabolism | Animals | Biological Transport | Signal Transduction - drug effects | Liver X Receptors | Inflammation Mediators - metabolism | Ligands | Atherosclerosis - prevention & control
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11. Full Text Action mechanisms of Liver X Receptors
by Gabbi, Chiara and Warner, Margaret and Gustafsson, Jan-Åke
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2014, Volume 446, Issue 3, pp. 647 - 650
The two Liver X Receptors, LXRα and LXRβ, are nuclear receptors belonging to the superfamily of ligand-activated transcription factors. They share more than... 
Nuclear receptor | LXR | Oxysterol | TRANSCRIPTIONAL ACTIVITY | ACTIVATION | AQUAPORIN-1 EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | FEMALE MICE | ALPHA | MIDBRAIN NEUROGENESIS | LXR-BETA | BIOPHYSICS | CO-REPRESSOR | BILE-ACIDS | Transcription Factors - metabolism | Animals | Humans | Liver X Receptors | Orphan Nuclear Receptors - physiology | Homeostasis | Hydroxycholesterols - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Physiological aspects | Glucose metabolism | TRANSCRIPTION FACTORS | BIOLOGICAL PATHWAYS | HOMEOSTASIS | CHOLESTEROL | BIOLOGICAL AVAILABILITY | CENTRAL NERVOUS SYSTEM | 60 APPLIED LIFE SCIENCES | LIGANDS | METABOLISM | AMINO ACID SEQUENCE | GLUCOSE | INFLAMMATION | LIVER | RECEPTORS | LIPIDS | WATER
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