Cochrane Database of Systematic Reviews, ISSN 1469-493X, 11/2018, Volume 2018, Issue 11, p. CD008218
Background This is an updated version of the original Cochrane Review published in September 2014. The most common primary brain tumours in adults are gliomas....
MEDICINE, GENERAL & INTERNAL | STANDARD TREATMENT | RECURSIVE PARTITIONING ANALYSIS | NEWLY-DIAGNOSED GLIOBLASTOMA | RANDOMIZED PHASE-III | SINGLE-AGENT BEVACIZUMAB | BEVACIZUMAB PLUS IRINOTECAN | CENTRAL-NERVOUS-SYSTEM | OPEN-LABEL | QUALITY-OF-LIFE | ADJUVANT TEMOZOLOMIDE | Neovascularization, Pathologic - mortality | Bevacizumab - therapeutic use | Snake Venoms - therapeutic use | Dacarbazine - therapeutic use | Humans | Neoplasm Recurrence, Local - drug therapy | Antineoplastic Agents - therapeutic use | Brain Neoplasms - blood supply | Irinotecan - therapeutic use | Temozolomide - therapeutic use | Proteinuria - chemically induced | Hypertension - chemically induced | Dacarbazine - analogs & derivatives | Angiogenesis Inhibitors - therapeutic use | Lomustine - therapeutic use | Brain Neoplasms - mortality | Angiogenesis Inhibitors - adverse effects | Camptothecin - analogs & derivatives | Antibodies, Monoclonal, Humanized - adverse effects | Antibodies, Monoclonal, Humanized - therapeutic use | Camptothecin - therapeutic use | Brain Neoplasms - drug therapy | Randomized Controlled Trials as Topic | Neovascularization, Pathologic - drug therapy | Progression-Free Survival | Glioblastoma - drug therapy | Glioblastoma - blood supply | Glioblastoma - mortality
MEDICINE, GENERAL & INTERNAL | STANDARD TREATMENT | RECURSIVE PARTITIONING ANALYSIS | NEWLY-DIAGNOSED GLIOBLASTOMA | RANDOMIZED PHASE-III | SINGLE-AGENT BEVACIZUMAB | BEVACIZUMAB PLUS IRINOTECAN | CENTRAL-NERVOUS-SYSTEM | OPEN-LABEL | QUALITY-OF-LIFE | ADJUVANT TEMOZOLOMIDE | Neovascularization, Pathologic - mortality | Bevacizumab - therapeutic use | Snake Venoms - therapeutic use | Dacarbazine - therapeutic use | Humans | Neoplasm Recurrence, Local - drug therapy | Antineoplastic Agents - therapeutic use | Brain Neoplasms - blood supply | Irinotecan - therapeutic use | Temozolomide - therapeutic use | Proteinuria - chemically induced | Hypertension - chemically induced | Dacarbazine - analogs & derivatives | Angiogenesis Inhibitors - therapeutic use | Lomustine - therapeutic use | Brain Neoplasms - mortality | Angiogenesis Inhibitors - adverse effects | Camptothecin - analogs & derivatives | Antibodies, Monoclonal, Humanized - adverse effects | Antibodies, Monoclonal, Humanized - therapeutic use | Camptothecin - therapeutic use | Brain Neoplasms - drug therapy | Randomized Controlled Trials as Topic | Neovascularization, Pathologic - drug therapy | Progression-Free Survival | Glioblastoma - drug therapy | Glioblastoma - blood supply | Glioblastoma - mortality
Journal Article
Neuro-Oncology, ISSN 1522-8517, 11/2016, Volume 18, Issue 11, pp. 1529 - 1537
Background. Optimal treatment and precise classification for anaplastic glioma are needed. Methods. The objective for long-term follow-up of NOA-04 is to...
1p/19q | Anaplastic gliomas | MGMT | CIMP | SURVIVAL | OLIGODENDROGLIOMA | ASTROCYTOMAS | ATRX | MGMT PROMOTER METHYLATION | CLASSIFICATION | PROCARBAZINE | TUMORS | CLINICAL NEUROLOGY | anaplastic gliomas | ONCOLOGY | DIFFUSE | AGE | Glioma - diagnosis | Dacarbazine - therapeutic use | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Glioma - radiotherapy | Young Adult | Dacarbazine - analogs & derivatives | Adult | Female | Lomustine - therapeutic use | Antineoplastic Agents, Phytogenic - therapeutic use | Brain Neoplasms - radiotherapy | Chemoradiotherapy - methods | Brain Neoplasms - diagnosis | Treatment Outcome | Brain Neoplasms - drug therapy | Antineoplastic Agents, Alkylating - therapeutic use | Disease-Free Survival | Procarbazine - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Vincristine - therapeutic use | Aged | Temozolomide | Glioma - drug therapy | 19q | Clinical Investigation
1p/19q | Anaplastic gliomas | MGMT | CIMP | SURVIVAL | OLIGODENDROGLIOMA | ASTROCYTOMAS | ATRX | MGMT PROMOTER METHYLATION | CLASSIFICATION | PROCARBAZINE | TUMORS | CLINICAL NEUROLOGY | anaplastic gliomas | ONCOLOGY | DIFFUSE | AGE | Glioma - diagnosis | Dacarbazine - therapeutic use | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Glioma - radiotherapy | Young Adult | Dacarbazine - analogs & derivatives | Adult | Female | Lomustine - therapeutic use | Antineoplastic Agents, Phytogenic - therapeutic use | Brain Neoplasms - radiotherapy | Chemoradiotherapy - methods | Brain Neoplasms - diagnosis | Treatment Outcome | Brain Neoplasms - drug therapy | Antineoplastic Agents, Alkylating - therapeutic use | Disease-Free Survival | Procarbazine - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Vincristine - therapeutic use | Aged | Temozolomide | Glioma - drug therapy | 19q | Clinical Investigation
Journal Article
The Cochrane database of systematic reviews, ISSN 1469-493X, 2014, Volume 9, Issue 9, pp. CD008218 - CD008218
Background The most common primary brain tumours in adults are gliomas. Gliomas span a spectrum from low to high-grade and are graded pathologically on a scale...
MALIGNANT GLIOMA | MEDICINE, GENERAL & INTERNAL | RECURSIVE PARTITIONING ANALYSIS | BEVACIZUMAB | NEWLY-DIAGNOSED GLIOBLASTOMA | PHASE-III | RANDOMIZED-TRIAL | RADIOTHERAPY | RESPONSE ASSESSMENT CRITERIA | RADIATION-THERAPY | TEMOZOLOMIDE | Antibodies, Monoclonal, Humanized - adverse effects | Antibodies, Monoclonal, Humanized - therapeutic use | Camptothecin - therapeutic use | Snake Venoms - therapeutic use | Dacarbazine - therapeutic use | Humans | Neoplasm Recurrence, Local - drug therapy | Antineoplastic Agents - therapeutic use | Brain Neoplasms - blood supply | Brain Neoplasms - drug therapy | Bevacizumab | Randomized Controlled Trials as Topic | Proteinuria - chemically induced | Neovascularization, Pathologic - drug therapy | Hypertension - chemically induced | Dacarbazine - analogs & derivatives | Angiogenesis Inhibitors - therapeutic use | Lomustine - therapeutic use | Brain Neoplasms - mortality | Glioblastoma - drug therapy | Angiogenesis Inhibitors - adverse effects | Glioblastoma - blood supply | Glioblastoma - mortality | Camptothecin - analogs & derivatives | Index Medicus
MALIGNANT GLIOMA | MEDICINE, GENERAL & INTERNAL | RECURSIVE PARTITIONING ANALYSIS | BEVACIZUMAB | NEWLY-DIAGNOSED GLIOBLASTOMA | PHASE-III | RANDOMIZED-TRIAL | RADIOTHERAPY | RESPONSE ASSESSMENT CRITERIA | RADIATION-THERAPY | TEMOZOLOMIDE | Antibodies, Monoclonal, Humanized - adverse effects | Antibodies, Monoclonal, Humanized - therapeutic use | Camptothecin - therapeutic use | Snake Venoms - therapeutic use | Dacarbazine - therapeutic use | Humans | Neoplasm Recurrence, Local - drug therapy | Antineoplastic Agents - therapeutic use | Brain Neoplasms - blood supply | Brain Neoplasms - drug therapy | Bevacizumab | Randomized Controlled Trials as Topic | Proteinuria - chemically induced | Neovascularization, Pathologic - drug therapy | Hypertension - chemically induced | Dacarbazine - analogs & derivatives | Angiogenesis Inhibitors - therapeutic use | Lomustine - therapeutic use | Brain Neoplasms - mortality | Glioblastoma - drug therapy | Angiogenesis Inhibitors - adverse effects | Glioblastoma - blood supply | Glioblastoma - mortality | Camptothecin - analogs & derivatives | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 2010, Volume 16, Issue 5, pp. 1597 - 1604
PURPOSE: Recent studies have shown the prognostic significance of IDH1 mutations in glioma. It is yet unclear if IDH1 mutations are predictive for outcome to...
GLIOMAS | PROMOTER HYPERMETHYLATION | GLIOBLASTOMAS | ONCOLOGY | CODON 132 MUTATION | OLIGOASTROCYTOMAS | Prognosis | Oligodendroglioma - genetics | Humans | Middle Aged | DNA Repair Enzymes - genetics | Male | Young Adult | Tumor Suppressor Proteins - genetics | Polymerase Chain Reaction | Adult | Female | Lomustine - therapeutic use | Brain Neoplasms - mortality | Oligodendroglioma - mortality | Promoter Regions, Genetic | Kaplan-Meier Estimate | Brain Neoplasms - genetics | In Situ Hybridization, Fluorescence | Isocitrate Dehydrogenase - genetics | Treatment Outcome | Combined Modality Therapy | Radiotherapy | Disease-Free Survival | DNA Modification Methylases - genetics | Genes, erbB-1 | Oligodendroglioma - therapy | Procarbazine - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Adolescent | Brain Neoplasms - therapy | Vincristine - therapeutic use | Aged | Mutation
GLIOMAS | PROMOTER HYPERMETHYLATION | GLIOBLASTOMAS | ONCOLOGY | CODON 132 MUTATION | OLIGOASTROCYTOMAS | Prognosis | Oligodendroglioma - genetics | Humans | Middle Aged | DNA Repair Enzymes - genetics | Male | Young Adult | Tumor Suppressor Proteins - genetics | Polymerase Chain Reaction | Adult | Female | Lomustine - therapeutic use | Brain Neoplasms - mortality | Oligodendroglioma - mortality | Promoter Regions, Genetic | Kaplan-Meier Estimate | Brain Neoplasms - genetics | In Situ Hybridization, Fluorescence | Isocitrate Dehydrogenase - genetics | Treatment Outcome | Combined Modality Therapy | Radiotherapy | Disease-Free Survival | DNA Modification Methylases - genetics | Genes, erbB-1 | Oligodendroglioma - therapy | Procarbazine - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Adolescent | Brain Neoplasms - therapy | Vincristine - therapeutic use | Aged | Mutation
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 06/2006, Volume 24, Issue 18, pp. 2707 - 2714
Purpose Anaplastic oligodendroglioma (AO) and anaplastic oligoastrocytoma (AOA) are treated with surgery and radiotherapy (BT) at diagnosis, but they also...
MALIGNANT GLIOMA | SURVIVAL | ONCOLOGY | OLIGOASTROCYTOMAS | CHROMOSOME ARMS 1P | 19Q | TUMORS | DELETIONS | TEMOZOLOMIDE | Oligodendroglioma - surgery | Oligodendroglioma - genetics | Humans | Middle Aged | Male | Loss of Heterozygosity | Oligodendroglioma - radiotherapy | Brain Neoplasms - surgery | Chromosomes, Human, Pair 1 | Adult | Dose Fractionation | Female | Lomustine - therapeutic use | Chemotherapy, Adjuvant | Brain Neoplasms - radiotherapy | Oligodendroglioma - drug therapy | Proportional Hazards Models | Radiotherapy, High-Energy | Brain Neoplasms - genetics | Brain Neoplasms - drug therapy | Chromosomes, Human, Pair 19 | Procarbazine - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Vincristine - therapeutic use | Aged
MALIGNANT GLIOMA | SURVIVAL | ONCOLOGY | OLIGOASTROCYTOMAS | CHROMOSOME ARMS 1P | 19Q | TUMORS | DELETIONS | TEMOZOLOMIDE | Oligodendroglioma - surgery | Oligodendroglioma - genetics | Humans | Middle Aged | Male | Loss of Heterozygosity | Oligodendroglioma - radiotherapy | Brain Neoplasms - surgery | Chromosomes, Human, Pair 1 | Adult | Dose Fractionation | Female | Lomustine - therapeutic use | Chemotherapy, Adjuvant | Brain Neoplasms - radiotherapy | Oligodendroglioma - drug therapy | Proportional Hazards Models | Radiotherapy, High-Energy | Brain Neoplasms - genetics | Brain Neoplasms - drug therapy | Chromosomes, Human, Pair 19 | Procarbazine - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Vincristine - therapeutic use | Aged
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 06/2006, Volume 24, Issue 18, pp. 2715 - 2722
Purpose Anaplastic oligodendrogliomas are more responsive to chemotherapy than high-grade astrocytomas. We investigated, in a multicenter randomized controlled...
GLIOMAS | GLIOBLASTOMA | RADIOTHERAPY | TUMORS | UMCG Approved | CHEMOTHERAPY | TEMOZOLOMIDE | ONCOLOGY | Oligodendroglioma - genetics | Humans | Middle Aged | Brain Neoplasms - genetics | Male | Brain Neoplasms - drug therapy | Loss of Heterozygosity | Oligodendroglioma - radiotherapy | Chromosomes, Human, Pair 19 | Chromosomes, Human, Pair 1 | Procarbazine - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Vincristine - therapeutic use | Adult | Dose Fractionation | Female | Lomustine - therapeutic use | Aged | Chemotherapy, Adjuvant | Brain Neoplasms - radiotherapy | Oligodendroglioma - drug therapy
GLIOMAS | GLIOBLASTOMA | RADIOTHERAPY | TUMORS | UMCG Approved | CHEMOTHERAPY | TEMOZOLOMIDE | ONCOLOGY | Oligodendroglioma - genetics | Humans | Middle Aged | Brain Neoplasms - genetics | Male | Brain Neoplasms - drug therapy | Loss of Heterozygosity | Oligodendroglioma - radiotherapy | Chromosomes, Human, Pair 19 | Chromosomes, Human, Pair 1 | Procarbazine - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Vincristine - therapeutic use | Adult | Dose Fractionation | Female | Lomustine - therapeutic use | Aged | Chemotherapy, Adjuvant | Brain Neoplasms - radiotherapy | Oligodendroglioma - drug therapy
Journal Article
Radiotherapy and Oncology, ISSN 0167-8140, 2010, Volume 98, Issue 1, pp. 1 - 14
Abstract Background and purpose: Despite the given advances in neuro-oncology most patients with high grade malignant glioma ultimately fail locally or...
Hematology, Oncology and Palliative Medicine | Malignant glioma | Relapse | Temozolomide | Radiotherapy | Bevacizumab | PROGNOSTIC-FACTORS | FRACTIONATED STEREOTACTIC RADIOSURGERY | BEVACIZUMAB PLUS IRINOTECAN | DI-NEURO-ONCOLOGIA | INTERSTITIAL PHOTODYNAMIC THERAPY | ANAPLASTIC ASTROCYTOMA | PHASE-II TRIAL | ONCOLOGY | BRAIN-TUMOR CONSORTIUM | TEMOZOLOMIDE-REFRACTORY GLIOBLASTOMA | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | HIGH-GRADE GLIOMA | Radiotherapy Dosage | Humans | Neoplasm Recurrence, Local - therapy | Brain Neoplasms - therapy | Glioma - therapy | Radiosurgery | Salvage Therapy | Angiogenesis Inhibitors - therapeutic use | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Brachytherapy | Care and treatment | Phosphatases | Radioisotope brachytherapy | Mortality | Etoposide | Photochemotherapy | Chemotherapy | Cyclophosphamide | Gliomas | Analysis | Lomustine | Vascular endothelial growth factor | Health aspects | Growth factors | Cancer
Hematology, Oncology and Palliative Medicine | Malignant glioma | Relapse | Temozolomide | Radiotherapy | Bevacizumab | PROGNOSTIC-FACTORS | FRACTIONATED STEREOTACTIC RADIOSURGERY | BEVACIZUMAB PLUS IRINOTECAN | DI-NEURO-ONCOLOGIA | INTERSTITIAL PHOTODYNAMIC THERAPY | ANAPLASTIC ASTROCYTOMA | PHASE-II TRIAL | ONCOLOGY | BRAIN-TUMOR CONSORTIUM | TEMOZOLOMIDE-REFRACTORY GLIOBLASTOMA | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | HIGH-GRADE GLIOMA | Radiotherapy Dosage | Humans | Neoplasm Recurrence, Local - therapy | Brain Neoplasms - therapy | Glioma - therapy | Radiosurgery | Salvage Therapy | Angiogenesis Inhibitors - therapeutic use | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Brachytherapy | Care and treatment | Phosphatases | Radioisotope brachytherapy | Mortality | Etoposide | Photochemotherapy | Chemotherapy | Cyclophosphamide | Gliomas | Analysis | Lomustine | Vascular endothelial growth factor | Health aspects | Growth factors | Cancer
Journal Article
Neuro-Oncology, ISSN 1522-8517, 08/2016, Volume 18, Issue 8, pp. 1146 - 1156
The combination of galunisertib, a transforming growth factor (TGF)-beta receptor (R)1 kinase inhibitor, and lomustine was found to have antitumor activity in...
Antitumor activity | Galunisertib monohydrate (LY2157299) | Bayesian design | Safety | Pharmacokinetics | Phase II randomized study | SURVIVAL | CELLS | DIAGNOSIS | TGF-BETA | KINASE INHIBITOR | CLINICAL NEUROLOGY | INHIBITOR LY2157299 MONOHYDRATE | ONCOLOGY | antitumor activity | safety | GROWTH | pharmacokinetics | galunisertib monohydrate (LY2157299) | ASSOCIATION | Pyrazoles - therapeutic use | Humans | Lomustine - adverse effects | Middle Aged | Kaplan-Meier Estimate | Male | Treatment Outcome | Brain Neoplasms - drug therapy | Antineoplastic Agents, Alkylating - therapeutic use | Quinolines - pharmacokinetics | Disease-Free Survival | Drug Therapy, Combination - adverse effects | Drug Therapy, Combination - methods | Lomustine - pharmacokinetics | Female | Lomustine - therapeutic use | Quinolines - therapeutic use | Antineoplastic Agents, Alkylating - adverse effects | Glioblastoma - drug therapy | Pyrazoles - pharmacokinetics | Quinolines - adverse effects | Pyrazoles - adverse effects | Clinical Investigations
Antitumor activity | Galunisertib monohydrate (LY2157299) | Bayesian design | Safety | Pharmacokinetics | Phase II randomized study | SURVIVAL | CELLS | DIAGNOSIS | TGF-BETA | KINASE INHIBITOR | CLINICAL NEUROLOGY | INHIBITOR LY2157299 MONOHYDRATE | ONCOLOGY | antitumor activity | safety | GROWTH | pharmacokinetics | galunisertib monohydrate (LY2157299) | ASSOCIATION | Pyrazoles - therapeutic use | Humans | Lomustine - adverse effects | Middle Aged | Kaplan-Meier Estimate | Male | Treatment Outcome | Brain Neoplasms - drug therapy | Antineoplastic Agents, Alkylating - therapeutic use | Quinolines - pharmacokinetics | Disease-Free Survival | Drug Therapy, Combination - adverse effects | Drug Therapy, Combination - methods | Lomustine - pharmacokinetics | Female | Lomustine - therapeutic use | Quinolines - therapeutic use | Antineoplastic Agents, Alkylating - adverse effects | Glioblastoma - drug therapy | Pyrazoles - pharmacokinetics | Quinolines - adverse effects | Pyrazoles - adverse effects | Clinical Investigations
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 12/2014, Volume 20, Issue 24, pp. 6304 - 6313
Purpose: Preclinical data indicate anti-invasive activity of APG101, a CD95 ligand (CD95L)-binding fusion protein, in glioblastoma. Experimental Design:...
TRIAL | CELLS | CD95 | INVASION | RECURRENT MALIGNANT GLIOMA | EFFICACY | ONCOLOGY | LOMUSTINE | TOLERABILITY | COMBINATION | TEMOZOLOMIDE | fas Receptor - administration & dosage | Prognosis | Recombinant Fusion Proteins - adverse effects | Humans | Middle Aged | Recombinant Fusion Proteins - therapeutic use | Male | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Glioblastoma - radiotherapy | Young Adult | Antineoplastic Agents - adverse effects | Adult | Female | Recombinant Fusion Proteins - administration & dosage | Drug Administration Schedule | Immunoglobulin G - therapeutic use | Treatment Outcome | Combined Modality Therapy | Tumor Burden | fas Receptor - adverse effects | fas Receptor - therapeutic use | Immunoglobulin G - administration & dosage | Immunoglobulin G - adverse effects | Glioblastoma - pathology | Biomarkers | Quality of Life | Aged | Glioblastoma - drug therapy | Glioblastoma - mortality
TRIAL | CELLS | CD95 | INVASION | RECURRENT MALIGNANT GLIOMA | EFFICACY | ONCOLOGY | LOMUSTINE | TOLERABILITY | COMBINATION | TEMOZOLOMIDE | fas Receptor - administration & dosage | Prognosis | Recombinant Fusion Proteins - adverse effects | Humans | Middle Aged | Recombinant Fusion Proteins - therapeutic use | Male | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Glioblastoma - radiotherapy | Young Adult | Antineoplastic Agents - adverse effects | Adult | Female | Recombinant Fusion Proteins - administration & dosage | Drug Administration Schedule | Immunoglobulin G - therapeutic use | Treatment Outcome | Combined Modality Therapy | Tumor Burden | fas Receptor - adverse effects | fas Receptor - therapeutic use | Immunoglobulin G - administration & dosage | Immunoglobulin G - adverse effects | Glioblastoma - pathology | Biomarkers | Quality of Life | Aged | Glioblastoma - drug therapy | Glioblastoma - mortality
Journal Article
Journal of Neuro-Oncology, ISSN 0167-594X, 5/2016, Volume 128, Issue 1, pp. 147 - 155
We conducted a randomized, non-comparative, multi center, phase II clinical trial in order to investigate the efficacy of axitinib, an oral small molecule...
Neurology | Medicine & Public Health | Glioblastoma | Oncology | Axitinib | Recurrent | Bevacizumab | Bevacizumab - therapeutic use | Brain Neoplasms - diagnostic imaging | Humans | Middle Aged | Neoplasm Recurrence, Local - drug therapy | Male | Positron-Emission Tomography | Protein Kinase Inhibitors - adverse effects | Young Adult | Glioblastoma - diagnostic imaging | Glioblastoma - genetics | Neoplasm Recurrence, Local - diagnostic imaging | Angiogenesis Inhibitors - therapeutic use | Adult | Female | Lomustine - therapeutic use | Steroids - therapeutic use | Imidazoles - therapeutic use | Radiopharmaceuticals | Angiogenesis Inhibitors - adverse effects | Imidazoles - adverse effects | Brain Neoplasms - genetics | Treatment Outcome | Brain Neoplasms - drug therapy | Antineoplastic Agents, Alkylating - therapeutic use | Disease-Free Survival | Protein Kinase Inhibitors - therapeutic use | Fluorodeoxyglucose F18 | Neoplasm Recurrence, Local - genetics | Aged | Indazoles - adverse effects | Glioblastoma - drug therapy | Indazoles - therapeutic use | Protein-Tyrosine Kinases - antagonists & inhibitors | Tyrosine | Medical research | Care and treatment | Relapse | Corticosteroids | Endothelial growth factors | Physicians | Clinical trials | Medicine, Experimental | Glioblastoma multiforme | Diseases
Neurology | Medicine & Public Health | Glioblastoma | Oncology | Axitinib | Recurrent | Bevacizumab | Bevacizumab - therapeutic use | Brain Neoplasms - diagnostic imaging | Humans | Middle Aged | Neoplasm Recurrence, Local - drug therapy | Male | Positron-Emission Tomography | Protein Kinase Inhibitors - adverse effects | Young Adult | Glioblastoma - diagnostic imaging | Glioblastoma - genetics | Neoplasm Recurrence, Local - diagnostic imaging | Angiogenesis Inhibitors - therapeutic use | Adult | Female | Lomustine - therapeutic use | Steroids - therapeutic use | Imidazoles - therapeutic use | Radiopharmaceuticals | Angiogenesis Inhibitors - adverse effects | Imidazoles - adverse effects | Brain Neoplasms - genetics | Treatment Outcome | Brain Neoplasms - drug therapy | Antineoplastic Agents, Alkylating - therapeutic use | Disease-Free Survival | Protein Kinase Inhibitors - therapeutic use | Fluorodeoxyglucose F18 | Neoplasm Recurrence, Local - genetics | Aged | Indazoles - adverse effects | Glioblastoma - drug therapy | Indazoles - therapeutic use | Protein-Tyrosine Kinases - antagonists & inhibitors | Tyrosine | Medical research | Care and treatment | Relapse | Corticosteroids | Endothelial growth factors | Physicians | Clinical trials | Medicine, Experimental | Glioblastoma multiforme | Diseases
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 03/2010, Volume 28, Issue 7, pp. 1168 - 1174
Purpose This phase III open-label study compared the efficacy and safety of enzastaurin versus lomustine in patients with recurrent glioblastoma (WHO grade 4)....
MALIGNANT GLIOMA | TRIAL | PROTEIN-KINASE-C | THERAPY | ONCOLOGY | MULTIFORME | CANCER | CHEMOTHERAPY | ENDOTHELIAL GROWTH-FACTOR | BRAIN-TUMORS | TEMOZOLOMIDE | Humans | Lomustine - adverse effects | Middle Aged | Neoplasm Recurrence, Local - drug therapy | Male | Brain Neoplasms - drug therapy | Indoles - adverse effects | Adult | Female | Indoles - pharmacokinetics | Indoles - therapeutic use | Lomustine - therapeutic use | Aged | Brain Neoplasms - mortality | Glioblastoma - drug therapy | Glioblastoma - mortality | Index Medicus | Neur6 | Original Reports | Neur1
MALIGNANT GLIOMA | TRIAL | PROTEIN-KINASE-C | THERAPY | ONCOLOGY | MULTIFORME | CANCER | CHEMOTHERAPY | ENDOTHELIAL GROWTH-FACTOR | BRAIN-TUMORS | TEMOZOLOMIDE | Humans | Lomustine - adverse effects | Middle Aged | Neoplasm Recurrence, Local - drug therapy | Male | Brain Neoplasms - drug therapy | Indoles - adverse effects | Adult | Female | Indoles - pharmacokinetics | Indoles - therapeutic use | Lomustine - therapeutic use | Aged | Brain Neoplasms - mortality | Glioblastoma - drug therapy | Glioblastoma - mortality | Index Medicus | Neur6 | Original Reports | Neur1
Journal Article
Neuro-Oncology, ISSN 1522-8517, 01/2014, Volume 16, Issue 12, pp. 1570 - 1574
textabstractThe long-term follow-up of the RTOG 9802 trial that compared 54 Gy of radiotherapy (RT) with the same RT followed by adjuvant procarbazine, CCNU,...
Chemotherapy | PCV | Low grade glioma | Temozolomide | temozolomide | RANDOMIZED-TRIAL | VINCRISTINE CHEMOTHERAPY | chemotherapy | COGNITIVE FUNCTION | CLINICAL NEUROLOGY | PHASE-III TRIAL | RECURRENT OLIGODENDROGLIOMA | ONCOLOGY | ANAPLASTIC OLIGODENDROGLIOMA | CLINICAL-TRIALS | TERM-FOLLOW-UP | EUROPEAN-ORGANIZATION | low grade glioma | Humans | Male | Survival Rate | Treatment Outcome | Antineoplastic Agents - therapeutic use | Brain Neoplasms - drug therapy | Chemoradiotherapy, Adjuvant | Glioma - radiotherapy | Clinical Trials, Phase III as Topic | Procarbazine - therapeutic use | Brain Neoplasms - therapy | Glioma - therapy | Vincristine - therapeutic use | Female | Lomustine - therapeutic use | Brain Neoplasms - radiotherapy | Glioma - drug therapy | Index Medicus | Reviews
Chemotherapy | PCV | Low grade glioma | Temozolomide | temozolomide | RANDOMIZED-TRIAL | VINCRISTINE CHEMOTHERAPY | chemotherapy | COGNITIVE FUNCTION | CLINICAL NEUROLOGY | PHASE-III TRIAL | RECURRENT OLIGODENDROGLIOMA | ONCOLOGY | ANAPLASTIC OLIGODENDROGLIOMA | CLINICAL-TRIALS | TERM-FOLLOW-UP | EUROPEAN-ORGANIZATION | low grade glioma | Humans | Male | Survival Rate | Treatment Outcome | Antineoplastic Agents - therapeutic use | Brain Neoplasms - drug therapy | Chemoradiotherapy, Adjuvant | Glioma - radiotherapy | Clinical Trials, Phase III as Topic | Procarbazine - therapeutic use | Brain Neoplasms - therapy | Glioma - therapy | Vincristine - therapeutic use | Female | Lomustine - therapeutic use | Brain Neoplasms - radiotherapy | Glioma - drug therapy | Index Medicus | Reviews
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 04/2016, Volume 374, Issue 14, pp. 1344 - 1355
Patients with grade 2 glioma were randomly assigned to radiation therapy alone or radiation therapy plus six cycles of chemotherapy. The median overall...
MEDICINE, GENERAL & INTERNAL | PHASE-II TRIAL | RECURRENT GLIOMA | THERAPY | ANAPLASTIC OLIGODENDROGLIOMA | LOMUSTINE | TERM-FOLLOW-UP | RADIOTHERAPY | CANCER | CHEMOTHERAPY | Procarbazine - administration & dosage | Astrocytoma - radiotherapy | Oligodendroglioma - mortality | Follow-Up Studies | Humans | Male | Combined Modality Therapy | Brain Neoplasms - drug therapy | Oligodendroglioma - radiotherapy | Young Adult | Disease-Free Survival | Neoplasm Grading | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Astrocytoma - drug therapy | Survival Analysis | Vincristine - administration & dosage | Adult | Female | Brain Neoplasms - mortality | Brain Neoplasms - radiotherapy | Lomustine - administration & dosage | Astrocytoma - mortality | Oligodendroglioma - drug therapy | Procarbazine | Care and treatment | Chemotherapy | Usage | Gliomas | Lomustine | Dosage and administration | Cancer | Brain cancer | Radiation therapy | Oligoastrocytoma | Survival | Patients | Vincristine | Oligodendroglioma | Glioma | Biopsy | Astrocytoma | Tumors
MEDICINE, GENERAL & INTERNAL | PHASE-II TRIAL | RECURRENT GLIOMA | THERAPY | ANAPLASTIC OLIGODENDROGLIOMA | LOMUSTINE | TERM-FOLLOW-UP | RADIOTHERAPY | CANCER | CHEMOTHERAPY | Procarbazine - administration & dosage | Astrocytoma - radiotherapy | Oligodendroglioma - mortality | Follow-Up Studies | Humans | Male | Combined Modality Therapy | Brain Neoplasms - drug therapy | Oligodendroglioma - radiotherapy | Young Adult | Disease-Free Survival | Neoplasm Grading | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Astrocytoma - drug therapy | Survival Analysis | Vincristine - administration & dosage | Adult | Female | Brain Neoplasms - mortality | Brain Neoplasms - radiotherapy | Lomustine - administration & dosage | Astrocytoma - mortality | Oligodendroglioma - drug therapy | Procarbazine | Care and treatment | Chemotherapy | Usage | Gliomas | Lomustine | Dosage and administration | Cancer | Brain cancer | Radiation therapy | Oligoastrocytoma | Survival | Patients | Vincristine | Oligodendroglioma | Glioma | Biopsy | Astrocytoma | Tumors
Journal Article