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Nature Neuroscience, ISSN 1097-6256, 03/2012, Volume 15, Issue 5, pp. 746 - 53
Endocannabinoid mediated spike timing-dependent depression (t-LTD) is crucially involved in the development of the sensory neocortex. t-LTD at excitatory... 
Astrocytes/drug effects | Electric Stimulation | Rats, Wistar | 2-Amino-5-phosphonovalerate/pharmacology | Calcium/metabolism | Synapses/drug effects | Time Factors | Naphthalenes/pharmacology | Sodium Channel Blockers/pharmacology | Thalamus/cytology | Long-Term Synaptic Depression/drug effects | Animals, Newborn | Calcium Channel Blockers/pharmacology | Excitatory Amino Acid Antagonists/pharmacology | Dizocilpine Maleate/pharmacology | Excitatory Postsynaptic Potentials/drug effects | Probability | Rats | Benzoxazines/pharmacology | Biophysics | Signal Transduction/drug effects | Neocortex/cytology | Patch-Clamp Techniques | Animals | Glutamic Acid/metabolism | Morpholines/pharmacology | Pyrazoles/pharmacology | Piperidines/pharmacology | Tetrodotoxin/pharmacology | In Vitro Techniques | Receptor, Cannabinoid, CB1/antagonists & inhibitors | D-SERINE | NEUROTRANSMITTER RELEASE | INHIBITORY SYNAPSES | PYRAMIDAL CELLS | SYNAPTIC-TRANSMISSION | RAT SOMATOSENSORY CORTEX | LONG-TERM POTENTIATION | GLIAL-CELLS | PRESYNAPTIC NMDA | NEUROSCIENCES | PLASTICITY | Calcium - metabolism | 2-Amino-5-phosphonovalerate - pharmacology | Long-Term Synaptic Depression - drug effects | Excitatory Postsynaptic Potentials - drug effects | Piperidines - pharmacology | Tetrodotoxin - pharmacology | Pyrazoles - pharmacology | Astrocytes - drug effects | Long-Term Synaptic Depression - physiology | Synapses - drug effects | Synapses - physiology | Morpholines - pharmacology | Sodium Channel Blockers - pharmacology | Synapses - ultrastructure | Excitatory Amino Acid Antagonists - pharmacology | Calcium Channel Blockers - pharmacology | Naphthalenes - pharmacology | Astrocytes - ultrastructure | Astrocytes - physiology | Signal Transduction - drug effects | Benzoxazines - pharmacology | Thalamus - cytology | Neocortex - cytology | Signal Transduction - physiology | Glutamic Acid - metabolism | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Dizocilpine Maleate - pharmacology | Methyl aspartate | Depression, Mental | Physiological aspects | Genetic aspects | Research | Risk factors | Synapses
Journal Article
Nature Neuroscience, ISSN 1097-6256, 03/2013, Volume 16, Issue 3, pp. 300 - 308
Journal Article
Journal Article
Neuron, ISSN 0896-6273, 01/2012, Volume 73, Issue 2, pp. 374 - 390
Journal Article
Neuron, ISSN 0896-6273, 05/2006, Volume 50, Issue 3, pp. 443 - 452
Long-term depression (LTD) of the synapse formed between cortical pyramidal neurons and striatal medium spiny neurons is central to many theories of motor... 
SYSNEURO | MOLNEURO | SIGNALING | N-TYPE | ENDOCANNABINOID RELEASE | CA2+ CURRENTS | BASAL GANGLIA | MUSCARINIC RECEPTORS | CHANNELS | NEUROSCIENCES | RAT STRIATAL NEURONS | COORDINATED EXPRESSION | MODULATION | NUCLEUS-ACCUMBENS | Neural Pathways - drug effects | Synaptic Transmission - physiology | Calcium Signaling - physiology | Acetylcholine - metabolism | Long-Term Synaptic Depression - drug effects | Presynaptic Terminals - ultrastructure | Receptors, Dopamine D2 - metabolism | Cerebral Cortex - cytology | Corpus Striatum - cytology | Corpus Striatum - metabolism | Cerebral Cortex - metabolism | Neural Inhibition - physiology | Synaptic Transmission - drug effects | Dopamine - metabolism | Organ Culture Techniques | Long-Term Synaptic Depression - physiology | Presynaptic Terminals - drug effects | Mice, Inbred C57BL | Interneurons - drug effects | Mice, Transgenic | Mice, Knockout | Learning - physiology | Animals | Calcium Channels, L-Type - genetics | Interneurons - metabolism | Neural Pathways - cytology | Corpus Striatum - drug effects | Neural Pathways - metabolism | Presynaptic Terminals - metabolism | Mice | Calcium Channels, L-Type - metabolism | Excitatory Amino Acid Antagonists | Neural Inhibition - drug effects | Receptor, Muscarinic M1 - metabolism | Neurons | Neurosciences | Depression, Mental | Brain | Cocaine | Rodents
Journal Article
Neuron, ISSN 0896-6273, 10/2012, Volume 76, Issue 2, pp. 325 - 337
Fragile X syndrome (FXS) is the leading inherited cause of autism and intellectual disability. Aberrant synaptic translation has been implicated in the... 
MAMMALIAN TARGET | RAPAMYCIN SIGNALING PATHWAY | FMR1 KNOCKOUT MOUSE | MESSENGER-RNA | MEMORY | LONG-TERM DEPRESSION | PHOSPHOINOSITIDE 3-KINASE-AKT-MAMMALIAN TARGET | TRANSLATION | MENTAL-RETARDATION PROTEIN | NEUROSCIENCES | MTOR | Electric Stimulation | Fragile X Syndrome - pathology | Male | Fragile X Mental Retardation Protein - metabolism | Synapses - genetics | Recognition (Psychology) - physiology | Phosphorylation - genetics | TOR Serine-Threonine Kinases - genetics | Ribosomal Protein S6 Kinases, 70-kDa - deficiency | Excitatory Postsynaptic Potentials - genetics | Disease Models, Animal | Membrane Potentials - drug effects | Synapses - drug effects | Maze Learning - physiology | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Dendritic Spines - physiology | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Behavior, Animal - physiology | Mice, Transgenic | Hippocampus - pathology | Mutation - genetics | Patch-Clamp Techniques | Phenotype | Analysis of Variance | Mice | Long-Term Synaptic Depression - genetics | Neurons - pathology | Membrane Potentials - genetics | Fragile X Syndrome - physiopathology | Extracellular Signal-Regulated MAP Kinases - metabolism | Long-Term Synaptic Depression - drug effects | Excitatory Postsynaptic Potentials - drug effects | Extracellular Signal-Regulated MAP Kinases - genetics | Exploratory Behavior - physiology | Neurons - classification | Female | Interpersonal Relations | Fragile X Syndrome - genetics | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Biophysics | Methoxyhydroxyphenylglycol - analogs & derivatives | Methoxyhydroxyphenylglycol - pharmacology | Motor Activity - genetics | Rotarod Performance Test | Animals | Fragile X Syndrome - prevention & control | Dendritic Spines - classification | Fragile X Mental Retardation Protein - genetics | In Vitro Techniques | Depression, Mental | Analysis | Genetic research | Protein biosynthesis | Genetic aspects | Fragile X syndrome | Genetic translation | Proteins | Phosphorylation | Brain research | Kinases | Protein synthesis | Rodents | Animal models | Translation | Translation initiation | Pattern recognition | Mental retardation | Ribosomal protein S6 kinase | Autism | Dendritic spines | Molecular modelling | Social interactions | Etiology | p70 S6 kinase | Long-term depression | Elongation
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2013, Volume 110, Issue 10, pp. 4027 - 4032
NMDA receptor (NMDAR) activation controls long-term potentiation (LTP) as well as long-term depression (LTD) of synaptic transmission, cellular models of... 
Neuroscience | Calcium | Synaptic transmission | Neurons | N methyl D aspartate receptors | Plasticity | Long term potentiation | Long term depression | AMPA receptors | Synapses | AMPA receptor | Ion-flux independent | BAPTA | GluN2 | NR2 | SELECTIVE ANTAGONIST | BLOCKS INDUCTION | MULTIDISCIPLINARY SCIENCES | SYNAPTIC PLASTICITY | AREA CA1 | TRANSMISSION | AMPA RECEPTORS | POTENTIATION | SYNAPSES | CA2 | RAT HIPPOCAMPUS | ion-flux independent | Long-Term Synaptic Depression - physiology | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Synaptic Transmission - physiology | Tissue Culture Techniques | Calcium Signaling - physiology | Rats | Receptors, Metabotropic Glutamate - physiology | Chelating Agents - pharmacology | Hippocampus - drug effects | Long-Term Synaptic Depression - drug effects | Rats, Sprague-Dawley | Receptors, N-Methyl-D-Aspartate - physiology | Animals | Egtazic Acid - pharmacology | Neuronal Plasticity - physiology | Kynurenic Acid - analogs & derivatives | Egtazic Acid - analogs & derivatives | Synaptic Transmission - drug effects | Kynurenic Acid - pharmacology | Dizocilpine Maleate - pharmacology | Hippocampus - physiology | Receptors, Metabotropic Glutamate - antagonists & inhibitors | Methyl aspartate | Calcium, Dietary | Depression, Mental | Ligands (Biochemistry) | Physiological aspects | Neural transmission | Research | Health aspects | Protein binding | Biological Sciences
Journal Article
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 06/2013, Volume 18, Issue 6, pp. 729 - 737
Defining the drug-induced neuroadaptations specifically associated with the behavioral manifestation of addiction is a daunting task. To address this issue, we... 
endocannabinoid-mediated LTD | synaptic plasticity | mGluR2/3-mediated LTD | cocaine intravenous self-administration | prefrontal cortex | transition to addiction | INDUCED REINSTATEMENT | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCANNABINOID SYSTEM | NEUROSCIENCES | BED NUCLEUS | DOPAMINE NEURONS | STRIA TERMINALIS | LONG-TERM DEPRESSION | NUCLEUS-ACCUMBENS SYNAPSES | DRUG-ADDICTION | SELF-ADMINISTRATION ALTERS | RECEPTOR AGONIST | Dopamine Uptake Inhibitors - adverse effects | Electric Stimulation | Receptors, N-Methyl-D-Aspartate - metabolism | Substance-Related Disorders - pathology | Male | Long-Term Synaptic Depression - drug effects | Excitatory Postsynaptic Potentials - drug effects | Amino Acids - pharmacology | Prefrontal Cortex - pathology | Psychiatric Status Rating Scales | Self Administration | Synapses - metabolism | Conditioning, Operant - drug effects | Cocaine - adverse effects | Receptors, AMPA - metabolism | Disease Models, Animal | Synapses - drug effects | Substance-Related Disorders - metabolism | Rats | Excitatory Amino Acid Agonists - pharmacology | Biophysics | Rats, Sprague-Dawley | Dopamine Uptake Inhibitors - administration & dosage | Cocaine - administration & dosage | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Patch-Clamp Techniques | Animals | Analysis of Variance | Prefrontal Cortex - metabolism | Substance-Related Disorders - psychology | In Vitro Techniques | Physiological aspects | Drug abuse | Prefrontal cortex | Addiction | Excitatory Amino Acid Agonists | Life Sciences | Excitatory Postsynaptic Potentials | Receptors, AMPA | Dopamine Uptake Inhibitors | Bridged Bicyclo Compounds, Heterocyclic | Receptors, N-Methyl-D-Aspartate | Amino Acids | Long-Term Synaptic Depression | Prefrontal Cortex | Conditioning, Operant | Substance-Related Disorders | Cocaine | Synapses
Journal Article