Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (17034) 17034
Publication (3270) 3270
Book Review (316) 316
Book Chapter (204) 204
Conference Proceeding (67) 67
Reference (15) 15
Book / eBook (13) 13
Dissertation (5) 5
Data Set (3) 3
Magazine Article (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (13225) 13225
neurosciences (12404) 12404
long-term potentiation (10521) 10521
index medicus (8334) 8334
rats (5804) 5804
male (5584) 5584
synaptic plasticity (5012) 5012
humans (4617) 4617
hippocampus (3992) 3992
long-term depression (3881) 3881
mice (3581) 3581
neurons (3492) 3492
neuronal plasticity - physiology (3378) 3378
memory (2846) 2846
synapses - physiology (2793) 2793
plasticity (2729) 2729
brain (2620) 2620
long-term potentiation - physiology (2572) 2572
rats, sprague-dawley (2297) 2297
hippocampus - physiology (2254) 2254
nervous system (2188) 2188
synaptic transmission - physiology (2134) 2134
article (2117) 2117
in vitro techniques (2045) 2045
neurology (2031) 2031
neurons - physiology (1920) 1920
female (1893) 1893
neuroscience (1829) 1829
electric stimulation (1766) 1766
rats, wistar (1697) 1697
physiology (1679) 1679
physiological aspects (1643) 1643
synaptic transmission (1620) 1620
mice, inbred c57bl (1547) 1547
glutamate (1537) 1537
long-term potentiation - drug effects (1516) 1516
research (1498) 1498
rodents (1454) 1454
hippocampus - drug effects (1401) 1401
dentate gyrus (1395) 1395
analysis (1393) 1393
synapses (1392) 1392
hippocampus - metabolism (1383) 1383
ltp (1366) 1366
time factors (1348) 1348
excitatory postsynaptic potentials - physiology (1341) 1341
pharmacology & pharmacy (1303) 1303
biochemistry & molecular biology (1255) 1255
depression (1247) 1247
proteins (1231) 1231
learning (1212) 1212
long-term synaptic depression - physiology (1194) 1194
neurons - metabolism (1194) 1194
potentiation (1186) 1186
memory - physiology (1182) 1182
in-vivo (1176) 1176
synaptic transmission - drug effects (1151) 1151
multidisciplinary sciences (1146) 1146
rat hippocampus (1110) 1110
hippocampus - cytology (1108) 1108
excitatory postsynaptic potentials - drug effects (1107) 1107
receptors, n-methyl-d-aspartate - metabolism (1088) 1088
mice, knockout (1081) 1081
patch-clamp techniques (1059) 1059
synapses - metabolism (1044) 1044
cell biology (1035) 1035
neuronal plasticity - drug effects (1030) 1030
neurons - drug effects (1026) 1026
phosphorylation (1019) 1019
electrophysiology (1003) 1003
psychiatry (999) 999
models, neurological (982) 982
excitatory amino acid antagonists - pharmacology (978) 978
disease models, animal (971) 971
rat (960) 960
synapses - drug effects (955) 955
dendritic spines (935) 935
nmda receptors (930) 930
neuronal plasticity (919) 919
central-nervous-system (918) 918
activation (912) 912
behavioral sciences (911) 911
alzheimers-disease (910) 910
cells, cultured (893) 893
methyl aspartate (845) 845
receptors, ampa - metabolism (844) 844
learning - physiology (836) 836
receptors (832) 832
receptors, n-methyl-d-aspartate - physiology (825) 825
hippocampal-neurons (818) 818
calcium - metabolism (808) 808
cortex (803) 803
research article (802) 802
signal transduction - physiology (796) 796
expression (790) 790
biomedicine (769) 769
metabotropic glutamate receptors (768) 768
musculoskeletal, neural, and ocular physiology (767) 767
signal transduction (760) 760
action potentials - physiology (755) 755
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (10) 10
Providence Healthcare - Stacks (2) 2
Trillium Health Centre - Stacks (2) 2
Credit Valley Hospital - Stacks (1) 1
Holland Bloorview Kids Rehabilitation - Stacks (1) 1
Humber River Regional Hospital - Church Stacks (1) 1
Lakeridge Health Sciences - Oshawa (1) 1
OISE - Stacks (1) 1
Online Resources - Online (1) 1
Robarts - Stacks (1) 1
Royal Ontario Museum - Stacks (1) 1
Toronto East General Hospital - Stacks (1) 1
UTL at Downsview - May be requested (1) 1
UofT at Mississauga - Stacks (1) 1
UofT at Scarborough - Stacks (1) 1
West Park Healthcare Centre - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (17014) 17014
Russian (56) 56
Japanese (12) 12
Chinese (9) 9
French (7) 7
German (4) 4
Polish (3) 3
Ukrainian (3) 3
Spanish (2) 2
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Mechanisms of synaptic depression triggered by metabotropic glutamate receptors
by Bellone, C and Lüscher, C and Mameli, M
Cellular and Molecular Life Sciences, ISSN 1420-682X, 9/2008, Volume 65, Issue 18, pp. 2913 - 2923
Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity... 
Life Sciences | Biochemistry, general | Life Sciences, general | metabotropic glutamate receptors | synaptic transmission | AMPA receptors | Long-term depression | Biomedicine general | Cell Biology | Metabotropic glutamate receptors | Synaptic transmission | PROTEIN-KINASE-C | ENDOGENOUS CANNABINOIDS | PURKINJE CELL SYNAPSES | long-term depression | BIOCHEMISTRY & MOLECULAR BIOLOGY | HIPPOCAMPAL CA1 REGION | RAT PREFRONTAL CORTEX | X MENTAL-RETARDATION | VENTRAL TEGMENTAL AREA | CELL BIOLOGY | ENDOCANNABINOID RELEASE | GROUP-II | Excitatory Postsynaptic Potentials - physiology | Long-Term Synaptic Depression - physiology | Animals | Neuronal Plasticity - physiology | Protein Isoforms - metabolism | Synaptic Transmission - physiology | Synapses - physiology | Humans | Receptors, Metabotropic Glutamate - metabolism | Amino acids | Neurosciences | Universities and colleges | Glutamate | Depression, Mental | Signal transduction | Mental depression | Molecular biology | Neurons
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Group 1 mGluR-Dependent Synaptic Long-Term Depression: Mechanisms and Implications for Circuitry and Disease
by Lüscher, Christian and Huber, Kimberly M
Neuron, ISSN 0896-6273, 2010, Volume 65, Issue 4, pp. 445 - 459
Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate receptors (Gp1 mGluRs) at the periphery of their postsynaptic density.... 
CELLBIO | MOLNEURO | SIGNALING | Long-Term Synaptic Depression - physiology | Animals | Synaptic Transmission - physiology | Synapses - physiology | Humans | Receptors, Metabotropic Glutamate - physiology | Brain - physiology | Nerve Net - physiology | Neural Pathways - physiology | Brain Diseases - physiopathology | Neurosciences | Parkinson's disease | Glutamate | Neurons | Depression, Mental | Antiparkinsonian agents | Brain | Autism | Disease | Cognition & reasoning | Rodents | Addictive behaviors | Behavior | Kinases | Addictions
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Engineering a memory with LTD and LTP
by Nabavi, Sadegh and Fox, Rocky and Proulx, Christophe D and Lin, John Y and Tsien, Roger Y and Malinow, Roberto
Nature, ISSN 0028-0836, 2014, Volume 511, Issue 7509, pp. 348 - 352
It has been proposed that memories are encoded by modification of synaptic strengths through cellular mechanisms such as long-term potentiation (LTP) and... 
FEAR | CIRCUITS | MULTIDISCIPLINARY SCIENCES | ACQUISITION | NEURONS | NETWORKS | LONG-TERM POTENTIATION | INDUCTION | RECEPTORS | EXPRESSION | AMYGDALA | Long-Term Synaptic Depression - physiology | Electric Stimulation | Conditioning (Psychology) - physiology | Synapses - physiology | Electrophysiology | Rats | Male | Optogenetics | Fear - physiology | Rats, Sprague-Dawley | Synaptic Transmission | Animals | Fear - psychology | Long-Term Potentiation - physiology | Amygdala - physiology | Memory - physiology | Neuroplasticity | Bioengineering | Memory | Long-term potentiation | Research | Neurological research | Neurophysiology | Neurology | Rodents
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Synaptic plasticity and addiction
by Kauer, Julie A and Malenka, Robert C
Nature Reviews Neuroscience, ISSN 1471-003X, 11/2007, Volume 8, Issue 11, pp. 844 - 858
Addiction is caused, in part, by powerful and long-lasting memories of the drug experience. Relapse caused by exposure to cues associated with the drug... 
IN-VIVO EXPOSURE | CONDITIONED PLACE PREFERENCE | MIDBRAIN DOPAMINE NEURONS | BEHAVIORAL SENSITIZATION | LONG-TERM POTENTIATION | NUCLEUS-ACCUMBENS NEURONS | BRAIN REWARD AREAS | NEUROSCIENCES | VENTRAL TEGMENTAL AREA | COCAINE-INDUCED POTENTIATION | SINGLE DENDRITIC SPINES | Long-Term Synaptic Depression - physiology | Animals | Neuronal Plasticity - physiology | Humans | Long-Term Potentiation - physiology | Behavior, Addictive - physiopathology | Brain - physiology | Substance-Related Disorders - physiopathology | Neural transmission | Regulation | Neural circuitry | Research | Addiction
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Metabotropic NMDA receptor function is required for β-amyloid-induced synaptic depression
by Helmut W. Kessels and Sadegh Nabavi and Roberto Malinow
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2013, Volume 110, Issue 10, pp. 4033 - 4038
The mechanisms by which β-amyloid (A β), a peptide fragment believed to contribute to Alzheimer's disease, leads to synaptic deficits are not known. Here we... 
Oligomers | Neuroscience | Receptors | Neurons | N methyl D aspartate receptors | Plasticity | Amyloids | Alzheimers disease | T tests | Synapses | NR2B | Synapse | Ion-flow independent | NR2A | Amyloid-beta | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | TRAFFICKING | synapse | SUBUNIT COMPOSITION | ion-flow independent | AREA CA1 | MOUSE MODELS | OLIGOMERS | amyloid-beta | HIPPOCAMPUS | MEMORY | LONG-TERM POTENTIATION | PLASTICITY | Recombinant Proteins - metabolism | Amyloid beta-Peptides - physiology | Long-Term Synaptic Depression - physiology | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Alzheimer Disease - physiopathology | Peptide Fragments - metabolism | CA1 Region, Hippocampal - physiology | Calcium Signaling - physiology | Humans | Rats | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Receptors, N-Methyl-D-Aspartate - physiology | Peptide Fragments - chemistry | Animals | Amyloid beta-Peptides - genetics | Receptors, N-Methyl-D-Aspartate - chemistry | Protein Structure, Quaternary | Protein Conformation | Amyloid beta-Peptides - chemistry | Dizocilpine Maleate - pharmacology | Peptide Fragments - genetics | Biological Sciences
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text MGlu5 receptors and cellular prion protein mediate amyloid-β- facilitated synaptic long-term depression in vivo
by Hu, Neng-Wei and Nicoll, Andrew J and Zhang, Dainan and Mably, Alexandra J and O'Malley, Tiernan and Purro, Silvia A and Terry, Cassandra and Collinge, John and Walsh, Dominic M and Rowan, Michael J
Nature Communications, ISSN 2041-1723, 03/2014, Volume 5, Issue 1, p. 3374
NMDA-type glutamate receptors (NMDARs) are currently regarded as paramount in the potent and selective disruption of synaptic plasticity by Alzheimer's disease... 
ACTIVATION | NR2B-CONTAINING NMDA RECEPTORS | POTENTIATION | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | A-BETA | COUPLED RECEPTORS | PRECURSOR PROTEIN | NEURONAL DYSFUNCTION | OLIGOMERS | PLASTICITY | Hippocampus - metabolism | Long-Term Synaptic Depression - physiology | Prions - metabolism | Receptor, Metabotropic Glutamate 5 - genetics | Animals | Rats, Wistar | Amyloid beta-Peptides - metabolism | Rats | Male | Receptor, Metabotropic Glutamate 5 - metabolism
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Postsynaptic TRPV1 triggers cell type-specific long-term depression in the nucleus accumbens
by Grueter, Brad A and Brasnjo, Gabor and Malenka, Robert C
Nature Neuroscience, ISSN 1097-6256, 12/2010, Volume 13, Issue 12, pp. 1519 - 1526
Synaptic modifications in the nucleus accumbens (NAc) are important for adaptive and pathological reward-dependent learning. Medium spiny neurons (MSNs), the... 
IN-VIVO EXPOSURE | ANANDAMIDE | BEHAVIORAL SENSITIZATION | COCAINE-INDUCED REINSTATEMENT | CENTRAL-NERVOUS-SYSTEM | CHANNELS | RECEPTORS | SYNAPTIC PLASTICITY | EXPRESSION | NEUROSCIENCES | ADDICTION | Long-Term Synaptic Depression - physiology | Synaptic Potentials - physiology | TRPV Cation Channels - physiology | Mice, Inbred C57BL | Synaptic Potentials - drug effects | Mice, Transgenic | Long-Term Synaptic Depression - drug effects | Nucleus Accumbens - physiology | Cocaine - pharmacology | Animals | Piperidines - pharmacology | TRPV Cation Channels - antagonists & inhibitors | Nucleus Accumbens - cytology | Mice | Nucleus Accumbens - drug effects | Pyrazoles - pharmacology | Nucleus accumbens | Physiological aspects | Ion channels | Research | Neurons
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Synaptic depression enables neuronal gain control
by Rothman, Jason S and Cathala, Laurence and Steuber, Volker and Silver, R. Angus
Nature, ISSN 0028-0836, 02/2009, Volume 457, Issue 7232, pp. 1015 - 1018
To act as computational devices, neurons must perform mathematical operations as they transform synaptic and modulatory input into output firing rate(1).... 
SHUNTING INHIBITION | CELLS | TRANSMISSION | SINGLE | NMDA RECEPTORS | CAT VISUAL-CORTEX | MULTIDISCIPLINARY SCIENCES | IN-VIVO | NOISE | NEOCORTICAL PYRAMIDAL NEURONS | CEREBELLAR SYNAPSE | Pyramidal Cells - cytology | Long-Term Synaptic Depression - physiology | Synapses - physiology | Receptors, N-Methyl-D-Aspartate - metabolism | Rats | Neurons - cytology | Rats, Sprague-Dawley | Excitatory Postsynaptic Potentials - physiology | Animals | Nerve Fibers - physiology | Dendrites - physiology | Neurons - physiology | Neocortex - cytology | Models, Neurological | Receptors, AMPA - metabolism | GABA | Physiological aspects | Neural transmission | Research | Neurons | Trains | Mental depression | Noise
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text Long-term depression in the CNS
by Howland, John G and Collingridge, Graham L and Wang, Yu Tian and Peineau, Stephane
Nature Reviews Neuroscience, ISSN 1471-003X, 07/2010, Volume 11, Issue 7, pp. 459 - 473
Long-term depression (LTD) in the CNS has been the subject of intense investigation as a process that may be involved in learning and memory and in various... 
AMPA-RECEPTOR | ACTIVATED PROTEIN-KINASE | NR2B-CONTAINING NMDA RECEPTORS | TYROSINE PHOSPHORYLATION | CA1 REGION | FRAGILE-X-SYNDROME | BEHAVIORAL SENSITIZATION | METABOTROPIC GLUTAMATE RECEPTORS | BIDIRECTIONAL SYNAPTIC PLASTICITY | NEUROSCIENCES | NUCLEUS-ACCUMBENS | Long-Term Synaptic Depression - physiology | Humans | Neurodegenerative Diseases - drug therapy | Receptors, N-Methyl-D-Aspartate - physiology | Substance-Related Disorders - physiopathology | Central Nervous System - physiology | Animals | Neurodegenerative Diseases - physiopathology | Neuronal Plasticity - physiology | Excitatory Amino Acid Agents - therapeutic use | Excitatory Amino Acid Agents - pharmacology | Long-Term Potentiation - physiology | Signal Transduction - physiology | Substance-Related Disorders - drug therapy | Neuroplasticity | Complications and side effects | Depression, Mental | Central nervous system | Physiological aspects | Research | Risk factors
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights