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PLoS ONE, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, p. e0146140
The common fruit fly Drosophila melanogaster (Dm) is a simple animal species that contributed significantly to the development of neurobiology whose... 
LOCALIZATION | PINK1 | GENE | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIA | NEURONS | MUTATIONS | DYSFUNCTION | BRAIN | EARLY-ONSET PARKINSONISM | DEGENERATION | Single-Blind Method | Antiparkinson Agents - isolation & purification | Protein-Serine-Threonine Kinases - deficiency | Antiparkinson Agents - pharmacology | Plant Extracts - toxicity | Longevity - drug effects | Neuromuscular Junction - drug effects | Plant Extracts - pharmacology | Synaptic Potentials - drug effects | Antiparkinson Agents - toxicity | Mitochondria - ultrastructure | Antiparkinson Agents - therapeutic use | Parkinsonian Disorders - drug therapy | Reaction Time - drug effects | Endosomes - drug effects | Phytotherapy | Drug Evaluation, Preclinical | Ganglia, Invertebrate - ultrastructure | Locomotion - drug effects | Methanol | Parkinsonian Disorders - physiopathology | Ganglia, Invertebrate - drug effects | Protein-Serine-Threonine Kinases - genetics | Mitochondria - drug effects | Neuromuscular Junction - physiopathology | Drosophila melanogaster - drug effects | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Animals | Larva | Parkinsonian Disorders - pathology | Plant Roots - chemistry | Drosophila Proteins - deficiency | Drosophila melanogaster - growth & development | Drosophila Proteins - genetics | Plant Extracts - therapeutic use | Withania - chemistry | Care and treatment | Parkinson's disease | Drosophila | Dosage and administration | Research | Risk factors | Neurophysiology | Antiparkinsonian agents
Journal Article
Nature Medicine, ISSN 1078-8956, 12/2016, Volume 22, Issue 12, pp. 1428 - 1438
Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine... 
MEDICINE, RESEARCH & EXPERIMENTAL | PRESSURE-OVERLOAD | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIAL AUTOPHAGY | PRESERVED EJECTION FRACTION | TANDEM MASS-SPECTROMETRY | DIASTOLIC HEART-FAILURE | ROBUST QUANTIFICATION | ARGININE BIOAVAILABILITY | CELL BIOLOGY | SALT-SENSITIVE RATS | AMINO-ACIDS | MYOCARDIAL HYPERTROPHY | Mitochondria, Heart - metabolism | Prospective Studies | Diastole | Gene Expression - drug effects | Longevity - drug effects | Humans | Middle Aged | Aging - drug effects | Immunoblotting | Male | Autophagy-Related Protein 5 - genetics | Chromatography, High Pressure Liquid | Mitochondria, Heart - drug effects | Autophagy - drug effects | Aging - immunology | Mass Spectrometry | Cardiovascular Diseases - epidemiology | Heart Failure | Adult | Female | Surveys and Questionnaires | Blood Pressure - drug effects | Rats, Inbred Dahl | Phosphorylation - drug effects | Cytokines - immunology | Glucose Tolerance Test | Echocardiography | Diet - statistics & numerical data | Connectin - drug effects | Cardiomegaly - diagnostic imaging | Rats | Inflammation | Cardiotonic Agents - pharmacology | Heart - diagnostic imaging | Animals | Myocytes, Cardiac - drug effects | Connectin - metabolism | Cytokines - drug effects | Mitochondrial Degradation - drug effects | Spermidine - pharmacology | Heart - drug effects | Aged | Mice | Aging - metabolism | Cardiovascular diseases | Polyamines | Research | Aging | Cardiomyocytes | Mitochondria | Kardiologi | Biological Sciences | Clinical Medicine | Cardiac and Cardiovascular Systems | Naturvetenskap | Medical and Health Sciences | Medicin och hälsovetenskap | Biologiska vetenskaper | Natural Sciences | Klinisk medicin
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2013, Volume 123, Issue 8, pp. 3272 - 3291
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 503, Issue 7477, pp. 493 - 499
Adiponectin secreted from adipocytes binds to adiponectin receptors AdipoR1 and AdipoR2, and exerts antidiabetic effects via activation of AMPK and PPAR-alpha... 
CRUCIAL ROLE | SKELETAL-MUSCLE | ACTIVATED PROTEIN-KINASE | FATTY-ACID OXIDATION | INSULIN-RESISTANCE | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | DISEASE | MECHANISMS | ADIPONECTIN LEVELS | EXPRESSION | Liver - pathology | Obesity - drug therapy | Longevity - drug effects | Adipose Tissue, White - metabolism | Receptors, Adiponectin - metabolism | Diabetes Mellitus, Type 2 - metabolism | Muscle Fibers, Skeletal - drug effects | Obesity - genetics | Glucose Intolerance - drug therapy | Liver - drug effects | Piperidines - pharmacology | Inflammation - drug therapy | Adenylate Kinase - metabolism | Diet, High-Fat | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Receptors, Adiponectin - agonists | Adiponectin - metabolism | Drug Evaluation, Preclinical | Diabetes Mellitus, Type 2 - complications | Adipose Tissue, White - pathology | Adiponectin - pharmacology | Dyslipidemias - drug therapy | Piperidines - administration & dosage | Administration, Oral | Obesity - complications | Piperidines - metabolism | Liver - metabolism | Diabetes Mellitus, Type 2 - prevention & control | Insulin Resistance | Obesity - physiopathology | Transcription Factors - biosynthesis | Mitochondria - metabolism | Mitochondria - drug effects | Enzyme Activation - drug effects | Triglycerides - metabolism | Small Molecule Libraries - chemistry | Receptors, Adiponectin - deficiency | Animals | Signal Transduction - drug effects | Piperidines - therapeutic use | Muscle Fibers, Skeletal - cytology | Mice | Oxidative Stress - drug effects | PPAR alpha - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Adipose Tissue, White - drug effects | Receptors, Adiponectin - genetics | Muscles - cytology | Obesity | Insulin resistance | Muscular system | Kinases | Rodents
Journal Article
Nature, ISSN 0028-0836, 05/2011, Volume 473, Issue 7348, pp. 478 - 483
The honeybee (Apis mellifera) forms two female castes: the queen and the worker. This dimorphism depends not on genetic differences, but on ingestion of royal... 
APIS-MELLIFERA-L | CULTURED RAT HEPATOCYTES | PROTEIN | DROSOPHILA-MELANOGASTER | CASTE DIFFERENTIATION | BODY-SIZE | PROTHORACIC GLAND | MULTIDISCIPLINARY SCIENCES | ENHANCES PROLIFERATION | JUVENILE-HORMONE | REGULATES GROWTH | Temperature | Drosophila melanogaster - physiology | Longevity - drug effects | Glycoproteins - metabolism | Body Weight - drug effects | Receptor, Epidermal Growth Factor - deficiency | Bees - growth & development | Glycoproteins - pharmacology | Ovary - growth & development | Receptor, Epidermal Growth Factor - metabolism | RNA Interference | Time Factors | Larva - drug effects | Larva - growth & development | Fertility - drug effects | Female | Glycoproteins - deficiency | Ovary - drug effects | Protein Stability | Fat Body - metabolism | Fatty Acids - metabolism | Insect Proteins - metabolism | Glycoproteins - genetics | Body Size - drug effects | Fatty Acids - chemistry | Insect Proteins - pharmacology | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Juvenile Hormones - metabolism | Cell Size - drug effects | Drosophila melanogaster - cytology | Insect Proteins - genetics | Social Dominance | Drosophila melanogaster - drug effects | Bees - physiology | Phenotype | Animals | Signal Transduction - drug effects | Body Size - physiology | Bees - drug effects | Drosophila melanogaster - enzymology | Bees - genetics | Fat Body - drug effects | Caseins - pharmacology | Fatty Acids - pharmacology | Mitogen-Activated Protein Kinases - metabolism | Mass spectrometry | Bees
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 2192 - 2192
Metformin is a drug commonly prescribed to treat patients with type 2 diabetes. Here we show that long-term treatment with metformin (0.1% w/w in diet)... 
COMPLEX I | HEPATIC GLUCONEOGENESIS | OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | RESPIRATION | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | AMPK | DIETARY RESTRICTION | ANTIDIABETIC DRUG METFORMIN | CANCER | Index Medicus
Journal Article
Science, ISSN 0036-8075, 06/2016, Volume 352, Issue 6292, pp. 1436 - 1443
Journal Article
Aging Cell, ISSN 1474-9718, 08/2012, Volume 11, Issue 4, pp. 675 - 682
Journal Article