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1. Full Text Statins Upregulate PCSK9, the Gene Encoding the Proprotein Convertase Neural Apoptosis-Regulated Convertase-1 Implicated in Familial Hypercholesterolemia
by Dubuc, Geneviéve and Chamberland, Ann and Wassef, Hanny and Davignon, Jean and Seidah, Nabil G and Bernier, Lise and Prat, Annik
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 08/2004, Volume 24, Issue 8, pp. 1454 - 1459
HepG2 | QPCR | Primary hepatocytes | Cholesterol | SRE | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Cardiology. Vascular system | Biological and medical sciences | Medical sciences | Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous | Atherosclerosis (general aspects, experimental research) | Blood and lymphatic vessels | Consensus Sequence | Lovastatin - pharmacology | Species Specificity | Humans | Regulatory Sequences, Nucleic Acid | Homeostasis | Lovastatin - analogs & derivatives | Hepatocytes - metabolism | Simvastatin - pharmacology | Promoter Regions, Genetic - genetics | Quinolines - pharmacology | RNA, Messenger - biosynthesis | Cell Line - drug effects | Base Sequence | Liver X Receptors | Serine Endopeptidases - genetics | Orphan Nuclear Receptors | Proprotein Convertases | Sp1 Transcription Factor - physiology | Hepatocytes - drug effects | Heptanoic Acids - pharmacology | Tretinoin - pharmacology | Mevalonic Acid - pharmacology | Cell Line - metabolism | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Serine Endopeptidases - biosynthesis | Receptors, Cytoplasmic and Nuclear - drug effects | Rats | Hydroxymethylglutaryl CoA Reductases - physiology | Reverse Transcriptase Polymerase Chain Reaction | Hydroxycholesterols - pharmacology | Sequence Homology, Nucleic Acid | Gene Expression Regulation - drug effects | Mevalonic Acid - analogs & derivatives | Atorvastatin Calcium | Pyrroles - pharmacology | Sequence Alignment | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Cholesterol - pharmacology | Mice | Pyridines - pharmacology | Cholesterol - biosynthesis | Sterol Regulatory Element Binding Protein 2 | Proprotein Convertase 9 | Index Medicus
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2. Full Text Lysosomotropic cationic drugs induce cytostatic and cytotoxic effects: Role of liposolubility and autophagic flux and antagonism by cholesterol ablation
by Parks, Alexandre and Marceau, François
Toxicology and applied pharmacology, ISSN 0041-008X, 08/2016, Volume 305, pp. 55 - 65
Lysosomotropic drugs | Quinacrine | Antiproliferative effect | Cation trapping | Autophagic flux | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Human Umbilical Vein Endothelial Cells | Lidocaine - pharmacology | Lovastatin - pharmacology | Microtubule-Associated Proteins - metabolism | Humans | Cells, Cultured | Lysosomes | Poly (ADP-Ribose) Polymerase-1 - metabolism | Cholesterol - metabolism | beta-Cyclodextrins - pharmacology | Autophagy - drug effects | Chloroquine - pharmacology | Quinacrine - pharmacology | Cytotoxins - pharmacology | Procainamide - pharmacology | Cell Line, Tumor | Hydroxychloroquine - pharmacology | Cell Proliferation - drug effects | Cytostatic Agents - pharmacology | Anticholesteremic Agents - pharmacology | Amiodarone - pharmacology | Drugs | Cyclodextrins | Hydroxychloroquine | Tumor proteins | Analysis | Cholesterol | Lymphomas | Index Medicus | APOPTOSIS | OLIGOSACCHARIDES | CHOLESTEROL | ANTIMITOTIC DRUGS | COMPARTMENTS | TOXICITY | TUMOR CELLS | 60 APPLIED LIFE SCIENCES | CONCENTRATION RATIO | ABUNDANCE | LYMPHOMAS | INHIBITION | BIOLOGICAL MARKERS | ABLATION | CELL CYCLE
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3. Full Text Cholesterol-independent neuroprotective and neurotoxic activities of statins: Perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders
by Butterfield, D. Allan and Barone, Eugenio and Mancuso, Cesare
Pharmacological research, ISSN 1043-6618, 09/2011, Volume 64, Issue 3, pp. 180 - 186
Alzheimer disease | Pleiotropic functions | Statins | Statins as Janus molecules | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Fatty Acids, Monounsaturated - pharmacology | Lovastatin - pharmacology | Heptanoic Acids - therapeutic use | Humans | Heptanoic Acids - adverse effects | Neurodegenerative Diseases - drug therapy | Quinolines - pharmacology | Fluorobenzenes - pharmacology | Fatty Acids, Monounsaturated - therapeutic use | Fatty Acids, Monounsaturated - adverse effects | Pyrroles - adverse effects | Indoles - pharmacology | Pyrroles - therapeutic use | Heptanoic Acids - pharmacology | Lovastatin - therapeutic use | Lovastatin - adverse effects | Alzheimer Disease - drug therapy | Rosuvastatin Calcium | Pyrimidines - pharmacology | Cholesterol - metabolism | Sulfonamides - pharmacology | Atorvastatin Calcium | Pyrroles - pharmacology | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Indoles - adverse effects | Sulfonamides - therapeutic use | Pyrimidines - therapeutic use | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Pyrimidines - adverse effects | Sulfonamides - adverse effects | Indoles - therapeutic use | Fluorobenzenes - adverse effects | Quinolines - therapeutic use | Fluorobenzenes - therapeutic use | Quinolines - adverse effects | Alzheimer's disease | Neuroprotection | Neurotoxicity | Neurodegenerative diseases | statins | Dyslipidemia | Clinical trials | Age | Cholesterol | Index Medicus
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4. Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs
by Katchman, Alexander N and Koerner, John and Tosaka, Toshimasa and Woosley, Raymond L and Ebert, Steven N
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 03/2006, Volume 316, Issue 3, pp. 1098 - 1106
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Terfenadine - pharmacology | Rabbits | Lovastatin - pharmacology | Arsenicals - pharmacology | Humans | Cells, Cultured | Torsades de Pointes - chemically induced | Electrocardiography - drug effects | ERG1 Potassium Channel | Ether-A-Go-Go Potassium Channels - antagonists & inhibitors | Oxides - pharmacology | Animals | Ether-A-Go-Go Potassium Channels - physiology | Haloperidol - pharmacology | Potassium Channel Blockers - pharmacology | Loratadine - pharmacology | Methadone - pharmacology | Pentamidine - pharmacology | Index Medicus
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5. Full Text Differential interactions between statins and P‐glycoprotein: Implications for exploiting statins as anticancer agents
by Goard, Carolyn A and Mather, Richard G and Vinepal, Balpreet and Clendening, James W and Martirosyan, Anna and Boutros, Paul C and Sharom, Frances J and Penn, Linda Z
International journal of cancer, ISSN 0020-7136, 12/2010, Volume 127, Issue 12, pp. 2936 - 2948
multidrug resistance | P‐glycoprotein | doxorubicin | chemotherapy | statins | P-glycoprotein | Chemotherapy | Doxorubicin | Multidrug resistance | Statins | Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Medical sciences | Tumors | Fatty Acids, Monounsaturated - pharmacology | Lovastatin - pharmacology | Apoptosis - drug effects | Drug Resistance, Multiple - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Ovarian Neoplasms - pathology | Fluorobenzenes - pharmacology | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Ovarian Neoplasms - metabolism | Tumor Cells, Cultured | Ovarian Neoplasms - drug therapy | Heptanoic Acids - pharmacology | Rosuvastatin Calcium | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Blotting, Western | Atorvastatin Calcium | Pyrroles - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Cell Proliferation - drug effects | Doxorubicin - pharmacology | Drug Resistance, Neoplasm - drug effects | Drugs | Tumor cells | fluvastatin | DNA damage | Lovastatin | Drug resistance | Cholesterol | Antitumor agents | Atorvastatin | Antitumor activity | mevalonic acid | P-Glycoprotein | Apoptosis | Index Medicus
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6. Full Text A cell‐based screening assay to identify pharmaceutical compounds that enhance the regenerative quality of corneal repair
by Gordon, Gabriel M and LaGier, Adriana J and Ponchel, Corinne and Bauskar, Aditi and Itakura, Tatsuo and Jeong, Shinwu and Patel, Nitin and Fini, M. Elizabeth
Wound repair and regeneration, ISSN 1067-1927, 01/2016, Volume 24, Issue 1, pp. 89 - 99
Life Sciences & Biomedicine | Dermatology | Surgery | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Lovastatin - pharmacology | Epithelium, Corneal - cytology | Humans | Actins - drug effects | Dichlororibofuranosylbenzimidazole - pharmacology | Actins - genetics | Tubercidin - pharmacology | Cornea - drug effects | Transforming Growth Factor beta2 - drug effects | Epithelium, Corneal - drug effects | Cornea - cytology | Protein Synthesis Inhibitors - pharmacology | Thiazolidines - pharmacology | Wound Healing - drug effects | Cell Line | Rabbits | Enzyme Inhibitors - pharmacology | Corneal Keratocytes - drug effects | Imidazoles - pharmacology | Tyrphostins - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Regeneration - drug effects | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Corneal Keratocytes - cytology | Cytological Techniques | Anisomycin - pharmacology | Pyridines - pharmacology | Transforming Growth Factor beta2 - genetics | Tubercidin - analogs & derivatives | Index Medicus
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7. Full Text Curcumin Inhibits TGFβ1-induced CCN2 via Src, JNK, and Smad3 in Gingiva
by Yang, W.-H and Kuo, M.Y.-P and Liu, C.-M and Deng, Y.-T and Chang, H.-H and Chang, J.Z.-C
Journal of dental research, ISSN 0022-0345, 7/2013, Volume 92, Issue 7, pp. 629 - 634
connective tissue growth factor | TGFβ1 | CTGF/CCN2 | transforming growth factor β | gingival overgrowth | curcumin | Fibroblasts - enzymology | Phosphorylation | Lovastatin - pharmacology | Transforming Growth Factor beta1 - antagonists & inhibitors | Humans | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Gingival Overgrowth - pathology | Gingiva - drug effects | Gingiva - enzymology | MAP Kinase Kinase 4 - antagonists & inhibitors | Flavonoids - pharmacology | Cell Culture Techniques | Catechin - pharmacology | Connective Tissue Growth Factor - antagonists & inhibitors | src-Family Kinases - antagonists & inhibitors | Cells, Cultured | Curcumin - pharmacology | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | Pyrimidines - pharmacology | Smad3 Protein - antagonists & inhibitors | Anthracenes - pharmacology | Cell Movement - drug effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Fibroblasts - drug effects | Gingiva - cytology | Signal Transduction - physiology | Catechin - analogs & derivatives | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Immunoglobulins | Transforming growth factor-a | Connective tissue growth factor | Smad3 protein | Cell adhesion & migration | Connective tissues | Proteins | Fibrosis | Fibroblasts | Curcumin | Scleroderma | Growth factors | Index Medicus | Dentistry
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8. Full Text Efficacy and safety of long-term treatment with statins for coronary heart disease: A Bayesian network meta-analysis
by Lu, Yongbin and Cheng, Zhiyuan and Zhao, Yaxue and Chang, Xiaoyu and Chan, Cynthia and Bai, Yana and Cheng, Ning
Atherosclerosis, ISSN 0021-9150, 2016, Volume 254, pp. 215 - 227
Cardiovascular | Efficacy | Statin | Safety | Mortality | CHD | Blood-lipid | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Pravastatin - pharmacology | Fatty Acids, Monounsaturated - pharmacology | Lovastatin - pharmacology | Atorvastatin Calcium - pharmacology | Humans | Kidney Diseases - drug therapy | Treatment Outcome | Lovastatin - analogs & derivatives | Simvastatin - pharmacology | Quinolines - pharmacology | Randomized Controlled Trials as Topic | Coronary Disease - pathology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Lipids - blood | Muscles - drug effects | Bayes Theorem | Patient Safety | Coronary Disease - drug therapy | Indoles - pharmacology | Network Meta-Analysis | Anticholesteremic Agents - pharmacology | Epidemiology | Coronary heart disease | Analysis | Statins | Cardiovascular agents | Blood lipids | Index Medicus
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