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Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 08/2004, Volume 24, Issue 8, pp. 1454 - 1459
OBJECTIVE—Neural apoptosis-regulated convertase (NARC)-1 is the newest member of the proprotein convertase family implicated in the cleavage of a variety of... 
HepG2 | QPCR | Primary hepatocytes | Cholesterol | SRE | CELLS | ELEMENT-BINDING PROTEIN-2 | primary hepatocytes | AUTOSOMAL-DOMINANT HYPERCHOLESTEROLEMIA | LOW-DENSITY-LIPOPROTEIN | NUCLEAR RECEPTOR LXR | TARGET GENES | PATHWAY | LIVER | cholesterol | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | EXPRESSION | Consensus Sequence | Lovastatin - pharmacology | Species Specificity | Humans | Regulatory Sequences, Nucleic Acid | Homeostasis | Lovastatin - analogs & derivatives | Hepatocytes - metabolism | Simvastatin - pharmacology | Promoter Regions, Genetic - genetics | Quinolines - pharmacology | RNA, Messenger - biosynthesis | Cell Line - drug effects | Base Sequence | Liver X Receptors | Serine Endopeptidases - genetics | Orphan Nuclear Receptors | Proprotein Convertases | Sp1 Transcription Factor - physiology | Hepatocytes - drug effects | Heptanoic Acids - pharmacology | Tretinoin - pharmacology | Mevalonic Acid - pharmacology | Cell Line - metabolism | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Serine Endopeptidases - biosynthesis | Receptors, Cytoplasmic and Nuclear - drug effects | Rats | Hydroxymethylglutaryl CoA Reductases - physiology | Reverse Transcriptase Polymerase Chain Reaction | Hydroxycholesterols - pharmacology | Sequence Homology, Nucleic Acid | Gene Expression Regulation - drug effects | Mevalonic Acid - analogs & derivatives | Atorvastatin Calcium | Pyrroles - pharmacology | Sequence Alignment | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Cholesterol - pharmacology | Mice | Pyridines - pharmacology | Cholesterol - biosynthesis | Sterol Regulatory Element Binding Protein 2 | Proprotein Convertase 9
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, p. e0141719
Journal Article
Pharmacological Research, ISSN 1043-6618, 09/2011, Volume 64, Issue 3, pp. 180 - 186
Statins, long known to be beneficial in conditions where dyslipidemia occurs by lowering serum cholesterol levels, also have been proposed for use in... 
Alzheimer disease | Pleiotropic functions | Statins | Statins as Janus molecules | OXIDATIVE STRESS | COA REDUCTASE INHIBITORS | CLINICAL-TRIAL COHORT | DRUG-INTERACTIONS | NITRIC-OXIDE SYNTHASE | MILD COGNITIVE IMPAIRMENT | CELL-DEATH | COENZYME Q | AMYLOID-BETA | PHARMACOLOGY & PHARMACY | AUTOIMMUNE-DISEASE | Fatty Acids, Monounsaturated - pharmacology | Lovastatin - pharmacology | Heptanoic Acids - therapeutic use | Humans | Heptanoic Acids - adverse effects | Neurodegenerative Diseases - drug therapy | Quinolines - pharmacology | Fluorobenzenes - pharmacology | Fatty Acids, Monounsaturated - therapeutic use | Fatty Acids, Monounsaturated - adverse effects | Pyrroles - adverse effects | Indoles - pharmacology | Pyrroles - therapeutic use | Heptanoic Acids - pharmacology | Lovastatin - therapeutic use | Lovastatin - adverse effects | Alzheimer Disease - drug therapy | Rosuvastatin Calcium | Pyrimidines - pharmacology | Cholesterol - metabolism | Sulfonamides - pharmacology | Atorvastatin Calcium | Pyrroles - pharmacology | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Indoles - adverse effects | Sulfonamides - therapeutic use | Pyrimidines - therapeutic use | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Pyrimidines - adverse effects | Sulfonamides - adverse effects | Indoles - therapeutic use | Fluorobenzenes - adverse effects | Quinolines - therapeutic use | Fluorobenzenes - therapeutic use | Quinolines - adverse effects | Alzheimer's disease | Neuroprotection | Neurotoxicity | Neurodegenerative diseases | statins | Dyslipidemia | Clinical trials | Age | Cholesterol | Index Medicus
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 08/2016, Volume 305, pp. 55 - 65
Journal Article
International Journal of Cancer, ISSN 0020-7136, 12/2010, Volume 127, Issue 12, pp. 2936 - 2948
Statins, prescribed for decades to control cholesterol, have more recently been shown to have promising anticancer activity. Statins induce tumor‐selective... 
multidrug resistance | P‐glycoprotein | doxorubicin | chemotherapy | statins | P-glycoprotein | Chemotherapy | Doxorubicin | Multidrug resistance | Statins | MULTIPLE-MYELOMA | MULTIDRUG TRANSPORTER | TUMOR-SPECIFIC APOPTOSIS | HMG-COA REDUCTASE | THERAPEUTIC IMPLICATIONS | OVARIAN-CANCER | LOVASTATIN-INDUCED APOPTOSIS | CELL-LINES | ONCOLOGY | ABC TRANSPORTERS | DRUG TRANSPORT | Fatty Acids, Monounsaturated - pharmacology | Lovastatin - pharmacology | Apoptosis - drug effects | Drug Resistance, Multiple - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Ovarian Neoplasms - pathology | Fluorobenzenes - pharmacology | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Ovarian Neoplasms - metabolism | Tumor Cells, Cultured | Ovarian Neoplasms - drug therapy | Heptanoic Acids - pharmacology | Rosuvastatin Calcium | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Blotting, Western | Atorvastatin Calcium | Pyrroles - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Cell Proliferation - drug effects | Doxorubicin - pharmacology | Drug Resistance, Neoplasm - drug effects | Drugs | Tumor cells | fluvastatin | DNA damage | Lovastatin | Drug resistance | Cholesterol | Antitumor agents | Atorvastatin | Antitumor activity | mevalonic acid | P-Glycoprotein | Apoptosis
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 11/2004, Volume 110, Issue 19, pp. 3136 - 3142
Background-Cultivation of endothelial progenitor cells (EPCs) leads to premature replicative senescence, limiting ex vivo expansion for potential clinical cell... 
Aging | Telomere repeat-binding factor 2 | Telomere | Stem cells | stem cells | CORONARY-ARTERY DISEASE | CARDIAC & CARDIOVASCULAR SYSTEMS | MAMMALIAN TELOMERES | telomere | REVERSE-TRANSCRIPTASE | DNA-DAMAGE | LENGTH | CHRONIC MYELOID-LEUKEMIA | telomere repeat-binding factor 2 | HEMATOPOIETIC STEM-CELLS | ACUTE MYOCARDIAL-INFARCTION | PERIPHERAL VASCULAR DISEASE | SENESCENCE | aging | TOPCARE-AMI | HEMATOLOGY | Telomeric Repeat Binding Protein 2 - biosynthesis | Lovastatin - pharmacology | Cells, Cultured - cytology | Humans | Cellular Senescence - drug effects | Molecular Sequence Data | Endothelium, Vascular - drug effects | Lovastatin - analogs & derivatives | Interleukin-4 - pharmacology | Flow Cytometry | Adenoviridae - genetics | Enzyme Induction - drug effects | Macrophage Colony-Stimulating Factor - pharmacology | Telomere - metabolism | Vascular Endothelial Growth Factor A - pharmacology | Heptanoic Acids - pharmacology | Hematopoietic Stem Cells - drug effects | Amino Acid Sequence | Cells, Cultured - drug effects | Endothelial Cells - metabolism | Protein-Serine-Threonine Kinases - genetics | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | In Situ Hybridization, Fluorescence | Hematopoietic Stem Cells - metabolism | Recombinant Proteins - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Genetic Vectors - genetics | Protein-Serine-Threonine Kinases - biosynthesis | Atorvastatin Calcium | Cell Movement - drug effects | Pyrroles - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Genetic Vectors - pharmacology | Endothelium, Vascular - metabolism | Hematopoietic Stem Cells - cytology | Checkpoint Kinase 2 | Cells, Cultured - metabolism | Telomeric Repeat Binding Protein 2 - genetics | Endothelial Cells - drug effects
Journal Article
Wound Repair and Regeneration, ISSN 1067-1927, 01/2016, Volume 24, Issue 1, pp. 89 - 99
Journal Article
Molecular Reproduction and Development, ISSN 1040-452X, 10/2006, Volume 73, Issue 10, pp. 1277 - 1283
Progesterone receptor (PR) stimulation promotes survival in human and rat periovulatory granulosa cells. PR antagonists, Org 31710 and RU 486, both increase... 
ovary | progesterone receptor | progesterone | ovulation | Ovary | Progesterone | Progesterone receptor | Ovulation | PHOSPHATE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEVELOPMENTAL BIOLOGY | INDUCE APOPTOSIS | LOVASTATIN-INDUCED APOPTOSIS | CELL BIOLOGY | RAB GERANYLGERANYL TRANSFERASE | IN-VITRO | REPRODUCTIVE BIOLOGY | A REDUCTASE INHIBITORS | MESSENGER-RNA | PROGESTERONE-RECEPTOR ANTAGONISTS | MEVALONATE PATHWAY | OVARIAN FOLLICLE ATRESIA | Diterpenes - pharmacology | Protein Prenylation - drug effects | Leucine - pharmacology | Apoptosis - drug effects | Granulosa Cells - physiology | Farnesol - pharmacology | Furans - pharmacology | Humans | Cells, Cultured | Imidazoles - pharmacology | Quinolones - pharmacology | Granulosa Cells - drug effects | Granulosa Cells - metabolism | Receptors, Progesterone - antagonists & inhibitors | Hormone Antagonists - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Estrenes - pharmacology | Female | Farnesyltranstransferase - antagonists & inhibitors | Cholesterol - biosynthesis | Mifepristone - pharmacology | Leucine - analogs & derivatives | MEDICIN OCH HÄLSOVETENSKAP | Granulosa Cells/drug effects/metabolism/physiology | Receptors | Farnesyltranstransferase/antagonists & inhibitors | Imidazoles/pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology | Progesterone/antagonists & inhibitors | Physiology | Cultured | Estrenes/pharmacology | MEDICAL AND HEALTH SCIENCES | Diterpenes/pharmacology | Farnesol/pharmacology | Hormone Antagonists/pharmacology | Fysiologi | Apoptosis/drug effects | Furans/pharmacology | Cholesterol/biosynthesis | Leucine/analogs & derivatives/pharmacology | Cells | Protein Isoprenylation/drug effects | Mifepristone/pharmacology | Quinolones/pharmacology
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 09/2011, Volume 226, Issue 9, pp. 2316 - 2328
Journal Article