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1. Full Text Statins Upregulate PCSK9, the Gene Encoding the Proprotein Convertase Neural Apoptosis-Regulated Convertase-1 Implicated in Familial Hypercholesterolemia
by Dubuc, Geneviéve and Chamberland, Ann and Wassef, Hanny and Davignon, Jean and Seidah, Nabil G and Bernier, Lise and Prat, Annik
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 08/2004, Volume 24, Issue 8, pp. 1454 - 1459
OBJECTIVE—Neural apoptosis-regulated convertase (NARC)-1 is the newest member of the proprotein convertase family implicated in the cleavage of a variety of... 
HepG2 | QPCR | Primary hepatocytes | Cholesterol | SRE | CELLS | ELEMENT-BINDING PROTEIN-2 | primary hepatocytes | AUTOSOMAL-DOMINANT HYPERCHOLESTEROLEMIA | LOW-DENSITY-LIPOPROTEIN | NUCLEAR RECEPTOR LXR | TARGET GENES | PATHWAY | LIVER | cholesterol | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | EXPRESSION | Consensus Sequence | Lovastatin - pharmacology | Species Specificity | Humans | Regulatory Sequences, Nucleic Acid | Homeostasis | Lovastatin - analogs & derivatives | Hepatocytes - metabolism | Simvastatin - pharmacology | Promoter Regions, Genetic - genetics | Quinolines - pharmacology | RNA, Messenger - biosynthesis | Cell Line - drug effects | Base Sequence | Liver X Receptors | Serine Endopeptidases - genetics | Orphan Nuclear Receptors | Proprotein Convertases | Sp1 Transcription Factor - physiology | Hepatocytes - drug effects | Heptanoic Acids - pharmacology | Tretinoin - pharmacology | Mevalonic Acid - pharmacology | Cell Line - metabolism | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Serine Endopeptidases - biosynthesis | Receptors, Cytoplasmic and Nuclear - drug effects | Rats | Hydroxymethylglutaryl CoA Reductases - physiology | Reverse Transcriptase Polymerase Chain Reaction | Hydroxycholesterols - pharmacology | Sequence Homology, Nucleic Acid | Gene Expression Regulation - drug effects | Mevalonic Acid - analogs & derivatives | Atorvastatin Calcium | Pyrroles - pharmacology | Sequence Alignment | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Cholesterol - pharmacology | Mice | Pyridines - pharmacology | Cholesterol - biosynthesis | Sterol Regulatory Element Binding Protein 2 | Proprotein Convertase 9
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2. Full Text Potential compounds for oral cancer treatment: Resveratrol, nimbolide, lovastatin, bortezomib, vorinostat, berberine, pterostilbene, deguelin, andrographolide, and colchicine
by Bundela, Saurabh and Sharma, Anjana and Bisen, Prakash S
PLoS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, p. e0141719
Oral cancer is one of the main causes of cancer-related deaths in South-Asian countries. There are very limited treatment options available for oral cancer.... 
GROWTH-FACTOR RECEPTOR | APOPTOSIS | INHIBITION | CARCINOGENESIS | CURCUMIN | NATURAL-PRODUCTS | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | SQUAMOUS-CELL CARCINOMA | SUPPRESSION | EXPRESSION | Diterpenes - pharmacology | Colchicine - pharmacology | Predictive Value of Tests | Mouth Neoplasms - drug therapy | Lovastatin - pharmacology | Administration, Oral | Humans | Rotenone - analogs & derivatives | Bortezomib - pharmacology | Models, Statistical | Stilbenes - pharmacology | Support Vector Machine | Databases, Pharmaceutical | Berberine - pharmacology | Limonins - pharmacology | Algorithms | Databases, Protein | Rotenone - pharmacology | Mouth Neoplasms - pathology | Antineoplastic Agents - pharmacology | Hydroxamic Acids - pharmacology | Prognosis | Development and progression | Lovastatin | Dosage and administration | Research | Drug therapy | Mouth cancer | Drugs | Berberine | Bortezomib | Disease | Oral cancer | Bioassays | Pharmacology | Chemical compounds | Cancer therapies | Biological activity | Data bases | Anticancer properties | Studies | Side effects | Regression models | Databases | Natural products | Resveratrol | Colchicine | Physicochemical properties | Cancer | Apoptosis
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3. Full Text Cholesterol-independent neuroprotective and neurotoxic activities of statins: Perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders
by Butterfield, D. Allan and Barone, Eugenio and Mancuso, Cesare
Pharmacological Research, ISSN 1043-6618, 09/2011, Volume 64, Issue 3, pp. 180 - 186
Statins, long known to be beneficial in conditions where dyslipidemia occurs by lowering serum cholesterol levels, also have been proposed for use in... 
Alzheimer disease | Pleiotropic functions | Statins | Statins as Janus molecules | OXIDATIVE STRESS | COA REDUCTASE INHIBITORS | CLINICAL-TRIAL COHORT | DRUG-INTERACTIONS | NITRIC-OXIDE SYNTHASE | MILD COGNITIVE IMPAIRMENT | CELL-DEATH | COENZYME Q | AMYLOID-BETA | PHARMACOLOGY & PHARMACY | AUTOIMMUNE-DISEASE | Fatty Acids, Monounsaturated - pharmacology | Lovastatin - pharmacology | Heptanoic Acids - therapeutic use | Humans | Heptanoic Acids - adverse effects | Neurodegenerative Diseases - drug therapy | Quinolines - pharmacology | Fluorobenzenes - pharmacology | Fatty Acids, Monounsaturated - therapeutic use | Fatty Acids, Monounsaturated - adverse effects | Pyrroles - adverse effects | Indoles - pharmacology | Pyrroles - therapeutic use | Heptanoic Acids - pharmacology | Lovastatin - therapeutic use | Lovastatin - adverse effects | Alzheimer Disease - drug therapy | Rosuvastatin Calcium | Pyrimidines - pharmacology | Cholesterol - metabolism | Sulfonamides - pharmacology | Atorvastatin Calcium | Pyrroles - pharmacology | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Indoles - adverse effects | Sulfonamides - therapeutic use | Pyrimidines - therapeutic use | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Pyrimidines - adverse effects | Sulfonamides - adverse effects | Indoles - therapeutic use | Fluorobenzenes - adverse effects | Quinolines - therapeutic use | Fluorobenzenes - therapeutic use | Quinolines - adverse effects | Alzheimer's disease | Neuroprotection | Neurotoxicity | Neurodegenerative diseases | statins | Dyslipidemia | Clinical trials | Age | Cholesterol | Index Medicus
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4. Full Text Lysosomotropic cationic drugs induce cytostatic and cytotoxic effects: Role of liposolubility and autophagic flux and antagonism by cholesterol ablation
by Parks, Alexandre and Marceau, François
Toxicology and Applied Pharmacology, ISSN 0041-008X, 08/2016, Volume 305, pp. 55 - 65
Cation trapping in acidic cell compartments determines an antiproliferative effect that has a potential interest in oncology, as shown by clinical data and... 
Lysosomotropic drugs | Quinacrine | Antiproliferative effect | Cation trapping | Autophagic flux | CELLS | CHLOROQUINE | VACUOLAR ATPASE | IN-VITRO | INDUCED PHOSPHOLIPIDOSIS | INHIBITION | DNA | PHARMACOLOGY & PHARMACY | TOXICOLOGY | EXPRESSION | CAPTURE | Human Umbilical Vein Endothelial Cells | Lidocaine - pharmacology | Lovastatin - pharmacology | Microtubule-Associated Proteins - metabolism | Humans | Cells, Cultured | Lysosomes | Poly (ADP-Ribose) Polymerase-1 - metabolism | Cholesterol - metabolism | beta-Cyclodextrins - pharmacology | Autophagy - drug effects | Chloroquine - pharmacology | Quinacrine - pharmacology | Cytotoxins - pharmacology | Procainamide - pharmacology | Cell Line, Tumor | Hydroxychloroquine - pharmacology | Cell Proliferation - drug effects | Cytostatic Agents - pharmacology | Anticholesteremic Agents - pharmacology | Amiodarone - pharmacology | Drugs | Cyclodextrins | Hydroxychloroquine | Tumor proteins | Analysis | Cholesterol | Lymphomas | Index Medicus | APOPTOSIS | OLIGOSACCHARIDES | CHOLESTEROL | ANTIMITOTIC DRUGS | COMPARTMENTS | TOXICITY | TUMOR CELLS | 60 APPLIED LIFE SCIENCES | CONCENTRATION RATIO | ABUNDANCE | LYMPHOMAS | BIOLOGICAL MARKERS | ABLATION | CELL CYCLE
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5. Full Text Differential interactions between statins and P‐glycoprotein: Implications for exploiting statins as anticancer agents
by Goard, Carolyn A and Mather, Richard G and Vinepal, Balpreet and Clendening, James W and Martirosyan, Anna and Boutros, Paul C and Sharom, Frances J and Penn, Linda Z
International Journal of Cancer, ISSN 0020-7136, 12/2010, Volume 127, Issue 12, pp. 2936 - 2948
Statins, prescribed for decades to control cholesterol, have more recently been shown to have promising anticancer activity. Statins induce tumor‐selective... 
multidrug resistance | P‐glycoprotein | doxorubicin | chemotherapy | statins | P-glycoprotein | Chemotherapy | Doxorubicin | Multidrug resistance | Statins | MULTIPLE-MYELOMA | MULTIDRUG TRANSPORTER | TUMOR-SPECIFIC APOPTOSIS | HMG-COA REDUCTASE | THERAPEUTIC IMPLICATIONS | OVARIAN-CANCER | LOVASTATIN-INDUCED APOPTOSIS | CELL-LINES | ONCOLOGY | ABC TRANSPORTERS | DRUG TRANSPORT | Fatty Acids, Monounsaturated - pharmacology | Lovastatin - pharmacology | Apoptosis - drug effects | Drug Resistance, Multiple - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Ovarian Neoplasms - pathology | Fluorobenzenes - pharmacology | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Ovarian Neoplasms - metabolism | Tumor Cells, Cultured | Ovarian Neoplasms - drug therapy | Heptanoic Acids - pharmacology | Rosuvastatin Calcium | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Blotting, Western | Atorvastatin Calcium | Pyrroles - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Cell Proliferation - drug effects | Doxorubicin - pharmacology | Drug Resistance, Neoplasm - drug effects | Drugs | Tumor cells | fluvastatin | DNA damage | Lovastatin | Drug resistance | Cholesterol | Antitumor agents | Atorvastatin | Antitumor activity | mevalonic acid | P-Glycoprotein | Apoptosis
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6. Full Text Curcumin Inhibits TGFβ1-induced CCN2 via Src, JNK, and Smad3 in Gingiva
by Yang, W.-H and Kuo, M.Y.-P and Liu, C.-M and Deng, Y.-T and Chang, H.-H and Chang, J.Z.-C
Journal of Dental Research, ISSN 0022-0345, 7/2013, Volume 92, Issue 7, pp. 629 - 634
Transforming growth factor β (TGFβ) is a key regulator associated with the pathogenesis of gingival overgrowth (GO). Connective tissue growth factor... 
connective tissue growth factor | TGFβ1 | CTGF/CCN2 | transforming growth factor β | gingival overgrowth | curcumin | Fibroblasts - enzymology | Phosphorylation | Lovastatin - pharmacology | Transforming Growth Factor beta1 - antagonists & inhibitors | Humans | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Gingival Overgrowth - pathology | Gingiva - drug effects | Gingiva - enzymology | MAP Kinase Kinase 4 - antagonists & inhibitors | Flavonoids - pharmacology | Cell Culture Techniques | Catechin - pharmacology | Connective Tissue Growth Factor - antagonists & inhibitors | src-Family Kinases - antagonists & inhibitors | Cells, Cultured | Curcumin - pharmacology | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | Pyrimidines - pharmacology | Smad3 Protein - antagonists & inhibitors | Anthracenes - pharmacology | Cell Movement - drug effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Fibroblasts - drug effects | Gingiva - cytology | Signal Transduction - physiology | Catechin - analogs & derivatives | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology
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7. Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs
by Katchman, Alexander N and Koerner, John and Tosaka, Toshimasa and Woosley, Raymond L and Ebert, Steven N
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 03/2006, Volume 316, Issue 3, pp. 1098 - 1106
The purpose of the present study was to comparatively evaluate human HERG currents and QT intervals following challenge with suspected torsadogenic and... 
TORSADES-DE-POINTES | ISOLATED RABBIT HEART | FEMALE GENDER | POTASSIUM CURRENTS | CARDIAC REPOLARIZATION | VENTRICULAR-TACHYCARDIA | PENTAMIDINE THERAPY | PHARMACOLOGY & PHARMACY | PNEUMOCYSTIS-CARINII PNEUMONIA | K+ CHANNELS | ARSENIC TRIOXIDE | Terfenadine - pharmacology | Rabbits | Lovastatin - pharmacology | Arsenicals - pharmacology | Humans | Cells, Cultured | Torsades de Pointes - chemically induced | Electrocardiography - drug effects | ERG1 Potassium Channel | Ether-A-Go-Go Potassium Channels - antagonists & inhibitors | Oxides - pharmacology | Animals | Ether-A-Go-Go Potassium Channels - physiology | Haloperidol - pharmacology | Potassium Channel Blockers - pharmacology | Loratadine - pharmacology | Methadone - pharmacology | Pentamidine - pharmacology
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8. Full Text Statins enhance migratory capacity by upregulation of the telomere repeat-binding factor TRF2 in endothelial progenitor cells
by Spyridopoulos, Ioakim and Haendeler, Judith and Urbich, Carmen and Brummendorf, Tim H and Oh, Hidemasa and Schneider, Michael D and Zeiher, Andreas M and Dimmeler, Stefanie
Circulation, ISSN 0009-7322, 11/2004, Volume 110, Issue 19, pp. 3136 - 3142
Background-Cultivation of endothelial progenitor cells (EPCs) leads to premature replicative senescence, limiting ex vivo expansion for potential clinical cell... 
Aging | Telomere repeat-binding factor 2 | Telomere | Stem cells | stem cells | CORONARY-ARTERY DISEASE | CARDIAC & CARDIOVASCULAR SYSTEMS | MAMMALIAN TELOMERES | telomere | REVERSE-TRANSCRIPTASE | DNA-DAMAGE | LENGTH | CHRONIC MYELOID-LEUKEMIA | telomere repeat-binding factor 2 | HEMATOPOIETIC STEM-CELLS | ACUTE MYOCARDIAL-INFARCTION | PERIPHERAL VASCULAR DISEASE | SENESCENCE | aging | TOPCARE-AMI | HEMATOLOGY | Telomeric Repeat Binding Protein 2 - biosynthesis | Lovastatin - pharmacology | Cells, Cultured - cytology | Humans | Cellular Senescence - drug effects | Molecular Sequence Data | Endothelium, Vascular - drug effects | Lovastatin - analogs & derivatives | Interleukin-4 - pharmacology | Flow Cytometry | Adenoviridae - genetics | Enzyme Induction - drug effects | Macrophage Colony-Stimulating Factor - pharmacology | Telomere - metabolism | Vascular Endothelial Growth Factor A - pharmacology | Heptanoic Acids - pharmacology | Hematopoietic Stem Cells - drug effects | Amino Acid Sequence | Cells, Cultured - drug effects | Endothelial Cells - metabolism | Protein-Serine-Threonine Kinases - genetics | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | In Situ Hybridization, Fluorescence | Hematopoietic Stem Cells - metabolism | Recombinant Proteins - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Genetic Vectors - genetics | Protein-Serine-Threonine Kinases - biosynthesis | Atorvastatin Calcium | Cell Movement - drug effects | Pyrroles - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Genetic Vectors - pharmacology | Endothelium, Vascular - metabolism | Hematopoietic Stem Cells - cytology | Checkpoint Kinase 2 | Cells, Cultured - metabolism | Telomeric Repeat Binding Protein 2 - genetics | Endothelial Cells - drug effects
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9. Full Text A cell‐based screening assay to identify pharmaceutical compounds that enhance the regenerative quality of corneal repair
by Gordon, Gabriel M and LaGier, Adriana J and Ponchel, Corinne and Bauskar, Aditi and Itakura, Tatsuo and Jeong, Shinwu and Patel, Nitin and Fini, M. Elizabeth
Wound Repair and Regeneration, ISSN 1067-1927, 01/2016, Volume 24, Issue 1, pp. 89 - 99
ABSTRACT The goal of this study was to develop and validate a simple but quantitative cell‐based assay to identify compounds that might be used... 
MEDICINE, RESEARCH & EXPERIMENTAL | SURGERY | ACTIVATED PROTEIN-KINASE | DRUG DISCOVERY | SURGICAL OUTCOMES | HEPATIC-FIBROSIS | CELL BIOLOGY | DERMATOLOGY | EPITHELIAL-CELLS | GENE-EXPRESSION | INFLAMMATORY RESPONSE | MYOFIBROBLAST DIFFERENTIATION | REPORTER GENE | TRANSGENIC MICE | Lovastatin - pharmacology | Epithelium, Corneal - cytology | Humans | Actins - drug effects | Dichlororibofuranosylbenzimidazole - pharmacology | Actins - genetics | Tubercidin - pharmacology | Cornea - drug effects | Transforming Growth Factor beta2 - drug effects | Epithelium, Corneal - drug effects | Cornea - cytology | Protein Synthesis Inhibitors - pharmacology | Thiazolidines - pharmacology | Wound Healing - drug effects | Cell Line | Rabbits | Enzyme Inhibitors - pharmacology | Corneal Keratocytes - drug effects | Imidazoles - pharmacology | Tyrphostins - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Regeneration - drug effects | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Corneal Keratocytes - cytology | Cytological Techniques | Anisomycin - pharmacology | Pyridines - pharmacology | Transforming Growth Factor beta2 - genetics | Tubercidin - analogs & derivatives
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10. Full Text Depletion of substrates for protein prenylation increases apoptosis in human periovulatory granulosa cells
by Rung, Emilia and Friberg, P. Anders and Bergh, Christina and Billig, Håkan and Institute of Clinical Sciences, Section for the Health of Women and Children and Göteborgs universitet and Gothenburg University and Institute of Neuroscience and Physiology, Department of Physiology and Sahlgrenska Academy and Sahlgrenska akademin and Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi and Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa
Molecular Reproduction and Development, ISSN 1040-452X, 10/2006, Volume 73, Issue 10, pp. 1277 - 1283
Progesterone receptor (PR) stimulation promotes survival in human and rat periovulatory granulosa cells. PR antagonists, Org 31710 and RU 486, both increase... 
ovary | progesterone receptor | progesterone | ovulation | Ovary | Progesterone | Progesterone receptor | Ovulation | PHOSPHATE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEVELOPMENTAL BIOLOGY | INDUCE APOPTOSIS | LOVASTATIN-INDUCED APOPTOSIS | CELL BIOLOGY | RAB GERANYLGERANYL TRANSFERASE | IN-VITRO | REPRODUCTIVE BIOLOGY | A REDUCTASE INHIBITORS | MESSENGER-RNA | PROGESTERONE-RECEPTOR ANTAGONISTS | MEVALONATE PATHWAY | OVARIAN FOLLICLE ATRESIA | Diterpenes - pharmacology | Protein Prenylation - drug effects | Leucine - pharmacology | Apoptosis - drug effects | Granulosa Cells - physiology | Farnesol - pharmacology | Furans - pharmacology | Humans | Cells, Cultured | Imidazoles - pharmacology | Quinolones - pharmacology | Granulosa Cells - drug effects | Granulosa Cells - metabolism | Receptors, Progesterone - antagonists & inhibitors | Hormone Antagonists - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Estrenes - pharmacology | Female | Farnesyltranstransferase - antagonists & inhibitors | Cholesterol - biosynthesis | Mifepristone - pharmacology | Leucine - analogs & derivatives | MEDICIN OCH HÄLSOVETENSKAP | Granulosa Cells/drug effects/metabolism/physiology | Receptors | Farnesyltranstransferase/antagonists & inhibitors | Imidazoles/pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology | Progesterone/antagonists & inhibitors | Physiology | Cultured | Estrenes/pharmacology | MEDICAL AND HEALTH SCIENCES | Diterpenes/pharmacology | Farnesol/pharmacology | Hormone Antagonists/pharmacology | Fysiologi | Apoptosis/drug effects | Furans/pharmacology | Cholesterol/biosynthesis | Leucine/analogs & derivatives/pharmacology | Cells | Protein Isoprenylation/drug effects | Mifepristone/pharmacology | Quinolones/pharmacology
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11. Full Text Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib
by Irwin, Mary E and Mueller, Kelly L and Bohin, Natacha and Ge, Yubin and Boerner, Julie L
Journal of Cellular Physiology, ISSN 0021-9541, 09/2011, Volume 226, Issue 9, pp. 2316 - 2328
Epidermal growth factor receptor (EGFR) is overexpressed in many cancer types including ∼30% of breast cancers. Several small molecule tyrosine kinase... 
BREAST-CANCER | IRESSA | LUNG-CANCER | LOVASTATIN | PHYSIOLOGY | GROWTH-FACTOR-RECEPTOR | CHOLESTEROL DEPLETION | STATIN USE | PHASE-II | LINES | C-SRC | CELL BIOLOGY | Lovastatin - pharmacology | Humans | Protein Transport - drug effects | beta-Cyclodextrins - pharmacology | Breast Neoplasms - enzymology | Receptor, Epidermal Growth Factor - metabolism | Female | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Heptanoic Acids - pharmacology | Cell Survival - drug effects | Membrane Microdomains - enzymology | Thiophenes - pharmacology | Cholesterol - metabolism | Breast Neoplasms - drug therapy | Drug Synergism | Atorvastatin Calcium | Pyrroles - pharmacology | Membrane Microdomains - drug effects | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Quinazolines - pharmacology | Benzylamines - pharmacology | Drug Resistance, Neoplasm - drug effects | Drug Screening Assays, Antitumor | Index Medicus | TKI resistance | Breast cancer | Lipid rafts | EGFR | Statins
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