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Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 03/2014, Volume 34, Issue 3, pp. 487 - 498
Low-density lipoprotein receptor–related protein-1 (LRP1) is a large endocytic and signaling receptor that is widely expressed. In the liver, LRP1 plays an... 
Extracellular matrix | LRP1 | fVIII | Elastin | Aneurysm | aneurysm | GROWTH-FACTOR-RECEPTOR | FACTOR-VIII | DEPENDENT PHOSPHATIDYLINOSITOL 3-KINASE | MUSCLE-CELL PROLIFERATION | elastin | VON-WILLEBRAND-FACTOR | BLOOD-BRAIN-BARRIER | ALPHA-2-MACROGLOBULIN RECEPTOR | APOLIPOPROTEIN-E | PLASMINOGEN-ACTIVATOR | UROKINASE RECEPTOR | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | extracellular matrix | Muscle, Smooth, Vascular - metabolism | Humans | Low Density Lipoprotein Receptor-Related Protein-1 - chemistry | Extracellular Matrix - metabolism | Low Density Lipoprotein Receptor-Related Protein-1 - physiology | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | Receptors, LDL - deficiency | Models, Animal | Lipoproteins, LDL - metabolism | Peptide Hydrolases - metabolism | von Willebrand Factor - metabolism | Elastin - metabolism | Receptors, LDL - genetics | Signal Transduction | Liver - metabolism | Transforming Growth Factor beta - physiology | Models, Molecular | Organ Specificity | Atherosclerosis - metabolism | Endocytosis - physiology | Mice, Knockout | Tumor Suppressor Proteins - physiology | Macrophages - metabolism | Platelet-Derived Growth Factor - metabolism | Animals | Protein Conformation | Mice | Blood Coagulation - physiology | Factor VIII - metabolism | Receptors, LDL - physiology | Thromboplastin - metabolism | Aneurysm - prevention & control
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2012, Volume 109, Issue 9, pp. 3510 - 3515
A 30-d course of oral administration of a semipurif ied extract of the root of Withania somnifera consisting predominantly of withanolides and withanosides... 
Oligomers | Anger | Pathology | Brain | Messenger RNA | Liver | Medical treatment | LDL lipoproteins | Amyloids | Alzheimers disease | Herbal extract | Neurodegenerative disease | Dementia | CLEARANCE | neurodegenerative disease | MEMORY | MULTIDISCIPLINARY SCIENCES | herbal extract | AMYLOID-BETA-PEPTIDE | dementia | BLOOD-BRAIN-BARRIER | SYNAPTIC PLASTICITY | STRATEGIES | Up-Regulation | Liver - pathology | Male | Low Density Lipoprotein Receptor-Related Protein-1 - physiology | Low Density Lipoprotein Receptor-Related Protein-1 - genetics | Neprilysin - biosynthesis | Amyloid beta-Peptides - blood | Alzheimer Disease - pathology | Brain - metabolism | Liver - drug effects | Microglia - pathology | Neprilysin - genetics | Phytotherapy | Drug Evaluation, Preclinical | Neprilysin - physiology | Disease Models, Animal | Oligonucleotides, Antisense - pharmacology | Microglia - drug effects | Plaque, Amyloid - pathology | Administration, Oral | Liver - metabolism | Alzheimer Disease - drug therapy | Presenilin-1 - genetics | Mice, Transgenic | Plant Extracts - isolation & purification | Low Density Lipoprotein Receptor-Related Protein-1 - biosynthesis | Maze Learning - drug effects | Organ Specificity | Brain - drug effects | Amyloid beta-Protein Precursor - genetics | Animals | Plant Roots - chemistry | Brain - pathology | Mice | Plant Extracts - therapeutic use | Alzheimer Disease - blood | Withania - chemistry | Prevention | Physiological aspects | Alzheimer's disease | Health aspects | Low density lipoproteins | Biological Sciences
Journal Article
NeuroMolecular Medicine, ISSN 1535-1084, 9/2017, Volume 19, Issue 2, pp. 300 - 308
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 08/2008, Volume 106, Issue 4, pp. 1534 - 1544
Journal Article
Science, ISSN 0036-8075, 4/2003, Volume 300, Issue 5617, pp. 329 - 332
Vascular smooth muscle cell (SMC) proliferation and migration are important events in the development of atherosclerosis. The low-density lipoprotein... 
Phosphorylation | Cell growth | Atherosclerosis | Blood vessels | Aneurysms | Aorta | Reports | Mice | Lesions | Cholesterols | Mesenteric arteries | INACTIVATION | RECEPTOR-RELATED PROTEIN | GENE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MUSCLE CELL-MIGRATION | MICE | PROGRESSION | APOLIPOPROTEIN-E | Muscle, Smooth, Vascular - metabolism | Cholesterol, Dietary - administration & dosage | Mesenteric Arteries - pathology | Low Density Lipoprotein Receptor-Related Protein-1 - physiology | Aorta - metabolism | Low Density Lipoprotein Receptor-Related Protein-1 - genetics | Cattle | Cell Division | Myocytes, Smooth Muscle - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Mesenteric Arteries - cytology | Cell Line | Signal Transduction | Proto-Oncogene Proteins c-sis | Arteriosclerosis - physiopathology | Enzyme Inhibitors - pharmacology | Myocytes, Smooth Muscle - physiology | Low Density Lipoprotein Receptor-Related Protein-1 - metabolism | Mice, Transgenic | Platelet-Derived Growth Factor - pharmacology | Pyrimidines - pharmacology | Muscle, Smooth, Vascular - cytology | Imatinib Mesylate | Piperazines - pharmacology | Elastin - analysis | Mice, Knockout | Aorta - pathology | Diet, Atherogenic | Arteriosclerosis - prevention & control | Muscle, Smooth, Vascular - pathology | Platelet-Derived Growth Factor - metabolism | Animals | Ligands | Aorta - cytology | Benzamides | Arteriosclerosis - pathology | Blood circulation disorders | Low density lipoproteins | Causes of | Research | Observations | Health aspects | Cholesterol | Proteins | Cells | Muscular system
Journal Article
Journal Article
Arthritis & Rheumatology, ISSN 2326-5191, 06/2017, Volume 69, Issue 6, pp. 1246 - 1256
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 5/2018, Volume 75, Issue 9, pp. 1671 - 1685
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e82026
Valvular disease is common in patients with Marfan syndrome and can lead to cardiomyopathy. However, some patients develop cardiomyopathy in the absence of... 
TISSUE GROWTH-FACTOR | TGF-BETA | ULTRASOUND | MULTIDISCIPLINARY SCIENCES | SIGNIFICANT VALVULAR REGURGITATION | MARFAN-SYNDROME | NONINVASIVE MEASUREMENT | ANEURYSM | CORONARY-ARTERY | EXPRESSION | LEFT-VENTRICULAR FUNCTION | Blood Pressure | Aortic Valve Insufficiency - diagnostic imaging | Cardiomyopathies - diagnostic imaging | Phosphorylation | Smad2 Protein - metabolism | Male | Low Density Lipoprotein Receptor-Related Protein-1 - physiology | Muscle, Smooth - metabolism | Low Density Lipoprotein Receptor-Related Protein-1 - genetics | MAP Kinase Signaling System | Mice, Knockout | Blood Vessels - physiopathology | Cardiomyopathies - physiopathology | Animals | Aging - physiology | Gene Deletion | Ultrasonography | Aortic Valve Insufficiency - genetics | Mice | Measurement | Cardiomyopathy | Captopril | Low density lipoproteins | Aortic valve insufficiency | Aneurysms | Smooth muscle | Blood pressure | Heart diseases | Marfan syndrome | Heart | Lipoproteins (low density) | Animal models | Marfan's syndrome | Disease | Medical services | Homeostasis | Activation | Inactivation | Blood | Defects | Proteins | Genotype & phenotype | Ultrasonic imaging | Clonal deletion | Rodents | Atherosclerosis | Deletion | Aorta | Rheumatic heart disease | Growth factors | Hypertension | Echocardiography | Deactivation | Internal medicine | Medical treatment | Muscles | Cardiomyocytes | Patients | Abdomen | Medicine | Dilated cardiomyopathy | Coronary vessels | Dilation | Flow velocity | Metabolic disorders
Journal Article