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Journal of Biological Chemistry, ISSN 0021-9258, 08/2012, Volume 287, Issue 32, pp. 26464 - 26477
Journal Article
Gastroenterology, ISSN 0016-5085, 2017, Volume 152, Issue 6, pp. 1477 - 1491
Abstract Background & Aims Stearoyl-CoA desaturase (SCD) synthesizes monounsaturated fatty acids (MUFAs) and has been associated with development of metabolic... 
Gastroenterology and Hepatology | HCC | HuR | Hepatocarcinogenesis | Cancer Stem Cells | NUCLEAR IMPORT | INTEGRIN-LINKED KINASE | STELLATE CELL ACTIVATION | BETA-CATENIN | FEEDBACK LOOP | HEPATOCELLULAR-CARCINOMA | PATHWAY | INHIBITOR | GASTROENTEROLOGY & HEPATOLOGY | GLYCOGEN-SYNTHASE KINASE | EXPRESSION | Neoplasm Transplantation | Carcinoma, Hepatocellular - chemically induced | Low Density Lipoprotein Receptor-Related Protein-5 - genetics | Cholestasis - complications | Rats, Wistar | Humans | Liver Neoplasms - chemically induced | Male | RNA, Messenger - metabolism | Case-Control Studies | Low Density Lipoprotein Receptor-Related Protein-6 - genetics | ELAV-Like Protein 1 - metabolism | Fatty Acids, Monounsaturated - metabolism | Carcinoma, Hepatocellular - genetics | Diethylnitrosamine | Liver Cirrhosis - metabolism | Liver Neoplasms - pathology | Transcription, Genetic | Liver Cirrhosis - etiology | Liver Neoplasms - genetics | Rats | Survival Rate | ran GTP-Binding Protein - metabolism | Neoplastic Stem Cells | Stearoyl-CoA Desaturase - genetics | beta Catenin - metabolism | Low Density Lipoprotein Receptor-Related Protein-6 - metabolism | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | Wnt Signaling Pathway - genetics | Hepatic Stellate Cells | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Low Density Lipoprotein Receptor-Related Protein-5 - metabolism | Cell Line, Tumor | Liver Cirrhosis - pathology | Stearoyl-CoA Desaturase - metabolism | Mice | beta Karyopherins - metabolism | Neoplasm Staging | Carcinoma, Hepatocellular - metabolism | Medical research | Medical colleges | Monounsaturated fatty acids | Low density lipoproteins | Therapeutics | Fibrosis | Stem cells | Medicine, Experimental | Liver cirrhosis | Homeopathy | Materia medica and therapeutics | Tumors | Liver diseases | Analysis | Liver | Index Medicus | Abridged Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 365 - 13
Wnt-induced beta-catenin-mediated transcription is a driving force for stem cell self-renewal during adult tissue homeostasis. Enhanced Wnt receptor expression... 
PROPELLER DOMAIN | COMPLEX | INHIBITION | ANTIBODY FRAGMENT | MULTIDISCIPLINARY SCIENCES | IN-VITRO SELECTION | CANONICAL WNT | RECEPTOR | COLON | BINDING | LRP6 | Wnt3A Protein - metabolism | Low Density Lipoprotein Receptor-Related Protein-5 - genetics | Cell Proliferation | Single-Domain Antibodies - metabolism | Humans | Low Density Lipoprotein Receptor-Related Protein-5 - chemistry | Crystallography, X-Ray | Stem Cells - cytology | Low Density Lipoprotein Receptor-Related Protein-6 - chemistry | Stem Cells - metabolism | Low Density Lipoprotein Receptor-Related Protein-6 - genetics | Organoids - metabolism | HEK293 Cells | Transcription, Genetic | Cell Differentiation | Protein Interaction Domains and Motifs | Binding Sites | Low Density Lipoprotein Receptor-Related Protein-5 - antagonists & inhibitors | Fibroblasts - metabolism | Wnt3A Protein - genetics | Gene Expression Regulation | Organoids - cytology | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Low Density Lipoprotein Receptor-Related Protein-6 - antagonists & inhibitors | beta Catenin - metabolism | beta Catenin - genetics | Low Density Lipoprotein Receptor-Related Protein-6 - metabolism | Animals | Intestine, Small - cytology | Protein Conformation, beta-Strand | Single-Domain Antibodies - chemistry | Fibroblasts - drug effects | Intestine, Small - drug effects | Low Density Lipoprotein Receptor-Related Protein-5 - metabolism | Organoids - drug effects | Cell Line, Tumor | Protein Binding | Stem Cells - drug effects | Fibroblasts - cytology | Mice | Intestine, Small - metabolism | Single-Domain Antibodies - genetics | Ubiquitin-Protein Ligases - genetics | Uncertainty | Organoids | Animal behavior | Neural networks | Circuits | Stem cells | Inactivation | Cancer | Structural analysis
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2012, Volume 287, Issue 15, pp. 12016 - 12026
Journal Article
FEBS Letters, ISSN 0014-5793, 05/2014, Volume 588, Issue 10, pp. 1913 - 1920
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2011, Volume 108, Issue 41, pp. 17022 - 17027
Journal Article
Circulation, ISSN 0009-7322, 12/2016, Volume 134, Issue 24, pp. 1991 - 2007
BACKGROUND:Myocardial infarction is one of the leading causes of morbidity and mortality worldwide, triggering irreversible myocardial cell damage and heart... 
beta-catenin | insulin-like growth factor binding protein 4 | Dkk1 protein, mouse | low-density lipoprotein receptor-related proteins 5 and 6 | myocardial infarction | ischemia | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | HEART-FAILURE | DNA-DAMAGE | DOWN-REGULATION | RECEPTOR | LRP6 | SIGNAL-TRANSDUCTION | mouse | PATHWAY | PERIPHERAL VASCULAR DISEASE | Dkk1 protein | PROTEINS | Recombinant Proteins - therapeutic use | Myocardial Ischemia - metabolism | Low Density Lipoprotein Receptor-Related Protein-5 - genetics | Insulin-Like Growth Factor Binding Protein 4 - pharmacology | Male | Recombinant Proteins - biosynthesis | Wnt Proteins - metabolism | Low Density Lipoprotein Receptor-Related Protein-6 - genetics | RNA Interference | Low Density Lipoprotein Receptor-Related Protein-5 - antagonists & inhibitors | Disease Models, Animal | DNA Damage - drug effects | Hydrogen Peroxide - toxicity | Myocytes, Cardiac - cytology | Mice, Inbred C57BL | Intercellular Signaling Peptides and Proteins - genetics | Myocardial Ischemia - prevention & control | Recombinant Proteins - pharmacology | Down-Regulation - drug effects | Low Density Lipoprotein Receptor-Related Protein-6 - antagonists & inhibitors | Insulin-Like Growth Factor Binding Protein 4 - genetics | beta Catenin - metabolism | beta Catenin - genetics | Mice, Knockout | Myocardial Ischemia - pathology | Low Density Lipoprotein Receptor-Related Protein-6 - metabolism | Animals | Wnt Signaling Pathway - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | beta Catenin - antagonists & inhibitors | Low Density Lipoprotein Receptor-Related Protein-5 - metabolism | Myocytes, Cardiac - metabolism | Intercellular Signaling Peptides and Proteins - therapeutic use | Mice | Histones - metabolism | Wnt Proteins - antagonists & inhibitors | Insulin-Like Growth Factor Binding Protein 4 - therapeutic use | RNA, Small Interfering - metabolism | Heart failure | Catenanes | Care and treatment | Research
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2012, Volume 287, Issue 10, pp. 7213 - 7223
Body fat, insulin resistance, and type 2 diabetes are often linked together, but the molecular mechanisms that unify their association are poorly understood.... 
GENE | PHOSPHORYLATION | INSULIN-RESISTANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | WNT CORECEPTOR LRP6 | LEPTIN RECEPTOR | DIET-INDUCED OBESITY | BETA-CATENIN | OXIDATIVE-METABOLISM | BROWN ADIPOCYTE DIFFERENTIATION | GENOME-WIDE ASSOCIATION | Glucose-6-Phosphatase - genetics | Receptors, Leptin - genetics | Diabetes Mellitus, Type 2 - genetics | Multiprotein Complexes | Wnt Signaling Pathway - physiology | Diabetes Mellitus, Type 2 - metabolism | Obesity - genetics | Mechanistic Target of Rapamycin Complex 1 | Low Density Lipoprotein Receptor-Related Protein-6 - genetics | Mitochondria - genetics | Dietary Fats - pharmacology | Forkhead Transcription Factors - metabolism | Homeostasis - drug effects | Energy Metabolism - physiology | Dietary Fats - adverse effects | Obesity - chemically induced | Glucose - genetics | Mitochondria - metabolism | Forkhead Transcription Factors - genetics | Glucose-6-Phosphatase - metabolism | Mice, Knockout | Obesity - metabolism | Proteins - genetics | Gluconeogenesis - physiology | Low Density Lipoprotein Receptor-Related Protein-6 - metabolism | Animals | Proteins - metabolism | Homeostasis - physiology | Alleles | Insulin Resistance - genetics | Glucose - metabolism | Adipose Tissue, Brown - metabolism | Adiposity - physiology | Forkhead Box Protein O1 | Mice | TOR Serine-Threonine Kinases | Diabetes Mellitus, Type 2 - chemically induced | Receptors, Leptin - metabolism | Energy Metabolism - drug effects | Metabolic Regulation | Metabolic Syndrome | Glucose Metabolism | Insulin Resistance | Diabetes | Metabolism | Adipogenesis | Gluconeogenesis
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2013, Volume 288, Issue 9, pp. 6478 - 6487
Gene expression profiling has identified breast cancer (BCa) subtypes, including an aggressive basal-like (BL) subtype. The molecular signals underlying the... 
SRY-RELATED GENE | INTESTINAL EPITHELIUM | WNT PROTEINS | AUTOSOMAL SEX REVERSAL | CAMPOMELIC DYSPLASIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAMMARY STEM-CELLS | BETA-CATENIN | TRANSCRIPTION FACTOR | GLAND DEVELOPMENT | CHONDROCYTE DIFFERENTIATION | Immunohistochemistry | Humans | Gene Expression Regulation, Neoplastic | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - biosynthesis | Mammary Glands, Human - metabolism | Neoplasm Proteins - metabolism | Wnt Proteins - metabolism | Breast Neoplasms - metabolism | Low Density Lipoprotein Receptor-Related Protein-6 - genetics | Wnt Proteins - genetics | Female | Neoplasm Proteins - genetics | Wnt Signaling Pathway | Low Density Lipoprotein Receptor-Related Protein-6 - biosynthesis | Mammary Neoplasms, Animal - genetics | SOX9 Transcription Factor - metabolism | Transcription Factor 4 | Mammary Glands, Animal - pathology | Mammary Glands, Human - pathology | Mice, Transgenic | Transcription Factors - biosynthesis | Transcription Factors - genetics | beta Catenin - metabolism | beta Catenin - genetics | Mammary Neoplasms, Animal - pathology | Animals | Breast Neoplasms - genetics | Mammary Glands, Animal - metabolism | Breast Neoplasms - pathology | Mammary Neoplasms, Animal - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Cell Line, Tumor | Mice | SOX9 Transcription Factor - genetics | Wnt Signaling | Molecular Bases of Disease | T-cell Factor (TCF) | Transcription Regulation | TCF4 | SOX9 | Wnt Pathway | Breast Cancer | LRP6
Journal Article