Cell, ISSN 0092-8674, 2006, Volume 125, Issue 2, pp. 247 - 260
Postmenopausal osteoporosis, a global public health problem, has for decades been attributed solely to declining estrogen levels. Although FSH levels rise...
MENSTRUAL-CYCLE | IN-VITRO | BIOCHEMICAL MARKERS | OSTEOCLAST FORMATION | CD38/ADP-RIBOSYL CYCLASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FEMALE MICE | FOLLICLE-STIMULATING-HORMONE | ESTROGEN DEFICIENCY | RECEPTOR FUNCTION | TURNOVER MARKERS | CELL BIOLOGY | Receptors, FSH - genetics | Humans | GTP-Binding Protein alpha Subunit, Gi2 - metabolism | NF-kappa B - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Osteoclasts - cytology | Protein Subunits - metabolism | Bone and Bones - anatomy & histology | Osteoporosis - metabolism | Female | Cell Differentiation | Estrogens - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Follicle Stimulating Hormone - genetics | Protein Subunits - genetics | Receptors, FSH - metabolism | Bone Resorption | Follicle Stimulating Hormone - metabolism | Bone and Bones - physiology | Mice, Inbred C57BL | Cells, Cultured | Osteoclasts - metabolism | Hypogonadism | Mice, Knockout | Animals | Signal Transduction - physiology | Mice | Enzyme Activation | Osteoporosis | Bones | Postmenopausal women | Research | Health aspects | Density | Risk factors | Medical colleges | Methyl ethyl ketone | Public health
MENSTRUAL-CYCLE | IN-VITRO | BIOCHEMICAL MARKERS | OSTEOCLAST FORMATION | CD38/ADP-RIBOSYL CYCLASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FEMALE MICE | FOLLICLE-STIMULATING-HORMONE | ESTROGEN DEFICIENCY | RECEPTOR FUNCTION | TURNOVER MARKERS | CELL BIOLOGY | Receptors, FSH - genetics | Humans | GTP-Binding Protein alpha Subunit, Gi2 - metabolism | NF-kappa B - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Osteoclasts - cytology | Protein Subunits - metabolism | Bone and Bones - anatomy & histology | Osteoporosis - metabolism | Female | Cell Differentiation | Estrogens - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Follicle Stimulating Hormone - genetics | Protein Subunits - genetics | Receptors, FSH - metabolism | Bone Resorption | Follicle Stimulating Hormone - metabolism | Bone and Bones - physiology | Mice, Inbred C57BL | Cells, Cultured | Osteoclasts - metabolism | Hypogonadism | Mice, Knockout | Animals | Signal Transduction - physiology | Mice | Enzyme Activation | Osteoporosis | Bones | Postmenopausal women | Research | Health aspects | Density | Risk factors | Medical colleges | Methyl ethyl ketone | Public health
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2015, Volume 112, Issue 39, pp. 12157 - 12162
It is unclear how physical activity stimulates new bone synthesis. We explored whether irisin, a newly discovered myokine released upon physical activity,...
Osteoporosis | Sarcopenia | Mechanical loading | CLIMBING EXERCISE | CELLS | ADIPOCYTES | MULTIDISCIPLINARY SCIENCES | STRENGTH | BROWN ADIPOSE-TISSUE | BODY-COMPOSITION | osteoporosis | mechanical loading | MINERAL DENSITY | WHITE FAT | GROWTH | OSTEOPOROTIC FRACTURES | sarcopenia | Immunohistochemistry | Fibronectins - pharmacology | Mice, Inbred C57BL | Osteoblasts - drug effects | Osteogenesis - drug effects | Immunoblotting | Male | Muscle, Skeletal - metabolism | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | Dose-Response Relationship, Drug | Gene Expression Regulation - drug effects | Animals | Polymerase Chain Reaction | Fibronectins - genetics | Mice | Adipose Tissue - drug effects | Biomechanics | Bones | Exercise | Observations | Health aspects | Density | Biological Sciences
Osteoporosis | Sarcopenia | Mechanical loading | CLIMBING EXERCISE | CELLS | ADIPOCYTES | MULTIDISCIPLINARY SCIENCES | STRENGTH | BROWN ADIPOSE-TISSUE | BODY-COMPOSITION | osteoporosis | mechanical loading | MINERAL DENSITY | WHITE FAT | GROWTH | OSTEOPOROTIC FRACTURES | sarcopenia | Immunohistochemistry | Fibronectins - pharmacology | Mice, Inbred C57BL | Osteoblasts - drug effects | Osteogenesis - drug effects | Immunoblotting | Male | Muscle, Skeletal - metabolism | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | Dose-Response Relationship, Drug | Gene Expression Regulation - drug effects | Animals | Polymerase Chain Reaction | Fibronectins - genetics | Mice | Adipose Tissue - drug effects | Biomechanics | Bones | Exercise | Observations | Health aspects | Density | Biological Sciences
Journal Article
Nature Reviews Rheumatology, ISSN 1759-4790, 2019, Volume 15, Issue 3, pp. 128 - 128
Journal Article
Osteoporosis International, ISSN 0937-941X, 12/2000, Volume 11, Issue 12, pp. 985 - 1009
LIFETIME MILK CONSUMPTION | DEPOT MEDROXYPROGESTERONE ACETATE | MINERAL DENSITY | NONHEME-IRON-ABSORPTION | URINARY CALCIUM EXCRETION | ENDOCRINOLOGY & METABOLISM | ORAL-CONTRACEPTIVE USE | NONCIRRHOTIC MALE ALCOHOLICS | PHYSICAL-ACTIVITY | ADOLESCENT GIRLS | CORONARY HEART-DISEASE | Smoking - adverse effects | Body Weight | Bone Density - physiology | Calcium - metabolism | Bone Development - physiology | Humans | Middle Aged | Child, Preschool | Menarche | Infant | Male | Bone Density - genetics | Nutritional Physiological Phenomena - physiology | Fractures, Bone - etiology | Adult | Female | Child | Infant, Newborn | Body Mass Index | Amenorrhea - physiopathology | Feeding and Eating Disorders - physiopathology | Pregnancy | Adolescent | Aged | Bone Development - genetics
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2006, Volume 116, Issue 5, pp. 1202 - 1209
Wnt proteins are a family of secreted proteins that regulate many aspects of cell growth, differentiation, function, and death. Considerable progress has been...
MEDICINE, RESEARCH & EXPERIMENTAL | PPAR-GAMMA INSUFFICIENCY | IN-VITRO | OSTEOBLAST DIFFERENTIATION | MESENCHYMAL PROGENITORS | RECEPTOR-RELATED PROTEIN-5 | PARATHYROID-HORMONE | FRIZZLED-RELATED PROTEIN-1 | BETA-CATENIN | CELL-DIFFERENTIATION | MORPHOGENETIC PROTEIN-2 | Animals | Bone Diseases - therapy | Signal Transduction | Models, Biological | Bone and Bones - metabolism | Humans | Bone Diseases - metabolism | Osteoblasts - metabolism | Wnt Proteins - metabolism | beta Catenin - metabolism | Proteins | Bones | Research | Properties | Density | Review Series
MEDICINE, RESEARCH & EXPERIMENTAL | PPAR-GAMMA INSUFFICIENCY | IN-VITRO | OSTEOBLAST DIFFERENTIATION | MESENCHYMAL PROGENITORS | RECEPTOR-RELATED PROTEIN-5 | PARATHYROID-HORMONE | FRIZZLED-RELATED PROTEIN-1 | BETA-CATENIN | CELL-DIFFERENTIATION | MORPHOGENETIC PROTEIN-2 | Animals | Bone Diseases - therapy | Signal Transduction | Models, Biological | Bone and Bones - metabolism | Humans | Bone Diseases - metabolism | Osteoblasts - metabolism | Wnt Proteins - metabolism | beta Catenin - metabolism | Proteins | Bones | Research | Properties | Density | Review Series
Journal Article
Sports Medicine, ISSN 0112-1642, 2009, Volume 39, Issue 6, pp. 439 - 468
There is a substantial body of evidence indicating that exercise prior to the pubertal growth spurt stimulates bone growth and skeletal muscle hypertrophy to a...
HIGH-IMPACT EXERCISE | SPORT SCIENCES | MINERAL DENSITY | WEIGHT-BEARING | PHYSICAL-ACTIVITY | RANDOMIZED CONTROLLED-TRIAL | PREMENOPAUSAL WOMEN | FEMORAL BONE | POSTMENOPAUSAL WOMEN | SITE-SPECIFIC RESPONSE | WHOLE-BODY VIBRATION | Age Factors | Bone Density - physiology | Osteoporosis - prevention & control | Humans | Middle Aged | Male | Animals | Aging - physiology | Sex Factors | Adult | Female | Weight-Bearing | Aged | Exercise - physiology
HIGH-IMPACT EXERCISE | SPORT SCIENCES | MINERAL DENSITY | WEIGHT-BEARING | PHYSICAL-ACTIVITY | RANDOMIZED CONTROLLED-TRIAL | PREMENOPAUSAL WOMEN | FEMORAL BONE | POSTMENOPAUSAL WOMEN | SITE-SPECIFIC RESPONSE | WHOLE-BODY VIBRATION | Age Factors | Bone Density - physiology | Osteoporosis - prevention & control | Humans | Middle Aged | Male | Animals | Aging - physiology | Sex Factors | Adult | Female | Weight-Bearing | Aged | Exercise - physiology
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 06/2012, Volume 27, Issue 6, pp. 1357 - 1367
The gut microbiota modulates host metabolism and development of immune status. Here we show that the gut microbiota is also a major regulator of bone mass in...
SEROTONIN | OSTEOIMMUNOLOGY | BONE METABOLISM | OSTEOPOROSIS | GERM FREE | RHEUMATOID-ARTHRITIS | SEROTONIN TRANSPORTER | FACTOR-ALPHA | TUMOR-NECROSIS-FACTOR | IMMUNE-SYSTEM | IN-VIVO | OSTEOPROTEGERIN LIGAND | ENDOCRINOLOGY & METABOLISM | RECEPTOR ACTIVATOR | TNF-ALPHA | T-CELLS | Tumor Necrosis Factor-alpha - metabolism | Bone Marrow - immunology | Calcium - metabolism | Tumor Necrosis Factor-alpha - genetics | Homeostasis | Colony Count, Microbial | Osteoclasts - cytology | Metagenome - physiology | CD4-Positive T-Lymphocytes - immunology | Bone and Bones - anatomy & histology | Serotonin - blood | Bone Marrow - metabolism | Bone Marrow Cells - immunology | Female | Interleukin-6 - metabolism | Femur - anatomy & histology | Interleukin-6 - genetics | Bone Marrow Cells - cytology | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Gastrointestinal Tract - microbiology | Organ Size - physiology | Femur - immunology | Animals | Organ Size - immunology | Germ-Free Life | Lymphocyte Count | Mice | Bone and Bones - immunology | Original | Clinical Medicine | serotonin | bone metabolism | Medical and Health Sciences | Endokrinologi och diabetes | Medicin och hälsovetenskap | germ free | Klinisk medicin | osteoporosis | Endocrinology and Diabetes | osteoimmunology
SEROTONIN | OSTEOIMMUNOLOGY | BONE METABOLISM | OSTEOPOROSIS | GERM FREE | RHEUMATOID-ARTHRITIS | SEROTONIN TRANSPORTER | FACTOR-ALPHA | TUMOR-NECROSIS-FACTOR | IMMUNE-SYSTEM | IN-VIVO | OSTEOPROTEGERIN LIGAND | ENDOCRINOLOGY & METABOLISM | RECEPTOR ACTIVATOR | TNF-ALPHA | T-CELLS | Tumor Necrosis Factor-alpha - metabolism | Bone Marrow - immunology | Calcium - metabolism | Tumor Necrosis Factor-alpha - genetics | Homeostasis | Colony Count, Microbial | Osteoclasts - cytology | Metagenome - physiology | CD4-Positive T-Lymphocytes - immunology | Bone and Bones - anatomy & histology | Serotonin - blood | Bone Marrow - metabolism | Bone Marrow Cells - immunology | Female | Interleukin-6 - metabolism | Femur - anatomy & histology | Interleukin-6 - genetics | Bone Marrow Cells - cytology | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Gastrointestinal Tract - microbiology | Organ Size - physiology | Femur - immunology | Animals | Organ Size - immunology | Germ-Free Life | Lymphocyte Count | Mice | Bone and Bones - immunology | Original | Clinical Medicine | serotonin | bone metabolism | Medical and Health Sciences | Endokrinologi och diabetes | Medicin och hälsovetenskap | germ free | Klinisk medicin | osteoporosis | Endocrinology and Diabetes | osteoimmunology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2006, Volume 103, Issue 3, pp. 696 - 701
The endogenous cannabinoids bind to and activate two G proteincoupled receptors, the predominantly central cannabinoid receptor type 1 (CB1) and peripheral...
Receptors | Bone formation | Messenger RNA | Stromal cells | Cell lines | Bones | Osteoclasts | Cultured cells | Agonists | Osteoblasts | Osteoblast | Osteoclast | Bone remodeling | HU-308 | CELLS | ACTIVATION | MESSENGER-RNA EXPRESSION | MICE DEFICIENT | MULTIDISCIPLINARY SCIENCES | osteoblast | SIGNAL-TRANSDUCTION | TRABECULAR BONE | GROWTH | NITRIC-OXIDE | bone remodeling | osteoclast | OSTEOCLAST DIFFERENTIATION | AGONIST | Receptor, Cannabinoid, CB2 - physiology | Receptor, Cannabinoid, CB2 - agonists | Humans | Male | Osteoclasts - cytology | Receptor, Cannabinoid, CB2 - genetics | Bone and Bones - drug effects | Cell Differentiation - genetics | Bone and Bones - metabolism | Female | Osteoblasts - cytology | Bone and Bones - cytology | Cell Line | Ovariectomy | Mice, Inbred C57BL | Osteoblasts - drug effects | Cells, Cultured | Signal Transduction - genetics | Osteoclasts - metabolism | Mice, Inbred C3H | Cannabinoids - pharmacology | Mice, Knockout | Animals | Mice | Osteoblasts - metabolism | Osteoclasts - drug effects | Receptor, Cannabinoid, CB2 - deficiency | Cannabinoids | Osteoclasis | Research | Bone regeneration | Biological Sciences
Receptors | Bone formation | Messenger RNA | Stromal cells | Cell lines | Bones | Osteoclasts | Cultured cells | Agonists | Osteoblasts | Osteoblast | Osteoclast | Bone remodeling | HU-308 | CELLS | ACTIVATION | MESSENGER-RNA EXPRESSION | MICE DEFICIENT | MULTIDISCIPLINARY SCIENCES | osteoblast | SIGNAL-TRANSDUCTION | TRABECULAR BONE | GROWTH | NITRIC-OXIDE | bone remodeling | osteoclast | OSTEOCLAST DIFFERENTIATION | AGONIST | Receptor, Cannabinoid, CB2 - physiology | Receptor, Cannabinoid, CB2 - agonists | Humans | Male | Osteoclasts - cytology | Receptor, Cannabinoid, CB2 - genetics | Bone and Bones - drug effects | Cell Differentiation - genetics | Bone and Bones - metabolism | Female | Osteoblasts - cytology | Bone and Bones - cytology | Cell Line | Ovariectomy | Mice, Inbred C57BL | Osteoblasts - drug effects | Cells, Cultured | Signal Transduction - genetics | Osteoclasts - metabolism | Mice, Inbred C3H | Cannabinoids - pharmacology | Mice, Knockout | Animals | Mice | Osteoblasts - metabolism | Osteoclasts - drug effects | Receptor, Cannabinoid, CB2 - deficiency | Cannabinoids | Osteoclasis | Research | Bone regeneration | Biological Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2008, Volume 3, Issue 8, pp. e2942 - e2942
Osteocytes, former osteoblasts buried within bone, are thought to orchestrate skeletal adaptation to mechanical stimuli. However, it remains unknown whether...
OSTEOBLAST-DERIVED PTHRP | TRABECULAR BONE | PRIMARY HYPERPARATHYROIDISM | DIFFERENTIATED OSTEOBLASTS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GENE-EXPRESSION | PTH/PTHRP RECEPTOR | PARATHYROID-HORMONE | BETA-CATENIN | OSTEOCLAST DIFFERENTIATION | Bone and Bones - physiology | Extracellular Matrix Proteins - genetics | Humans | Mice, Transgenic | Bone Remodeling - physiology | Phosphoproteins - genetics | Osteoclasts - cytology | Osteocytes - physiology | Bone and Bones - anatomy & histology | Animals | Receptor, Parathyroid Hormone, Type 1 - genetics | Signal Transduction - physiology | Mice | Osteoblasts - cytology | Receptors, Parathyroid Hormone - physiology | Bones | Genetic engineering | Parathyroid hormone | Density | Apoptosis | Lipoproteins (low density) | Wnt protein | Homeostasis | Osteocytes | SOST protein | Biology | Hormones | Bone diseases | Kinases | Remodeling | Osteoblasts | Bone surgery | Proteins | Bone resorption | Osteoporosis | Bone growth | Clonal deletion | Deletion | Bone marrow | LRP5 protein | Biocompatibility | Bone loss | Parathyroid | Bone remodelling | Transgenic mice | Metabolism | Gene expression | Bone mass | Ligands | Bone | Mechanical stimuli | Endocrinology
OSTEOBLAST-DERIVED PTHRP | TRABECULAR BONE | PRIMARY HYPERPARATHYROIDISM | DIFFERENTIATED OSTEOBLASTS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GENE-EXPRESSION | PTH/PTHRP RECEPTOR | PARATHYROID-HORMONE | BETA-CATENIN | OSTEOCLAST DIFFERENTIATION | Bone and Bones - physiology | Extracellular Matrix Proteins - genetics | Humans | Mice, Transgenic | Bone Remodeling - physiology | Phosphoproteins - genetics | Osteoclasts - cytology | Osteocytes - physiology | Bone and Bones - anatomy & histology | Animals | Receptor, Parathyroid Hormone, Type 1 - genetics | Signal Transduction - physiology | Mice | Osteoblasts - cytology | Receptors, Parathyroid Hormone - physiology | Bones | Genetic engineering | Parathyroid hormone | Density | Apoptosis | Lipoproteins (low density) | Wnt protein | Homeostasis | Osteocytes | SOST protein | Biology | Hormones | Bone diseases | Kinases | Remodeling | Osteoblasts | Bone surgery | Proteins | Bone resorption | Osteoporosis | Bone growth | Clonal deletion | Deletion | Bone marrow | LRP5 protein | Biocompatibility | Bone loss | Parathyroid | Bone remodelling | Transgenic mice | Metabolism | Gene expression | Bone mass | Ligands | Bone | Mechanical stimuli | Endocrinology
Journal Article