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Circulation, ISSN 0009-7322, 06/2013, Volume 127, Issue 24, pp. 2403 - 2413
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2012, Volume 109, Issue 9, pp. 3510 - 3515
A 30-d course of oral administration of a semipurif ied extract of the root of Withania somnifera consisting predominantly of withanolides and withanosides... 
Oligomers | Anger | Pathology | Brain | Messenger RNA | Liver | Medical treatment | LDL lipoproteins | Amyloids | Alzheimers disease | Herbal extract | Neurodegenerative disease | Dementia | CLEARANCE | neurodegenerative disease | MEMORY | MULTIDISCIPLINARY SCIENCES | herbal extract | AMYLOID-BETA-PEPTIDE | dementia | BLOOD-BRAIN-BARRIER | SYNAPTIC PLASTICITY | STRATEGIES | Up-Regulation | Liver - pathology | Male | Low Density Lipoprotein Receptor-Related Protein-1 - physiology | Low Density Lipoprotein Receptor-Related Protein-1 - genetics | Neprilysin - biosynthesis | Amyloid beta-Peptides - blood | Alzheimer Disease - pathology | Brain - metabolism | Liver - drug effects | Microglia - pathology | Neprilysin - genetics | Phytotherapy | Drug Evaluation, Preclinical | Neprilysin - physiology | Disease Models, Animal | Oligonucleotides, Antisense - pharmacology | Microglia - drug effects | Plaque, Amyloid - pathology | Administration, Oral | Liver - metabolism | Alzheimer Disease - drug therapy | Presenilin-1 - genetics | Mice, Transgenic | Plant Extracts - isolation & purification | Low Density Lipoprotein Receptor-Related Protein-1 - biosynthesis | Maze Learning - drug effects | Organ Specificity | Brain - drug effects | Amyloid beta-Protein Precursor - genetics | Animals | Plant Roots - chemistry | Brain - pathology | Mice | Plant Extracts - therapeutic use | Alzheimer Disease - blood | Withania - chemistry | Prevention | Physiological aspects | Alzheimer's disease | Health aspects | Low density lipoproteins | Flowers & plants | Peptides | Low density lipoprotein | Rodents | Animal models | Neurodegenerative diseases | Proteinase | Roots | Oral administration | Transgenic mice | beta -Amyloid | Amyloid precursor protein | Monomers | Lipoproteins | Presenilin 1 | Models | Neprilysin | Plaques | Index Medicus | Biological Sciences
Journal Article
Annals of Neurology, ISSN 0364-5134, 02/2011, Volume 69, Issue 2, pp. 418 - 422
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 05/2018, Volume 38, Issue 5, pp. 1178 - 1190
OBJECTIVE—Bempedoic acid (BemA; ETC-1002) is a novel drug that targets hepatic ATP-citrate lyase to reduce cholesterol biosynthesis. In phase 2 studies, BemA... 
Receptors | LDL | Swine | Atherosclerosis | Therapeutics | Lipids | Cholesterol | atherosclerosis | lipids | therapeutics | ACTIVATED PROTEIN-KINASE | receptors | HYPERCHOLESTEROLEMIA | APOLIPOPROTEIN-B | DECREASES | ATORVASTATIN | swine | INHIBITION | ATP-CITRATE LYASE | ETC-1002 | cholesterol | PERIPHERAL VASCULAR DISEASE | DYSLIPIDEMIA | HEMATOLOGY | CARDIOVASCULAR RISK | Index Medicus
Journal Article
European Heart Journal, ISSN 0195-668X, 01/2019, Volume 40, Issue 4, pp. 392 - 392
Journal Article
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 11/2011, Volume 89, Issue 5, pp. 619 - 627
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 09/2013, Volume 33, Issue 9, pp. 2065 - 2074
OBJECTIVE—Chylomicron and very low-density lipoprotein remnants are cleared from the circulation in the liver by heparan sulfate proteoglycan (HSPG) receptors... 
low-density lipoprotein receptor-related protein-1 | low-density lipoprotein receptor | cholesterol | syndecan-1 | triglycerides | heparan sulfate proteoglycans | lipoproteins | CHYLOMICRON REMNANTS | LDL RECEPTOR | TRIGLYCERIDE-RICH LIPOPROTEINS | APOLIPOPROTEIN-E | III HYPERLIPOPROTEINEMIA | PLASMA | METABOLISM | NONFASTING TRIGLYCERIDES | IN-VIVO | LIVER | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Hyperlipidemias - genetics | Heparan Sulfate Proteoglycans - blood | Cholesterol, Dietary - administration & dosage | Cholesterol, Dietary - metabolism | Hepatocytes - metabolism | Chylomicron Remnants - blood | Time Factors | Tumor Suppressor Proteins - deficiency | Diet, High-Fat | Tumor Suppressor Proteins - genetics | Postprandial Period | Receptors, LDL - deficiency | Chylomicron Remnants - metabolism | Sulfotransferases - metabolism | Dietary Sucrose - metabolism | Sulfotransferases - genetics | Receptors, LDL - genetics | Tumor Suppressor Proteins - metabolism | Hyperlipidemias - metabolism | Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Receptors, LDL - metabolism | Mice, Knockout | Triglycerides - metabolism | Particle Size | Animals | Heparan Sulfate Proteoglycans - metabolism | Dietary Sucrose - administration & dosage | Mice | Index Medicus | heparan sulfate | LRP1 | Syndecan-1 | Triglycerides | LDLR
Journal Article