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Journal of Biological Chemistry, ISSN 0021-9258, 12/2005, Volume 280, Issue 48, pp. 39914 - 39924
The CATERPILLER (CLR, also NOD and NLR) proteins share structural similarities with the nucleotide binding domain ( NBD)leucine- rich repeat (LRR) superfamily... 
ENDOTOXIN-TOLERANT CELLS | CROHNS-DISEASE | AUTOINFLAMMATORY DISORDERS | HOST RECOGNITION | NEGATIVE REGULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BACTERIAL PEPTIDOGLYCAN | NF-KAPPA-B | CIAS1 MUTATIONS | CUTTING EDGE | FAMILY | Protein Kinases - metabolism | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Immunoprecipitation | Luciferases - metabolism | Humans | Transcriptional Activation | Interleukin-1 Receptor-Associated Kinases | Monocytes - metabolism | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Transfection | Retroviridae - genetics | Antigens, Differentiation - metabolism | Toll-Like Receptors - metabolism | Caspases - chemistry | Mycobacterium tuberculosis - metabolism | Genes, Reporter | RNA - metabolism | Protein Structure, Tertiary | Cell Line | Promoter Regions, Genetic | Cytokines - metabolism | Enzyme-Linked Immunosorbent Assay | Signal Transduction | Nuclear Pore Complex Proteins - metabolism | TNF Receptor-Associated Factor 2 - metabolism | Inflammation | Cytoskeletal Proteins - chemistry | Myeloid Differentiation Factor 88 | Reverse Transcriptase Polymerase Chain Reaction | Plasmids - metabolism | Pyrin | Amino Acid Motifs | Transcription Factor RelA - metabolism | TNF Receptor-Associated Factor 6 - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Intracellular Signaling Peptides and Proteins - physiology | RNA-Binding Proteins - metabolism | Receptors, Immunologic - metabolism | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 03/2003, Volume 95, Issue 6, pp. 437 - 448
Background: Interferon alpha (IFN-alpha) has antiangiogenic activity, although the underlying mechanism of action is unclear. Because human neuroendocrine (NE)... 
CELLS | INHIBITION | THERAPY | ONCOLOGY | SP1 | CLINICAL-APPLICATIONS | PROTEIN-KINASE | DOWN-REGULATION | EXPRESSION | CANCER | BINDING | Immunohistochemistry | Interferon-alpha - pharmacology | Transcription, Genetic - drug effects | Vascular Endothelial Growth Factor A | Endothelial Growth Factors - metabolism | Luciferases - metabolism | Vascular Endothelial Growth Factors | Receptors, Vascular Endothelial Growth Factor - drug effects | Transplantation, Heterologous | Pregnancy Proteins - metabolism | Promoter Regions, Genetic - drug effects | RNA, Messenger - metabolism | Biomarkers, Tumor | Intercellular Signaling Peptides and Proteins - metabolism | Lymphokines - genetics | Receptors, Vascular Endothelial Growth Factor - metabolism | Time Factors | Lymphokines - metabolism | Antineoplastic Agents - pharmacology | Electrophoretic Mobility Shift Assay | Gene Expression Regulation, Neoplastic - drug effects | Receptors, Vascular Endothelial Growth Factor - genetics | Tumor Cells, Cultured | Lymphokines - drug effects | Enzyme-Linked Immunosorbent Assay | Neuroendocrine Tumors - metabolism | Intercellular Signaling Peptides and Proteins - genetics | Angiogenesis Inhibitors - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Animals | Mice, Nude | Neovascularization, Pathologic - drug therapy | Endothelial Growth Factors - genetics | Neuroendocrine Tumors - drug therapy | Genes, Reporter - drug effects | Mice | Neovascularization, Pathologic - metabolism | Neuroendocrine Tumors - blood supply | Receptors, Immunologic - metabolism | Measurement | Physiological aspects | Vascular endothelial growth factor | Interferon alpha | Blood vessels | Therapy | Genes | Tumors | Index Medicus | Interferon-alpha/pharmacology | Endothelial Growth Factors/genetics/metabolism | Tumor Cells; Cultured | Tumor Markers; Biological | Neuroendocrine Tumors/blood supply/drug therapy/metabolism | Antineoplastic Agents/pharmacology | Pregnancy Proteins/metabolism | Luciferases/metabolism | Promoter Regions (Genetics)/drug effects | Research Support; Non-U.S. Gov't | Genes; Reporter/drug effects | Mice; Nude | Gene Expression Regulation; Neoplastic/drug effects | RNA; Messenger/metabolism | Receptors; Vascular Endothelial Growth Factor/drug effects/genetics/metabolism | Receptors; Immunologic/metabolism | Intercellular Signaling Peptides and Proteins/genetics/metabolism | Neovascularization; Pathologic/drug therapy/metabolism | Angiogenesis Inhibitors/pharmacology | Lymphokines/drug effects/genetics/metabolism | Transcription; Genetic/drug effects | Transplantation; Heterologous
Journal Article
Nature Cell Biology, ISSN 1465-7392, 02/2015, Volume 17, Issue 2, pp. 183 - 194
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 11/2007, Volume 152, Issue 5, pp. 734 - 743
Background and purpose: Although CB1 receptor activation evokes neuroprotection in response to cannabinoids, some cannabinoids have been reported to be... 
Neuroprotection | Peroxisome proliferator-activated receptors (PPARs) | Cannabinoids | N-oleoylethanolamine | GAMMA | CELLS | FOCAL CEREBRAL-ISCHEMIA | ANANDAMIDE | ENDOCANNABINOID SYSTEM | NUCLEAR RECEPTOR | peroxisome proliferator-activated receptors (PPARs) | neuroprotection | cannabinoids | THERAPEUTIC TARGETS | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | TRANSCRIPTION FACTOR | BRAIN | Luciferases - metabolism | Humans | Benzoxazines - metabolism | Male | Recombinant Fusion Proteins - metabolism | Cerebral Cortex - metabolism | Neuroprotective Agents - metabolism | Luciferases - genetics | Oleic Acids - metabolism | Arachidonic Acids - metabolism | Fenofibrate - pharmacology | Neuroprotective Agents - pharmacology | Transfection | I-kappa B Kinase - metabolism | Cerebral Cortex - drug effects | Oleic Acids - pharmacology | Dronabinol - pharmacology | Naphthalenes - metabolism | Cannabinoids - metabolism | Endocannabinoids | Fenofibrate - metabolism | Mice, Inbred C57BL | Morpholines - pharmacology | Fatty Acids, Unsaturated - pharmacology | Morpholines - metabolism | PPAR alpha - genetics | Polyunsaturated Alkamides - metabolism | Arachidonic Acids - pharmacology | Cannabinoids - pharmacology | Mice, Knockout | Naphthalenes - pharmacology | Animals | Benzoxazines - pharmacology | Cyclooxygenase 2 - metabolism | Polyunsaturated Alkamides - pharmacology | Protein Binding | Recombinant Fusion Proteins - genetics | Ligands | PPAR alpha - agonists | Mice | HeLa Cells | PPAR alpha - metabolism | Dronabinol - metabolism | Index Medicus | Research Papers
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2017, Volume 114, Issue 9, pp. 2343 - 2348
Rotaviruses (RVs) are highly important pathogens that cause severe diarrhea among infants and young children worldwide. The understanding of the molecular... 
Vaccine | Reporter virus | Rotavirus | Reverse genetics | reverse genetics | NSP1 | PROTEIN | MULTIDISCIPLINARY SCIENCES | reporter virus | INNATE IMMUNE-RESPONSE | VACCINIA VIRUS | BLUETONGUE VIRUS | CLONED CDNA | vaccine | MESSENGER-RNA | rotavirus | RNA-CAPPING ENZYME | SYNTHETIC RNA | EXPRESSION | Luciferases - metabolism | Cricetulus | Humans | Methyltransferases - metabolism | Reverse Genetics - methods | DNA, Complementary - genetics | Methyltransferases - genetics | Multienzyme Complexes - metabolism | Green Fluorescent Proteins - genetics | Orthoreovirus - metabolism | Vaccinia virus - genetics | Viral Proteins - metabolism | Luciferases - genetics | Base Sequence | Nucleotidyltransferases - metabolism | Genes, Reporter | Cell Line | Green Fluorescent Proteins - metabolism | Phosphoric Monoester Hydrolases - genetics | Transduction, Genetic | Vaccinia virus - metabolism | Orthoreovirus - genetics | Orthoreovirus, Mammalian - genetics | Gene Expression Regulation | Viral Nonstructural Proteins - genetics | Viral Proteins - genetics | DNA-Directed RNA Polymerases - genetics | Multienzyme Complexes - genetics | Plasmids - metabolism | Animals | Epithelial Cells - virology | Plasmids - chemistry | Cell Line, Tumor | Nucleotidyltransferases - genetics | Viral Nonstructural Proteins - metabolism | DNA-Directed RNA Polymerases - metabolism | Phosphoric Monoester Hydrolases - metabolism | DNA, Complementary - metabolism | Orthoreovirus, Mammalian - metabolism | Genetic aspects | Gene expression | Health aspects | Rotaviruses | Viruses | Genetics | Microbiology | Pathogenesis | Plasmids | Medical immunity | Index Medicus | Biological Sciences
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 2005, Volume 46, Issue 6, pp. 1133 - 1149
Mitochondrial cytopathy has been associated with modifications of lipid metabolism in various situations, such as the acquisition of an abnormal adipocyte... 
AMP-dependent kinase | Peroxisome proliferator- activated receptor γ | Phosphatidylinositol 3-kinase/Akt1/glycogen synthase kinase 3β | Muscle carnitine palmitoyl transferase-1 | Carbohydrate-responsive element binding protein | ACTIVATED PROTEIN-KINASE | LIPID-METABOLISM | INTRACELLULAR CALCIUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLYCOGEN-SYNTHASE KINASE-3 | ACETYL-COA CARBOXYLASE | SKELETAL-MUSCLE | carbohydrate-responsive element binding protein | TRANSPORT | muscle carnitine palmitoyl transferase-1 | CPT-I | phosphatidylinositol 3 kinase/Akt1/glycogen synthase kinase 3 beta AMP-dependent kinase | GENE-EXPRESSION | MULTIPLE SYMMETRICAL LIPOMATOSIS | peroxisome proliferator activated receptor gamma | Luciferases - metabolism | Retinoid X Receptor alpha - metabolism | Calcium - metabolism | Adipocytes - cytology | Phosphatidylinositol 3-Kinases - metabolism | PPAR gamma - metabolism | RNA, Messenger - metabolism | Oxygen - metabolism | Transfection | Time Factors | Muscle Proteins - metabolism | Cell Differentiation | Cell Membrane - metabolism | Fatty Acids - metabolism | Monosaccharide Transport Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Carnitine O-Palmitoyltransferase - biosynthesis | Proto-Oncogene Proteins - metabolism | Glucose Transporter Type 4 | Down-Regulation | Carbohydrate Metabolism | Cells, Cultured | Enzyme Inhibitors - pharmacology | Lipid Metabolism | Mitochondria - metabolism | DNA - metabolism | Mitochondria - pathology | 3T3-L1 Cells | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Protein Transport | Triglycerides - metabolism | Proto-Oncogene Proteins c-akt | Microscopy, Confocal | Phenotype | Animals | Muscles - enzymology | Models, Biological | Glucose - pharmacokinetics | Glucose - metabolism | Protein Binding | Mice | Microscopy, Fluorescence | Index Medicus
Journal Article
Molecular Cancer, ISSN 1476-4598, 09/2011, Volume 10, Issue 1, pp. 117 - 117
Journal Article
Cancer Research, ISSN 0008-5472, 05/2010, Volume 70, Issue 10, pp. 4174 - 4184
Transforming growth factor-beta (TGF-beta) is a potent inducer of epithelial to mesenchymal transition (EMT). However, it remains elusive about which molecular... 
CANCER-CELLS | OVEREXPRESSION | IN-VITRO | TGF-BETA | ONCOLOGY | KERATINOCYTES | SENESCENCE | MIR-200 FAMILY | REPRESSORS ZEB1 | EXPRESSION | EMT | Receptor, Epidermal Growth Factor - genetics | Cell Proliferation | Epithelial Cells - metabolism | Luciferases - metabolism | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Homeodomain Proteins - metabolism | Humans | RNA, Messenger - metabolism | Zinc Finger E-box Binding Homeobox 2 | Tumor Suppressor Protein p53 - genetics | Esophageal Neoplasms - pathology | Receptor, Epidermal Growth Factor - metabolism | Telomerase - genetics | Cellular Senescence | Cyclin-Dependent Kinase Inhibitor p15 - genetics | Esophageal Neoplasms - metabolism | Telomerase - metabolism | Esophagus - cytology | Repressor Proteins - metabolism | Signal Transduction | RNA, Messenger - genetics | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Esophagus - metabolism | Repressor Proteins - genetics | Epithelial Cells - pathology | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Transforming Growth Factor beta - pharmacology | Esophageal Neoplasms - genetics | Cell Transformation, Neoplastic | Fluorescent Antibody Technique | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Mesoderm - metabolism | Cyclin-Dependent Kinase Inhibitor p15 - metabolism | Mesoderm - pathology | Zinc Finger E-box-Binding Homeobox 1 | Index Medicus
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2017, Volume 486, Issue 2, pp. 451 - 457
Klotho, an antiaging protein, can extend the lifespan and modulate cellular responses to inflammation and oxidative stress which can ameliorate chronic kidney... 
Cyclosporine A | PDLIM2 | Nephropathy | Klotho | NF-kB p65 | GLOMERULONEPHRITIS | OXIDATIVE STRESS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MODEL | BIOPHYSICS | DISEASE | MICE | KIDNEY | ANTIAGING GENE | RENAL INJURY | EXPRESSION | Tumor Necrosis Factor-alpha - metabolism | RNA, Small Interfering - genetics | Epithelial Cells - metabolism | Interleukin-12 - genetics | Blood Urea Nitrogen | Epithelial Cells - drug effects | Tumor Necrosis Factor-alpha - genetics | Glucuronidase - metabolism | Male | Cyclosporine | LIM Domain Proteins - metabolism | Transcription Factor RelA - genetics | Nephritis, Interstitial - metabolism | Nephritis, Interstitial - pathology | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Adenoviridae - genetics | Chemokine CCL2 - metabolism | Interleukin-6 - metabolism | Nephritis, Interstitial - chemically induced | Cell Line | Kidney Tubules, Proximal - pathology | Genetic Vectors - chemistry | Interleukin-6 - genetics | Macrophages - pathology | Signal Transduction | LIM Domain Proteins - antagonists & inhibitors | Gene Expression Regulation | Genetic Vectors - metabolism | Chemokine CCL2 - genetics | Epithelial Cells - pathology | Interleukin-12 - metabolism | Mice, Inbred ICR | Macrophages - metabolism | Animals | Glucuronidase - genetics | Nephritis, Interstitial - genetics | Nitric Oxide Synthase Type II - genetics | Transcription Factor RelA - metabolism | Adaptor Proteins, Signal Transducing - genetics | Kidney Tubules, Proximal - metabolism | Creatinine - blood | LIM Domain Proteins - genetics | Mice | Adenoviridae - metabolism | Glucuronidase - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Nitric Oxide Synthase Type II - metabolism | RNA, Small Interfering - metabolism | Medical research | Urea | Medical colleges | Chronic kidney failure | RNA | Luciferase | Medicine, Experimental | Index Medicus
Journal Article
Molecular and Cellular Proteomics, ISSN 1535-9476, 12/2011, Volume 10, Issue 12, pp. M111.012187 - M111.012187
Journal Article
Cell Metabolism, ISSN 1550-4131, 2005, Volume 2, Issue 3, pp. 153 - 163
Journal Article
Nature Cell Biology, ISSN 1465-7392, 11/2008, Volume 10, Issue 11, pp. 1291 - 1300
Journal Article