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Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2010, Volume 107, Issue 11, pp. 4878 - 4883
Firefly luciferase (FLuc), an ATP-dependent bioluminescent reporter enzyme, is broadly used in chemical biology and drug discovery assays. PTC124 (Ataluren;... 
Enzymes | Active sites | Reagents | Reporter genes | Ligands | Nonsense codon | Inhibitory concentration 50 | Carboxylates | Adducts | Crystal structure | X-ray crystallography | Reporter gene assay | Protein stability | Ataluren | Multisubstrate adduct inhibitor | MECHANISM | SPECIFICITY | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | multisubstrate adduct inhibitor | reporter gene assay | TRANSFORMYLASE | IDENTIFICATION | protein stability | REPORTER | ENZYME | ASSAYS | BIOLUMINESCENCE | Cell Line | Temperature | Enzyme Inhibitors - metabolism | Adenosine Monophosphate - metabolism | Humans | Enzyme Inhibitors - pharmacology | Models, Molecular | Crystallography, X-Ray | Enzyme Assays | Enzyme Stability - drug effects | Luciferases, Firefly - chemistry | Coenzyme A - metabolism | Isomerism | Substrate Specificity - drug effects | Solutions | Oxadiazoles - pharmacology | Enzyme Inhibitors - chemistry | Oxadiazoles - chemistry | Luciferases, Firefly - antagonists & inhibitors | Luciferases, Firefly - metabolism | Oxadiazoles - metabolism | Benzoic acid | Usage | Analysis | Luciferase | Physiological aspects | Research | Chemical properties | Structure | Chemical reactions | Molecular chemistry | Catalysis | Adenosine triphosphatase | Binding sites | BASIC BIOLOGICAL SCIENCES | STABILIZATION | ADDUCTS | COENZYMES | SIMULATION | LUCIFERASE | CODONS | SPECTROSCOPY | ACTIVITY LEVELS | BIOLOGY | GENES | GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE | DETECTION | POSITIONING | Biological Sciences | Physical Sciences
Journal Article