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1. Full Text Red-shifted Renilla reniformis luciferase variants for imaging in living subjects
by Loening, Andreas Markus and Wu, Anna M and Gambhir, Sanjiv Sam
Nature Methods, ISSN 1548-7091, 08/2007, Volume 4, Issue 8, pp. 641 - 643
The use of R. reniformis luciferase ( RLuc) as a reporter gene in small- animal imaging has been hampered by its 481 nm peaked emission spectrum, as blue... 
COELENTERAZINE | PROTEIN | IN-VIVO | BIOCHEMICAL RESEARCH METHODS | GENE-EXPRESSION | SENSITIVITY | TUMORS | Animals | Luciferases, Renilla - genetics | Mutagenesis, Site-Directed | Luciferases, Renilla - metabolism | Humans | Luminescence | Mice | Renilla - enzymology | Genetics | Scientific imaging | Research methodology | Light | Color
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2. Full Text Codon-Optimized Gaussia Luciferase cDNA for Mammalian Gene Expression in Culture and in Vivo
by Tannous, Bakhos A and Kim, Dong-Eog and Fernandez, Juliet L and Weissleder, Ralph and Breakefield, Xandra O
Molecular Therapy, ISSN 1525-0016, 03/2005, Volume 11, Issue 3, pp. 435 - 443
Photoproteins have played a major role in advancing our understanding of biological processes. A broader array of biocompatible, nontoxic, and novel reporters... 
MEDICINE, RESEARCH & EXPERIMENTAL | FIREFLY LUCIFERASE | ANALOGS | BIOLUMINESCENT REPORTER | HYBRIDIZATION | TUMORS | INDICATORS | CLONING | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PURIFICATION | GENETICS & HEREDITY | LABEL | RENILLA-RENIFORMIS LUCIFERASE | Gene Transfer Techniques | Copepoda - genetics | Luciferases - metabolism | Luciferases, Renilla - genetics | Humans | Copepoda - enzymology | Renilla - enzymology | Luciferases - genetics | Renilla - genetics | Animals | Luciferases, Renilla - metabolism | Mice, Nude | Luciferases, Firefly - genetics | Mice | Kinetics | Genes, Reporter | DNA, Complementary | Luciferases, Firefly - metabolism
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3. Full Text Replication competent molecular clones of HIV-1 expressing Renilla luciferase facilitate the analysis of antibody inhibition in PBMC
by Edmonds, Tara G and Ding, Haitao and Yuan, Xing and Wei, Qing and Smith, Kendra S and Conway, Joan A and Wieczorek, Lindsay and Brown, Bruce and Polonis, Victoria and West, John T and Montefiori, David C and Kappes, John C and Ochsenbauer, Christina
Virology, ISSN 0042-6822, 2010, Volume 408, Issue 1, pp. 1 - 13
Abstract Effective vaccine development for human immunodeficiency virus type 1 (HIV-1) will require assays that ascertain the capacity of vaccine immunogens to... 
Infectious Disease | HIV-1 | HIV reporter virus | Luciferase | HIV neutralization | PBMC assay | Vaccine assessment | Assay standardization | Neutralizing antibody | Envelope glycoprotein | NEUTRALIZING ANTIBODIES | CELL-LINES | CHIMERIC VIRUS | ENV CLONES | VIROLOGY | IMMUNODEFICIENCY-VIRUS TYPE-1 | VIRION INCORPORATION | DRUG SUSCEPTIBILITY | MONOCLONAL-ANTIBODIES | SUBTYPE-B | Staining and Labeling - methods | Luciferases, Renilla - genetics | Humans | AIDS Vaccines - immunology | Recombinant Proteins - genetics | Recombinant Proteins - biosynthesis | HIV-1 - genetics | Virology - methods | Leukocytes, Mononuclear - virology | Luciferases, Renilla - biosynthesis | Antibodies, Neutralizing - immunology | HIV-1 - immunology | HIV-1 - growth & development | HIV Antibodies - immunology | Virus Replication | Neutralization Tests - methods | Viral antibodies | Antigens | AIDS vaccines | Analysis | Cloning | Antibodies | HIV testing | HIV (Viruses) | luciferase | assay standardization | vaccine assessment | envelope glycoprotein
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4. Full Text Consensus guided mutagenesis of Renilla luciferase yields enhanced stability and light output
by Loening, Andreas Markus and Fenn, Timothy David and Wu, Anna M and Gambhir, Sanjiv Sam
Protein Engineering, Design and Selection, ISSN 1741-0126, 09/2006, Volume 19, Issue 9, pp. 391 - 400
Luciferases, which have seen expansive employment as reporter genes in biological research, could also be used in applications where the protein itself is... 
Reporter gene | Mutagenesis | Renilla luciferase | Enzyme stability | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | SENSITIVITY | LIVING MICE | mutagenesis | REPORTER | enzyme stability | RENIFORMIS LUCIFERASE | DATABASE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CONSTRUCTION | GENE-EXPRESSION | ENERGY-TRANSFER | reporter gene | BIOLUMINESCENCE | Amino Acid Sequence | Molecular Probe Techniques | Luciferases, Renilla - genetics | Luminescence | Models, Molecular | Molecular Sequence Data | Recombinant Proteins - genetics | Recombinant Proteins - biosynthesis | Sequence Analysis, DNA | Luciferases, Renilla - biosynthesis | Renilla - enzymology | Luciferases, Renilla - blood | Recombinant Proteins - blood | Renilla - genetics | Sequence Alignment | Animals | DNA Mutational Analysis | Base Sequence | Models, Genetic
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5. Full Text Effect of enhanced Renilla luciferase and fluorescent protein variants on the Förster distance of Bioluminescence resonance energy transfer (BRET)
by Dacres, Helen and Michie, Michelle and Wang, Jian and Pfleger, Kevin D.G and Trowell, Stephen C
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 08/2012, Volume 425, Issue 3, pp. 625 - 629
â–º First experimental determination of Förster distance (R ) for enhanced BRET systems. â–º Effect of brighter BRET components RLuc2, RLuc8 and Venus was... 
RLuc2 | Venus | Coelenterazine | RLuc8 | PROTEOLYTIC CLEAVAGE | BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIGAND | LIVE CELLS | Luciferases, Renilla - genetics | Sensitivity and Specificity | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Luciferases, Renilla - chemistry | Fluorescence | Luminescent Proteins - chemistry | Luminescent Proteins - genetics | Bioluminescence Resonance Energy Transfer Techniques | Luciferase
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6. Full Text A red-shifted Renilla luciferase for transient reporter-gene expression
by Gambhir, Sanjiv Sam and Loening, Andreas Markus and Dragulescu-Andrasi, Anca
Nature Methods, ISSN 1548-7091, 01/2010, Volume 7, Issue 1, pp. 5 - 6
RENIFORMIS | BIOCHEMICAL RESEARCH METHODS | Genetic Engineering - methods | Amino Acid Sequence | Catalytic Domain | Luciferases, Renilla - genetics | Gene Expression Regulation | Luminescence | Molecular Sequence Data | Genes, Reporter - genetics | Luminescent Measurements - methods | Renilla - enzymology | Aspartic Acid - genetics | Phenotype | Renilla - genetics | Animals | Luciferases, Renilla - metabolism | Mutagenesis | Time Factors | Mice | Aspartic Acid - chemistry | Usage | Animal models in research | Gene mutations | Luciferase | Genetic aspects | Research | Health aspects | Index Medicus
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7. Full Text Tissue-Specific Alternative Splicing Remodels Protein-Protein Interaction Networks
by Ellis, Jonathan D and Barrios-Rodiles, Miriam and Çolak, Recep and Irimia, Manuel and Kim, Philip M and Kim, TaeHyung and Calarco, John A and Wang, Xinchen and Pan, Qun and O'Hanlon, Dave and Wrana, Jeffrey L and Blencowe, Benjamin J
Molecular Cell, ISSN 1097-2765, 06/2012, Volume 46, Issue 6, pp. 884 - 892
Alternative splicing plays a key role in the expansion of proteomic and regulatory complexity, yet the functions of the vast majority of differentially spliced... 
COMPLEX | LIPRIN-ALPHA | CLONING | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISORDER | GABA(B) RECEPTORS | GRB2 ADAPTER | ISOFORM | ENDOCYTOSIS | CELL BIOLOGY | Tumor Suppressor Proteins - metabolism | Luciferases, Renilla - genetics | Alternative Splicing | Exons | Humans | Cells, Cultured | Dynamin II - genetics | Nuclear Proteins - metabolism | Protein Interaction Maps | Proteins - genetics | Proteins - metabolism | Luciferases, Renilla - metabolism | Tumor Suppressor Proteins - genetics | Adaptor Proteins, Signal Transducing - genetics | HEK293 Cells | Proteomics | Dynamin II - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Nuclear Proteins - genetics | Binding Sites | Proteins | Computer science | Universities and colleges
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8. Full Text Synthesizing and gate genetic circuits based on CRISPR-Cas9 for identification of bladder cancer cells
by Liu, Yuchen and Zeng, Yayue and Liu, Li and Zhuang, Chengle and Fu, Xing and Huang, Weiren and Cai, Zhiming
Nature Communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, p. 5393
The conventional strategy for cancer gene therapy offers limited control of specificity and efficacy. A possible way to overcome these limitations is to... 
TARGETED THERAPY | SYSTEM | VITRO | DESIGN | IGF2-P4 REGULATORY SEQUENCES | EXPRESSING DIPHTHERIA-TOXIN | MULTIDISCIPLINARY SCIENCES | IN-VIVO | IMPLEMENTATION | PROMOTER | BOOLEAN LOGIC GATES | Luciferases, Renilla - physiology | Luciferases, Renilla - genetics | Humans | Molecular Sequence Data | Apoptosis - genetics | bcl-2-Associated X Protein - physiology | Gene Regulatory Networks - physiology | Cell Movement - genetics | Cell Movement - physiology | Telomerase - genetics | Urinary Bladder Neoplasms - genetics | Urinary Bladder Neoplasms - physiopathology | Telomerase - physiology | Urinary Bladder Neoplasms - pathology | Uroplakin II - genetics | Uroplakin II - physiology | Cadherins - genetics | Gene Expression Regulation, Neoplastic - physiology | Gene Expression Regulation, Neoplastic - genetics | bcl-2-Associated X Protein - genetics | Gene Regulatory Networks - genetics | Cadherins - physiology | CRISPR-Cas Systems - genetics | CRISPR-Cas Systems - physiology | Cell Line, Tumor | Apoptosis - physiology
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9. Full Text Super RLuc8: A novel engineered Renilla luciferase with a red-shifted spectrum and stable light emission
by Rahnama, Somaieh and Saffar, Behnaz and Kahrani, Zahra Fanaei and Nazari, Mahboobeh and Emamzadeh, Rahman
Enzyme and Microbial Technology, ISSN 0141-0229, 01/2017, Volume 96, pp. 60 - 66
luciferase is a bioluminescent enzyme which is broadly used as a reporter protein in molecular biosensors. In this study, a novel luciferase with desired light... 
MD simulation | Renilla luciferase | Enzyme kinetics | Super RLuc8 | Emission spectrum | COELENTERAZINE | PROTEIN | REPORTER-GENE-EXPRESSION | STABILITY | RENIFORMIS | LUMINESCENCE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ASSAYS | BINDING | Recombinant Proteins - metabolism | Biotechnology | Luciferases, Renilla - genetics | Mutagenesis, Site-Directed | Luciferases, Renilla - chemistry | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Luminescent Measurements | Molecular Dynamics Simulation | Renilla - enzymology | Renilla - genetics | Animals | Luciferases, Renilla - metabolism | Protein Engineering | Enzyme Stability - genetics | Kinetics | Amino Acid Substitution | Monoclonal antibodies | Luciferase | Research institutes | Molecular dynamics | Analysis
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10. Full Text Analysis of MiR-195 and MiR-497 expression, regulation and role in breast cancer
by Li, Dan and Zhao, Yulan and Liu, Changxing and Chen, Xiaona and Qi, Yanting and Jiang, Yue and Zou, Chao and Zhang, Xiaolong and Liu, Shunying and Wang, Xuejing and Zhao, Dan and Sun, Qiang and Zeng, Zhenbing and Dress, Andreas and Lin, Marie C and Kung, Hsiang-Fu and Rui, Hallgeir and Liu, Ling-Zhi and Mao, Feng and Jiang, Bing-Hua and Lai, Lihui
Clinical Cancer Research, ISSN 1078-0432, 04/2011, Volume 17, Issue 7, pp. 1722 - 1730
Purpose: To investigate expression, regulation, potential role and targets of miR-195 and miR-497 in breast cancer. Experimental Design: The expression... 
CELLS | ACTIVATION | METASTASIS | GENE | ONCOLOGY | PROGNOSIS | PATHWAY | TARGETS | TRANSLATION | CARCINOMA | MICRORNA SIGNATURES | Cyclin D1 - metabolism | Cell Proliferation | Luciferases, Renilla - genetics | Neoplasm Invasiveness | Down-Regulation | Humans | Gene Silencing | MicroRNAs - metabolism | Restriction Mapping | Luciferases, Renilla - biosynthesis | Proto-Oncogene Proteins c-raf - metabolism | Breast Neoplasms - metabolism | DNA Methylation | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Base Sequence | Cell Line, Tumor | CpG Islands | Female | MicroRNAs - genetics | 3' Untranslated Regions | Genes, Reporter | Cell Movement
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11. Full Text Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells
by Yang, Mei and Chen, Jingqi and Su, Fang and Yu, Bin and Su, Fengxi and Lin, Ling and Liu, Yujie and Huang, Jian-Dong and Song, Erwei
Molecular Cancer, ISSN 1476-4598, 09/2011, Volume 10, Issue 1, pp. 117 - 117
Background: Tumor-associated macrophages (TAMs) are alternatively activated cells induced by interleukin-4 (IL-4)-releasing CD4(+) T cells. TAMs promote breast... 
ACTIVATION | METASTASIS | SIGNATURES | ONCOLOGY | PROGNOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | EXOSOMES | TUMOR-ASSOCIATED MACROPHAGES | ALPHA-T-CATENIN | EXPRESSION | PROGRESSION | Exosomes - metabolism | Breast Neoplasms - secretion | Luciferases, Renilla - genetics | Coculture Techniques | Humans | MicroRNAs - metabolism | Luciferases, Renilla - biosynthesis | Breast Neoplasms - metabolism | Interleukin-4 - pharmacology | Macrophages - secretion | MicroRNAs - secretion | RNA Interference | Female | Cell Culture Techniques | 3' Untranslated Regions | Interleukin-4 - physiology | Exosomes - secretion | Genes, Reporter | MEF2 Transcription Factors | Myogenic Regulatory Factors - genetics | Neoplasm Invasiveness | MADS Domain Proteins - genetics | Cell Communication | Myogenic Regulatory Factors - metabolism | beta Catenin - metabolism | beta Catenin - genetics | MADS Domain Proteins - metabolism | Macrophages - metabolism | Breast Neoplasms - pathology | Cell Line, Tumor | Macrophages - drug effects | MicroRNAs - genetics | Polymerase chain reaction | Usage | MicroRNA | Physiological aspects | Breast cancer | Genetic aspects | Research | Macrophages | Studies | Hospitals | Experiments | Manuscripts | Cell adhesion & migration
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12. Full Text Stabilization of luciferase from Renilla reniformis using random mutations
by Shigehisa, Megumi and Amaba, Norie and Arai, Shigeki and Higashi, Chisato and Kawanabe, Ryo and Matsunaga, Ayano and Laksmi, Fina Amreta and Tokunaga, Masao and Ishibashi, Matsujiro
Protein Engineering, Design and Selection, ISSN 1741-0126, 2017, Volume 30, Issue 1, pp. 7 - 13
We expressed luciferase (RLuc) from Renilla reniformis in Escherichia coli. RLuc was purified using a Ni-NTA column and subsequently characterized. It was... 
Error-prone PCR | Mutation | Renilla reniformis | Stabilization | Luciferase | stabilization | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEOSIDE DIPHOSPHATE KINASE | BIOLUMINESCENT REPORTER | CDNA | nerror-prone PCR | mutation | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SUBSTRATE | PURIFICATION | luciferase | PROTEINS | EXPRESSION | Temperature | Luciferases, Renilla - genetics | Luciferases, Renilla - metabolism | Mutagenesis | Protein Structure, Secondary | Enzyme Stability | Luciferases, Renilla - chemistry | Solubility | Models, Molecular | Hydrogen-Ion Concentration
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13. Full Text Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation
by Xue, Mingzhan and Rabbani, Naila and Momiji, Hiroshi and Imbasi, Precious and Anwar, M. Maqsud and Kitteringham, Neil and Park, B. Kevin and Souma, Tomokazu and Moriguchi, Takashi and Yamamoto, Masayuki and Thornalley, Paul J
Biochemical Journal, ISSN 0264-6021, 04/2012, Volume 443, Issue 1, pp. 213 - 222
Abnormal cellular accumulation of the dicarbonyl metabolite MG (methylglyoxal) occurs on exposure to high glucose concentrations, inflammation, cell aging and... 
Methylglyoxal | Glyoxalase | Nrf2 | Protein damage | DNA damage | Glycation | Consensus Sequence | Luciferases, Renilla - genetics | Oxidative Stress | Humans | Lactoylglutathione Lyase - genetics | Male | Luciferases, Renilla - biosynthesis | Pyruvaldehyde - metabolism | Base Sequence | NF-E2-Related Factor 2 - genetics | Transcription, Genetic | Genes, Reporter | Fibroblasts - metabolism | Response Elements | Lactoylglutathione Lyase - metabolism | Gene Expression Regulation | Cell Adhesion | Hep G2 Cells | Mice, Knockout | Animals | Mutagenesis | Glycation End Products, Advanced - metabolism | NF-E2-Related Factor 2 - metabolism | Protein Binding | Mice | DNA Damage | Index Medicus
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14. Full Text Expression and characterization of the Renilla luciferase with the cumulative mutation
by Ishibashi, Matsujiro and Kawanabe, Ryo and Amaba, Norie and Arai, Shigeki and Laksmi, Fina Amreta and Komori, Kenta and Tokunaga, Masao
Protein Expression and Purification, ISSN 1046-5928, 05/2018, Volume 145, pp. 39 - 44
Luciferase from (RLuc) is a good research tool as a reporter protein and bioimaging probes, yielding blue light using the substrate coelenterazine. However,... 
Thermostability | Organic solvent tolerance | Renilla reniformis | Luciferase | RENIFORMIS | LIMITED PROTEOLYSIS | DOMAIN | PROTEIN | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PURIFICATION | BIOCHEMICAL RESEARCH METHODS | Recombinant Proteins - metabolism | Animals | Luciferases, Renilla - genetics | Mutagenesis, Site-Directed | Luciferases, Renilla - metabolism | Enzyme Stability | Luciferases, Renilla - chemistry | Recombinant Proteins - genetics | Hot Temperature | Mutation | Renilla - enzymology | Proteases | Genetic aspects | Index Medicus
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15. Full Text NanoBRET-A Novel BRET Platform for the Analysis of Protein-Protein Interactions
by Machleidt, Thomas and Woodroofe, Carolyn C and Schwinn, Marie K and Méndez, Jacqui and Robers, Matthew B and Zimmerman, Kris and Otto, Paul and Daniels, Danette L and Kirkland, Thomas A and Wood, Keith V
ACS Chemical Biology, ISSN 1554-8929, 08/2015, Volume 10, Issue 8, pp. 1797 - 1804
Dynamic interactions between proteins comprise a key mechanism for temporal control of cellular function and thus hold promise for development of novel drug... 
RECRUITMENT | CELLS | IN-VITRO | INHIBITION | VIVO | ARRESTIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | COUPLED RECEPTORS | FLUORESCENT PROTEIN | BIOLUMINESCENCE | TECHNOLOGY | Fluorescent Dyes - chemistry | Protein Interaction Mapping - methods | Luciferases, Renilla - genetics | Humans | HEK293 Cells | Luciferases, Renilla - chemistry | Protein Engineering | Fluorescent Dyes - metabolism | Fluorescence Resonance Energy Transfer - methods | HeLa Cells | Protein Interaction Maps
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16. Full Text Silencing of microRNA families by seed-targeting tiny LNAs
by Obad, Susanna and Dos Santos, Camila O and Petri, Andreas and Heidenblad, Markus and Broom, Oliver and Ruse, Cristian and Fu, Cexiong and Lindow, Morten and Stenvang, Jan and Straarup, Ellen Marie and Hansen, Henrik Frydenlund and Koch, Troels and Pappin, Darryl and Hannon, Gregory J and Kauppinen, Sakari
Nature Genetics, ISSN 1061-4036, 02/2011, Volume 43, Issue 4, pp. 371 - 380
The challenge of understanding the widespread biological roles of animal microRNAs (miRNAs) has prompted the development of genetic and functional genomics... 
MESSENGER-RNA | SPECIFICITY | DETERMINANTS | LOCKED NUCLEIC-ACID | IN-VIVO | GENETICS & HEREDITY | MIR-21 | LET-7 | MICE | ANTISENSE OLIGONUCLEOTIDES | EXPRESSION | Oligonucleotides - genetics | Luciferases, Renilla - genetics | MicroRNAs - antagonists & inhibitors | Humans | Liver - metabolism | Gene Silencing | Genetic Techniques | Mammary Neoplasms, Experimental - genetics | Oligonucleotides - pharmacokinetics | Gene Knockdown Techniques | Mammary Neoplasms, Experimental - therapy | Animals | Base Sequence | Mammary Neoplasms, Experimental - pathology | Cell Line, Tumor | Female | Mice | Mice, Inbred BALB C | MicroRNAs - genetics | HeLa Cells | Oligonucleotides - administration & dosage | 3' Untranslated Regions | Genes, Reporter | Physiological aspects | Gene silencing | MicroRNA | Research | Studies | Animal diseases | Disease | Binding sites | Technological change | Cancer
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