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Science, ISSN 0036-8075, 11/2015, Volume 350, Issue 6261, pp. 678 - 680
Journal Article
Science, ISSN 0036-8075, 11/2012, Volume 338, Issue 6108, pp. 810 - 814
Fluorescent proteins (FPs) are widely used as optical sensors, whereas other light-absorbing domains have been used for optical control of protein localization... 
Proteins | Enzymes | Delta cells | NIH 3T3 cells | REPORTS | Fluorescence | Pseudopodia | Dimers | Cell membranes | Optical control | P branes | SPATIOTEMPORAL CONTROL | ACTIVATION | GTPASES | MULTIDISCIPLINARY SCIENCES | LIGHT | INDUCTION | EXCHANGE FACTORS | LOV DOMAIN | LIVING CELLS | MOTILITY | Darkness | NIH 3T3 Cells | Pseudopodia - ultrastructure | Native Polyacrylamide Gel Electrophoresis | Humans | Protein Multimerization | Adaptor Proteins, Vesicular Transport - genetics | Optogenetics | Adaptor Proteins, Vesicular Transport - metabolism | Recombinant Fusion Proteins - metabolism | Viral Nonstructural Proteins - chemistry | Light | Protein Engineering | Serine Endopeptidases - genetics | Luminescent Proteins - chemistry | Adaptor Proteins, Vesicular Transport - chemistry | Cell Membrane - metabolism | Protein Structure, Tertiary | Models, Molecular | Viral Nonstructural Proteins - genetics | Serine Endopeptidases - chemistry | Recombinant Fusion Proteins - chemistry | Animals | Pseudopodia - metabolism | Recombinant Fusion Proteins - genetics | Luminescent Proteins - genetics | Protein Conformation | Viral Nonstructural Proteins - metabolism | Mice | Serine Endopeptidases - metabolism | HeLa Cells | Luminescent Proteins - metabolism | Physiological aspects | Photoreception | Research | Fluorescent proteins | Sensors | Cellular biology | Activated | Exposure | Optical sensors | Detection
Journal Article
Neuron, ISSN 0896-6273, 09/2013, Volume 79, Issue 6, pp. 1169 - 1182
The gene is located in a chromosomal region linked to various neurological disorders, including intellectual disability, autism, and schizophrenia. CYFIP1... 
MAMMALIAN TARGET | LOCAL PROTEIN-SYNTHESIS | AUTISM | FMRP | MOUSE MODEL | FRAGILE-X-SYNDROME | MECHANISMS | RAC1 | SYNAPTIC PLASTICITY | NEUROSCIENCES | CRITICAL REGION | Humans | Male | Fragile X Mental Retardation Protein - metabolism | Green Fluorescent Proteins - genetics | RNA, Messenger - metabolism | Mental Disorders - genetics | Brain-Derived Neurotrophic Factor - pharmacology | Neurons - ultrastructure | Time Factors | Chromatography, Liquid | Nerve Tissue Proteins - ultrastructure | Enzyme Inhibitors - pharmacology | Mice, Transgenic | Pyrimidines - pharmacology | Synaptosomes - ultrastructure | Analysis of Variance | Indole Alkaloids - pharmacology | Protein Biosynthesis - drug effects | Mice | Carbazoles - pharmacology | Adaptor Proteins, Signal Transducing - chemistry | Synaptosomes - drug effects | Meta-Analysis as Topic | Immunoprecipitation | Age Factors | Synaptosomes - metabolism | Cerebral Cortex - cytology | Microscopy, Immunoelectron | DNA-Binding Proteins - metabolism | Tandem Mass Spectrometry | Nerve Tissue Proteins - chemistry | Transfection | Dendritic Spines - drug effects | Protein Biosynthesis - genetics | Neurons - drug effects | Aminoquinolines - pharmacology | Green Fluorescent Proteins - metabolism | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Cells, Cultured | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Animals | Adaptor Proteins, Signal Transducing - genetics | Fragile X Mental Retardation Protein - ultrastructure | Dendritic Spines - genetics | Fragile X Mental Retardation Protein - genetics | Adaptor Proteins, Signal Transducing - metabolism | In Vitro Techniques | Dendritic Spines - ultrastructure | Luminescent Proteins - metabolism | Nervous system diseases | Neurosciences | Neurons | Oncology, Experimental | Genes | Polymerization | Schizophrenia | Protein biosynthesis | Research | Genetic translation | Messenger RNA | Actin | Cancer | Proteins | Brain-derived neurotrophic factor | Protein synthesis | Crystal structure
Journal Article
Analytical Chemistry, ISSN 0003-2700, 04/2003, Volume 75, Issue 7, pp. 1584 - 1589
In this study we developed an inducible synthetic renilla luciferase protein-fragment-assisted complementation-based bioluminescence assay to quantitatively... 
RENIFORMIS LUCIFERASE | LIVING SUBJECTS | CHEMISTRY, ANALYTICAL | BETA-GALACTOSIDASE COMPLEMENTATION | GREEN FLUORESCENT PROTEIN | MAMMALIAN-CELLS | EXPRESSION | RECONSTITUTION | RECRUITMENT SYSTEM | INTEIN | STRATEGIES | Proteins | Bioluminescence | Chemistry, Analytic | Tumor necrosis factor | Analysis | Causes of | Research | Cells | Organic compounds
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 09/2009, Volume 106, Issue 37, pp. 15628 - 15632
In eukaryotes, the activation of the prereplicative complex and assembly of an active DNA unwinding complex are critical but poorly understood steps required... 
Cdc7-Dbf4 kinase | Cyclin-dependent kinase | Cdc45-Mcm-GINS complex | Bimolecular fluorescence complementation | BUDDING YEAST | INITIATION | MULTIDISCIPLINARY SCIENCES | EUKARYOTIC DNA-REPLICATION | POLYMERASE-ALPHA | SACCHAROMYCES-CEREVISIAE | CDC45 | ROTHMUND-THOMSON-SYNDROME | S-PHASE | TOPBP1 | bimolecular fluorescence complementation | cyclin-dependent kinase | PROGRESSION | Minichromosome Maintenance Proteins | Cyclin-Dependent Kinases - metabolism | RecQ Helicases - metabolism | Humans | Multiprotein Complexes | Bacterial Proteins - chemistry | RecQ Helicases - genetics | Minichromosome Maintenance Complex Component 7 | Minichromosome Maintenance Complex Component 2 | Recombinant Fusion Proteins - metabolism | Cell Cycle Proteins - chemistry | DNA-Binding Proteins - metabolism | Cell Cycle Proteins - genetics | Luminescent Proteins - chemistry | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Bacterial Proteins - genetics | Cell Cycle Proteins - metabolism | Nuclear Proteins - metabolism | Recombinant Fusion Proteins - chemistry | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Chromosomal Proteins, Non-Histone - genetics | Carrier Proteins - metabolism | Cell Cycle | Recombinant Fusion Proteins - genetics | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | RecQ Helicases - chemistry | HeLa Cells | Chromosomal Proteins, Non-Histone - chemistry | Luminescent Proteins - metabolism | Proteins | DNA replication | HeLa cells | Physiological aspects | Genetic aspects | Research | Molecular biology | Biological Sciences
Journal Article
Molecular Cell, ISSN 1097-2765, 09/2016, Volume 63, Issue 6, pp. 951 - 964
Huntington’s disease is one of several neurodegenerative disorders characterized by the aggregation of polyglutamine (polyQ)-expanded mutant protein. How polyQ... 
POLYGLUTAMINE | PROTEIN | FUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTANT HUNTINGTIN | PHASE-TRANSITION | DISEASE | MUTATIONS | INCLUSION-BODY FORMATION | AGGREGATION | PROTEOSTASIS | CELL BIOLOGY | Protein Aggregates | Neurons - pathology | Humans | Protein Multimerization | Peptides - genetics | Green Fluorescent Proteins - genetics | Recombinant Fusion Proteins - metabolism | Ribosomal Proteins - metabolism | Peptides - metabolism | Neurons - metabolism | Gene Ontology | Green Fluorescent Proteins - metabolism | Gene Expression | HSP40 Heat-Shock Proteins - metabolism | HSP40 Heat-Shock Proteins - genetics | Peptides - chemistry | Ribosomal Proteins - genetics | Huntingtin Protein - metabolism | Molecular Sequence Annotation | Bacterial Proteins - genetics | Solubility | Spectrometry, Fluorescence | Single Molecule Imaging - methods | Protein Interaction Mapping | Animals | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Mice | HeLa Cells | Huntingtin Protein - genetics | Mutation | Luminescent Proteins - metabolism | Ubiquitin | Fluorescence spectroscopy | Nervous system diseases | RNA | Heat shock proteins | Fluorescence | Biosynthesis | Genetic transcription | Oligomers | Analysis | Cellular signal transduction | Research institutes | Binding proteins | Protein binding
Journal Article
The Journal of Physiology, ISSN 0022-3751, 11/2008, Volume 586, Issue 22, pp. 5383 - 5401
Ca2+ entry through store‐operated Ca2+ release‐activated Ca2+ (CRAC) channels initiates key functions such as gene expression and exocytosis of inflammatory... 
PHYSIOLOGY | 2-AMINOETHOXYDIPHENYL BORATE | STIM1 | STROMAL INTERACTION MOLECULE-1 | OPERATED CALCIUM-CHANNELS | ACTIVATED CA2+ CHANNELS | STORE DEPLETION | OLIGOMERIZATION | PLASMA-MEMBRANE | NEUROSCIENCES | CRAC CHANNEL | T-LYMPHOCYTES | Protein Subunits | Calcium Channels - metabolism | Humans | Multiprotein Complexes | Bacterial Proteins - chemistry | Endoplasmic Reticulum - metabolism | Green Fluorescent Proteins - genetics | Neoplasm Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Protein Structure, Quaternary | Fluorescence Resonance Energy Transfer | Luminescent Proteins - chemistry | Severe Combined Immunodeficiency - metabolism | Membrane Proteins - metabolism | Protein Interaction Domains and Motifs | Green Fluorescent Proteins - chemistry | Neoplasm Proteins - genetics | Calcium Channels - genetics | Calcium Signaling | Stromal Interaction Molecule 1 | Cell Line | Green Fluorescent Proteins - metabolism | Mutagenesis, Site-Directed | Membrane Proteins - genetics | Bacterial Proteins - genetics | Neoplasm Proteins - chemistry | Recombinant Fusion Proteins - chemistry | ORAI1 Protein | Severe Combined Immunodeficiency - genetics | Membrane Proteins - chemistry | Calcium Channels - chemistry | Recombinant Fusion Proteins - genetics | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Protein Conformation | Ion Channel Gating | Luminescent Proteins - metabolism | Fluorescence | Physiological aspects | Gene expression | Index Medicus | Cellular
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 2/2008, Volume 17, Issue 3, pp. 345 - 356
Expanded polyglutamine (polyQ) repeats cause neurodegenerative disorders, but their cytotoxic structures remain to be elucidated. Although soluble polyQ... 
NEURONAL INTRANUCLEAR INCLUSIONS | EXPANSION PROTEINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTANT HUNTINGTIN | GENETICS & HEREDITY | AGGREGATE FORMATION | NEURODEGENERATION | TOXICITY | INHIBITORS | FIBRILLOGENESIS | MAMMALIAN-CELLS | PEPTIDE | Humans | Bacterial Proteins - chemistry | Peptides - genetics | Cercopithecus aethiops | DNA Primers - genetics | Green Fluorescent Proteins - genetics | Recombinant Fusion Proteins - metabolism | Nerve Tissue Proteins - chemistry | Peptides - metabolism | Peptides - toxicity | Transfection | Base Sequence | Protein Structure, Quaternary | Fluorescence Resonance Energy Transfer | Luminescent Proteins - chemistry | Neurons - metabolism | Green Fluorescent Proteins - chemistry | Inclusion Bodies - metabolism | Neurons - drug effects | Nuclear Proteins - genetics | Cell Line | Green Fluorescent Proteins - metabolism | Peptides - chemistry | Protein Structure, Secondary | Bacterial Proteins - genetics | Solubility | Models, Molecular | Nuclear Proteins - metabolism | Recombinant Fusion Proteins - chemistry | Nuclear Proteins - chemistry | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Huntingtin Protein | Animals | Recombinant Fusion Proteins - genetics | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | COS Cells | Luminescent Proteins - metabolism
Journal Article
Science, ISSN 0036-8075, 11/2008, Volume 322, Issue 5903, pp. 923 - 929
Ubiquitin-mediated proteolysis regulates all aspects of cellular function, and defects in this process are associated with human diseases. The limited number... 
Proteins | Polymerase chain reaction | DNA | Cell cycle | Cell lines | Viruses | Protein stability | Libraries | Research Articles | Open reading frames | F box proteins | COMPLEX | CYCLIN-E | PATHWAY | MULTIDISCIPLINARY SCIENCES | F-BOX PROTEINS | S-PHASE | DEGRADATION | KAPPA-B-ALPHA | BETA-CATENIN | HISTONE MESSENGER-RNA | REVEALS | Oligonucleotide Array Sequence Analysis | SKP Cullin F-Box Protein Ligases - genetics | Humans | Open Reading Frames | Half-Life | Substrate Specificity | Proteins - isolation & purification | Recombinant Fusion Proteins - metabolism | Luminescent Proteins - analysis | Cullin Proteins - metabolism | Protein Stability | cdc25 Phosphatases - metabolism | Cell Line | Green Fluorescent Proteins - metabolism | Cell Cycle Proteins - isolation & purification | cdc25 Phosphatases - isolation & purification | Green Fluorescent Proteins - analysis | Signal Transduction | Cell Cycle Proteins - metabolism | SKP Cullin F-Box Protein Ligases - metabolism | SKP Cullin F-Box Protein Ligases - antagonists & inhibitors | Cullin Proteins - genetics | Proteins - genetics | Proteins - metabolism | Cell Cycle | Apoptosis | Luminescent Proteins - metabolism | Evaluation | Protein research | Substrates (Biochemistry) | Proteolysis | Research | Ubiquitin-proteasome system | Properties | Genetics | Cellular biology | Research methodology | Substrates
Journal Article
The EMBO Journal, ISSN 0261-4189, 11/2001, Volume 20, Issue 21, pp. 5971 - 5981
Journal Article
Science, ISSN 0036-8075, 3/2006, Volume 311, Issue 5767, pp. 1600 - 1603
Journal Article