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Science, ISSN 0036-8075, 3/2006, Volume 311, Issue 5767, pp. 1600 - 1603
We directly observed real-time production of single protein molecules in individual Escherichia coli cells. A fusion protein of a fast-maturing yellow... 
Proteins | Molecules | Messenger RNA | Lasers | DNA | Cell lines | Cell cycle | Polynesian studies | Fluorescence | Reports | Gene expression | MESSENGER-RNA DEGRADATION | SINGLE-CELL | GREEN FLUORESCENT PROTEIN | OPERATOR | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | TRANSCRIPTION | NOISE | TRANSLATION | REPRESSOR | Molecular Probe Techniques | Recombinant Fusion Proteins - analysis | Bacterial Proteins - analysis | RNA, Messenger - metabolism | Membrane Proteins - analysis | Luminescent Proteins - biosynthesis | Escherichia coli K12 - metabolism | Luminescent Proteins - analysis | Stochastic Processes | Escherichia coli Proteins - biosynthesis | RNA, Bacterial - genetics | Escherichia coli Proteins - analysis | RNA, Bacterial - metabolism | Recombinant Fusion Proteins - biosynthesis | Promoter Regions, Genetic | Gene Expression | Membrane Proteins - genetics | RNA, Messenger - genetics | Bacterial Proteins - genetics | Gene Expression Profiling - methods | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Membrane Proteins - biosynthesis | Escherichia coli Proteins - genetics | Luminescent Proteins - genetics | Poisson Distribution | Bacterial Proteins - biosynthesis | Escherichia coli K12 - genetics | Microscopy, Fluorescence | Research | Molecular biology | Structure | Genes | Analysis | Bacteria | Peptides | Cells
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2016, Volume 113, Issue 11, pp. 2868 - 2873
A central challenge to the development of protein-based therapeutics is the inefficiency of delivery of protein cargo across the mammalian cell membrane,... 
Protein delivery | Genome editing | CRISPR/Cas9 | Cre recombinase | Lipid nanoparticle | THERAPEUTICS | genome editing | COMBINATORIAL LIBRARY | VIVO | RNA | CELLS IN-VITRO | CAS9 PROTEIN | TRANSFECTION | MULTIDISCIPLINARY SCIENCES | CANCER-THERAPY | lipid nanoparticle | protein delivery | INTRACELLULAR DELIVERY | Endonucleases - genetics | Thalamus - metabolism | Nanoparticles - chemistry | Humans | Green Fluorescent Proteins - genetics | Structure-Activity Relationship | Recombinant Proteins - biosynthesis | Endosomes - metabolism | Drug Carriers | Luminescent Proteins - biosynthesis | RNA - genetics | Cholesterol - chemistry | Endocytosis | Lipids - chemistry | Integrases - administration & dosage | Endonucleases - administration & dosage | Recombination, Genetic | Nanoparticles - metabolism | Molecular Structure | Genes, Reporter | Genetic Engineering - methods | Bacterial Proteins - genetics | Genes, Synthetic | Ceramides - chemistry | Lipids - administration & dosage | Gene Knockout Techniques | Static Electricity | Nanoparticles - toxicity | Bacterial Proteins - administration & dosage | Animals | Hypothalamus - metabolism | Lipids - chemical synthesis | Green Fluorescent Proteins - biosynthesis | CRISPR-Cas Systems | Luminescent Proteins - genetics | Mice | Nanoparticles - administration & dosage | HeLa Cells | Integrases - genetics | Phosphatidylethanolamines - chemistry | Nanoparticles | Genetic aspects | Nucleotide sequencing | Lipid metabolism | Health aspects | Methods | DNA sequencing | Proteins | Lipids | Genomes | Ribonucleic acid--RNA | CRISPR | Physical Sciences | Cas9
Journal Article
Scientific Reports, ISSN 2045-2322, 02/2014, Volume 4, Issue 1, p. 4012
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2012, Volume 287, Issue 15, pp. 11911 - 11923
Mucin-type O-glycosylation is an important post-translational modification that confers a variety of biological properties and functions to proteins. This... 
ARABIDOPSIS-THALIANA | NICOTIANA-BENTHAMIANA | THERAPEUTIC PROTEINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | GOLGI-APPARATUS | POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE | ENDOPLASMIC-RETICULUM | NUCLEOTIDE-SUGAR TRANSPORTERS | GALNAC-TRANSFERASES | PROLYL 4-HYDROXYLASE | Interferons - biosynthesis | CA-125 Antigen - genetics | Humans | Molecular Sequence Data | Recombinant Proteins - biosynthesis | Luminescent Proteins - biosynthesis | Acetylgalactosamine - metabolism | Galactosyltransferases | CA-125 Antigen - biosynthesis | Pseudomonas aeruginosa - enzymology | N-Acetylgalactosaminyltransferases - genetics | Plants, Genetically Modified | Cloning, Molecular | Interferons - genetics | Genes, Reporter | Glycoproteins - genetics | Amino Acid Sequence | N-Acetylgalactosaminyltransferases - biosynthesis | Membrane Proteins - genetics | Tobacco - metabolism | Carbohydrate Epimerases - biosynthesis | Bacterial Proteins - genetics | Glycosylation | Recombinant Proteins - genetics | Glycoproteins - biosynthesis | Mucins - biosynthesis | Plant Proteins - genetics | Membrane Proteins - biosynthesis | Peptide Fragments - chemistry | Genetic Engineering | Procollagen-Proline Dioxygenase - genetics | Tobacco - genetics | Luminescent Proteins - genetics | Bacterial Proteins - biosynthesis | Protein Processing, Post-Translational | Carbohydrate Epimerases - genetics | Tobacco - enzymology | Vaccine Development | Plant | Nicotiana benthamiana | Glycoprotein Biosynthesis | O-Glycosylation | Mucins | Glycoengineering | Protein Expression | Glycobiology and Extracellular Matrices | GalNAc
Journal Article
Science, ISSN 0036-8075, 2/2012, Volume 335, Issue 6069, pp. 678 - 685
Long-term memory (LTM) depends on the synthesis of new proteins. Using a temperature-sensitive ribosome-inactivating toxin to acutely inhibit protein... 
Brain | Axons | Neurons | Protein synthesis | RESEARCH ARTICLES | Memory | Drosophila | Genes | Memory recall | Tequila | Neurotransmission | Transcriptional Activation | Cryptochromes - genetics | Gene Expression Profiling | Drosophila Proteins - metabolism | Brain - physiology | Drosophila - physiology | Odorants | Drosophila Proteins - biosynthesis | Luminescent Proteins - biosynthesis | Period Circadian Proteins - biosynthesis | Neurons - ultrastructure | Period Circadian Proteins - genetics | Sensory Receptor Cells - physiology | Axons - ultrastructure | Neurons - physiology | Serine Endopeptidases - genetics | Trans-Activators - genetics | Drosophila - genetics | Genes, Insect | Brain - cytology | Mushroom Bodies - physiology | Serine Endopeptidases - biosynthesis | Animals, Genetically Modified | Gene Expression Regulation | Drosophila - cytology | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - biosynthesis | Memory, Long-Term - physiology | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics | Ricin - pharmacology | Cyclic AMP Response Element-Binding Protein - genetics | Animals | Conditioning (Psychology) | Cyclic AMP Response Element-Binding Protein - metabolism | Luminescent Proteins - genetics | Trans-Activators - metabolism | Drosophila Proteins - genetics | Cryptochromes - biosynthesis | OLFACTORY MEMORY | TRACE | RICIN-A-CHAIN | EUKARYOTIC RIBOSOMES | NMDA RECEPTORS | GENE | MULTIDISCIPLINARY SCIENCES | CONSOLIDATED MEMORY | MUSHROOM BODY NEURONS | FLUORESCENT PROTEIN | RETRIEVAL | Physiological aspects | Long-term memory | Research
Journal Article
Science, ISSN 0036-8075, 3/2005, Volume 307, Issue 5717, pp. 1965 - 1969
Journal Article
Science, ISSN 0036-8075, 3/2005, Volume 307, Issue 5717, pp. 1962 - 1965
Journal Article
Journal Article
Neuron, ISSN 0896-6273, 09/2013, Volume 79, Issue 6, pp. 1169 - 1182
The gene is located in a chromosomal region linked to various neurological disorders, including intellectual disability, autism, and schizophrenia. CYFIP1... 
MAMMALIAN TARGET | LOCAL PROTEIN-SYNTHESIS | AUTISM | FMRP | MOUSE MODEL | FRAGILE-X-SYNDROME | MECHANISMS | RAC1 | SYNAPTIC PLASTICITY | NEUROSCIENCES | CRITICAL REGION | Humans | Male | Fragile X Mental Retardation Protein - metabolism | Green Fluorescent Proteins - genetics | RNA, Messenger - metabolism | Mental Disorders - genetics | Brain-Derived Neurotrophic Factor - pharmacology | Neurons - ultrastructure | Time Factors | Chromatography, Liquid | Nerve Tissue Proteins - ultrastructure | Enzyme Inhibitors - pharmacology | Mice, Transgenic | Pyrimidines - pharmacology | Synaptosomes - ultrastructure | Analysis of Variance | Indole Alkaloids - pharmacology | Protein Biosynthesis - drug effects | Mice | Carbazoles - pharmacology | Adaptor Proteins, Signal Transducing - chemistry | Synaptosomes - drug effects | Meta-Analysis as Topic | Immunoprecipitation | Age Factors | Synaptosomes - metabolism | Cerebral Cortex - cytology | Microscopy, Immunoelectron | DNA-Binding Proteins - metabolism | Tandem Mass Spectrometry | Nerve Tissue Proteins - chemistry | Transfection | Dendritic Spines - drug effects | Protein Biosynthesis - genetics | Neurons - drug effects | Aminoquinolines - pharmacology | Green Fluorescent Proteins - metabolism | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Cells, Cultured | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Animals | Adaptor Proteins, Signal Transducing - genetics | Fragile X Mental Retardation Protein - ultrastructure | Dendritic Spines - genetics | Fragile X Mental Retardation Protein - genetics | Adaptor Proteins, Signal Transducing - metabolism | In Vitro Techniques | Dendritic Spines - ultrastructure | Luminescent Proteins - metabolism | Nervous system diseases | Neurosciences | Neurons | Oncology, Experimental | Genes | Polymerization | Schizophrenia | Protein biosynthesis | Research | Genetic translation | Messenger RNA | Actin | Cancer | Proteins | Brain-derived neurotrophic factor | Protein synthesis | Crystal structure
Journal Article