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1. Full Text Microbiota abnormalities in inflammatory airway diseases — Potential for therapy
by Gollwitzer, Eva S and Marsland, Benjamin J
Pharmacology and Therapeutics, ISSN 0163-7258, 01/2014, Volume 141, Issue 1, pp. 32 - 39
Increasingly the development of novel therapeutic strategies is taking into consideration the contribution of the intestinal microbiota to health and disease.... 
Probiotics | Airways | Microbiota | Chronic lung disease | Intestinal tract | Microbiome | GERMINATED BARLEY FOODSTUFF | PERENNIAL ALLERGIC RHINITIS | BOWEL-DISEASE | OBSTRUCTIVE PULMONARY-DISEASE | LACTOBACILLUS-CASEI | MOUSE MODEL | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | PLACEBO-CONTROLLED TRIAL | ACTIVE ULCERATIVE-COLITIS | CYSTIC-FIBROSIS | Inflammation - microbiology | Lung Diseases - microbiology | Humans | Respiratory System - microbiology | Dysbiosis - complications | Synbiotics | Prebiotics | Inflammation - complications | Inflammation - diet therapy | Respiratory System - drug effects | Lung Diseases - diet therapy | Probiotics - therapeutic use | Lung Diseases - complications | Dysbiosis - diet therapy | Development and progression | Asthma
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2. Full Text Retinal and Nonocular Abnormalities in Cyp27a1 −/− Cyp46a1 −/− Mice with Dysfunctional Metabolism of Cholesterol
by Saadane, Aicha and Mast, Natalia and Charvet, Casey D and Omarova, Saida and Zheng, Wenchao and Huang, Suber S and Kern, Timothy S and Peachey, Neal S and Pikuleva, Irina A
American Journal of Pathology, The, ISSN 0002-9440, 2014, Volume 184, Issue 9, pp. 2403 - 2419
Cholesterol elimination from nonhepatic cells involves metabolism to side-chain oxysterols, which serve as transport forms of cholesterol and bioactive... 
Pathology | DIABETIC-RETINOPATHY | LIVER-X RECEPTORS | IN-VIVO | MACULAR DEGENERATION | CEREBROTENDINOUS XANTHOMATOSIS | MICROGLIAL CELLS | MOUSE RETINA | PATHOLOGY | MEMBRANE-PROTEINS | MASS-SPECTROMETRY | STEROL 27-HYDROXYLASE | Liver - pathology | Lung - pathology | Retina - metabolism | Cholesterol 24-Hydroxylase | Liver - metabolism | Mice, Inbred C57BL | Cholesterol - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Cholestanetriol 26-Monooxygenase - deficiency | Mice, Knockout | Animals | Spleen - metabolism | Steroid Hydroxylases - deficiency | Lung - metabolism | Mice | Spleen - pathology | Retina - pathology | Regular
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3. Full Text Chromosomal Abnormalities in Cancer
by Fröhling, Stefan and Döhner, Hartmut
The New England Journal of Medicine, ISSN 0028-4793, 08/2008, Volume 359, Issue 7, pp. 722 - 734
This review gives an account of chromosomal aberrations in cancer cells. Such abnormalities have typically been associated with hematologic cancers, but recent... 
BREAST-CANCER | LUNG-CANCER | MEDICINE, GENERAL & INTERNAL | TUMOR-SUPPRESSOR GENES | ACUTE LYMPHOBLASTIC-LEUKEMIA | PROSTATE-CANCER | BCR-ABL | CHRONIC LYMPHOCYTIC-LEUKEMIA | COMPARATIVE GENOMIC HYBRIDIZATION | TRANSCRIPTION FACTOR | CHRONIC MYELOID-LEUKEMIA | Translocation, Genetic | Protein-Tyrosine Kinases - genetics | Neoplasms - genetics | Humans | Chromosome Aberrations | Gene Expression Regulation, Neoplastic | Transcription Factors - genetics | Chromosomes, Human - ultrastructure | Tyrosine | Care and treatment | Human chromosome abnormalities | Causes of | Research | Risk factors | Methods | Cancer
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4. Full Text Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1 −/− mice
by Gaur, Arti and Marck, Brett T and Bennett, Michael J and Ding, Kan and Shelton, John M and Scortegagna, Marzia and Thurmond, Frederick and Richardson, James A and Garcia, Joseph A and Oktay, Yavuz and Matsumoto, Alvin M and Yan, Liang-Jun
Nature Genetics, ISSN 1061-4036, 12/2003, Volume 35, Issue 4, pp. 331 - 340
Hypoxia-inducible factor (HIF) transcription factors respond to multiple environmental stressors, including hypoxia and hypoglycemia. We report that mice... 
SYSTEMIC CARNITINE DEFICIENCY | OXIDATIVE STRESS | MITOCHONDRIAL ABNORMALITIES | MANGANESE SUPEROXIDE-DISMUTASE | LUNG EPITHELIAL-CELLS | ENDOTHELIAL-CELLS | GENETICS & HEREDITY | GENE-EXPRESSION | DILATED CARDIOMYOPATHY | KNOCKOUT MICE | HYPOXIA-INDUCIBLE FACTOR-1 | Reactive Oxygen Species | Oxidative Stress | Heart - physiology | Electron Transport Complex IV | Cell Hypoxia | Molecular Mimicry | Transfection | Neoplasm Proteins | Trans-Activators - genetics | Basic Helix-Loop-Helix Transcription Factors | Mice, Inbred C57BL | Gene Expression Regulation | Muscle, Skeletal - ultrastructure | Abnormalities, Multiple | Survival Rate | Peroxiredoxin III | Mice, Knockout | Peroxiredoxins | Homozygote | Animals | Trans-Activators - deficiency | Peroxidases | Homeostasis - physiology | Superoxides | Trans-Activators - metabolism | Mice | Superoxide Dismutase | Multiple organ failure | Metabolic diseases | Acid-base imbalances | Genetic aspects | Diagnosis | Risk factors
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5. Full Text MUC5B Promoter Polymorphism and Interstitial Lung Abnormalities
by Hunninghake, Gary M and Hatabu, Hiroto and Okajima, Yuka and Gao, Wei and Dupuis, Josée and Latourelle, Jeanne C and Nishino, Mizuki and Araki, Tetsuro and Zazueta, Oscar E and Kurugol, Sila and Ross, James C and San José Estépar, Raúl and Murphy, Elissa and Steele, Mark P and Loyd, James E and Schwarz, Marvin I and Fingerlin, Tasha E and Rosas, Ivan O and Washko, George R and O'Connor, George T and Schwartz, David A
The New England Journal of Medicine, ISSN 0028-4793, 06/2013, Volume 368, Issue 23, pp. 2192 - 2200
Variants in the gene encoding mucin 5B ( MUC5B ) have been associated with interstitial fibrosis. This study shows a relationship between the presence of the... 
SAMPLE | POPULATION | CAPACITY | MEDICINE, GENERAL & INTERNAL | DISEASE | SMOKING | PREVALENCE | IDIOPATHIC PULMONARY-FIBROSIS | CLINICAL-COURSE | PATHOLOGICAL FEATURES | REFERENCE VALUES | Mucin-5B - genetics | Humans | Middle Aged | Genotype | Male | Tomography, X-Ray Computed | Total Lung Capacity | Lung - diagnostic imaging | Polymorphism, Genetic | Lung Diseases, Interstitial - diagnostic imaging | Lung Diseases, Interstitial - genetics | Female | Aged | Lung Diseases, Interstitial - physiopathology | Respiratory Function Tests | Longitudinal Studies | Smoking | Causes of | Lung diseases, Interstitial | Research | Genetic polymorphisms | Chest | Mucin | Computed tomography | Lungs | Lung diseases | Fibrosis | Tomography | Cigarette smoking | Gene polymorphism | Cough
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6. Full Text Risk of selected structural abnormalities in infants after increased nuchal translucency measurement
by Baer, Rebecca J., MPH and Norton, Mary E., MD and Shaw, Gary M., DrPH and Flessel, Monica C., PhD and Goldman, Sara, MPH and Currier, Robert J., PhD and Jelliffe-Pawlowski, Laura L., PhD
American Journal of Obstetrics and Gynecology, ISSN 0002-9378, 2014, Volume 211, Issue 6, pp. 675.e1 - 675.e19
Objective We sought to examine the association between increased first-trimester fetal nuchal translucency (NT) measurement and major noncardiac structural... 
Obstetrics and Gynecology | congenital birth defects | increased nuchal translucency | normal karyotype | prenatal screening | 1ST-TRIMESTER | GESTATION | CHROMOSOMALLY NORMAL FETUSES | PROGRAM | PREGNANCY | PATHOPHYSIOLOGY | OBSTETRICS & GYNECOLOGY | Urogenital Abnormalities - diagnostic imaging | Bone Diseases, Metabolic - epidemiology | Congenital Abnormalities - epidemiology | Intestine, Small - abnormalities | Musculoskeletal Abnormalities - epidemiology | Urogenital Abnormalities - epidemiology | Humans | Lung - abnormalities | Risk | Lung - diagnostic imaging | Nervous System Malformations - diagnostic imaging | Lung Diseases - diagnostic imaging | Young Adult | Hydrocephalus - diagnostic imaging | Abnormalities, Multiple - epidemiology | Hydrocephalus - epidemiology | Adult | Female | Intestinal Atresia - epidemiology | Diaphragm - abnormalities | Bone Diseases, Metabolic - diagnostic imaging | Musculoskeletal Abnormalities - diagnostic imaging | Abnormalities, Multiple - diagnostic imaging | Logistic Models | Congenital Abnormalities - diagnostic imaging | Nervous System Malformations - epidemiology | Pregnancy | Bone Diseases, Metabolic - congenital | Ultrasonography, Prenatal | Intestinal Atresia - diagnostic imaging | Nuchal Translucency Measurement | Adolescent | Intestine, Small - diagnostic imaging | Lung Diseases - epidemiology | Cohort Studies | Measurement | Infants | Birth defects | Public health
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7. Full Text Utility of Electrocardiogram in the Assessment and Monitoring of Pulmonary Hypertension (Idiopathic or Secondary to Pulmonary Developmental Abnormalities) in Patients ≤18 Years of Age
by Lau, Kelvin C., MD, MPH and Frank, David B., MD, PhD and Hanna, Brian D., MD, PhD and Patel, Akash R., MD
American Journal of Cardiology, The, ISSN 0002-9149, 2014, Volume 114, Issue 2, pp. 294 - 299
Electrocardiograms have utility in disease stratification and monitoring in adult pulmonary arterial hypertension (PAH). We examined the electrocardiographic... 
Cardiovascular | ECG | CARDIAC & CARDIOVASCULAR SYSTEMS | Hypertension, Pulmonary - diagnosis | Lung Diseases - congenital | Reproducibility of Results | Follow-Up Studies | Humans | Child, Preschool | Hypertension, Pulmonary - physiopathology | Lung - abnormalities | Familial Primary Pulmonary Hypertension | Infant | Male | Electrocardiography - utilization | Cardiac Catheterization | Monitoring, Physiologic - utilization | Adolescent | Monitoring, Physiologic - methods | Female | Lung Diseases - complications | Lung Diseases - physiopathology | Retrospective Studies | Child | Hypertension, Pulmonary - etiology | Infant, Newborn | Electrocardiography | Development and progression | Catheterization | Electrocardiogram | Pulmonary hypertension | Hypertension | Variables | Mortality | Cardiovascular disease | Intubation | Age | Children & youth
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8. Full Text Pulmonary gas exchange abnormalities in mild chronic obstructive pulmonary disease: Implications for dyspnea and exercise intolerance
by Elbehairy, Amany F and Ciavaglia, Casey E and Webb, Katherine A and Guenette, Jordan A and Jensen, Dennis and Mourad, Sahar M and Neder, J. Alberto and O'Donnell, Denis E and Canadian Respiratory Research Network, Respiratory Research Network and Canadian Resp Res Network and Canadian Respiratory Research Network
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 06/2015, Volume 191, Issue 12, pp. 1384 - 1394
Rationale: Several studies in mild chronic obstructive pulmonary disease (COPD) have shown a higher than normal ventilatory equivalent for carbon dioxide... 
Dyspnea | Exercise | Gas exchange | Mild chronic obstructive pulmonary disease | Ventilatory inefficiency | mild chronic obstructive pulmonary disease | AIR-FLOW LIMITATION | CHRONIC HEART-FAILURE | STANDARDIZATION | ventilatory inefficiency | exercise | dyspnea | gas exchange | DEAD SPACE | RESPIRATORY SYSTEM | QUALITY-OF-LIFE | CARBON-DIOXIDE | HEALTH-STATUS | LUNG STRUCTURE | COPD | CRITICAL CARE MEDICINE | Cross-Sectional Studies | Humans | Middle Aged | Oximetry | Exercise Test - statistics & numerical data | Male | Dyspnea - etiology | Dyspnea - physiopathology | Pulmonary Disease, Chronic Obstructive - physiopathology | Pulmonary Disease, Chronic Obstructive - complications | Dyspnea - blood | Pulmonary Gas Exchange - physiology | Pulmonary Disease, Chronic Obstructive - blood | Female
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9. Full Text Association Between Interstitial Lung Abnormalities and All-Cause Mortality
by Putman, Rachel K and Hatabu, Hiroto and Araki, Tetsuro and Gudmundsson, Gunnar and Gao, Wei and Nishino, Mizuki and Okajima, Yuka and Dupuis, Josée and Latourelle, Jeanne C and Cho, Michael H and El-Chemaly, Souheil and Coxson, Harvey O and Celli, Bartolome R and Fernandez, Isis E and Zazueta, Oscar E and Ross, James C and Harmouche, Rola and Estépar, Raúl San José and Diaz, Alejandro A and Sigurdsson, Sigurdur and Gudmundsson, Elías F and Eiríksdottír, Gudny and Aspelund, Thor and Budoff, Matthew J and Kinney, Gregory L and Hokanson, John E and Williams, Michelle C and Murchison, John T and MacNee, William and Hoffmann, Udo and O’Donnell, Christopher J and Launer, Lenore J and Harrris, Tamara B and Gudnason, Vilmundur and Silverman, Edwin K and O’Connor, George T and Washko, George R and Rosas, Ivan O and Hunninghake, Gary M and ECLIPSE Investigator and COPDGene Investigator and COPDGene Investigators and Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators and for the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) and COPDGene Investigators
JAMA, ISSN 0098-7484, 02/2016, Volume 315, Issue 7, pp. 672 - 681
IMPORTANCE: Interstitial lung abnormalities have been associated with lower 6-minute walk distance, diffusion capacity for carbon monoxide, and total lung... 
MEDICINE, GENERAL & INTERNAL | MUC5B PROMOTER POLYMORPHISM | SUSCEPTIBILITY | DISEASE | PREVALENCE | IDIOPATHIC PULMONARY-FIBROSIS | EPIDEMIOLOGY | Pulmonary Disease, Chronic Obstructive - mortality | Prevalence | Prospective Studies | Humans | Proportional Hazards Models | Neoplasms - mortality | Male | Coronary Artery Disease - mortality | Pulmonary Disease, Chronic Obstructive - epidemiology | Cause of Death | Radiography | Smoking - epidemiology | Female | Pulmonary Disease, Chronic Obstructive - diagnostic imaging | Coronary Artery Disease - epidemiology | Pulmonary Emphysema - epidemiology | Pulmonary Emphysema - mortality | Cohort Studies | Lung diseases | Mortality | undiagnosed | subclinical | interstitial lung disease | Idiopathic pulmonary fibrosis | interstitial lung abnormalities (ILA)
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10. Full Text Lung Volumes and Emphysema in Smokers with Interstitial Lung Abnormalities
by Washko, George R and Hunninghake, Gary M and Fernandez, Isis E and Nishino, Mizuki and Okajima, Yuka and Yamashiro, Tsuneo and Ross, James C and Estépar, Raúl San José and Lynch, David A and Brehm, John M and Andriole, Katherine P and Diaz, Alejandro A and Khorasani, Ramin and D'Aco, Katherine and Sciurba, Frank C and Silverman, Edwin K and Hatabu, Hiroto and Rosas, Ivan O and COPDGene Investigators
The New England Journal of Medicine, ISSN 0028-4793, 03/2011, Volume 364, Issue 10, pp. 897 - 906
Smokers with more than a 10-pack-year history of smoking who were part of an ongoing study had CT scans and lung-function tests. Approximately 1 in 12 had... 
MEDICINE, GENERAL & INTERNAL | PULMONARY-FIBROSIS | DISEASE | REFERENCE VALUES | COPD | Lung Diseases, Interstitial - etiology | Smoking - adverse effects | Spirometry | Lung - pathology | Pulmonary Emphysema - etiology | Lung Diseases, Interstitial - pathology | Humans | Pulmonary Emphysema - pathology | Tomography, X-Ray Computed - methods | Linear Models | Logistic Models | Total Lung Capacity | Lung - diagnostic imaging | Pulmonary Fibrosis - pathology | Pulmonary Disease, Chronic Obstructive - etiology | Pulmonary Disease, Chronic Obstructive - pathology | Pulmonary Emphysema - diagnostic imaging | Lung Diseases, Interstitial - diagnostic imaging | Pulmonary Fibrosis - diagnostic imaging | Smoking - pathology | Pulmonary Disease, Chronic Obstructive - diagnostic imaging | Cohort Studies | CT imaging | Logistic regression | Usage | Care and treatment | Smokers | Emphysema, Pulmonary | Causes of | Diagnosis | Health aspects | Chronic obstructive pulmonary disease | Lungs | Lung diseases | Smoking
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11. Full Text Airway acidification initiates host defense abnormalities in cystic fibrosis mice
by Shah, Viral S and Meyerholz, David K and Tang, Xiao Xiao and Reznikov, Leah and Alaiwa, Mahmoud Abou and Ernst, Sarah E and Karp, Philip H and Wohlford-Lenane, Christine L and Heilmann, Kristopher P and Leidinger, Mariah R and Allen, Patrick D and Zabner, Joseph and McCray, Paul B and Ostedgaard, Lynda S and Stoltz, David A and Randak, Christoph O and Welsh, Michael J
Science, ISSN 0036-8075, 01/2016, Volume 351, Issue 6272, pp. 503 - 507
Cystic fibrosis (CF) is caused by mutations in the gene that encodes the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. In humans... 
CELLS | TRANSPORT | SURFACE PH | LIQUID PH | EPITHELIUM | CHANNEL | MULTIDISCIPLINARY SCIENCES | DISEASE | BASE SECRETION | MODEL | BICARBONATE SECRETION | Lung - microbiology | H(+)-K(+)-Exchanging ATPase - metabolism |