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Nature Cell Biology, ISSN 1465-7392, 03/2010, Volume 12, Issue 3, pp. 247 - 256
MicroRNAs (miRNAs) are increasingly implicated in regulating the malignant progression of cancer. Here we show that miR-9, which is upregulated in breast... 
ADHESION | STEM-CELLS | INVASION | N-MYC | C-MYC | TUMOR ANGIOGENESIS | HUMAN BREAST-CANCER | MESENCHYMAL TRANSITION | EXPRESSION | MAMMARY EPITHELIAL-CELLS | CELL BIOLOGY | Oncogene Proteins - genetics | RNA, Small Interfering - genetics | Protein Binding - genetics | Cell Proliferation | MicroRNAs - antagonists & inhibitors | Cadherins - metabolism | Gene Expression - genetics | Humans | 3' Untranslated Regions - genetics | Vascular Endothelial Growth Factor A - genetics | N-Myc Proto-Oncogene Protein | Cadherins - genetics | Oncogene Proteins - metabolism | Vascular Endothelial Growth Factor A - blood | Epithelial Cells - pathology | DNA - metabolism | Neuroblastoma - diagnosis | beta Catenin - metabolism | Down-Regulation - genetics | Cell Line, Tumor | Mice, Inbred NOD | Mice | Mice, Inbred BALB C | Neovascularization, Pathologic - metabolism | Neuroblastoma - metabolism | Proto-Oncogene Proteins c-myc - genetics | Histones - metabolism | MicroRNAs - physiology | Neoplasms - metabolism | Epithelial Cells - metabolism | Vimentin - metabolism | Lung Neoplasms - pathology | Breast Neoplasms - metabolism | Neovascularization, Pathologic - pathology | Neoplasms - blood | Transfection | Lung Neoplasms - secondary | Neoplasm Invasiveness - pathology | Female | Nuclear Proteins - genetics | Gene Expression Regulation, Neoplastic - physiology | Neuroblastoma - pathology | Cell Line | Neuroblastoma - genetics | Nuclear Proteins - metabolism | Gene Dosage | Mice, SCID | Proto-Oncogene Proteins c-myc - metabolism | beta Catenin - genetics | Neoplasm Metastasis - genetics | Animals | Breast Neoplasms - pathology | Neoplasm Metastasis - pathology | Signal Transduction - physiology | Transplantation, Heterologous - pathology | Neoplasm Invasiveness - genetics | Neoplasms - pathology | MicroRNA | Physiological aspects | Cadherins | Development and progression | Genetic aspects | Metastasis | Research | Oncogenes | Index Medicus
Journal Article
International Journal of Cancer, ISSN 0020-7136, 02/2005, Volume 113, Issue 5, pp. 752 - 760
The role of platelets in tumor progression and metastasis has been recognized but the mechanism of their action remains unclear. Five human lung cancer cell... 
lung cancer | platelet microvesicles | metastasis | matrix metalloproteinases | exosomes | Matrix metalloproteinases | Metastasis | Platelet microvesicles | Exosomes | Lung cancer | SURVIVAL | VESICLES | MEMBRANE-TYPE-1 MATRIX-METALLOPROTEINASE | ADHESION | IN-VITRO | ONCOLOGY | GROWTH | SURFACE | RHABDOMYOSARCOMA CELLS | GENERATION | ENDOTHELIAL MICROPARTICLES | Phosphorylation | Cell Proliferation | Humans | Lung Neoplasms - metabolism | Carcinoma, Lewis Lung - secondary | Lung Neoplasms - pathology | Metalloendopeptidases - metabolism | Vascular Endothelial Growth Factor A - metabolism | Carcinoma, Lewis Lung - blood supply | Cyclin D2 | Neovascularization, Pathologic - pathology | Mitogen-Activated Protein Kinase Kinases - metabolism | Matrix Metalloproteinase 9 - metabolism | Matrix Metalloproteinases, Membrane-Associated | Cyclins - metabolism | Neoplasm Invasiveness - pathology | Bone Marrow - metabolism | Platelet Membrane Glycoproteins - metabolism | Female | Interleukin-8 - metabolism | Tumor Cells, Cultured | Lung Neoplasms - blood supply | Matrix Metalloproteinase 14 | Endothelial Cells - metabolism | Mice, Inbred C57BL | Umbilical Veins | Carcinoma, Lewis Lung - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Cell Adhesion | Chemotaxis | Disease Progression | Hepatocyte Growth Factor - metabolism | Animals | Blood Platelets - metabolism | Endothelial Cells - cytology | Platelet Activation | Bone Marrow - pathology | Fibrinogen - metabolism | Mice | Neovascularization, Pathologic - metabolism | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2014, Volume 111, Issue 7, pp. 2554 - 2559
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 04/2010, Volume 5, Issue 4, pp. 442 - 447
The emergence of treatments for non-small cell lung carcinoma (NSCLC) with differential efficacy and toxicity between subtypes has highlighted the importance... 
Immunohistochemistry | NSCLC subtype | Non-small cell lung carcinoma | NSCLC-NOS | Bronchial biopsy diagnosis | Predictive value | Undifferentiated carcinoma | TTF1 | p63 | P63 | DIFFERENTIAL-DIAGNOSIS | PRIMARY LUNG-CANCER | TTF-1 | OBSERVER VARIABILITY | HISTOLOGICAL CLASSIFICATION | PULMONARY ADENOCARCINOMAS | ONCOLOGY | RESPIRATORY SYSTEM | TISSUE MICROARRAY | TRANSCRIPTION FACTOR-I | EXPRESSION | Thyroid Nuclear Factor 1 | Adenocarcinoma - pathology | Prognosis | Prospective Studies | Adenocarcinoma - classification | Carcinoma, Large Cell - pathology | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Immunoenzyme Techniques | Adenocarcinoma - metabolism | Carcinoma, Non-Small-Cell Lung - classification | Sensitivity and Specificity | Mucins - metabolism | Biomarkers, Tumor - metabolism | Bronchi - metabolism | Cell Differentiation | Bronchi - pathology | Carcinoma, Non-Small-Cell Lung - pathology | S100 Calcium Binding Protein A7 | Tumor Suppressor Proteins - metabolism | Carcinoma, Large Cell - metabolism | Carcinoma, Non-Small-Cell Lung - metabolism | Nuclear Proteins - metabolism | S100 Proteins - metabolism | Survival Rate | Transcription Factors - metabolism | Biopsy, Fine-Needle | Lung Neoplasms - classification | Carcinoma, Squamous Cell - classification | Keratin-5 - metabolism | Carcinoma, Large Cell - classification | Trans-Activators - metabolism | Keratin-6 - metabolism | Neoplasm Staging | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 06/2017, Volume 546, Issue 7656, pp. 168 - 172
Metabolic reprogramming by oncogenic signals promotes cancer initiation and progression. The oncogene KRAS and tumour suppressor STK11, which encodes the... 
REPLICATION | METABOLISM | PATHWAY | MULTIDISCIPLINARY SCIENCES | GROWTH | AMPK | LKB1 | Carbamyl Phosphate - metabolism | Metabolomics | AMP-Activated Protein Kinases - metabolism | Cell Proliferation | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Male | Pyrimidines - metabolism | S Phase | Cell Death | DNA - biosynthesis | Female | Transcription, Genetic | Protein-Serine-Threonine Kinases - metabolism | Carbamoyl-Phosphate Synthase (Ammonia) - genetics | Carcinoma, Non-Small-Cell Lung - pathology | DNA Damage - drug effects | Lung Neoplasms - genetics | Nitrogen - metabolism | Lung Neoplasms - enzymology | Ammonia - metabolism | Carcinoma, Non-Small-Cell Lung - genetics | Purines - metabolism | Carcinoma, Non-Small-Cell Lung - metabolism | Gene Silencing | Protein-Serine-Threonine Kinases - genetics | DNA Replication | Mitochondria - metabolism | Pyrimidines - pharmacology | Xenograft Model Antitumor Assays | Animals | Carbamoyl-Phosphate Synthase (Ammonia) - metabolism | Bicarbonates - metabolism | Mice | Carcinoma, Non-Small-Cell Lung - enzymology | DNA-Directed DNA Polymerase - metabolism | Carbamoyl-Phosphate Synthase (Ammonia) - deficiency | Pyrimidines | Gene mutations | Lung cancer | Cancer cells | Genetic aspects | Nucleotide sequencing | Health aspects | Methods | DNA sequencing | Correlation | Transcription | Toxicity | Lung | DNA damage | Oncology | K-Ras protein | LKB1 protein | Bicarbonate | Mitochondria | Phosphate | Carbonates | Signatures | Damage | Stalling | Deoxyribonucleic acid--DNA | Enzymes | Mortality | Nitrogen | Pools | Metabolism | Gene expression | Flow | Polymerase | DNA biosynthesis | Ammonia | Urea | Depletion | Carbamoyl phosphate | Cell death | Human behavior | Tumors | Cancer | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 05/2014, Volume 19, Issue 5, pp. 795 - 809
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2012, Volume 131, Issue 2, pp. 501 - 511.e1
Background Sphingosine-1-phosphate (S1P), which is produced by 2 sphingosine kinase (SphK) isoenzymes, SphK1 and SphK2, has been implicated in IgE-mediated... 
Allergy and Immunology | airway hyperresponsiveness | asthma | nuclear factor κB | mast cells | sphingosine kinase | Sphingosine-1-phosphate | IMMUNITY | FC-EPSILON-RI | nuclear factor kappa B | FACTOR-KAPPA-B | IMMUNOLOGY | MULTIPLE FEATURES | REGULATES MUCIN PRODUCTION | RESPONSES | CYTOKINE PRODUCTION | ALLERGY | GENE-EXPRESSION | MICE | Tumor Necrosis Factor-alpha - metabolism | Lysophospholipids - metabolism | Asthma - metabolism | Bronchial Hyperreactivity - drug therapy | Humans | Goblet Cells - drug effects | NF-kappa B - metabolism | Amino Alcohols - pharmacology | Interferon-gamma - metabolism | Interleukins - metabolism | Inflammation - metabolism | Inflammation - drug therapy | Methacholine Chloride - pharmacology | Mast Cells - metabolism | Bronchial Hyperreactivity - metabolism | Female | Chemokine CCL2 - metabolism | Hyperplasia - drug therapy | Lung - metabolism | Sphingosine - metabolism | Hyperplasia - metabolism | Asthma - enzymology | Immunoglobulin E - metabolism | Mice, Inbred C57BL | Cells, Cultured | Ovalbumin - pharmacology | Asthma - drug therapy | Goblet Cells - metabolism | Mast Cells - drug effects | Asthma - chemically induced | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Bronchial Hyperreactivity - enzymology | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Bronchial Hyperreactivity - pathology | Sphingosine - analogs & derivatives | Animals | Lung - drug effects | Mice | Bronchoalveolar Lavage Fluid - chemistry | Phosphates | Medical colleges | Isoenzymes | Analysis | Sphingosine | Inflammation | Asthma | Studies | Cytokines | Lungs | Rodents | Kinases | Laboratory animals | Allergies | Index Medicus | Abridged Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2010, Volume 107, Issue 19, pp. 8788 - 8793
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 08/2007, Volume 293, Issue 2, pp. 641 - 649
Journal Article
Nature Cell Biology, ISSN 1465-7392, 09/2010, Volume 12, Issue 9, pp. 863 - 875
Accumulation of unwanted/misfolded proteins in aggregates has been observed in airways of patients with cystic fibrosis (CF), a life-threatening genetic... 
APOPTOSIS | UNFOLDED PROTEIN RESPONSE | BECLIN 1 | DOWN-REGULATION | ENDOPLASMIC-RETICULUM | MICE | GENE-TRANSFER | TISSUE TRANSGLUTAMINASE | NEURODEGENERATIVE DISEASES | CELL-DEATH | CELL BIOLOGY | Reactive Oxygen Species - metabolism | Respiratory Mucosa - drug effects | Sequestosome-1 Protein | Humans | Transglutaminases - genetics | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Autophagy - drug effects | Young Adult | Cystamine - therapeutic use | Inflammation - metabolism | Autophagy - genetics | Nasal Polyps - metabolism | Mice, Inbred CFTR | Respiratory Mucosa - cytology | Cystic Fibrosis - metabolism | Membrane Proteins - genetics | Mice, Transgenic | Protein Transport - genetics | Apoptosis Regulatory Proteins - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Models, Biological | Cystic Fibrosis - genetics | Transglutaminases - metabolism | Adolescent | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Mice | GTP-Binding Proteins | Cystic Fibrosis - drug therapy | Protein Binding - physiology | Microtubule-Associated Proteins - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Salicylates - pharmacology | Epithelial Sodium Channels - genetics | Apoptosis Regulatory Proteins - genetics | Adult | Cystamine - pharmacology | Membrane Proteins - metabolism | Acetylcysteine - therapeutic use | Beclin-1 | Cystic Fibrosis Transmembrane Conductance Regulator - antagonists & inhibitors | Cell Line | Small Ubiquitin-Related Modifier Proteins - metabolism | Heat-Shock Proteins - metabolism | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Antioxidants - pharmacology | Mice, Inbred Strains | Nasal Polyps - drug therapy | Antioxidants - therapeutic use | Animals | Acetylcysteine - pharmacology | Adaptor Proteins, Signal Transducing - genetics | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Organometallic Compounds - pharmacology | Complications and side effects | Active oxygen | Gene mutations | Lung diseases | Physiological aspects | Cystic fibrosis | Genetic aspects | Research | Health aspects | Risk factors | Index Medicus
Journal Article