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1. Full Text Radiation and checkpoint blockade immunotherapy: radiosensitisation and potential mechanisms of synergy
by Sharabi, Andrew B, Dr and Lim, Michael, MD and DeWeese, Theodore L, Prof and Drake, Charles G, Prof
The lancet oncology, ISSN 1470-2045, 2015, Volume 16, Issue 13, pp. e498 - e509
Hematology, Oncology and Palliative Medicine | Life Sciences & Biomedicine | Oncology | Science & Technology | Cell Death - radiation effects | Immunotherapy - methods | Dendritic Cells - immunology | Humans | Radiation Tolerance | Antibodies, Monoclonal - therapeutic use | Molecular Targeted Therapy | Radiation-Sensitizing Agents - therapeutic use | CD8-Positive T-Lymphocytes - radiation effects | Neoplasms - therapy | Dendritic Cells - drug effects | Cell Death - drug effects | Signal Transduction - radiation effects | Cytotoxicity, Immunologic - drug effects | Chemoradiotherapy - methods | Treatment Outcome | Lymphocytes, Tumor-Infiltrating - drug effects | Radiation Dosage | Dendritic Cells - diagnostic imaging | Radiography | Animals | Signal Transduction - drug effects | Neoplasms - immunology | CD8-Positive T-Lymphocytes - drug effects | CD8-Positive T-Lymphocytes - immunology | Neoplasms - pathology | Cytotoxicity, Immunologic - radiation effects | Lymphocytes, Tumor-Infiltrating - radiation effects | Lymphocytes, Tumor-Infiltrating - immunology | Chemotherapy | Lung cancer | Analysis | Immunotherapy | Melanoma | Radiation | Lymphomas | Cancer | Index Medicus
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2. Full Text Inhibition of Radiation-Induced Ccl2 Signaling Protects Lungs from Vascular Dysfunction and Endothelial Cell Loss
by Wiesemann, Alina and Ketteler, Julia and Slama, Alexis and Wirsdörfer, Florian and Hager, Thomas and Röck, Katharina and Engel, Daniel R and Fischer, Jens W and Aigner, Clemens and Jendrossek, Verena and Klein, Diana
Antioxidants & redox signaling, ISSN 1523-0864, 01/2019, Volume 30, Issue 2, pp. 213 - 231
Original Research Communications | senescence | radiotherapy | radiation-induced normal tissue toxicity | Ccl2 | vascular damage | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Receptors, CCR2 - genetics | Humans | Lung Neoplasms - metabolism | Pneumonia - pathology | Cell Survival - genetics | Cellular Senescence - drug effects | Lung Neoplasms - radiotherapy | Lung Neoplasms - pathology | Respiratory Mucosa - radiation effects | Respiratory Mucosa - pathology | Protective Agents - pharmacology | Cellular Senescence - radiation effects | Lung - radiation effects | Chemokine CCL2 - metabolism | Lung - metabolism | Signal Transduction - radiation effects | Disease Models, Animal | Cell Survival - drug effects | Cellular Senescence - genetics | Lung - pathology | Pneumonia - etiology | Endothelial Cells - metabolism | Endothelial Cells - radiation effects | Cell Survival - radiation effects | Mice, Knockout | Receptors, CCR2 - metabolism | Animals | Biopsy | Endothelium, Vascular - metabolism | Biomarkers | Protein Binding | Radiation Injuries - pathology | Mice | Respiratory Mucosa - metabolism | Chemokine CCL2 - antagonists & inhibitors | Pneumonia - metabolism | Radiation Injuries - metabolism | Endothelium, Vascular - radiation effects | CC chemokine receptors | Senescence | Toxicity | Epithelial cells | Cytology | Radiation | Innovations | Tissues | Metastases | Radiosensitization | CCR2 protein | Inhibition | Acute effects | Deoxyribonucleic acid--DNA | Carbon-carbon composites | Radiation effects | Phenotypes | Secretome | Radiation therapy | Radioprotection | Endothelial cells | Signaling | Lungs | Morphology | Fibrosis | Irradiation | Monocyte chemoattractant protein 1 | Tumors | Index Medicus
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3. Full Text Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy
by Bos, Paula D and Plitas, George and Rudra, Dipayan and Lee, Sue Y and Rudensky, Alexander Y
The Journal of experimental medicine, ISSN 0022-1007, 10/2013, Volume 210, Issue 11, pp. 2435 - 2466
Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Cell Death - radiation effects | Tumor Burden - radiation effects | CD4-Positive T-Lymphocytes - radiation effects | Lung Neoplasms - pathology | Interferon-gamma - metabolism | Lymphocyte Depletion | T-Lymphocytes, Regulatory - immunology | T-Lymphocytes, Regulatory - radiation effects | CD4-Positive T-Lymphocytes - immunology | CD8-Positive T-Lymphocytes - radiation effects | Mammary Neoplasms, Animal - radiotherapy | Lung Neoplasms - secondary | Killer Cells, Natural - immunology | Female | Radiation, Ionizing | Oncogenes - genetics | Mammary Neoplasms, Animal - immunology | Killer Cells, Natural - radiation effects | Disease Progression | Tumor Microenvironment - radiation effects | Mammary Neoplasms, Animal - pathology | Animals | Cell Cycle Checkpoints - radiation effects | Mice | CD8-Positive T-Lymphocytes - immunology | Cell Proliferation - radiation effects | Tumor Burden - immunology | Index Medicus
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4. Full Text Delayed Effects of Acute Radiation Exposure (Deare) in Juvenile and Old Rats: Mitigation by Lisinopril
by Medhora, Meetha and Gao, Feng and Gasperetti, Tracy and Narayanan, Jayashree and Khan, Abdul Hye and Jacobs, Elizabeth R and Fish, Brian L
Health physics (1958), ISSN 0017-9078, 04/2019, Volume 116, Issue 4, pp. 529 - 545
Life Sciences & Biomedicine | Technology | Radiology, Nuclear Medicine & Medical Imaging | Nuclear Science & Technology | Public, Environmental & Occupational Health | Environmental Sciences & Ecology | Science & Technology | Environmental Sciences | Acute Radiation Syndrome - mortality | Age Factors | Rats, Wistar | Medical Countermeasures | Acute Radiation Syndrome - prevention & control | Rats | Male | Radiation Injuries, Experimental - pathology | Radiation Injuries, Experimental - prevention & control | Animals | Lisinopril - therapeutic use | Time Factors | Acute Radiation Syndrome - drug therapy | Acute Radiation Syndrome - pathology | Radiation Injuries, Experimental - drug therapy | Radiation-Protective Agents - therapeutic use | Female | Radiation Injuries, Experimental - mortality | Radiation effects | Animal models | Hypersensitivity (delayed) | Radiation | Organs | Irradiated | Lethality | Exposure | Males | Mitigation | Pneumonitis | Infectious diseases | Nephropathy | Lungs | Rodents | Radiation injuries | Irradiation | Radiation shielding | Females | Index Medicus | acute radiation syndrome | ARS | Late effects of radiation | ACE inhibitors | special populations
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5. Full Text Ipilimumab with stereotactic ablative radiation therapy: Phase i results and immunologic correlates from peripheral T cells
by Tang, Chad and Welsh, James W and De Groot, Patricia and Massarelli, Erminia and Chang, Joe Y and Hess, Kenneth R and Basu, Sreyashi and Curran, Michael A and Cabanillas, Maria E and Subbiah, Vivek and Fu, Siqing and Tsimberidou, Apostolia M and Karp, Daniel and Gomez, Daniel R and Diab, Adi and Komaki, Ritsuko and Heymach, John V and Sharma, Padmanee and Naing, Aung and Hong, David S
Clinical cancer research, ISSN 1078-0432, 03/2017, Volume 23, Issue 6, pp. 1388 - 1396
Life Sciences & Biomedicine | Oncology | Science & Technology | Lung Neoplasms - drug therapy | Liver - pathology | Humans | Middle Aged | CD4-Positive T-Lymphocytes - radiation effects | Lung Neoplasms - radiotherapy | Liver - radiation effects | Lung Neoplasms - pathology | Male | Radiosurgery - adverse effects | CD8-Positive T-Lymphocytes - radiation effects | Flow Cytometry | Aged, 80 and over | Adult | Female | Liver Neoplasms - pathology | Lung - radiation effects | Ipilimumab - administration & dosage | Lung - pathology | Liver Neoplasms - drug therapy | Treatment Outcome | Combined Modality Therapy | Ipilimumab - adverse effects | CD8-Positive T-Lymphocytes - drug effects | Liver Neoplasms - radiotherapy | Lung - drug effects | Aged | Biomarkers, Tumor - genetics | CD4-Positive T-Lymphocytes - drug effects | Flow cytometry | Toxicity | CD8 antigen | Liver | Radiation | Lymphocytes T | T cell receptors | Radiation therapy | Patients | CD4 antigen | Liver cancer | Cytometry | Cell activation | Lungs | Experimental design | Lymphocytes | Immunotherapy | Irradiation | Cancer | Index Medicus | trial correlates | Stereotactic ablative radiation therapy | immunotherapy | ipilimumab
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6. Full Text Alectinib induced CNS radiation necrosis in an ALK+ NSCLC patient with a remote (7 years) history of brain radiation
by Ou, Sai-Hong Ignatius and Weitz, Michael and Jalas, John R and Kelly, Daniel F and Wong, Vanessa and Azada, Michele C and Quines, Oliver and Klempner, Samuel J
Lung cancer (Amsterdam, Netherlands), ISSN 0169-5002, 2016, Volume 96, pp. 15 - 18
Hematology, Oncology and Palliative Medicine | Pulmonary/Respiratory | Alectinib | Pseudo-progression | ALK-positive non-small cell lung cancer | Radiation necrosis | Adenocarcinoma - pathology | Adenocarcinoma of Lung | Radiation Injuries - chemically induced | Humans | Lung Neoplasms - metabolism | Middle Aged | Lung Neoplasms - pathology | Male | Necrosis - pathology | Brain Neoplasms - secondary | Adenocarcinoma - metabolism | Anaplastic Lymphoma Kinase | Piperidines - pharmacology | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Brain Neoplasms - radiotherapy | Pyrazoles - pharmacology | Crizotinib | Carbazoles - adverse effects | Treatment Outcome | Brain - radiation effects | Lung Neoplasms - therapy | Brain Neoplasms - drug therapy | Disease Progression | Necrosis - chemically induced | Radiation Injuries - etiology | Brain - drug effects | Adenocarcinoma - therapy | Protein Kinase Inhibitors - therapeutic use | Piperidines - adverse effects | Brain - pathology | Radiation Injuries - pathology | Pyridines - pharmacology | Carbazoles - pharmacology | Medical colleges | Lung cancer, Non-small cell | Emergency medicine | Brain tumors | Radiation | Necrosis | Development and progression | Lymphomas | Metastasis | Index Medicus
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7. Full Text Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair
by Mahmoud Toulany and Rainer Kehlbach and Urszula Florczak and Ali Sak and Shaomeng Wang and Jianyong Chen and Markus Lobrich and H. Peter Rodemann
Molecular cancer therapeutics, ISSN 1535-7163, 07/2008, Volume 7, Issue 7, pp. 1772 - 1781
Radiosensitization | NSCLC | DNA repair | PI3K/AKT targeting | Life Sciences & Biomedicine | Oncology | Science & Technology | DNA-Activated Protein Kinase - antagonists & inhibitors | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Apoptosis - drug effects | Apoptosis - radiation effects | Humans | DNA Repair - radiation effects | Lung Neoplasms - pathology | DNA Breaks, Double-Stranded - radiation effects | Radiation Tolerance - radiation effects | Caspases - metabolism | DNA Breaks, Double-Stranded - drug effects | DNA-Activated Protein Kinase - metabolism | Protein Binding - drug effects | Protein Binding - radiation effects | Phosphorylation - drug effects | Radiation, Ionizing | Carcinoma, Non-Small-Cell Lung - pathology | DNA Repair - drug effects | Lung Neoplasms - enzymology | Proto-Oncogene Proteins - genetics | Mutation - genetics | Radiation Tolerance - drug effects | Phosphorylation - radiation effects | Poly(ADP-ribose) Polymerases - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - enzymology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Cell Proliferation - radiation effects | Index Medicus
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8. Full Text Mesenchymal stem cells – A new hope for radiotherapy-induced tissue damage?
by Nicolay, Nils H and Lopez Perez, Ramon and Debus, Juergen and Huber, Peter E
Cancer letters, ISSN 0304-3835, 2015, Volume 366, Issue 2, pp. 133 - 140
Hematology, Oncology and Palliative Medicine | Mesenchymal stem cell | Acute radiation injury | Radiotherapy | Fibrosis | Side effect | Life Sciences & Biomedicine | Oncology | Science & Technology | Bone and Bones - physiology | Humans | Intestines - radiation effects | Cell Proliferation - physiology | Liver - radiation effects | Salivary Glands - physiology | Lung - physiology | Regeneration - physiology | Radiation Injuries - prevention & control | Bone Marrow - metabolism | Salivary Glands - radiation effects | Liver - physiology | Lung - radiation effects | Radiation Injuries - physiopathology | Bone and Bones - radiation effects | Skin Physiological Phenomena - radiation effects | Intestines - physiology | Mesenchymal Stem Cell Transplantation | Mesenchymal Stromal Cells - physiology | Radiation Injuries - therapy | Stem cells | Index Medicus
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9. Full Text INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis
by Niture, S.K and Jaiswal, A.K
Cell death and differentiation, ISSN 1350-9047, 03/2011, Volume 18, Issue 3, pp. 439 - 451
Bcl-2 | Anti-apoptotic | Nrf2 | INrf2 (Keap1)