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Publication DateAnnals of the ICRP, ISSN 0146-6453, 10/2012, Volume 41, Issue 3-4, pp. 4 - 11
International Commission on Radiological Protection (ICRP) Committee 1 (C1) considers the risk of induction of cancer and heritable disease; the underlying...
Dose response | Tissue reactions | DDREF | Epidemiology | Cancer | Guidelines as Topic | Lung Neoplasms - etiology | Risk Assessment | Humans | Neoplasms, Radiation-Induced - etiology | Stem Cells - radiation effects | Radiation Effects | International Agencies - standards | International Agencies - organization & administration | Dose-Response Relationship, Radiation | Radon - toxicity | Radiation Protection - standards | Prevention | Nuclear radiation | Lung cancer | Recommendations | Radiation effects | Tasks | Radon | Risk | Estimates | Radiation protection
Dose response | Tissue reactions | DDREF | Epidemiology | Cancer | Guidelines as Topic | Lung Neoplasms - etiology | Risk Assessment | Humans | Neoplasms, Radiation-Induced - etiology | Stem Cells - radiation effects | Radiation Effects | International Agencies - standards | International Agencies - organization & administration | Dose-Response Relationship, Radiation | Radon - toxicity | Radiation Protection - standards | Prevention | Nuclear radiation | Lung cancer | Recommendations | Radiation effects | Tasks | Radon | Risk | Estimates | Radiation protection
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Radiation effects on the tumor microenvironment: Implications for nanomedicine delivery
Advanced Drug Delivery Reviews, ISSN 0169-409X, 01/2017, Volume 109, pp. 119 - 130
The tumor microenvironment has an important influence on cancer biological and clinical behavior and radiation treatment (RT) response. However, RT also...
Nanoparticles | Drug transport | Enhanced permeability and retention (EPR) effect | Interstitial fluid pressure (IFP) | Tumor microenvironment | Tumor-associated macrophages (TAMs) | Radiotherapy | Nanomedicine | INTERSTITIAL FLUID PRESSURE | VASCULAR NORMALIZATION | SOLID TUMORS | DRUG-DELIVERY | BLOOD-FLOW | NECK-CANCER | CELL LUNG-CANCER | LIPOSOMAL DOXORUBICIN | FRACTIONATED RADIOTHERAPY | PHARMACOLOGY & PHARMACY | PHASE-I | Tumor Microenvironment - radiation effects | Animals | Humans | Neoplasms - radiotherapy | Nanoparticles - administration & dosage | Drug Delivery Systems | Neoplasms - drug therapy | Drugs | Drug delivery systems | Radiation | Vehicles | Tumors | Endothelial growth factors | Permeability | Macrophages | Cancer
Nanoparticles | Drug transport | Enhanced permeability and retention (EPR) effect | Interstitial fluid pressure (IFP) | Tumor microenvironment | Tumor-associated macrophages (TAMs) | Radiotherapy | Nanomedicine | INTERSTITIAL FLUID PRESSURE | VASCULAR NORMALIZATION | SOLID TUMORS | DRUG-DELIVERY | BLOOD-FLOW | NECK-CANCER | CELL LUNG-CANCER | LIPOSOMAL DOXORUBICIN | FRACTIONATED RADIOTHERAPY | PHARMACOLOGY & PHARMACY | PHASE-I | Tumor Microenvironment - radiation effects | Animals | Humans | Neoplasms - radiotherapy | Nanoparticles - administration & dosage | Drug Delivery Systems | Neoplasms - drug therapy | Drugs | Drug delivery systems | Radiation | Vehicles | Tumors | Endothelial growth factors | Permeability | Macrophages | Cancer
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Loading RightsAnnual Review of Genetics, ISSN 0066-4197, 11/2013, Volume 47, Issue 1, pp. 33 - 50
In experimental organisms such as fruit flies and mice, increased frequencies in germ cell mutations have been detected following exposure to ionizing...
human genome | chromosome aberrations | sex ratios | birth defects | cancer incidence | germ cell mutations | Cancer incidence | Birth defects | Germ cell mutations | Sex ratios | Human genome | Chromosome aberrations | ATOMIC-BOMB SURVIVORS | MALE-MICE | BIRTH-REGISTRY-ANALYSIS | FEMALE GERM-CELLS | LUNG-TUMOR INDUCTION | CHILDHOOD-CANCER SURVIVORS | GENETICS & HEREDITY | MINISATELLITE MUTATION-RATE | CHERNOBYL CLEANUP WORKERS | PATERNAL X-IRRADIATION | IONIZING-RADIATION | Abnormalities, Radiation-Induced - etiology | Genome, Human - radiation effects | Radioactive Hazard Release | Follow-Up Studies | Humans | Occupational Exposure | Radiation Tolerance | Male | Radiotherapy - adverse effects | Germ-Line Mutation - radiation effects | Neoplasms, Radiation-Induced - genetics | Radiation Injuries - genetics | Female | Models, Animal | Drosophila melanogaster - radiation effects | Abnormalities, Radiation-Induced - genetics | Survivors | Chromosomes - radiation effects | Sex Ratio | Animals | Mutagenesis | Chromosome Aberrations | Nuclear Weapons | Mice | DNA Damage | Neoplasms, Radiation-Induced - epidemiology | Dose-Response Relationship, Radiation | Epigenetic inheritance | Research | Health aspects | Radiation
human genome | chromosome aberrations | sex ratios | birth defects | cancer incidence | germ cell mutations | Cancer incidence | Birth defects | Germ cell mutations | Sex ratios | Human genome | Chromosome aberrations | ATOMIC-BOMB SURVIVORS | MALE-MICE | BIRTH-REGISTRY-ANALYSIS | FEMALE GERM-CELLS | LUNG-TUMOR INDUCTION | CHILDHOOD-CANCER SURVIVORS | GENETICS & HEREDITY | MINISATELLITE MUTATION-RATE | CHERNOBYL CLEANUP WORKERS | PATERNAL X-IRRADIATION | IONIZING-RADIATION | Abnormalities, Radiation-Induced - etiology | Genome, Human - radiation effects | Radioactive Hazard Release | Follow-Up Studies | Humans | Occupational Exposure | Radiation Tolerance | Male | Radiotherapy - adverse effects | Germ-Line Mutation - radiation effects | Neoplasms, Radiation-Induced - genetics | Radiation Injuries - genetics | Female | Models, Animal | Drosophila melanogaster - radiation effects | Abnormalities, Radiation-Induced - genetics | Survivors | Chromosomes - radiation effects | Sex Ratio | Animals | Mutagenesis | Chromosome Aberrations | Nuclear Weapons | Mice | DNA Damage | Neoplasms, Radiation-Induced - epidemiology | Dose-Response Relationship, Radiation | Epigenetic inheritance | Research | Health aspects | Radiation
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Loading RightsInternational Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2010, Volume 76, Issue 3, pp. S135 - S139
The actual distribution of radiation dose accumulated in normal tissues over the complete course of radiation therapy is, in general, poorly quantified....
Radiology | Hematology, Oncology and Palliative Medicine | Dose accumulation | Four-dimensional | Deformation | Normal tissue effects | Informatics | MULTI-INSTITUTION | INTENSITY-MODULATED RADIOTHERAPY | MODEL | CELL LUNG-CANCER | THERAPY | PHOTON BEAMS | ONCOLOGY | CONFORMAL RADIOTHERAPY | MEGAVOLTAGE CT | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | DEFORMABLE IMAGE REGISTRATION | ORGAN MOTION | Humans | Body Burden | Neoplasms - radiotherapy | Neoplasms - pathology | Dose-Response Relationship, Radiation | Radiation Oncology - methods | Remission Induction | Medical colleges | Algorithms | Radiotherapy | Radiation | NEOPLASMS | RADIATION DOSES | SYMPTOMS | ALGORITHMS | MEDICINE | NUCLEAR MEDICINE | ACCURACY | RADIATION DOSE DISTRIBUTIONS | DISEASES | DOSES | EDEMA | RADIOLOGY AND NUCLEAR MEDICINE | RADIOTHERAPY | MATHEMATICAL LOGIC | PATHOLOGICAL CHANGES | RADIOLOGY
Radiology | Hematology, Oncology and Palliative Medicine | Dose accumulation | Four-dimensional | Deformation | Normal tissue effects | Informatics | MULTI-INSTITUTION | INTENSITY-MODULATED RADIOTHERAPY | MODEL | CELL LUNG-CANCER | THERAPY | PHOTON BEAMS | ONCOLOGY | CONFORMAL RADIOTHERAPY | MEGAVOLTAGE CT | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | DEFORMABLE IMAGE REGISTRATION | ORGAN MOTION | Humans | Body Burden | Neoplasms - radiotherapy | Neoplasms - pathology | Dose-Response Relationship, Radiation | Radiation Oncology - methods | Remission Induction | Medical colleges | Algorithms | Radiotherapy | Radiation | NEOPLASMS | RADIATION DOSES | SYMPTOMS | ALGORITHMS | MEDICINE | NUCLEAR MEDICINE | ACCURACY | RADIATION DOSE DISTRIBUTIONS | DISEASES | DOSES | EDEMA | RADIOLOGY AND NUCLEAR MEDICINE | RADIOTHERAPY | MATHEMATICAL LOGIC | PATHOLOGICAL CHANGES | RADIOLOGY
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Loading RightsPLoS ONE, ISSN 1932-6203, 02/2015, Volume 10, Issue 2, p. e0117784
Radiation effects on mortality from solid cancers other than lung, liver, and bone cancer in the Mayak worker cohort: 1948-2008. The cohort of Mayak Production...
DISEASES | ATOMIC-BOMB SURVIVORS | MULTIDISCIPLINARY SCIENCES | URINE | PLUTONIUM EXCRETION | RISK | NUCLEAR-COMPLEX | MODEL | DOSIMETRY | EXPOSURE | Gamma Rays | Nuclear Reactors | Plutonium - toxicity | Humans | Middle Aged | Neoplasms - mortality | Male | Radiation Dosage | Siberia | Adult | Female | Neoplasms - epidemiology | Occupational Exposure - statistics & numerical data | Cohort Studies | Radiation Exposure - statistics & numerical data | Liver cancer | Bone cancer | Health aspects | Analysis | Liver | Radiation | Radiation effects | Statistical analysis | Mortality | Lung cancer | Health risks | Risk | Exposure | Dosage | Occupational exposure | Esophagus | Studies | Nuclear weapons | Plutonium | Bone | Colon | Dosimetry | Health risk assessment | Monitoring | Cancer
DISEASES | ATOMIC-BOMB SURVIVORS | MULTIDISCIPLINARY SCIENCES | URINE | PLUTONIUM EXCRETION | RISK | NUCLEAR-COMPLEX | MODEL | DOSIMETRY | EXPOSURE | Gamma Rays | Nuclear Reactors | Plutonium - toxicity | Humans | Middle Aged | Neoplasms - mortality | Male | Radiation Dosage | Siberia | Adult | Female | Neoplasms - epidemiology | Occupational Exposure - statistics & numerical data | Cohort Studies | Radiation Exposure - statistics & numerical data | Liver cancer | Bone cancer | Health aspects | Analysis | Liver | Radiation | Radiation effects | Statistical analysis | Mortality | Lung cancer | Health risks | Risk | Exposure | Dosage | Occupational exposure | Esophagus | Studies | Nuclear weapons | Plutonium | Bone | Colon | Dosimetry | Health risk assessment | Monitoring | Cancer
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Loading RightsEnvironmental and Molecular Mutagenesis, ISSN 0893-6692, 01/2008, Volume 49, Issue 1, pp. 16 - 25
It is now well accepted that the effects of ionizing radiation (IR) exposure can be noticed far beyond the borders of the directly irradiated tissue. IR can...
bystander effect | indirect effects | transgeneration genome instability | radiation | epigenetics | Epigenetics | Transgeneration genome instability | Bystander effect | Indirect effects | Radiation | INDUCED TRANSGENERATIONAL INSTABILITY | DNA METHYLATION CHANGES | DOUBLE-STRAND BREAKS | RAT LUNG IRRADIATION | ENVIRONMENTAL SCIENCES | INDUCED GENOMIC INSTABILITY | IN-VIVO | GENETICS & HEREDITY | MINISATELLITE MUTATION-RATE | LOW-DOSE RADIATION | TOXICOLOGY | IONIZING-RADIATION | PRIMARY HUMAN FIBROBLASTS | Genomic Instability - radiation effects | Epigenesis, Genetic - radiation effects | Animals | Bystander Effect | Humans | Radiation, Ionizing
bystander effect | indirect effects | transgeneration genome instability | radiation | epigenetics | Epigenetics | Transgeneration genome instability | Bystander effect | Indirect effects | Radiation | INDUCED TRANSGENERATIONAL INSTABILITY | DNA METHYLATION CHANGES | DOUBLE-STRAND BREAKS | RAT LUNG IRRADIATION | ENVIRONMENTAL SCIENCES | INDUCED GENOMIC INSTABILITY | IN-VIVO | GENETICS & HEREDITY | MINISATELLITE MUTATION-RATE | LOW-DOSE RADIATION | TOXICOLOGY | IONIZING-RADIATION | PRIMARY HUMAN FIBROBLASTS | Genomic Instability - radiation effects | Epigenesis, Genetic - radiation effects | Animals | Bystander Effect | Humans | Radiation, Ionizing
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Loading RightsLancet Oncology, The, ISSN 1470-2045, 2015, Volume 16, Issue 13, pp. e498 - e509
Summary Checkpoint blockade immunotherapy has received mainstream attention as a result of striking and durable clinical responses in some patients with...
Hematology, Oncology and Palliative Medicine | MHC CLASS-I | BREAST-CANCER | CALRETICULIN EXPOSURE | DENDRITIC CELLS | ONCOLOGY | ANTITUMOR IMMUNE-RESPONSES | ADVANCED MELANOMA | PROSTATE-CANCER | TUMOR-CELLS | IONIZING-RADIATION | CD8(+) T-CELLS | Cell Death - radiation effects | Immunotherapy - methods | Dendritic Cells - immunology | Humans | Radiation Tolerance | Antibodies, Monoclonal - therapeutic use | Molecular Targeted Therapy | Radiation-Sensitizing Agents - therapeutic use | CD8-Positive T-Lymphocytes - radiation effects | Neoplasms - therapy | Dendritic Cells - drug effects | Cell Death - drug effects | Signal Transduction - radiation effects | Cytotoxicity, Immunologic - drug effects | Chemoradiotherapy - methods | Treatment Outcome | Lymphocytes, Tumor-Infiltrating - drug effects | Radiation Dosage | Dendritic Cells - diagnostic imaging | Radiography | Animals | Signal Transduction - drug effects | Neoplasms - immunology | CD8-Positive T-Lymphocytes - drug effects | CD8-Positive T-Lymphocytes - immunology | Neoplasms - pathology | Cytotoxicity, Immunologic - radiation effects | Lymphocytes, Tumor-Infiltrating - radiation effects | Lymphocytes, Tumor-Infiltrating - immunology | Chemotherapy | Lung cancer | Analysis | Immunotherapy | Melanoma | Radiation | Lymphomas | Cancer
Hematology, Oncology and Palliative Medicine | MHC CLASS-I | BREAST-CANCER | CALRETICULIN EXPOSURE | DENDRITIC CELLS | ONCOLOGY | ANTITUMOR IMMUNE-RESPONSES | ADVANCED MELANOMA | PROSTATE-CANCER | TUMOR-CELLS | IONIZING-RADIATION | CD8(+) T-CELLS | Cell Death - radiation effects | Immunotherapy - methods | Dendritic Cells - immunology | Humans | Radiation Tolerance | Antibodies, Monoclonal - therapeutic use | Molecular Targeted Therapy | Radiation-Sensitizing Agents - therapeutic use | CD8-Positive T-Lymphocytes - radiation effects | Neoplasms - therapy | Dendritic Cells - drug effects | Cell Death - drug effects | Signal Transduction - radiation effects | Cytotoxicity, Immunologic - drug effects | Chemoradiotherapy - methods | Treatment Outcome | Lymphocytes, Tumor-Infiltrating - drug effects | Radiation Dosage | Dendritic Cells - diagnostic imaging | Radiography | Animals | Signal Transduction - drug effects | Neoplasms - immunology | CD8-Positive T-Lymphocytes - drug effects | CD8-Positive T-Lymphocytes - immunology | Neoplasms - pathology | Cytotoxicity, Immunologic - radiation effects | Lymphocytes, Tumor-Infiltrating - radiation effects | Lymphocytes, Tumor-Infiltrating - immunology | Chemotherapy | Lung cancer | Analysis | Immunotherapy | Melanoma | Radiation | Lymphomas | Cancer
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Loading RightsInternational Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2010, Volume 76, Issue 3, pp. S70 - S76
The three-dimensional dose, volume, and outcome data for lung are reviewed in detail. The rate of symptomatic pneumonitis is related to many dosimetric...
Radiology | Hematology, Oncology and Palliative Medicine | Pneumonitis | QUANTEC | Radiation | Lung injury | REGIONAL DIFFERENCES | PULMONARY TOXICITY | HISTOGRAM ANALYSIS | INTENSITY-MODULATED RADIOTHERAPY | THERAPY-ONCOLOGY-GROUP | INTERSTITIAL PNEUMONITIS | CANCER-PATIENTS | ONCOLOGY | CONCURRENT CHEMOTHERAPY | CONFORMAL RADIOTHERAPY | TREATMENT-RELATED PNEUMONITIS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Radiotherapy Dosage | Radiation Pneumonitis - etiology | Models, Biological | Humans | Radiation Tolerance | Lung Neoplasms - radiotherapy | Lung - radiation effects | Lung Neoplasms - pathology | Models, Statistical | Medical colleges | Pneumonia | Bacterial pneumonia | IRRADIATION | ORGANS |
Radiology | Hematology, Oncology and Palliative Medicine | Pneumonitis | QUANTEC | Radiation | Lung injury | REGIONAL DIFFERENCES | PULMONARY TOXICITY | HISTOGRAM ANALYSIS | INTENSITY-MODULATED RADIOTHERAPY | THERAPY-ONCOLOGY-GROUP | INTERSTITIAL PNEUMONITIS | CANCER-PATIENTS | ONCOLOGY | CONCURRENT CHEMOTHERAPY | CONFORMAL RADIOTHERAPY | TREATMENT-RELATED PNEUMONITIS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Radiotherapy Dosage | Radiation Pneumonitis - etiology | Models, Biological | Humans | Radiation Tolerance | Lung Neoplasms - radiotherapy | Lung - radiation effects | Lung Neoplasms - pathology | Models, Statistical | Medical colleges | Pneumonia | Bacterial pneumonia | IRRADIATION | ORGANS |