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American journal of respiratory and critical care medicine, ISSN 1073-449X, 07/2019, Volume 200, Issue 2, pp. 247 - 249
To address this, Newton and colleagues conducted a retrospective observational cohort study of patients with interstitial pneumonia with autoimmune features... 
Pneumonia | Lung diseases | Genes | Critical care | Genomes | Studies | Proteins | Pulmonary fibrosis | Rheumatoid arthritis | Clinical medicine | Health risk assessment | Telomerase | Polymorphism
Journal Article
Clinics in Chest Medicine, ISSN 0272-5231, 03/2012, Volume 33, Issue 1, pp. 95 - 110
The interstitial lung diseases (ILDs), or diffuse parenchymal lung diseases, are a heterogeneous collection of more than 100 different pulmonary disorders that... 
Mutations | Genetics | Pulmonary fibrosis | Interstitial lung disease | SURFACTANT PROTEIN-C | COLONY-STIMULATING FACTOR | LINKED DYSKERATOSIS-CONGENITA | ENDOPLASMIC-RETICULUM STRESS | HERMANSKY-PUDLAK-SYNDROME | HYPER-IGE SYNDROME | PULMONARY ALVEOLAR PROTEINOSIS | TUBEROUS SCLEROSIS COMPLEX | RESPIRATORY SYSTEM | HOGG-DUBE-SYNDROME | THIN-SECTION CT | Calcinosis - genetics | Recurrence | Kidney Neoplasms - genetics | Lung Diseases, Interstitial - pathology | Humans | Genetic Diseases, Inborn - genetics | Pulmonary Fibrosis - genetics | INDEL Mutation | Pulmonary Surfactant-Associated Protein B - genetics | RNA - genetics | Lung Diseases, Interstitial - diagnostic imaging | Lung Diseases, Interstitial - therapy | Telomerase - genetics | Pulmonary Alveolar Proteinosis - genetics | Tumor Suppressor Proteins - genetics | Genetic Diseases, Inborn - complications | Sarcoidosis, Pulmonary - genetics | Adult | Female | Genetic Diseases, X-Linked - genetics | Siblings | Pulmonary Surfactant-Associated Protein B - deficiency | Pulmonary Surfactant-Associated Protein C - deficiency | Proto-Oncogene Proteins - genetics | Lung Diseases, Interstitial - complications | Pneumothorax - etiology | Birt-Hogg-Dube Syndrome - genetics | Radiography | Lung Diseases - genetics | Lung Diseases, Interstitial - genetics | Pedigree | Pulmonary Surfactant-Associated Protein C - genetics | Heterozygote | Mutation
Journal Article
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 03/2015, Volume 191, Issue 6, pp. 646 - 655
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 01/2015, Volume 308, Issue 1, pp. L33 - L47
Mutation of threonine for isoleucine at codon 73 (I73T) in the human surfactant protein C (hSP-C) gene (SFTPC) accounts for a significant portion of SFTPC... 
Surfactant protein | Pulmonary fibrosis | Alveolar epithelium | Autophagy | Amphisome | alveolar epithelium | autophagy | amphisome | surfactant protein | pulmonary fibrosis | DOMAIN | PHYSIOLOGY | SURFACTANT PROTEIN-C | FUSION | AGGRESOME FORMATION | ENDOPLASMIC-RETICULUM STRESS | MULTIVESICULAR BODIES | RESPIRATORY SYSTEM | MUTATION | DEGRADATION | PULMONARY-FIBROSIS | Proteostasis Deficiencies - metabolism | Lung Diseases, Interstitial - metabolism | Vacuoles - ultrastructure | Lung Diseases, Interstitial - pathology | Microtubule-Associated Proteins - genetics | Sequestosome-1 Protein | Humans | Lysosomes - genetics | Genetic Diseases, Inborn - genetics | Infant | rab GTP-Binding Proteins - genetics | Genetic Diseases, Inborn - pathology | Mutation, Missense | Mitochondria - ultrastructure | Lysosomes - metabolism | ATP-Binding Cassette Transporters - genetics | Mitochondria - genetics | HEK293 Cells | ATP-Binding Cassette Transporters - metabolism | Membrane Potential, Mitochondrial - genetics | Female | Genetic Diseases, Inborn - metabolism | Microfilament Proteins - genetics | Vacuoles - genetics | Gene Expression Regulation - genetics | Proteostasis Deficiencies - pathology | Pulmonary Surfactant-Associated Protein C - metabolism | Mitochondria - metabolism | Microtubule-Associated Proteins - biosynthesis | rab GTP-Binding Proteins - biosynthesis | Ubiquitin-Protein Ligases - biosynthesis | Lysosomes - ultrastructure | Autophagy-Related Protein 8 Family | Proteostasis Deficiencies - genetics | Microfilament Proteins - biosynthesis | Lung Diseases, Interstitial - genetics | Adaptor Proteins, Signal Transducing - genetics | Pulmonary Surfactant-Associated Protein C - genetics | Vacuoles - metabolism | Adaptor Proteins, Signal Transducing - biosynthesis | Ubiquitin-Protein Ligases - genetics | Amino Acid Substitution | Autophagy (Cytology) | Usage | Genetic aspects | Epithelium | Health aspects | Lung diseases | Call for Papers
Journal Article
Nature Medicine, ISSN 1078-8956, 12/2014, Volume 20, Issue 12, pp. 1410 - 1416
The protein cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of immune responses, and its loss causes fatal autoimmunity in mice.... 
PATHWAYS | MEDICINE, RESEARCH & EXPERIMENTAL | CLINICAL-PICTURE | HOMEOSTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | AUTOIMMUNITY | REGULATORY T-CELLS | GERMLINE MUTATIONS | MICE | BLOCKADE | IMMUNODEFICIENCY | ABATACEPT | Recurrence | Agammaglobulinemia - immunology | Agammaglobulinemia - genetics | Purpura, Thrombocytopenic, Idiopathic - genetics | Exons | Immune System Diseases - genetics | Humans | Middle Aged | Male | Anemia, Hemolytic, Autoimmune - genetics | Mutation, Missense | Respiratory Tract Infections - genetics | T-Lymphocytes, Regulatory - immunology | Autoimmune Diseases - genetics | Young Adult | Purpura, Thrombocytopenic, Idiopathic - immunology | Adult | Female | Endocytosis - genetics | Polyendocrinopathies, Autoimmune - genetics | Child | Endocytosis - immunology | Granuloma - genetics | Autoimmune Diseases - immunology | CTLA-4 Antigen - genetics | B7-1 Antigen - metabolism | Codon, Nonsense | CTLA-4 Antigen - immunology | Syndrome | Polyendocrinopathies, Autoimmune - immunology | Lung Diseases, Interstitial - immunology | Animals | B-Lymphocytes - immunology | Lung Diseases, Interstitial - genetics | Pedigree | Anemia, Hemolytic, Autoimmune - immunology | Adolescent | Respiratory Tract Infections - immunology | Granuloma - immunology | Heterozygote | Mice | Antigens | Gene mutations | Physiological aspects | Genetic aspects | Immunologic diseases | Research | Risk factors | Proteins | Homeostasis | Cytotoxicity | Ligands | T cell receptors | Mutation | Immune system
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 02/2015, Volume 191, Issue 4, pp. 417 - 426
Journal Article
Arthritis & Rheumatology, ISSN 2326-5191, 01/2016, Volume 68, Issue 1, pp. 210 - 217
Objective To examine whether lung endothelial cells (ECs) from patients with systemic sclerosis (SSc)–associated interstitial lung disease (ILD) express... 
PATHOGENESIS | FIBROSIS | TRANSITION CONTRIBUTES | ENDOMT | MYOFIBROBLAST | INDUCTION | RHEUMATOLOGY | FIBROBLASTS | MOLECULAR-MECHANISMS | Immunohistochemistry | Lung Diseases, Interstitial - etiology | Lung Diseases, Interstitial - pathology | Humans | Middle Aged | Transforming Growth Factor beta1 - metabolism | Actins - metabolism | Collagen Type III - metabolism | Scleroderma, Systemic - pathology | Male | Epithelial-Mesenchymal Transition - genetics | Actins - genetics | Neovascularization, Pathologic - pathology | Collagen Type I - genetics | Scleroderma, Systemic - complications | Adult | Female | Lung - metabolism | Nuclear Proteins - genetics | Snail Family Transcription Factors | Lung - pathology | Collagen Type I - metabolism | Endothelial Cells - metabolism | Scleroderma, Systemic - genetics | Nuclear Proteins - metabolism | Transforming Growth Factor beta1 - genetics | Collagen Type III - genetics | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Fibronectins - metabolism | Transcription Factors - metabolism | Microscopy, Confocal | Lung Diseases, Interstitial - genetics | Twist-Related Protein 1 - genetics | Neovascularization, Pathologic - genetics | Aged | Connective Tissue Growth Factor - genetics | Fibronectins - genetics | Twist-Related Protein 1 - metabolism | Connective Tissue Growth Factor - metabolism | Lungs | Microscopy | Growth factors | Lung diseases | Collagen
Journal Article
European Respiratory Journal, ISSN 0903-1936, 05/2017, Volume 49, Issue 5, pp. 1602314 - 1602314
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 08/2013, Volume 49, Issue 2, pp. 167 - 179
Interstitial lung fibrosis can develop as a consequence of occupational or medical exposure, as a result of genetic defects, and after trauma or acute lung... 
Aging | Cytokines | Fibroblast | Collagen | Fibrosis | SURFACTANT PROTEIN-C | GROWTH-FACTOR-RECEPTOR | FLUORESCEIN ISOTHIOCYANATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | collagen | NECROSIS-FACTOR-ALPHA | ENDOPLASMIC-RETICULUM STRESS | CELL BIOLOGY | MURINE MODEL | fibroblast | PROVIDE CLUES | EPITHELIAL-CELLS | INDUCED PULMONARY-FIBROSIS | RESPIRATORY SYSTEM | TRANSFORMING GROWTH-FACTOR-BETA-1 | fibrosis | cytokines | aging | Respiratory Distress Syndrome, Adult - pathology | Lung Diseases, Interstitial - metabolism | Epithelial Cells - metabolism | Respiratory Distress Syndrome, Adult - physiopathology | Lung Diseases, Interstitial - pathology | Humans | Genetic Diseases, Inborn - genetics | Pulmonary Fibrosis - genetics | Genetic Diseases, Inborn - pathology | Respiratory Distress Syndrome, Adult - metabolism | Respiratory Mucosa - pathology | Respiratory Distress Syndrome, Adult - genetics | Pulmonary Alveoli - metabolism | Respiratory Mucosa - physiopathology | Genetic Diseases, Inborn - metabolism | Pulmonary Fibrosis - metabolism | Lung Diseases, Interstitial - physiopathology | Pulmonary Alveoli - physiopathology | Disease Models, Animal | Pulmonary Alveoli - pathology | Cell Communication | Epithelial Cells - pathology | Pulmonary Fibrosis - pathology | Animals | Lung Diseases, Interstitial - genetics | Pulmonary Fibrosis - physiopathology | Genetic Diseases, Inborn - physiopathology | Respiratory Mucosa - metabolism | Translational Review
Journal Article