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JNCI : Journal of the National Cancer Institute, ISSN 0027-8874, 01/2018, Volume 110, Issue 1, pp. 109 - 120
Background: Cancer-associated fibroblasts (CAFs) are tumor-promoting and correlate with poor survival in many cancers, which has led to their emergence as... 
CELL LUNG-CANCER | PHASE-II TRIAL | OXIDATIVE STRESS | ONCOLOGY | NAB-PACLITAXEL | ACTIVATION PROTEIN | DEPENDENT INVASION | PANCREATIC-CANCER | MONOCLONAL-ANTIBODY | DIFFERENTIATION | STROMAL CELLS | Lung Neoplasms - drug therapy | Up-Regulation | Pyrazoles - therapeutic use | Reactive Oxygen Species - metabolism | Cell Count | Humans | Middle Aged | Male | Oropharyngeal Neoplasms - pathology | Head and Neck Neoplasms - chemistry | RNA Interference | Cancer-Associated Fibroblasts - chemistry | Aged, 80 and over | NADPH Oxidases - genetics | Adenocarcinoma - chemistry | Esophageal Neoplasms - chemistry | Lung Neoplasms - chemistry | NADPH Oxidases - antagonists & inhibitors | Head and Neck Neoplasms - drug therapy | Carcinoma, Squamous Cell - chemistry | Survival Rate | Adenocarcinoma - drug therapy | Disease Progression | Phenotype | Carcinoma, Squamous Cell - drug therapy | Head and Neck Neoplasms - genetics | Mice | Neoplasm Transplantation | Carcinoma, Non-Small-Cell Lung - chemistry | Carcinoma, Squamous Cell - genetics | Colorectal Neoplasms - chemistry | Cell Transdifferentiation - genetics | Myofibroblasts - chemistry | Actins - analysis | Cell Transdifferentiation - drug effects | Adult | Female | Adenocarcinoma - genetics | Cancer-Associated Fibroblasts - physiology | Pyridines - therapeutic use | Lung Neoplasms - genetics | Myofibroblasts - pathology | Carcinoma, Non-Small-Cell Lung - genetics | NADPH Oxidases - analysis | Mouth Neoplasms - chemistry | NADPH Oxidase 4 | Cancer-Associated Fibroblasts - pathology | Animals | Esophageal Neoplasms - genetics | Mouth Neoplasms - pathology | Oropharyngeal Neoplasms - chemistry | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Colorectal Neoplasms - pathology | Esophageal Neoplasms - drug therapy
Journal Article
Modern pathology, ISSN 1530-0285, 2011, Volume 24, Issue 12, pp. 1560 - 1570
Journal Article
European journal of cancer (1990), ISSN 0959-8049, 2016, Volume 68, pp. 156 - 162
Abstract Purpose To assess preliminary safety and efficacy results of the anti-programmed cell death ligand-1 (anti-PD-L1) durvalumab in combination with... 
Hematology, Oncology and Palliative Medicine | Immunoradiotherapy | Phase 2 | Phase 1 | Radiotherapy | Anti-PD-L1 | ABSCOPAL | ONCOLOGY | MECHANISMS | PATIENT | RADIATION-THERAPY | Lymphatic Metastasis - radiotherapy | Bone Neoplasms - therapy | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Carcinoma, Transitional Cell - secondary | Radiosurgery | Bone Neoplasms - secondary | Antibodies, Monoclonal - therapeutic use | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Carcinoma, Transitional Cell - therapy | Liver Neoplasms - therapy | Eye Neoplasms - therapy | Chemoradiotherapy | Small Cell Lung Carcinoma - secondary | Breast Neoplasms - therapy | Brain Neoplasms - secondary | Neoplasms - therapy | Squamous Cell Carcinoma of Head and Neck | Urinary Bladder Neoplasms - pathology | Aged, 80 and over | Adult | Female | Liver Neoplasms - secondary | Colonic Neoplasms - therapy | Eye Neoplasms - pathology | Head and Neck Neoplasms - therapy | Kaplan-Meier Estimate | Carcinoma, Squamous Cell - therapy | Survival Rate | Lung Neoplasms - therapy | Adenocarcinoma - secondary | Melanoma - secondary | Head and Neck Neoplasms - pathology | Disease-Free Survival | B7-H1 Antigen - antagonists & inhibitors | Adenocarcinoma - therapy | Breast Neoplasms - pathology | Colonic Neoplasms - pathology | Urinary Bladder Neoplasms - therapy | Brain Neoplasms - therapy | Radiotherapy, Conformal | Aged | Small Cell Lung Carcinoma - therapy | Melanoma - therapy | Biochemistry | Apoptosis
Journal Article
Nature communications, ISSN 2041-1723, 2015, Volume 6, Issue 1, p. 8839
Journal Article
Cochrane library, ISSN 1465-1858, 2009, Volume 2016, Issue 9, p. CD005004
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2011, Volume 331, Issue 6017, pp. 593 - 596
Satellite repeats in heterochromatin are transcribed into noncoding RNAs that have been linked to gene silencing and maintenance of chromosomal integrity.... 
Tumor cell line | Artificial satellites | RNA | Lungs | Genes | Liver | REPORTS | Cell lines | Pancreas | Tumors | Cancer | RNAS | ELEMENTS | DIFFERENTIATION | DATABASE | PERVASIVE TRANSCRIPTION | MULTIDISCIPLINARY SCIENCES | Colonic Neoplasms - genetics | RNA, Untranslated - metabolism | Humans | Ovarian Neoplasms - pathology | Lung Neoplasms - pathology | Male | Gene Expression Profiling | RNA, Neoplasm - metabolism | RNA, Untranslated - genetics | Heterochromatin - chemistry | Carcinoma, Pancreatic Ductal - genetics | Ovarian Neoplasms - genetics | DNA Methylation | Carcinoma in Situ - genetics | Prostatic Neoplasms - genetics | Neoplasms - genetics | Neurosecretory Systems - metabolism | Female | Transcription, Genetic | Lung Neoplasms - genetics | Prostatic Neoplasms - pathology | Gene Expression | Carcinoma in Situ - pathology | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - genetics | Carcinoma, Pancreatic Ductal - pathology | Animals | Heterochromatin - genetics | Long Interspersed Nucleotide Elements | Mice, Nude | Colonic Neoplasms - pathology | RNA, Neoplasm - genetics | DNA, Satellite - genetics | Mice | DNA, Neoplasm - genetics | Neoplasms - pathology | Epithelial cells | Analysis | Microsatellites (Genetics) | Genetic aspects | Gene expression | Health aspects | Biomarkers | Chromatin | Pancreatic cancer | Deoxyribonucleic acid--DNA
Journal Article
Nature (London), ISSN 1476-4687, 2013, Volume 497, Issue 7447, pp. 108 - 112
Cancers acquire resistance to systemic treatment as a result of clonal evolution and selection(1,2). Repeat biopsies to study genomic evolution as a result of... 
HETEROGENEITY | LUNG-CANCER | ACTIVATION | EVOLUTION | VARIANTS | AXL | MULTIDISCIPLINARY SCIENCES | TAMOXIFEN RESISTANCE | TUMOR-CELLS | MUTATIONS | Lung Neoplasms - drug therapy | Genomics | Humans | ErbB Receptors - genetics | Ovarian Neoplasms - pathology | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Ovarian Neoplasms - genetics | Neoplasms - genetics | DNA Mutational Analysis | Female | Antineoplastic Agents - pharmacology | DNA, Neoplasm - analysis | Ovarian Neoplasms - drug therapy | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Intercellular Signaling Peptides and Proteins - genetics | Breast Neoplasms - drug therapy | Genome, Human - genetics | Neoplasms - drug therapy | Phosphatidylinositol 3-Kinases - genetics | Drug Resistance, Neoplasm - genetics | Exome - genetics | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Breast Neoplasms - pathology | Retinoblastoma Protein - genetics | Plasma - chemistry | Alleles | Carcinoma, Non-Small-Cell Lung - drug therapy | DNA, Neoplasm - genetics | Neoplasms - pathology | Mediator Complex Subunit 1 - genetics | Drug Resistance, Neoplasm - drug effects | Evolution, Molecular | Antimitotic agents | Care and treatment | Physiological aspects | Dosage and administration | Genetic aspects | Research | Nucleotide sequencing | Drug resistance | Antineoplastic agents | DNA sequencing | Blood plasma | Cancer | Plasma | Biopsy | Breast cancer | Genomes | Mutation | Patients | Deoxyribonucleic acid--DNA | Tumors
Journal Article
Nature medicine, ISSN 1546-170X, 2015, Volume 21, Issue 11, pp. 1262 - 1271
Cancer-associated muscle weakness is a poorly understood phenomenon, and there is no effective treatment. Here we find that seven different mouse models of... 
MEDICINE, RESEARCH & EXPERIMENTAL | CANCER CACHEXIA | CELLS | INTRACELLULAR CALCIUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | RELEASE | CELL BIOLOGY | DYSTROPHIC MUSCLE | GROWTH-FACTOR-BETA | HORMONE-RELATED PROTEIN | RYANODINE RECEPTOR | CAMURATI-ENGELMANN-DISEASE | IN-VIVO | Neoplasms - metabolism | Prostatic Neoplasms - metabolism | Up-Regulation | Calcium - metabolism | Humans | Lung Neoplasms - metabolism | NADPH Oxidases - metabolism | Bone Neoplasms - secondary | Lung Neoplasms - pathology | Male | Muscle, Skeletal - metabolism | Osteolysis - etiology | Ryanodine Receptor Calcium Release Channel - metabolism | X-Ray Microtomography | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Neoplasms - complications | MCF-7 Cells | Osteolysis - diagnostic imaging | Muscle Proteins - metabolism | NADPH Oxidases - genetics | Female | Camurati-Engelmann Syndrome - metabolism | Muscle Strength | Calcium Signaling | Disease Models, Animal | Muscle Weakness - etiology | Prostatic Neoplasms - pathology | Oxidation-Reduction | Bone Neoplasms - diagnostic imaging | NADPH Oxidase 4 | Mice, SCID | Multiple Myeloma - metabolism | Absorptiometry, Photon | Osteolysis - metabolism | Multiple Myeloma - pathology | Animals | Muscle Contraction | Breast Neoplasms - pathology | Mice, Nude | Muscle Weakness - metabolism | Cell Line, Tumor | Mice | Neoplasms - pathology | Transforming Growth Factor beta - metabolism
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 3, p. e91811
Background: We aimed to evaluate the clinical significance of microvessel density (MVD), lymphatic vessel density (LVD), and cancer-associated fibroblasts... 
HETEROGENEITY | SURVIVAL | MULTIDISCIPLINARY SCIENCES | BREAST CARCINOMAS | PTEN | MICROVESSEL DENSITY | STROMA | MUTATIONS | LYMPHATIC VESSEL DENSITY | TUMOR-GROWTH | EXPRESSION | Prognosis | Lung Neoplasms - mortality | Colorectal Neoplasms - genetics | Humans | Middle Aged | Neovascularization, Pathologic | Microvessels - pathology | Male | Ovarian Neoplasms - mortality | Liver Neoplasms - mortality | Actins - genetics | Ovarian Neoplasms - genetics | Lymphatic Vessels - blood supply | Ovarian Neoplasms - secondary | Lung Neoplasms - secondary | Aged, 80 and over | Peritoneal Neoplasms - blood supply | Adult | Female | Ovarian Neoplasms - blood supply | Liver Neoplasms - secondary | Lung Neoplasms - blood supply | Peritoneal Neoplasms - secondary | Colorectal Neoplasms - mortality | Lung Neoplasms - genetics | PTEN Phosphohydrolase - genetics | Colorectal Neoplasms - blood supply | Liver Neoplasms - genetics | Lymphatic Metastasis | Fibroblasts - pathology | Peritoneal Neoplasms - mortality | Liver Neoplasms - blood supply | Peritoneal Neoplasms - genetics | Lymphatic Vessels - pathology | Survival Analysis | Desmin - genetics | Aged | Biomarkers, Tumor - genetics | Colorectal Neoplasms - pathology | Immunohistochemistry | Cancer patients | Care and treatment | Metastasis | Muscle proteins | Colorectal cancer | Liver | Colorectal carcinoma | Regional analysis | Muscles | Smooth muscle | Patients | Desmin | Lymph nodes | Metastases | Studies | Pathology | Heterogeneity | Lungs | Actin | Rodents | Fibroblasts | Microenvironments | Microvasculature | Mutation | PTEN protein | Cancer | Peritoneum
Journal Article
Modern pathology, ISSN 0893-3952, 09/2013, Volume 26, Issue 9, pp. 1197 - 1203
We previously demonstrated a high specificity of immunohistochemistry using epidermal growth factor receptor (EGFR) mutation-specific antibodies in lung... 
mutation-specific antibody | triple-negative breast cancer | immunohistochemistry | epidermal growth factor receptor | GENE-MUTATIONS | GEFITINIB | GROWTH-FACTOR-RECEPTOR | TYROSINE KINASE | PATHOLOGY | CANCER | TUMORS | SPECIMENS | INHIBITOR | EXPRESSION | AMERICAN-SOCIETY | Immunohistochemistry | Predictive Value of Tests | Mixed Tumor, Mullerian - genetics | Pancreatic Neoplasms - chemistry | Prognosis | Adenocarcinoma of Lung | Tissue Array Analysis | Uterine Neoplasms - pathology | Colorectal Neoplasms - genetics | Humans | Middle Aged | ErbB Receptors - genetics | Antibodies | Colorectal Neoplasms - chemistry | Male | False Positive Reactions | Triple Negative Breast Neoplasms - chemistry | Lung Neoplasms - secondary | DNA Mutational Analysis | Triple Negative Breast Neoplasms - pathology | Aged, 80 and over | Adult | Female | Adenocarcinoma - genetics | Mixed Tumor, Mullerian - chemistry | Adenocarcinoma - chemistry | Lung Neoplasms - genetics | Uterine Neoplasms - chemistry | Uterine Neoplasms - genetics | Lung Neoplasms - chemistry | Biomarkers, Tumor - analysis | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - genetics | Adenocarcinoma - secondary | Mixed Tumor, Mullerian - pathology | Triple Negative Breast Neoplasms - genetics | Biopsy | Aged | Biomarkers, Tumor - genetics | Mutation | Colorectal Neoplasms - pathology | ErbB Receptors - analysis | breast cancer | triple-negative
Journal Article