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Science, ISSN 0036-8075, 03/2016, Volume 351, Issue 6280, pp. 1463 - 1469
Journal Article
Science, ISSN 0036-8075, 07/2017, Volume 357, Issue 6349, pp. 409 - 413
The genomes of cancers deficient in mismatch repair contain exceptionally high numbers of somatic mutations. In a proof-of-concept study, we previously showed... 
CELL LUNG-CANCER | SURVIVAL | COLORECTAL CARCINOMAS | RECEIVING NIVOLUMAB | IMMUNOTHERAPY | MICROSATELLITE INSTABILITY | MULTIDISCIPLINARY SCIENCES | LONG-TERM SAFETY | NEOANTIGENS | CHECKPOINT BLOCKADE | LYMPHOCYTES | Neoplastic Syndromes, Hereditary - immunology | Colorectal Neoplasms - genetics | Humans | Middle Aged | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Neoplastic Syndromes, Hereditary - mortality | Young Adult | Colorectal Neoplasms - therapy | Brain Neoplasms - immunology | DNA Mismatch Repair | Aged, 80 and over | Adult | Female | Neoplastic Syndromes, Hereditary - genetics | Brain Neoplasms - mortality | Biomarkers, Tumor - antagonists & inhibitors | Colorectal Neoplasms - mortality | Antibodies, Monoclonal, Humanized - therapeutic use | Antigens, Neoplasm - immunology | Brain Neoplasms - genetics | Disease-Free Survival | Colorectal Neoplasms - immunology | Cell Cycle Checkpoints - drug effects | Brain Neoplasms - therapy | Neoplastic Syndromes, Hereditary - therapy | T-Lymphocytes - immunology | Aged | Mutation | Programmed Cell Death 1 Receptor - immunology | Colorectal cancer | Genetic aspects | Nucleotide sequencing | Health aspects | DNA repair | Methods | Tumors | DNA sequencing | Yeast | PD-1 protein | Antibodies | Clinical trials | Genomes | Functional analysis | Lymphocytes T | Patients | Survival | Colon cancer | Immune checkpoint | Immunotherapy | Mismatch repair | Pancreatic cancer | Biomarkers | Bioindicators | Colon | Solid tumors | Genetic recombination | Repair | Cancer | Apoptosis | Index Medicus
Journal Article
Cancer Discovery, ISSN 2159-8274, 06/2011, Volume 1, Issue 1, pp. 54 - 67
Immune-regulated pathways influence multiple aspects of cancer development. In this article we demonstrate that both macrophage abundance and T-cell abundance... 
CELL LUNG-CANCER | MAMMARY-TUMORS | COLONY-STIMULATING FACTOR | ONCOLOGY | ANGIOGENIC SWITCH | MOUSE MODEL | RECEPTOR EXPRESSION | TUMOR-ASSOCIATED MACROPHAGES | SUPPRESSOR-CELLS | MYELOID CELLS | ENDOTHELIAL GROWTH-FACTOR | Mammary Neoplasms, Experimental - immunology | Lung Neoplasms - drug therapy | Receptor, Macrophage Colony-Stimulating Factor - immunology | Epithelial Cells - metabolism | Paclitaxel - pharmacology | Prognosis | Follow-Up Studies | Breast Neoplasms - immunology | Epithelial Cells - drug effects | Humans | Lung Neoplasms - metabolism | Mammary Neoplasms, Experimental - metabolism | Receptor, Macrophage Colony-Stimulating Factor - metabolism | Breast Neoplasms - metabolism | Leukocytes - immunology | Signal Transduction - immunology | Neoplasm Metastasis | Lung Neoplasms - secondary | CD8-Positive T-Lymphocytes - metabolism | Female | Macrophages - immunology | Mammary Neoplasms, Experimental - drug therapy | Survival Rate | Macrophage Colony-Stimulating Factor - metabolism | Breast Neoplasms - drug therapy | Macrophage Colony-Stimulating Factor - immunology | Tumor Microenvironment - immunology | Disease-Free Survival | Lung Neoplasms - immunology | Macrophages - metabolism | Animals | Signal Transduction - drug effects | CD8-Positive T-Lymphocytes - drug effects | Epithelial Cells - immunology | Leukocytes - drug effects | Macrophages - drug effects | Aged | Mice | CD8-Positive T-Lymphocytes - immunology | Leukocytes - metabolism | Cohort Studies | Index Medicus
Journal Article
British Journal of Cancer, ISSN 0007-0920, 03/2015, Volume 112, Issue 6, pp. 1067 - 1075
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2017, Volume 127, Issue 8, pp. 2930 - 2940
Programmed death-1-directed (PD-1-directed) immune checkpoint blockade results in durable antitumor activity in many advanced malignancies. Recent studies... 
CELL LUNG-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | MELANOMA | PEMBROLIZUMAB | LIGANDS | IMMUNOTHERAPY | SAFETY | TOLERANCE | ADAPTIVE IMMUNE RESISTANCE | EXPRESSION | Immunohistochemistry | Lung Neoplasms - drug therapy | Skin Neoplasms - drug therapy | Humans | Gene Expression Regulation, Neoplastic | Tumor Microenvironment | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Gene Expression Profiling | Interferon-gamma - metabolism | Immune System | Carcinoma - drug therapy | Antibodies, Monoclonal, Humanized - therapeutic use | Signal Transduction | Skin Neoplasms - immunology | Carcinoma - immunology | Programmed Cell Death 1 Receptor - metabolism | Treatment Outcome | Stomach Neoplasms - drug therapy | Stomach Neoplasms - immunology | Carcinoma, Non-Small-Cell Lung - immunology | B7-H1 Antigen - metabolism | Lung Neoplasms - immunology | Pilot Projects | Sequence Analysis, RNA | Biopsy | Melanoma - immunology | Melanoma - drug therapy | ROC Curve | Carcinoma, Non-Small-Cell Lung - drug therapy | PD-1 protein | Lung cancer | Clinical trials | Cytotoxicity | Biology | Lymphocytes T | Cancer therapies | Metastases | Lymphocytes | Neck | Adaptation | Antigen presentation | Squamous cell carcinoma | Cytokines | Melanoma | Inflammation | Gene expression | Immune checkpoint | PD-L1 protein | Head and neck cancer | Antitumor activity | Ligands | Interferon | Chemokines | Apoptosis | Tumors | Index Medicus | Abridged Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 04/2011, Volume 71, Issue 7, pp. 2600 - 2610
Journal Article
AIDS, ISSN 0269-9370, 08/2006, Volume 20, Issue 12, pp. 1645 - 1654
Background: People with AIDS have heightened cancer risk from immunosuppression. HAART has been available since 1996 and has reduced AIDS-related mortality,... 
AIDS | United States | Cancer risk | HAART | MORTALITY | INFECTIOUS DISEASES | IMMUNODEFICIENCY-VIRUS-INFECTION | INITIATION | ADULTS | HUMAN-PAPILLOMAVIRUS | PREVALENCE | IMMUNOLOGY | EUROPE | LUNG-CANCER | VIROLOGY | ACTIVE ANTIRETROVIRAL THERAPY | SWISS HIV COHORT | cancer risk | Lymphoma, Non-Hodgkin - immunology | United States - epidemiology | Age Distribution | Kidney Neoplasms - epidemiology | Sarcoma, Kaposi - complications | Humans | Middle Aged | Uterine Cervical Neoplasms - epidemiology | Antiretroviral Therapy, Highly Active - adverse effects | Kidney Neoplasms - immunology | Male | Incidence | Neoplasms - complications | Lymphoma, Non-Hodgkin - complications | Adult | Female | Sarcoma, Kaposi - immunology | Kidney Neoplasms - complications | Sarcoma, Kaposi - epidemiology | Risk Factors | Uterine Cervical Neoplasms - immunology | Hodgkin Disease - epidemiology | Hodgkin Disease - complications | Lymphoma, Non-Hodgkin - epidemiology | Lung Neoplasms - complications | Lung Neoplasms - immunology | Lung Neoplasms - epidemiology | Neoplasms - immunology | Uterine Cervical Neoplasms - complications | Adolescent | Acquired Immunodeficiency Syndrome - epidemiology | Sex Distribution | Hodgkin Disease - immunology | Acquired Immunodeficiency Syndrome - complications | Neoplasms - epidemiology | Index Medicus | AIDS/HIV
Journal Article
Journal Article
Science Translational Medicine, ISSN 1946-6234, 11/2014, Volume 6, Issue 261, pp. 261ra151 - 261ra151
Translating the recent success of chimeric antigen receptor (CAR) T cell therapy for hematological malignancies to solid tumors will necessitate overcoming... 
MEDICINE, RESEARCH & EXPERIMENTAL | LOCALIZATION | OVEREXPRESSION | CHIMERIC ANTIGEN RECEPTORS | ADENOCARCINOMAS | HIGH-AFFINITY | MONOCLONAL-ANTIBODY | ANTITUMOR-ACTIVITY | EXPRESSION | CANCER | LYMPHOCYTES | CELL BIOLOGY | Mesothelioma - immunology | Pleural Neoplasms - genetics | Cell Proliferation | Mesothelioma - pathology | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Receptors, Antigen, T-Cell - biosynthesis | CD4-Positive T-Lymphocytes - immunology | Pleural Neoplasms - metabolism | Time Factors | HEK293 Cells | Female | Lymphocytes, Tumor-Infiltrating - metabolism | Receptors, Antigen, T-Cell - immunology | Cell Differentiation | Pleural Neoplasms - pathology | Lung Neoplasms - genetics | Immunotherapy, Adoptive - methods | Mesothelioma - therapy | Pleural Neoplasms - immunology | Transduction, Genetic | Lymphocyte Activation | CD4-Positive T-Lymphocytes - metabolism | Lymphocytes, Tumor-Infiltrating - transplantation | Lung Neoplasms - therapy | Mesothelioma - genetics | Mice, SCID | Pleural Neoplasms - therapy | GPI-Linked Proteins - metabolism | Xenograft Model Antitumor Assays | Lung Neoplasms - immunology | Animals | Mesothelioma - metabolism | CD4-Positive T-Lymphocytes - transplantation | Cell Line, Tumor | Mice, Inbred NOD | Receptors, Antigen, T-Cell - genetics | Chimerism | Cytotoxicity, Immunologic | Genetic Therapy - methods | Lymphocytes, Tumor-Infiltrating - immunology | Index Medicus
Journal Article