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1. Full Text The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
by Lee A. Honigberg and Ashley M. Smith and Mint Sirisawad and Erik Verner and David Loury and Betty Chang and Shyr Li and Zhengying Pan and Douglas H. Thamm and Richard A. Miller and Joseph J. Buggy and Ronald Levy
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2010, Volume 107, Issue 29, pp. 13075 - 13080
Activation of the B-cell antigen receptor (BCR) signaling pathway contributes to the initiation and maintenance of B-cell malignancies and autoimmune diseases.... 
T lymphocytes | Animal models | Disease models | Gels | B lymphocytes | B cell lymphoma | Arthritis | Mice | Autoimmune diseases | Tumors | X-linked agammaglobulinemia | Lymphoma | COLLAGEN-INDUCED ARTHRITIS | THERAPY | RITUXIMAB | MULTIDISCIPLINARY SCIENCES | lymphoma | DOGS | FAMILY KINASES | BTK | RECEPTOR | DEPLETION | MICE | Arthritis, Experimental - drug therapy | Pyrazoles - therapeutic use | Humans | Benzofurans - administration & dosage | Benzofurans - pharmacology | Autoantibodies - biosynthesis | Pyrimidines - chemistry | Benzofurans - chemistry | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Lymphoma, B-Cell - enzymology | Autoimmune Diseases - drug therapy | Disease Models, Animal | Lymphoma, B-Cell - drug therapy | Pyrazoles - pharmacology | B-Lymphocytes - enzymology | Benzofurans - therapeutic use | Autoimmune Diseases - enzymology | Administration, Oral | Pyrimidines - administration & dosage | Treatment Outcome | Pyrimidines - pharmacology | Receptors, Antigen, B-Cell - immunology | B-Lymphocytes - drug effects | Protein Kinase Inhibitors - administration & dosage | Pyrazoles - administration & dosage | Animals | B-Lymphocytes - immunology | Signal Transduction - drug effects | Lymphocyte Activation - drug effects | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Dogs | Protein Kinase Inhibitors - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors | Tyrosine | Cell receptors | Models | Lymphomas | Research | Properties | Antigens | Biochemistry | Mutation | Kinases | Cells | Cancer | Index Medicus | Biological Sciences
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2. Full Text Tolerance and short term efficacy of rituximab in 43 patients with systemic autoimmune diseases
by Gottenberg, J-E and Guillevin, L and Lambotte, O and Combe, B and Allanore, Y and Cantagrel, A and Larroche, C and Soubrier, M and Bouillet, L and Dougados, M and Fain, O and Farge, D and Kyndt, X and Lortholary, O and Masson, C and Moura, B and Remy, P and Thomas, T and Wendling, D and Anaya, J-M and Sibilia, J and Mariette, X and CRI and Club Rheumatismes et Inflammation (CRI)
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2005, Volume 64, Issue 6, pp. 913 - 920
Objective: To assess the tolerance and efficacy of rituximab in patients with various autoimmune diseases seen in daily rheumatological practice. Methods: 866... 
RHEUMATOID-ARTHRITIS | CELLS | THERAPY | MONOCLONAL-ANTIBODY RITUXIMAB | B-LYMPHOCYTE DEPLETION | ANTI-CD20 | LUPUS-ERYTHEMATOSUS | SERUM SICKNESS | RHEUMATOLOGY | Glucocorticoids - administration & dosage | Rheumatic Diseases - drug therapy | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Antibodies, Monoclonal - therapeutic use | Male | Arthritis, Rheumatoid - drug therapy | Lupus Erythematosus, Systemic - drug therapy | Aged, 80 and over | Antirheumatic Agents - adverse effects | Adult | Female | Retrospective Studies | Drug Therapy, Combination | Autoimmune Diseases - drug therapy | Antirheumatic Agents - therapeutic use | Antibodies, Monoclonal, Murine-Derived | Drug Administration Schedule | Sjogren's Syndrome - drug therapy | Rituximab | Treatment Outcome | Vasculitis - drug therapy | Aged | Immunologic Factors - adverse effects | Immunologic Factors - therapeutic use | Disease | Sarcoidosis | Internal medicine | Rheumatoid arthritis | Rheumatology | Tumor necrosis factor-TNF | Lymphomas | Autoimmune diseases | Drug dosages | Index Medicus | Extended Report
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3. Full Text In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology
by Tsai, Michelle and Kita, Ashley and Leach, Joseph and Rounsevell, Ross and Huang, James N and Moake, Joel and Ware, Russell E and Fletcher, Daniel A and Lam, Wilbur A
Journal of Clinical Investigation, ISSN 0021-9738, 01/2012, Volume 122, Issue 1, pp. 408 - 418
In hematologic diseases, such as sickle cell disease (SCD) and hemolytic uremic syndrome (HUS), pathological biophysical interactions among blood cells,... 
MEDICINE, RESEARCH & EXPERIMENTAL | ADHESION | HEMOLYTIC-UREMIC SYNDROME | PLATELET-AGGREGATION | ENDOTHELIAL-CELLS | SHEAR-STRESS | HYDROXYUREA THERAPY | MECHANISMS | SICKLE-CELL-DISEASE | VASCULAR ENDOTHELIUM | FLOW | Anemia, Sickle Cell - pathology | Human Umbilical Vein Endothelial Cells | Hematologic Diseases - pathology | Hydroxyurea - pharmacology | Microvessels - physiopathology | Anemia, Sickle Cell - physiopathology | Humans | Hemolytic-Uremic Syndrome - blood | Hematologic Diseases - drug therapy | Microvessels - pathology | Anemia, Sickle Cell - drug therapy | Hemorheology | Hemolytic-Uremic Syndrome - pathology | Hemolytic-Uremic Syndrome - physiopathology | Platelet Aggregation Inhibitors - pharmacology | Microfluidic Analytical Techniques | Thrombosis - physiopathology | Models, Cardiovascular | Microvessels - drug effects | Peptides - pharmacology | Thrombosis - pathology | Hematologic Diseases - physiopathology | Hematologic Diseases - etiology | Thrombosis - etiology | Thrombosis - drug therapy | Anemia, Sickle Cell - blood | In Vitro Techniques | Microscopy, Fluorescence | Hemolytic-Uremic Syndrome - drug therapy | Complications and side effects | Blood circulation disorders | Research | Blood diseases | Microfluidics | Risk factors | Index Medicus | Abridged Index Medicus | Technical Advance
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4. Full Text Modern Radiation Therapy for Hodgkin Lymphoma: Field and Dose Guidelines From the International Lymphoma Radiation Oncology Group (ILROG)
by Specht, Lena, MD, PhD and Yahalom, Joachim, MD and Illidge, Tim, MD, PhD and Berthelsen, Anne Kiil, MD and Constine, Louis S., MD and Eich, Hans Theodor, MD, PhD and Girinsky, Theodore, MD and Hoppe, Richard T., MD and Mauch, Peter, MD and Mikhaeel, N. George, MD and Ng, Andrea, MD, MPH and ILROG
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2014, Volume 89, Issue 4, pp. 854 - 862
Radiation therapy (RT) is the most effective single modality for local control of Hodgkin lymphoma (HL) and an important component of therapy for many... 
Radiology | Hematology, Oncology and Palliative Medicine | ONCOLOGY | INTENSITY-MODULATED RADIOTHERAPY | COMBINED-MODALITY TREATMENT | DISEASE | RETROSPECTIVE ANALYSIS | INVOLVED-NODE RADIOTHERAPY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | CHEMOTHERAPY | Radiotherapy Dosage | Organs at Risk - radiation effects | Lymph Nodes - pathology | Hodgkin Disease - pathology | Radiotherapy Planning, Computer-Assisted - methods | Humans | Hodgkin Disease - diagnosis | Radiotherapy, Image-Guided | Tumor Burden | Hodgkin Disease - radiotherapy | Radiation Injuries - prevention & control | Multimodal Imaging - methods | Hodgkin Disease - drug therapy | Lymphatic Irradiation - methods | Radiotherapy, Intensity-Modulated | Antimitotic agents | Care and treatment | Nuclear radiation | Lymphomas | Radiotherapy | Antineoplastic agents | Cancer | Index Medicus | REVIEWS | PATIENTS | NMR IMAGING | BIOMEDICAL RADIOGRAPHY | RECOMMENDATIONS | POSITRON COMPUTED TOMOGRAPHY | RADIOLOGY AND NUCLEAR MEDICINE | HODGKINS DISEASE | RADIOTHERAPY | ICRU | PLANNING
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5. Full Text Estimated risk of cardiovascular disease and secondary cancers with modern highly conformal radiotherapy for early-stage mediastinal Hodgkin lymphoma
by Maraldo, M.V and Brodin, N.P and Aznar, M.C and Vogelius, I.R and Munck af Rosenschöld, P and Petersen, P.M and Specht, L
Annals of Oncology, ISSN 0923-7534, 08/2013, Volume 24, Issue 8, pp. 2113 - 2118
Hodgkin lymphoma (HL) survivors have an increased morbidity and mortality from secondary cancers and cardiovascular disease (CD). We evaluate doses with... 
Cardiovascular disease | Secondary cancers | Highly conformal radiotherapy | Involved node radiotherapy | Hodgkin lymphoma | SURVIVAL | cardiovascular disease | highly conformal radiotherapy | involved node radiotherapy | FIELD | INTENSITY-MODULATED RADIOTHERAPY | INVOLVED-NODE RADIOTHERAPY | CHEMOTHERAPY | BREAST-CANCER | HEART | secondary cancers | THERAPY | ONCOLOGY | RADIATION TREATMENT | Organs at Risk - radiation effects | Humans | Middle Aged | Male | Risk | Young Adult | Hodgkin Disease - radiotherapy | Cardiovascular Diseases - complications | Mediastinal Neoplasms - drug therapy | Radiation Injuries | Heart - radiation effects | Cardiovascular Diseases - epidemiology | Hodgkin Disease - drug therapy | Adult | Female | Lung - radiation effects | Radiotherapy Planning, Computer-Assisted | Breast - radiation effects | Radiotherapy Dosage | Lymphatic Irradiation | Neoplasms, Second Primary - epidemiology | Mediastinal Neoplasms - radiotherapy | Adolescent | Radiotherapy, Conformal - adverse effects | Aged | Radiotherapy, Intensity-Modulated | Index Medicus
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6. Full Text Diagnostic and risk criteria for HSCT-associated thrombotic microangiopathy: A study in children and young adults
by Jodele, Sonata and Davies, Stella M and Lane, Adam and Khoury, Jane and Dandoy, Christopher and Goebel, Jens and Myers, Kasiani and Grimley, Michael and Bleesing, Jack and El-Bietar, Javier and Wallace, Gregory and Chima, Ranjit S and Paff, Zachary and Laskin, Benjamin L
Blood, ISSN 0006-4971, 07/2014, Volume 124, Issue 4, pp. 645 - 653
Transplant-associated thrombotic microangiopathy (TMA) leads to generalized endothelial dysfunction that can progress to multiorgan injury, and severe cases... 
ECULIZUMAB | COMPLEMENT | THERAPY | RENAL PATHOLOGY | INJURY | HAPTOGLOBIN | STEM-CELL TRANSPLANTATION | CHRONIC KIDNEY-DISEASE | HYPERTENSION | HEMATOLOGY | SURVIVORS | Prognosis | Prospective Studies | Follow-Up Studies | Humans | Immunosuppressive Agents - therapeutic use | Risk Factors | Child, Preschool | Thrombotic Microangiopathies - mortality | Male | Survival Rate | Transplantation, Homologous | Young Adult | Graft vs Host Disease - drug therapy | Graft vs Host Disease - mortality | Adolescent | Hematopoietic Stem Cell Transplantation - adverse effects | Adult | Female | Thrombotic Microangiopathies - diagnosis | Thrombotic Microangiopathies - etiology | Child | Graft vs Host Disease - diagnosis | Graft vs Host Disease - etiology | Thrombotic Microangiopathies - drug therapy | Index Medicus | Abridged Index Medicus | 100 | Transplantation
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7. Full Text Derivatives of Erythropoietin That Are Tissue Protective but Not Erythropoietic
by Marcel Leist and Pietro Ghezzi and Giovanni Grasso and Roberto Bianchi and Pia Villa and Maddalena Fratelli and Costanza Savino and Marina Bianchi and Jacob Nielsen and Jens Gerwien and Pekka Kallunki and Anna Kirstine Larsen and Lone Helboe and Søren Christensen and Lars O. Pedersen and Mette Nielsen and Lars Torup and Thomas Sager and Alessandra Sfacteria and Serhat Erbayraktar and Zubeyde Erbayraktar and Necati Gokmen and Osman Yilmaz and Carla Cerami-Hand and Qiao-wen Xie and Thomas Coleman and Anthony Cerami and Michael Brines
Science, ISSN 0036-8075, 7/2004, Volume 305, Issue 5681, pp. 239 - 242
Erythropoietin (EPO) is both hematopoietic and tissue protective, putatively through interaction with different receptors. We generated receptor... 
Erythropoiesis | Receptors | Diabetic neuropathies | Animals | Cytokines | Neurons | Reports | Cerebrospinal fluid | Epics | Hemoglobins | Blood plasma | INVITRO | MULTIDISCIPLINARY SCIENCES | BIOLOGICAL-ACTIVITY | IN-VIVO | NEURONS | RECEPTOR | NEUROPROTECTION | Erythropoietin - pharmacology | Neuroprotective Agents - therapeutic use | Erythropoietin - therapeutic use | Humans | Hematocrit | Structure-Activity Relationship | Recombinant Proteins | Neuroprotective Agents - metabolism | Erythropoietin - analogs & derivatives | Neuroprotective Agents - pharmacology | Drug Design | Female | Neurons - metabolism | Erythropoietin - metabolism | Binding Sites | Neuroprotective Agents - chemistry | Signal Transduction | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Cells, Cultured | Nervous System Diseases - drug therapy | Rats | Diabetic Neuropathies - drug therapy | Erythropoietin - chemistry | Stroke - drug therapy | Rats, Sprague-Dawley | Mice, Inbred C3H | Erythropoietin - genetics | Mutagenesis | Spinal Cord Compression - drug therapy | Ligands | Mice | Receptors, Erythropoietin - metabolism | Apoptosis | Erythropoietin | Physiological aspects | Research | Proteins | Tissue | Neurology | Cellular biology | Index Medicus
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8. Full Text Elimination and Eradication of Neglected Tropical Diseases with Mass Drug Administrations: A Survey of Experts
by Keenan, Jeremy D and Hotez, Peter J and Amza, Abdou and Stoller, Nicole E and Gaynor, Bruce D and Porco, Travis C and Lietman, Thomas M
PLoS Neglected Tropical Diseases, ISSN 1935-2727, 2013, Volume 7, Issue 12, pp. e2562 - e2562
Background Lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminths, and trachoma are the five most prevalent neglected tropical... 
AFRICA | BANCROFTIAN FILARIASIS | COMMUNITY | HELMINTH INFECTIONS | CHLAMYDIA-TRACHOMATIS | IVERMECTIN | ANTIBIOTIC DISTRIBUTIONS | AZITHROMYCIN | PARASITOLOGY | TROPICAL MEDICINE | CLUSTER-RANDOMIZED TRIAL | ONCHOCERCIASIS | Trachoma - drug therapy | Humans | Child, Preschool | Parasitic Diseases - drug therapy | Infant | Male | Neglected Diseases - drug therapy | Data Collection | Disease Eradication - methods | Anti-Bacterial Agents - therapeutic use | Antiparasitic Agents - therapeutic use | Drug Therapy - methods | Adolescent | Female | Child | Prevention | Disease transmission | Research | Tropical diseases | Infection control | Index Medicus | Studies | Fatalities | Lymphatic system | Medical malpractice | Medical errors
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9. Full Text VEGF-C-dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease
by D'Alessio, Silvia and Correale, Carmen and Tacconi, Carlotta and Gandelli, Alessandro and Pietrogrande, Giovanni and Vetrano, Stefania and Genua, Marco and Arena, Vincenzo and Spinelli, Antonino and Peyrin-Biroulet, Laurent and Fiocchi, Claudio and Danese, Silvio
Journal of Clinical Investigation, ISSN 0021-9738, 09/2014, Volume 124, Issue 9, pp. 3863 - 3878
Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBDs) of unknown etiology that are associated with an aberrant... 
MEDICINE, RESEARCH & EXPERIMENTAL | RESOLUTION-PHASE MACROPHAGES | CROHNS-DISEASE | VESSEL DENSITY | DSS-INDUCED COLITIS | SECONDARY LYMPHEDEMA | GROWTH FACTOR-C | INTERLEUKIN-10-DEFICIENT MICE | UP-REGULATION | ALTERNATIVE ACTIVATION | TRANSGENIC MICE | Inflammatory Bowel Diseases - drug therapy | Macrophages - physiology | Vascular Endothelial Growth Factor C - physiology | Lymphatic Vessels - physiology | Signal Transduction | Humans | Inflammatory Bowel Diseases - immunology | Mice, Inbred C57BL | Lymphangiogenesis - physiology | Colon - immunology | Male | Macrophage Activation | Animals | Female | Mice | Inflammatory Bowel Diseases - etiology | Vascular Endothelial Growth Factor Receptor-3 - physiology | Disease Models, Animal | Development and progression | Inflammatory bowel diseases | Vascular endothelial growth factor | Health aspects | Inflammatory bowel disease | Medical research | Lymphatic system | Cytokines | Index Medicus | Abridged Index Medicus | Life Sciences
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10. Full Text Upon entering an age of global ivermectin-based integrated mass drug administration for neglected tropical diseases and malaria
by Richards, Frank O
Malaria Journal, ISSN 1475-2875, 04/2017, Volume 16, Issue 1, pp. 168 - 168
Ivermectin mass drug administration (MDA) in humans to reduce malaria vectors is yet another use for this remarkable medicine whose discoverers shared the 2015... 
Ivermectin - therapeutic use | Humans | Neglected Diseases - drug therapy | Antimalarials - therapeutic use | Malaria - drug therapy | Mass Drug Administration | Tropical Medicine | Vector-borne diseases | Drugs | Human diseases | Malaria | Transmission | Artemisinin | Vectors | Progress reports | Tropical diseases | Diseases | Medicine | Chemotherapy | Disease transmission | Parasitic diseases | Tropical environment | Public health | Ivermectin | Index Medicus | Albendazole | Lymphatic Filariasis
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11. Full Text Ibrutinib treatment ameliorates murine chronic graft-versus-host disease
by Dubovsky, Jason A and Flynn, Ryan and Du, Jing and Harrington, Bonnie K and Zhong, Yiming and Kaffenberger, Benjamin and Yang, Carrie and Towns, William H and Lehman, Amy and Johnson, Amy J and Muthusamy, Natarajan and Devine, Steven M and Jaglowski, Samantha and Serody, Jonathan S and Murphy, William J and Munn, David H and Luznik, Leo and Hill, Geoffrey R and Wong, Henry K and MacDonald, Kelli K.P and Maillard, Ivan and Koreth, John and Elias, Laurence and Cutler, Corey and Soiffer, Robert J and Antin, Joseph H and Ritz, Jerome and Panoskaltsis-Mortari, Angela and Byrd, John C and Blazar, Bruce R
Journal of Clinical Investigation, ISSN 0021-9738, 11/2014, Volume 124, Issue 11, pp. 4867 - 4876
Chronic graft-versus-host disease (cGVHD) is a life-threatening impediment to allogeneic hematopoietic stem cell transplantation, and current therapies do not... 
BRONCHIOLITIS OBLITERANS | MEDICINE, RESEARCH & EXPERIMENTAL | ITK | BRUTONS TYROSINE KINASE | CHRONIC GVHD | BONE-MARROW | EXTRACORPOREAL PHOTOPHERESIS | THERAPEUTIC TARGET | CD4(+) T-CELLS | CHRONIC LYMPHOCYTIC-LEUKEMIA | MICE LACKING | Pyrazoles - therapeutic use | Mice, Inbred C57BL | Pyrimidines - pharmacology | Disease-Free Survival | Animals | Graft vs Host Disease - drug therapy | Lymphocyte Activation - drug effects | Pyrimidines - therapeutic use | Hematopoietic Stem Cell Transplantation - adverse effects | Drug Evaluation, Preclinical | Immunologic Factors - pharmacology | Immunologic Factors - therapeutic use | Pyrazoles - pharmacology | Physiological aspects | Graft versus host reaction | Research | Drug therapy | T cells | Studies | Skin | Kinases | Lymphocytes | Immune system | Index Medicus | Abridged Index Medicus
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12. Full Text Erythropoietin deficiency decreases vascular stability in mice
by Chen, Jing and Connor, Kip M and Aderman, Christopher M and Smith, Lois E. H
Journal of Clinical Investigation, ISSN 0021-9738, 02/2008, Volume 118, Issue 2, pp. 526 - 533
Erythropoietin (Epo), a hormone known to stimulate bone marrow erythrocyte production, is widely used to treat anemia in patients at risk for vascular disease.... 
Retina - drug effects | Erythropoietin - administration & dosage | Oxygen - toxicity | Apoptosis - drug effects | Retinal Diseases - chemically induced | NF-kappa B - metabolism | Retinal Vessels - drug effects | Erythropoietin - physiology | Retinal Vessels - pathology | Erythropoietin - genetics | Animals | Retinal Vessels - growth & development | Receptors, Erythropoietin - agonists | Retinal Diseases - pathology | Stem Cells - drug effects | Hypoxia | Neovascularization, Pathologic - genetics | Neovascularization, Pathologic - prevention & control | Mice | Retinal Diseases - drug therapy | Neurons - drug effects | Retina - pathology | Polymerase chain reaction | Usage | Erythropoietin | Physiological aspects | Neovascularization | Research | Health aspects | Index Medicus | Abridged Index Medicus
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