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2005, Current topics in microbiology and immunology, ISBN 3540252797, Volume 294., vi, 189
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world. It is also the prototype of B-cell chronic lymphoid malignancies and of... 
Lymphocytic leukemia | Hematology | Cancer Research | Biomedicine
Book
Journal Article
2011, 1. Aufl., ISBN 9781444393996, xxi, 416
This comprehensive book captures and compiles new and current information on hematologic malignancies. New knowledge of cellular disease processes, molecular... 
Leukemia, Lymphoid | Leukemia, Myeloid | Leukemia | therapy | Lymphomas | metabolism | Myelodysplastic syndromes
Book
Journal Article
International Journal of Hematology, ISSN 0925-5710, 12/2017, Volume 106, Issue 6, pp. 732 - 747
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s12185-017-2350-x Byline:... 
Medicine & Public Health | Hematology | Oncology | ADULTS | HEMATOLOGY | ACUTE LYMPHOCYTIC-LEUKEMIA | Medical colleges | Leukemia | Acute lymphatic leukemia | Lymphatic leukemia | Lymphoid tissue | Tissues | Lymphoma | Tumors | Hemopoiesis | Index Medicus
Journal Article
1999, Basic and clinical oncology, ISBN 9780824799014, Volume 16., xi, 442
Book
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2670 - 12
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2016, Volume 126, Issue 10, pp. 3961 - 3980
lmatinib-insensitive leukemia stem cells (LSCs) are believed to be responsible for resistance to BCR-ABL tyrosine kinase inhibitors and relapse of chronic... 
PROGENITOR CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | TYROSINE KINASE | SYMMETRIC DIMETHYLATION | PHILADELPHIA-CHROMOSOME | ARGININE METHYLTRANSFERASE | BONE-MARROW | BETA-CATENIN | IMATINIB MESYLATE | CHRONIC MYELOID-LEUKEMIA | ONCOGENE ADDICTION | RNA, Small Interfering - genetics | Cell Proliferation | Neoplastic Stem Cells - drug effects | Humans | Gene Expression Regulation, Neoplastic | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Protein-Arginine N-Methyltransferases - antagonists & inhibitors | Molecular Targeted Therapy | Gene Knockdown Techniques | STAT5 Transcription Factor - metabolism | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | 1-Naphthylamine - pharmacology | HEK293 Cells | Female | Antineoplastic Agents - pharmacology | Protein-Arginine N-Methyltransferases - genetics | Aminoquinolines - pharmacology | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Gene Expression | Cell Survival | Imatinib Mesylate - pharmacology | Mice, Inbred C57BL | Enzyme Induction | Pyrimidines - pharmacology | Mice, SCID | Protein-Arginine N-Methyltransferases - metabolism | 1-Naphthylamine - analogs & derivatives | Xenograft Model Antitumor Assays | Animals | Cell Line, Tumor | Mice, Inbred NOD | Carbazoles - pharmacology | Neoplastic Stem Cells - enzymology | Fusion Proteins, bcr-abl - metabolism | Care and treatment | Methyltransferases | Development and progression | Genetic aspects | Chronic myeloid leukemia | Properties | Gene expression | Health aspects | Cloning | Leukemia | Mortality | Science | Grants | Kinases | Experiments | Proteins | Stem cells | DNA methylation | Epigenetics | Mutation | Deoxyribonucleic acid--DNA | Cancer | Index Medicus | Abridged Index Medicus
Journal Article
Reference
Reference
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2010, Volume 107, Issue 38, pp. 16619 - 16624
The Notch signaling pathway plays an important role in cellular proliferation, differentiation, and apoptosis. Unregulated activation of Notch signaling can... 
T lymphocytes | Human T lymphotropic virus 1 | Acute T cell leukemia | Cell lines | Cell cycle | Transformed cell line | Pests | T cell leukemia | Genetic mutation | Tumors | APOPTOSIS | ACTIVATION | PATHWAY | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | RESISTANCE | GAMMA-SECRETASE INHIBITORS | MOLECULAR PATHOGENESIS | MECHANISMS | MUTATIONS | MASTERMIND | F-Box-WD Repeat-Containing Protein 7 | Neoplasm Transplantation | Humans | Receptor, Notch1 - chemistry | Transplantation, Heterologous | DNA Mutational Analysis | Adult | Protein Stability | Protein Structure, Tertiary | F-Box Proteins - metabolism | Leukemia-Lymphoma, Adult T-Cell - genetics | Cell Cycle Proteins - metabolism | Enzyme Inhibitors - pharmacology | Ubiquitin-Protein Ligases - metabolism | Leukemia-Lymphoma, Adult T-Cell - pathology | Receptor, Notch1 - metabolism | Animals | Signal Transduction - drug effects | Leukemia-Lymphoma, Adult T-Cell - metabolism | Leukemia-Lymphoma, Adult T-Cell - etiology | Cell Proliferation - drug effects | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Mutation | Receptor, Notch1 - genetics | Virus diseases | Cellular proteins | Leukemia | Development and progression | Chemical properties | T cells | Health aspects | Intervention | Genotype & phenotype | Rodents | T cell receptors | Polymorphism | Index Medicus | Glutamic acid | Acute lymphatic leukemia | Prognosis | Threonine | Therapeutic applications | Tumor cells | Serine | Frameshift mutation | Proline | Data processing | Lymphocytes T | Gene polymorphism | Cdc4 protein | Signal transduction | Notch protein | Differentiation | Secretase | Apoptosis | Cancer | Biological Sciences
Journal Article
British Journal of Haematology, ISSN 0007-1048, 04/2013, Volume 161, Issue 1, pp. 117 - 127
This study explored the anti‐leukaemic efficacy of novel irreversible inhibitors of the major nuclear export receptor, chromosome region maintenance 1 ( CRM 1,... 
all | aml | new drugs for leukaemia | new drugs for lymphoma | Acute leukaemia | All | Aml | New drugs for lymphoma | New drugs for leukaemia | NOTCH1 | SIGNALS | RECEPTOR | RESTORATION | CANCER | TRANSPORT | RESISTANCE | MUTATIONS | PROTEINS | HEMATOLOGY | EXPRESSION | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Apoptosis - drug effects | Humans | Leukemia, Myeloid, Acute - metabolism | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Dose-Response Relationship, Drug | Cell Nucleus - metabolism | Leukemia, Myeloid, Acute - drug therapy | Female | Antineoplastic Agents - pharmacology | Blood Cells - drug effects | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Leukemia, Myeloid, Acute - pathology | Nuclear Proteins - metabolism | Mice, SCID | Xenograft Model Antitumor Assays | Animals | Cell Cycle Checkpoints - drug effects | Active Transport, Cell Nucleus - drug effects | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Cell Line, Tumor | Mice, Inbred NOD | Mice | Karyopherins - antagonists & inhibitors | Drug Screening Assays, Antitumor | Models | Enzyme inhibitors | T cells | Tumor proteins | Index Medicus | Drugs | Animal models | Transcription factors | Acute lymphatic leukemia | Toxicity | Immunodeficiency | Antagonists | Lymphocytes T | Mutation | Nuclear transport | p53 protein | Apoptosis
Journal Article