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PLoS pathogens, ISSN 1553-7374, 2015, Volume 11, Issue 9, p. e1005142
Pharmacologically-induced activation of replication competent proviruses from latency in the presence of antiretroviral treatment (ART... 
ACTIVATION | RNA | PERSISTENCE | CD4(+) T-CELLS | MICROBIOLOGY | VIROLOGY | HISTONE DEACETYLASES | ACTIVE ANTIRETROVIRAL THERAPY | IMMUNODEFICIENCY-VIRUS TYPE-1 | STEM-CELL | INFECTION | PARASITOLOGY | VIRAL RESERVOIR | Follow-Up Studies | Humans | Middle Aged | Antiretroviral Therapy, Highly Active - adverse effects | Male | RNA, Viral - blood | AIDS Vaccines - therapeutic use | Virus Latency - drug effects | AIDS Vaccines - adverse effects | Anti-HIV Agents - administration & dosage | HIV Infections - immunology | Drug Interactions | HIV-1 - physiology | Lymphocytes - immunology | Protein Processing, Post-Translational - drug effects | HIV-1 - isolation & purification | Adult | Anti-HIV Agents - therapeutic use | Female | Depsipeptides - therapeutic use | RNA, Viral - metabolism | Depsipeptides - adverse effects | Biomarkers - metabolism | Lymphocytes - metabolism | HIV-1 - drug effects | Anti-HIV Agents - adverse effects | HIV Infections - virology | Biomarkers - blood | Histones - blood | Acetylation - drug effects | HIV-1 - immunology | Virus Activation - drug effects | Lymphocytes - drug effects | HIV Infections - drug therapy | Histones - metabolism | Infusions, Intravenous | Viral Load - drug effects | Cohort Studies | Depsipeptides - administration & dosage | HIV Infections - metabolism | Studies | Plasma | HIV | Acquired immune deficiency syndrome | Cytokines | Lymphocytes | Curing | AIDS | Infections | Human immunodeficiency virus | Research | Drug therapy
Journal Article
Journal of neuroimmunology, ISSN 0165-5728, 2015, Volume 284, pp. 18 - 29
...) and D5R, and how this modulation affects CD4+ T-cell activation and differentiation. Our pharmacologic and genetic evidence shows that D3R-stimulation reduced cAMP levels and ERK2-phosphorylation, consequently increasing CD4... 
Neurology | Allergy and Immunology | Knockout mice | Th1 differentiation | Neuroimmunology | TCR signalling | T-cell activation | Dopamine receptors | IMMUNITY | DENDRITIC CELLS | NEURODEGENERATION | PROLIFERATION | IMMUNOLOGY | NEUROSCIENCES | IN-VITRO | CD4+AND CD8+T CELLS | SECRETION | TH1 | CYTOTOXICITY | LYMPHOCYTES | T-Lymphocytes - physiology | Receptors, Dopamine D3 - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Dose-Response Relationship, Drug | Receptors, Dopamine D3 - genetics | Cell Differentiation - genetics | Lymphocyte Activation - genetics | Phosphorylation - genetics | Dopamine Agents - pharmacology | T-Lymphocytes - drug effects | Phosphorylation - drug effects | Cell Differentiation - physiology | Cyclic AMP - metabolism | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Signal Transduction - genetics | Enzyme Activation - drug effects | Mice, Knockout | Gene Expression Regulation - drug effects | Animals | Interleukin-2 Receptor alpha Subunit - metabolism | Signal Transduction - drug effects | Cell Differentiation - drug effects | Lymphocyte Activation - drug effects | Ionomycin - pharmacology | Receptors, Dopamine D5 - metabolism | Mice | Receptors, Dopamine D5 - genetics | Enzyme Activation - genetics | CD4 Antigens - metabolism
Journal Article
Journal of the American Heart Association, ISSN 2047-9980, 09/2016, Volume 5, Issue 9, p. n/a
...‐density lipoprotein (oxLDL) promotes immune activation and inflammation. We studied the effects of statins... 
atherosclerosis | dendritic cells | statin | immune system | microRNA | oxidized low‐density lipoprotein | T cells | MicroRNA | Dendritic cells | Oxidized low-density lipoprotein | Atherosclerosis | Statin | Immune system | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | INDUCTION | CANCER | ARTERIOSCLEROSIS | HEAT-SHOCK-PROTEIN | THERAPY | INHIBITION | INFLAMMATION | oxidized low-density lipoprotein | ASSOCIATION | LYMPHOCYTES | Interleukin-1beta - drug effects | Extracellular Signal-Regulated MAP Kinases - drug effects | Atorvastatin Calcium - pharmacology | Dendritic Cells - immunology | Humans | Interferon-gamma - drug effects | Interleukin-17 - immunology | Chaperonin 60 - immunology | Extracellular Signal-Regulated MAP Kinases - metabolism | Simvastatin - pharmacology | Th1 Cells - immunology | Mitochondrial Proteins - drug effects | Endarterectomy, Carotid | Lymphocyte Activation - immunology | Th17 Cells - drug effects | HSP90 Heat-Shock Proteins - immunology | T-Lymphocytes - drug effects | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | Tumor Necrosis Factor-alpha - immunology | Dendritic Cells - drug effects | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Real-Time Polymerase Chain Reaction | T-Box Domain Proteins - drug effects | Th1 Cells - drug effects | HSP90 Heat-Shock Proteins - drug effects | Interleukin-1beta - immunology | Lipoproteins, LDL - pharmacology | HSP27 Heat-Shock Proteins - immunology | Plaque, Atherosclerotic - immunology | MicroRNAs - immunology | Reverse Transcriptase Polymerase Chain Reaction | HSP27 Heat-Shock Proteins - drug effects | T-Box Domain Proteins - metabolism | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Tumor Necrosis Factor-alpha - drug effects | Cell Differentiation - drug effects | Lymphocyte Activation - drug effects | Interferon-gamma - immunology | Interleukin-6 - immunology | MicroRNAs - drug effects | Th17 Cells - immunology | T-Lymphocytes - immunology | Chaperonin 60 - drug effects | Mitochondrial Proteins - immunology | Nuclear Receptor Subfamily 1, Group F, Member 3 - drug effects | Proto-Oncogene Proteins c-akt - drug effects
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2015, Volume 112, Issue 50, pp. 15408 - 15413
.... Here, we find that enforced activation of STING by intratumoral injection of cyclic dinucleotide GMP-AMP (cGAMP... 
Antitumor immunity | STING | Type I IFNs | Tumor endothelial cells | CD8 T cells | type I IFNs | DENDRITIC CELLS | RECOGNITION | MULTIDISCIPLINARY SCIENCES | SENSOR | antitumor immunity | I INTERFERON | 2ND-MESSENGER | tumor endothelial cells | RESPONSES | INTRACELLULAR DNA | MELANOMA | IMMUNOGENIC TUMORS | IPILIMUMAB | Dose-Response Relationship, Immunologic | Dendritic Cells - immunology | Immunity | Neoplasms - therapy | Melanoma, Experimental - immunology | Injections, Intralesional | Interferon Type I - metabolism | Dendritic Cells - drug effects | Membrane Proteins - metabolism | Disease Models, Animal | Receptor, Interferon alpha-beta - metabolism | Nucleotides, Cyclic - pharmacology | Antigens, Neoplasm - immunology | Endothelial Cells - metabolism | Mice, Inbred C57BL | Melanoma, Experimental - pathology | Lymphocytes, Tumor-Infiltrating - drug effects | Melanoma - pathology | CTLA-4 Antigen - immunology | Animals | Signal Transduction - drug effects | Melanoma - immunology | Neoplasms - immunology | Cell Proliferation - drug effects | Nucleotides, Cyclic - administration & dosage | CD8-Positive T-Lymphocytes - immunology | Neoplasms - pathology | Endothelial Cells - drug effects | Lymphocytes, Tumor-Infiltrating - immunology | Growth | Cancer cells | Physiological aspects | Genetic aspects | T cells | Health aspects | Tumors | Endothelium | Biological Sciences
Journal Article
PLoS pathogens, ISSN 1553-7374, 2014, Volume 10, Issue 11, p. e1004473
Journal Article
Clinical cancer research, ISSN 1557-3265, 2018, Volume 24, Issue 5, pp. 1138 - 1151
Purpose: Agonist antibodies targeting the T-cell costimulatory receptor 4-1BB (CD137) are among the most effective immunotherapeutic agents across preclinical... 
ONCOLOGY | CHEMOKINES | REGULATORY T-CELLS | IL-27 | MONOCLONAL-ANTIBODY | CANCER-IMMUNOTHERAPY | BLOCKADE | COMBINATION | TUMORS | EXPRESSION | LYMPHOCYTES | Antineoplastic Agents, Immunological - administration & dosage | Liver - pathology | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Skin Neoplasms - drug therapy | Receptors, CCR2 - immunology | Humans | Melanoma, Experimental - drug therapy | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Cell Line, Tumor - transplantation | Interleukins - metabolism | Receptors, CCR2 - antagonists & inhibitors | Signal Transduction - immunology | Liver - immunology | Melanoma, Experimental - immunology | Liver - drug effects | Myeloid Cells - immunology | Interleukins - immunology | CD8-Positive T-Lymphocytes - metabolism | Myeloid Cells - drug effects | Tumor Necrosis Factor Receptor Superfamily, Member 9 - agonists | Chemical and Drug Induced Liver Injury - pathology | Drug Evaluation, Preclinical | Chemical and Drug Induced Liver Injury - etiology | Skin Neoplasms - pathology | Tumor Microenvironment - drug effects | Skin Neoplasms - immunology | Mice, Inbred C57BL | Melanoma, Experimental - pathology | CTLA-4 Antigen - immunology | Chemical and Drug Induced Liver Injury - immunology | Mice, Knockout | Tumor Microenvironment - immunology | Antineoplastic Agents, Immunological - adverse effects | Animals | Signal Transduction - drug effects | CD8-Positive T-Lymphocytes - drug effects | Myeloid Cells - metabolism | Liver - cytology | Mice | CD8-Positive T-Lymphocytes - immunology | CTLA-4 Antigen - antagonists & inhibitors | CC chemokine receptors | Flow cytometry | Animal models | PD-1 protein | Toxicity | CD8 antigen | Liver | Transaminase | Interleukin | Kupffer cells | Antibodies | Lymphocytes T | Activation | Immunity | Hepatitis | Cell activation | CTLA-4 protein | CCR2 protein | Lymphocytes | Rodents | Foxp3 protein | Hepatotoxicity | Immunoglobulins | Myeloid cells | CD137 antigen | Cytokines | Immunoregulation | Melanoma | Cytometry | Monocytes | Immune checkpoint | Hepatocytes | Experimental design | Chemokines | Monocyte chemoattractant protein 1 | Cancer | 4-1BB | Interleukin-27 | CTLA-4 | immunotherapy | CCR2
Journal Article
Journal Article
Journal Article
Journal of acquired immune deficiency syndromes (1999), ISSN 1525-4135, 07/2013, Volume 63, Issue 3, pp. 280 - 288
Journal Article