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Nature, ISSN 0028-0836, 01/2009, Volume 457, Issue 7229, pp. 585 - 588
Journal Article
Cell, ISSN 0092-8674, 2007, Volume 130, Issue 5, pp. 906 - 917
TLR4 and MD-2 form a heterodimer that recognizes LPS (lipopolysaccharide) from Gram-negative bacteria. Eritoran is an analog of LPS that antagonizes its... 
PROTEINS | MOLIMMUNO | BACTERIAL LIPOPOLYSACCHARIDE | MD-2 BINDS | CELL ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOLL-LIKE RECEPTORS | PROTEIN COMPLEXES | LEUCINE-RICH REPEAT | LIPID IVA | CONFERS LIPOPOLYSACCHARIDE RESPONSIVENESS | TLR4 | MONOMERIC ENDOTOXIN | CELL BIOLOGY | Disaccharides - metabolism | Lymphocyte Antigen 96 - metabolism | Humans | Immunoglobulin Variable Region - chemistry | Lipopolysaccharides - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Hagfishes | Lipopolysaccharides - antagonists & inhibitors | Disaccharides - chemistry | Lymphocyte Antigen 96 - genetics | Disaccharides - pharmacology | Sugar Phosphates - pharmacology | Lymphocyte Antigen 96 - chemistry | Cloning, Molecular | Protein Engineering | Molecular Structure | Toll-Like Receptor 4 - antagonists & inhibitors | Binding Sites | Dimerization | Protein Structure, Tertiary | Amino Acid Sequence | Fish Proteins - chemistry | Sugar Phosphates - chemistry | Models, Molecular | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - chemistry | Recombinant Fusion Proteins - chemistry | Toll-Like Receptor 4 - metabolism | Animals | Sugar Phosphates - metabolism | Hydrophobic and Hydrophilic Interactions | Protein Binding | Protein Conformation | Lipopolysaccharides - chemistry | Mice | Structural Homology, Protein | Mutation | Structure | Crystals | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 06/2010, Volume 30, Issue 24, pp. 8285 - 8295
Toll-like receptors play an important role in the innate immune response, although emerging evidence indicates their role in brain injury and... 
ETHANOL TREATMENT | ALZHEIMERS-DISEASE | IN-VIVO | TOLL-LIKE RECEPTORS | INJURY | NEURODEGENERATION | ENHANCES INFLAMMATORY MEDIATORS | ASTROGLIAL CELLS | ASTROCYTES | NEUROSCIENCES | CELL-DEATH | Tumor Necrosis Factor-alpha - metabolism | Rats, Wistar | Lymphocyte Antigen 96 - metabolism | Tumor Necrosis Factor-alpha - genetics | Caspase 3 - metabolism | Ethanol - administration & dosage | Green Fluorescent Proteins - genetics | Brain Injuries - metabolism | Interleukin-1beta - genetics | Lipopolysaccharides - adverse effects | Lipopolysaccharide Receptors - metabolism | Lymphocyte Antigen 96 - genetics | Ethanol - blood | Time Factors | Toll-Like Receptor 4 - deficiency | Cyclooxygenase 2 - genetics | Interleukin-1beta - metabolism | Encephalitis - metabolism | Statistics, Nonparametric | Brain Injuries - blood | Female | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Astrocytes - drug effects | Mice, Inbred C57BL | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Brain Injuries - chemically induced | Encephalitis - pathology | Rats | Mice, Knockout | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Toll-Like Receptor 4 - physiology | Animals | Microfilament Proteins | Central Nervous System Depressants - administration & dosage | Cyclooxygenase 2 - metabolism | Mice | Encephalitis - chemically induced | Central Nervous System Depressants - blood | Brain Injuries - pathology | Encephalitis - blood | Astrocytes - metabolism | Calcium-Binding Proteins - genetics | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2012, Volume 109, Issue 16, pp. 6325 - 6330
Opioids create a neuroinflammatory response within the CNS, compromising opioid-induced analgesia and contributing to various unwanted actions. How this occurs... 
Analgesia | Receptors | Messenger RNA | Opioid receptors | Toll like receptors | Central nervous system | Antibodies | Morphine | Behavioral neuroscience | Opioid analgesics | Protein-protein interaction | Pain management therapy | Drug discovery | ANTAGONIST | RECOGNITION | MULTIDISCIPLINARY SCIENCES | LIPID-IVA | RECEPTOR 4 | LPS | INHIBITION | drug discovery | OPIOID ANALGESIA | pain management therapy | MD-2 | LIPOPOLYSACCHARIDE | protein-protein interaction | TLR4 | Lymphocyte Antigen 96 - metabolism | Humans | Analgesics, Opioid - pharmacology | Male | Interleukin-1beta - genetics | Spodoptera | Lymphocyte Antigen 96 - genetics | RNA Interference | Interleukin-1beta - metabolism | Endotoxins - chemistry | Lymphocyte Antigen 96 - chemistry | HEK293 Cells | Female | Dimerization | Endotoxins - metabolism | Cell Line | Morphine - pharmacology | Morphine - chemistry | Morphine - metabolism | Models, Molecular | Rats | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - chemistry | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Toll-Like Receptor 4 - metabolism | Blotting, Western | Mice, Knockout | Animals | Protein Binding | Mice | Mice, Inbred BALB C | Analgesics, Opioid - metabolism | Endotoxins - pharmacology | Neuroimmunomodulation - drug effects | Neural circuitry | Endotoxins | Physiological aspects | Development and progression | Inflammation | Health aspects | Proteins | T cell receptors | Toxins | Narcotics | Analgesics | Index Medicus | Pain perception | Oligomerization | RNA-mediated interference | Toll-like receptors | TLR4 protein | Differentiation | protein–protein interaction | Biological Sciences | Physical Sciences
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2015, Volume 212, Issue 1, pp. 5 - 14
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2008, Volume 283, Issue 36, pp. 24748 - 24759
The generation of reactive oxygen species is a central feature of inflammation that results in the oxidation of host phospholipids. Oxidized phospholipids,... 
ACTIVATION | ESCHERICHIA-COLI LIPOPOLYSACCHARIDE | INDUCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIPID RAFTS | ENDOTHELIAL-CELLS | LOW-DENSITY-LIPOPROTEIN | HEME OXYGENASE-1 | MONOCYTE CHEMOTACTIC PROTEIN-1 | OXIDATION-PRODUCTS | T-LYMPHOCYTES | Phosphatidylcholines - immunology | Reactive Oxygen Species - metabolism | Toll-Like Receptor 2 - genetics | Membrane Glycoproteins - metabolism | Lymphocyte Antigen 96 - metabolism | Humans | Tumor Necrosis Factor-alpha - genetics | Macrophages, Peritoneal - cytology | Flagellin - pharmacology | Lymphocyte Antigen 96 - agonists | Oxidation-Reduction - drug effects | Tumor Necrosis Factor-alpha - immunology | Toll-Like Receptor 4 - agonists | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Carrier Proteins - immunology | Guanosine - analogs & derivatives | Poly I-C - pharmacology | Macrophages, Peritoneal - immunology | Toll-Like Receptor 4 - genetics | Lipopolysaccharide Receptors - immunology | Toll-Like Receptor 4 - immunology | p38 Mitogen-Activated Protein Kinases - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | I-kappa B Kinase - immunology | Mice | Mice, Inbred BALB C | Macrophages, Peritoneal - metabolism | Oligodeoxyribonucleotides - pharmacology | Immunologic Factors - pharmacology | Lymphocyte Antigen 96 - immunology | Tumor Necrosis Factor-alpha - metabolism | Toll-Like Receptor 2 - agonists | Acute-Phase Proteins - genetics | Lipopolysaccharide Receptors - metabolism | Lymphocyte Antigen 96 - genetics | Carrier Proteins - agonists | I-kappa B Kinase - metabolism | Reactive Oxygen Species - immunology | Female | Membrane Glycoproteins - immunology | Cell Line | Acute-Phase Proteins - metabolism | Phosphatidylcholines - pharmacology | Membrane Glycoproteins - agonists | p38 Mitogen-Activated Protein Kinases - genetics | I-kappa B Kinase - genetics | Membrane Glycoproteins - genetics | Carrier Proteins - genetics | Phosphatidylcholines - genetics | Animals | Carrier Proteins - metabolism | RNA - pharmacology | Guanosine - pharmacology | Lipopolysaccharide Receptors - genetics | Signal Transduction - physiology | Acute-Phase Proteins - agonists | Acute-Phase Proteins - immunology | Index Medicus | Lipids and Lipoproteins | Metabolism, Regulation, and Signaling
Journal Article
EMBO reports, ISSN 1469-221X, 12/2012, Volume 13, Issue 12, pp. 1109 - 1115
Development of contact allergy requires cooperation of adaptive and innate immunity. Ni 2+ stimulates innate immunity via TLR4/MD2, the bacterial LPS receptor.... 
contact allergy | Toll‐like receptor | dermatitis | innate immunity | inflammation | Toll-like receptor | TOLL-LIKE-RECEPTORS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | KAPPA-B | CELL BIOLOGY | CONTACT-DERMATITIS | LIPID-A | ENDOTHELIAL-CELLS | GENE-EXPRESSION | HUMAN EPIDERMAL-KERATINOCYTES | Inflammation - chemically induced | Dermatitis, Allergic Contact - immunology | Lymphocyte Antigen 96 - metabolism | Humans | Protein Multimerization | Immunity, Innate - genetics | Lipopolysaccharides - metabolism | Nickel - toxicity | Lipopolysaccharides - immunology | Dermatitis, Allergic Contact - metabolism | Adaptive Immunity - genetics | Lymphocyte Antigen 96 - genetics | Signal Transduction - immunology | Inflammation - metabolism | T-Lymphocytes - drug effects | Lymphocyte Antigen 96 - chemistry | Allergens - toxicity | Human Umbilical Vein Endothelial Cells - drug effects | Dermatitis, Allergic Contact - genetics | Mutant Proteins - genetics | Toll-Like Receptor 4 - genetics | Mutant Proteins - metabolism | Toll-Like Receptor 4 - chemistry | Toll-Like Receptor 4 - metabolism | Cobalt - toxicity | Animals | Mutant Proteins - chemistry | T-Lymphocytes - immunology | Mice | Proteins | Nickel | Molecular biology | Cobalt | Dermatitis | Allergies | Immune system | Index Medicus | Allergens | Cooperation | Hypersensitivity | Toll-like receptors | Haptens | TLR4 protein | Immunity | Heavy metals | Lipopolysaccharides | Scientific Reports
Journal Article
The Journal of Immunology, ISSN 0022-1767, 07/2006, Volume 177, Issue 1, pp. 322 - 332
Journal Article
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 03/2011, Volume 300, Issue 3, pp. 433 - 441
Toll-like receptor 4 (TLR4) and its coreceptor, myeloid differentiation factor-2 (MD-2), are key in recognition of lipopolysaccharide (LPS) and activation of... 
α-smooth muscle actin | Inflammation | Fatty liver | Endotoxin | Nictoinamide adenine dinucleotide phosphate | alpha-smooth muscle actin | PHYSIOLOGY | PROTEIN | FATTY LIVER-DISEASE | fatty liver | nictoinamide adenine dinucleotide phosphate | PATHOGENESIS | LIPID-ACCUMULATION | DANGER SIGNALS | HEPATIC STELLATE CELLS | inflammation | LIPOPOLYSACCHARIDE | MD-2 | GASTROENTEROLOGY & HEPATOLOGY | TLR4 | endotoxin | Oxidative Stress | Tumor Necrosis Factor-alpha - blood | NADPH Oxidases - metabolism | Choline Deficiency - complications | Alanine Transaminase - blood | RNA, Messenger - metabolism | Actins - genetics | Lymphocyte Antigen 96 - genetics | Liver Cirrhosis, Experimental - prevention & control | Liver - immunology | Toll-Like Receptor 4 - deficiency | Non-alcoholic Fatty Liver Disease | NADPH Oxidases - genetics | Female | Collagen - genetics | Lymphocyte Antigen 96 - deficiency | Methionine - deficiency | Fatty Liver - genetics | Fatty Liver - metabolism | Liver Cirrhosis, Experimental - immunology | Liver - metabolism | Mice, Inbred C57BL | Fatty Liver - prevention & control | Toll-Like Receptor 4 - genetics | Genotype | Thiobarbituric Acid Reactive Substances - metabolism | Transforming Growth Factor beta1 - genetics | Liver Cirrhosis, Experimental - genetics | Mice, Knockout | Triglycerides - metabolism | Matrix Metalloproteinase 2 - genetics | Tissue Inhibitor of Metalloproteinase-1 - genetics | Phenotype | Animals | Fatty Liver - immunology | Mice | Lipid Peroxidation | Liver Cirrhosis, Experimental - metabolism | Fibrosis | Physiological aspects | Toll-like receptors | Development and progression | Research | Muscle proteins | Hypothesis testing | Carbohydrates | Disease | Liver | Rodents | Bone marrow | Cell division | Index Medicus | Liver and Biliary Tract
Journal Article
Journal of Immunology, ISSN 0022-1767, 08/2013, Volume 191, Issue 4, pp. 1529 - 1535
Allergic responses can be triggered by structurally diverse allergens. Most allergens are proteins, yet extensive research has not revealed how they initiate... 
DOG LIPOCALIN ALLERGEN | RESPONSES | CRYSTAL-STRUCTURE | CROSS-REACTIVITY | LIPOPOLYSACCHARIDE | ASTHMA | BACTERIAL FLAGELLIN | IMMUNOLOGY | RECEPTOR 4 | INNATE IMMUNITY | CUTTING EDGE | Recombinant Fusion Proteins - immunology | Cats - immunology | Toll-Like Receptor 2 - genetics | Species Specificity | Lymphocyte Antigen 96 - metabolism | Humans | Lipopolysaccharides - metabolism | Structure-Activity Relationship | Lipopolysaccharides - immunology | Lymphocyte Antigen 96 - genetics | Transfection | Allergens - immunology | Allergens - chemistry | Granulocytes - metabolism | Glycoproteins - chemistry | Macrophages - immunology | Flagellin - immunology | Specific Pathogen-Free Organisms | Respiratory Hypersensitivity - etiology | Cells, Cultured | Toll-Like Receptor 4 - genetics | Lipopolysaccharide Receptors - immunology | Glycosylation | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Immunity, Innate | Respiratory Hypersensitivity - immunology | Toll-Like Receptor 4 - metabolism | Macromolecular Substances | Glycoproteins - immunology | Macrophages - metabolism | Models, Immunological | Animals | Lipocalins - immunology | Dogs | Lipopolysaccharide Receptors - genetics | Protein Binding | Toll-Like Receptor 2 - immunology | Ligands | Mice | Protein Processing, Post-Translational | Cytokines - biosynthesis | Granulocytes - immunology | Lymphocyte Antigen 96 - immunology | Index Medicus | Abridged Index Medicus
Journal Article