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Nature Immunology, ISSN 1529-2908, 03/2019, Volume 20, Issue 3, pp. 326 - 336
T cell dysfunction is a hallmark of many cancers, but the basis for T cell dysfunction and the mechanisms by which antibody blockade of the inhibitory receptor... 
ANALYSIS REVEALS | PATHWAYS | SURVIVAL | APOPTOSIS | CHROMATIN | PERSISTENCE | INFECTION | DYSFUNCTION | IMMUNOLOGY | PD-1 | EXPRESSION | Lymphocytic choriomeningitis virus - immunology | Humans | Lymphocytic choriomeningitis virus - drug effects | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antibodies, Blocking - pharmacology | Lymphocytes, Tumor-Infiltrating - virology | Lymphocyte Subsets - virology | Lymphocytic Choriomeningitis - immunology | Lymphocyte Subsets - immunology | Melanoma, Experimental - prevention & control | Melanoma, Experimental - immunology | Female | Lymphocytic choriomeningitis virus - physiology | Melanoma, Experimental - virology | Lymphocytic Choriomeningitis - virology | Lymphocyte Subsets - drug effects | Mice, Inbred C57BL | Programmed Cell Death 1 Receptor - metabolism | Lymphocytes, Tumor-Infiltrating - drug effects | Animals | Lymphocytic Choriomeningitis - prevention & control | CD8-Positive T-Lymphocytes - virology | CD8-Positive T-Lymphocytes - drug effects | Antibodies, Blocking - immunology | Cell Line, Tumor | Mice, Congenic | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | Lymphocytes, Tumor-Infiltrating - immunology | Therapy | Stability | Tumor-infiltrating lymphocytes | Transcription | PD-1 protein | CD8 antigen | Melanoma | Chronic infection | Lymphocytes T | Immune checkpoint | Lymphocytes | Exhaustion | Tumors
Journal Article
Journal Article
Journal of Acquired Immune Deficiency Syndromes, ISSN 1525-4135, 04/2010, Volume 53, Issue 5, pp. 553 - 563
Background: Clinical studies support biologically independent roles of cell-free HIV particles and HIV-infected cells in disease progression. The associations... 
HIV-specific T lymphocytes | HIV DNA | Perinatal HIV infection | Immune activation | HIV RNA | INFECTIOUS DISEASES | perinatal HIV infection | immune activation | PERIPHERAL-BLOOD | IMMUNOLOGY | SEXUAL TRANSMISSION | BLOOD MONONUCLEAR-CELLS | ACTIVE ANTIRETROVIRAL THERAPY | IMMUNODEFICIENCY-VIRUS TYPE-1 | INFECTED PATIENTS | PLASMA VIRAL LOADS | DISEASE PROGRESSION | THYMIC EMIGRANTS | T-Lymphocyte Subsets - immunology | Humans | Child, Preschool | Infant | RNA, Viral - blood | Leukocytes, Mononuclear - virology | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | Flow Cytometry | RNA, Viral - genetics | Leukocytes, Mononuclear - immunology | Polymerase Chain Reaction | Statistics, Nonparametric | Female | CD4-Positive T-Lymphocytes - virology | Child | Enzyme-Linked Immunosorbent Assay | HIV Infections - virology | Immunophenotyping | HIV-1 - genetics | T-Lymphocyte Subsets - virology | DNA, Viral - blood | DNA, Viral - immunology | HIV-1 - immunology | CD8-Positive T-Lymphocytes - virology | Adolescent | RNA, Viral - immunology | CD8-Positive T-Lymphocytes - immunology | DNA, Viral - genetics | Pediatrics | T-Lymphocyte Subsets/virology | DNA, Viral/blood | HIV-1/immunology | DNA, Viral/immunology | HIV Infections/immunology | Adaptive immunology | Life Sciences | CD8-Positive T-Lymphocytes/immunology | Immunology | T-Lymphocyte Subsets/immunology | CD8-Positive T-Lymphocytes/virology | RNA, Viral/immunology | HIV-1/genetics | RNA, Viral/genetics | DNA, Viral/genetics | Virology | Microbiology and Parasitology | Human health and pathology | Infectious diseases | RNA, Viral/blood | CD4-Positive T-Lymphocytes/immunology | Leukocytes, Mononuclear/virology | Leukocytes, Mononuclear/immunology | HIV Infections/virology | CD4-Positive T-Lymphocytes/virology
Journal Article
Journal Article
Immunity, ISSN 1074-7613, 09/2015, Volume 43, Issue 3, pp. 554 - 565
Journal Article
Gastroenterology, ISSN 0016-5085, 2017, Volume 152, Issue 8, pp. 2052 - 2062.e2
Background & Aims Interferon-free direct-acting antiviral (DAA) therapies are effective in patients with hepatitis C virus–induced cryoglobulinemia vasculitis... 
Gastroenterology and Hepatology | Immune Regulation | PDCD1 | Response To Treatment | Liver Disease | BAFF | ENVELOPE PROTEIN | RANDOMIZED CONTROLLED-TRIAL | MIXED CRYOGLOBULINEMIA | DEFICIENCY | AUTOIMMUNITY | RITUXIMAB | EXPANSION | REGULATORY T-CELL | GASTROENTEROLOGY & HEPATOLOGY | LYMPHOCYTES | T-Lymphocyte Subsets - immunology | Prospective Studies | Hepatitis C - drug therapy | Humans | Middle Aged | Cryoglobulinemia - diagnosis | Male | Vasculitis - virology | Cryoglobulinemia - virology | Hepatitis Viruses - drug effects | Simeprevir - therapeutic use | Case-Control Studies | Simeprevir - adverse effects | Viral Load | Vasculitis - immunology | Hepatitis C - immunology | Immunity, Cellular - drug effects | Time Factors | T-Lymphocyte Subsets - drug effects | B-Lymphocyte Subsets - immunology | Female | Hepatitis C - complications | Imidazoles - therapeutic use | Sofosbuvir - adverse effects | Drug Therapy, Combination | B-Lymphocyte Subsets - virology | Cytokines - blood | Immune Tolerance - drug effects | Sofosbuvir - therapeutic use | B-Lymphocyte Subsets - drug effects | Antiviral Agents - therapeutic use | Hepatitis Viruses - immunology | Cryoglobulinemia - drug therapy | Imidazoles - adverse effects | Ribavirin - therapeutic use | Treatment Outcome | Biomarkers - blood | T-Lymphocyte Subsets - virology | Cryoglobulinemia - immunology | Hepatitis C - diagnosis | Phenotype | B-Lymphocyte Subsets - metabolism | Vasculitis - diagnosis | Ribavirin - adverse effects | T-Lymphocyte Subsets - metabolism | Antiviral Agents - adverse effects | Vasculitis - drug therapy | Aged | Care and treatment | Vasculitis | Analysis | Gastrointestinal diseases | Interferon | Biological response modifiers | Hepatitis C virus | Antiviral agents | Medical research | Liver | Medicine, Experimental | Life Sciences | Immunology
Journal Article
Immunology, ISSN 0019-2805, 10/2014, Volume 143, Issue 2, pp. 202 - 218
Summary Differentiation of CD4+ T cells into type 1 or type 2 subsets is mediated by the expression of the opposing lineage defining transcription factors... 
interleukin‐12 | humanized mice | T‐cell plasticity | Humanized mice | T-cell plasticity | Interleukin-12 | DENDRITIC CELLS | POPULATIONS | IMMUNOLOGY | interleukin-12 | SYSTEM MICE | GENE | IMMUNE-RESPONSES | HUMAN-BLOOD | IN-VIVO | TRANSCRIPTION FACTOR | RECONSTITUTION | EXPRESSION | Liver - virology | T-Lymphocyte Subsets - immunology | Dendritic Cells - immunology | Humans | Transplantation, Heterologous | Adenoviridae - pathogenicity | Interferon-gamma - metabolism | Viral Load | CD4-Positive T-Lymphocytes - immunology | Liver - immunology | T-Lymphocyte Subsets - drug effects | CD8-Positive T-Lymphocytes - metabolism | Cell Differentiation | CD4-Positive T-Lymphocytes - virology | GATA3 Transcription Factor - metabolism | Dendritic Cells - metabolism | Interleukin-4 - metabolism | Liver - metabolism | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Injections, Intraperitoneal | Hematopoietic Stem Cell Transplantation | Mice, Transgenic | Interleukin-12 - metabolism | Mice, SCID | T-Box Domain Proteins - metabolism | T-Lymphocyte Subsets - virology | Host-Pathogen Interactions | Cell Lineage | Phenotype | Animals | Interleukin-12 - administration & dosage | Signal Transduction - drug effects | CD8-Positive T-Lymphocytes - virology | T-Lymphocyte Subsets - metabolism | CD8-Positive T-Lymphocytes - drug effects | Mice, Inbred NOD | Mice | Mice, Inbred BALB C | Kinetics | CD8-Positive T-Lymphocytes - immunology | CD4-Positive T-Lymphocytes - drug effects | Interleukins | T cells | Original
Journal Article