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PLoS Biology, ISSN 1544-9173, 03/2009, Volume 7, Issue 3, pp. 0525 - 0536
Journal Article
Nature Immunology, ISSN 1529-2908, 03/2019, Volume 20, Issue 3, pp. 326 - 336
T cell dysfunction is a hallmark of many cancers, but the basis for T cell dysfunction and the mechanisms by which antibody blockade of the inhibitory receptor... 
ANALYSIS REVEALS | PATHWAYS | SURVIVAL | APOPTOSIS | CHROMATIN | PERSISTENCE | INFECTION | DYSFUNCTION | IMMUNOLOGY | PD-1 | EXPRESSION | Lymphocytic choriomeningitis virus - immunology | Humans | Lymphocytic choriomeningitis virus - drug effects | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antibodies, Blocking - pharmacology | Lymphocytes, Tumor-Infiltrating - virology | Lymphocyte Subsets - virology | Lymphocytic Choriomeningitis - immunology | Lymphocyte Subsets - immunology | Melanoma, Experimental - prevention & control | Melanoma, Experimental - immunology | Female | Lymphocytic choriomeningitis virus - physiology | Melanoma, Experimental - virology | Lymphocytic Choriomeningitis - virology | Lymphocyte Subsets - drug effects | Mice, Inbred C57BL | Programmed Cell Death 1 Receptor - metabolism | Lymphocytes, Tumor-Infiltrating - drug effects | Animals | Lymphocytic Choriomeningitis - prevention & control | CD8-Positive T-Lymphocytes - virology | CD8-Positive T-Lymphocytes - drug effects | Antibodies, Blocking - immunology | Cell Line, Tumor | Mice, Congenic | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | Lymphocytes, Tumor-Infiltrating - immunology | Therapy | Stability | Transcription | Tumor-infiltrating lymphocytes | PD-1 protein | CD8 antigen | Melanoma | Chronic infection | Lymphocytes T | Immune checkpoint | Lymphocytes | Exhaustion | Tumors
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e48304
Background: The worldwide burden of malaria remains a major public health problem due, in part, to the lack of an effective vaccine against the Plasmodium... 
IMMUNITY | DESIGN | DENDRITIC CELLS | DNA VACCINE | VIVAX | IFN-GAMMA | MULTIDISCIPLINARY SCIENCES | SPOROZOITES | MALARIA PARASITES | DELIVERY | Plasmodium berghei - immunology | Malaria, Falciparum - prevention & control | Epitopes, B-Lymphocyte - chemistry | Humans | Plasmodium berghei - genetics | Protein Multimerization | Vaccines, DNA - immunology | Molecular Sequence Data | Epitopes, T-Lymphocyte - genetics | Epitopes, B-Lymphocyte - immunology | Adoptive Transfer | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Vaccines, DNA - administration & dosage | Epitopes, B-Lymphocyte - genetics | Plasmodium falciparum - genetics | Malaria Vaccines - immunology | CD8-Positive T-Lymphocytes - metabolism | Female | Plasmodium falciparum - metabolism | Protozoan Proteins - chemistry | Epitopes, T-Lymphocyte - immunology | Amino Acid Sequence | Microscopy, Electron, Transmission | Antibodies, Protozoan - immunology | Malaria - immunology | Mice, Inbred C57BL | Nanoparticles - ultrastructure | Models, Molecular | Mice, Knockout | Epitopes, T-Lymphocyte - chemistry | Malaria - prevention & control | Plasmodium berghei - metabolism | Animals | Malaria Vaccines - administration & dosage | Malaria, Falciparum - immunology | Mice | Mice, Inbred BALB C | Nanoparticles - administration & dosage | CD8-Positive T-Lymphocytes - immunology | Protozoan Proteins - immunology | CD8 antigen | Amino acids | Materials science | Lymphocytes T | Biology | Infections | Vaccines | Parasites | Nanoparticles | Proteins | Immunology | Interleukin 2 | Public health | Circumsporozoite protein | Vector-borne diseases | Antigens | Immunological memory | Memory cells | Immune response | Malaria | Transgenic mice | Epitopes | CD4 antigen | Transmission electron microscopy | Lymphocytes B | γ-Interferon
Journal Article
Immunity, ISSN 1074-7613, 11/2008, Volume 29, Issue 5, pp. 758 - 770
CD4 Foxp3 regulatory T (Treg) cells originate primarily from thymic differentiation, but conversion of mature T lymphocytes to Foxp3 positivity can be elicited... 
MOLIMMUNO | CELLIMUNO | Forkhead Transcription Factors - immunology | T-Lymphocyte Subsets - immunology | T-Lymphocytes, Regulatory - metabolism | Dendritic Cells - immunology | Homeostasis | Interferon-gamma - metabolism | Interleukins - metabolism | Gene Knockdown Techniques | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Tretinoin - metabolism | Forkhead Transcription Factors - metabolism | Interleukins - immunology | Receptors, Retinoic Acid - immunology | Dendritic Cells - metabolism | Transforming Growth Factor beta - immunology | Receptors, Retinoic Acid - deficiency | Signal Transduction | Interleukin-4 - metabolism | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Gene Expression Regulation | Receptors, Retinoic Acid - metabolism | Hyaluronan Receptors - analysis | Interleukin-4 - immunology | Animals | T-Lymphocyte Subsets - metabolism | Interferon-gamma - immunology | Mice | Retinoic Acid Receptor alpha | Transforming Growth Factor beta - metabolism | Medical research | Ligands | Mutation | Diabetes | Rodents | Antigens, CD44 | T-Lymphocyte Subsets | Interferon-gamma | Interleukin-4 | Dendritic Cells | Biochemistry, Molecular Biology | Life Sciences | Immunology | Interleukins | Receptors, Retinoic Acid | T-Lymphocytes, Regulatory | CD4-Positive T-Lymphocytes | Forkhead Transcription Factors | Transforming Growth Factor beta | Tretinoin
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2014, Volume 111, Issue 35, pp. 12835 - 12840
Journal Article
The Journal of Immunology, ISSN 0022-1767, 11/2004, Volume 173, Issue 9, pp. 5372 - 5380
Journal Article
The Journal of Immunology, ISSN 0022-1767, 06/2006, Volume 176, Issue 12, pp. 7745 - 7752
Journal Article
Journal of Autoimmunity, ISSN 0896-8411, 12/2010, Volume 35, Issue 4, pp. 336 - 341
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 04/2012, Volume 109, Issue 16, pp. 6187 - 6192
IL-15 has potential as an immunotherapeutic agent for cancer treatment because of its ability to effectively stimulate CD8 T cell, natural killer T cell, and... 
LUNG-CANCER | RESPONSES | IMMUNITY | GROWTH-FACTOR-BETA | TOLERANCE | MULTIDISCIPLINARY SCIENCES | CTLA-4 | PROLIFERATION | PD-1 | IL-10 | CUTTING EDGE | T-Lymphocyte Subsets - immunology | T-Lymphocytes, Regulatory - metabolism | Humans | Male | Interferon-gamma - metabolism | Prostatic Neoplasms - immunology | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Flow Cytometry | T-Lymphocyte Subsets - drug effects | Antibodies - immunology | CD8-Positive T-Lymphocytes - metabolism | Lymphocytes, Tumor-Infiltrating - metabolism | Cytotoxicity, Immunologic - drug effects | Prostatic Neoplasms - drug therapy | Disease Models, Animal | Amino Acid Sequence | Prostatic Neoplasms - pathology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Kaplan-Meier Estimate | CTLA-4 Antigen - metabolism | Treatment Outcome | Interleukin-5 - administration & dosage | Lymphocytes, Tumor-Infiltrating - drug effects | CTLA-4 Antigen - immunology | B7-H1 Antigen - immunology | Antibodies - administration & dosage | B7-H1 Antigen - metabolism | T-Lymphocytes, Regulatory - drug effects | Animals | Tumor Burden - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | T-Lymphocyte Subsets - metabolism | CD8-Positive T-Lymphocytes - drug effects | Interferon-gamma - immunology | Cell Line, Tumor | Mice | CD8-Positive T-Lymphocytes - immunology | Cytotoxicity, Immunologic - immunology | CD4-Positive T-Lymphocytes - drug effects | Lymphocytes, Tumor-Infiltrating - immunology | Tumor Burden - immunology | Interleukins | Immunotherapy | Physiological aspects | Development and progression | T cells | Health aspects | Prostate cancer | Biological Sciences
Journal Article
Seminars in Immunology, ISSN 1044-5323, 2013, Volume 25, Issue 4, pp. 273 - 281
Highlights • The thymic CD4 Th-lineage commitment is not fixed. • ThPOK, directs the Th-lineage fate of MHC class II restricted thymocytes. • ThPOK suppresses... 
Allergy and Immunology | Autoimmunity | CD8αβ cytotoxic T lymphocyte | Intestine | CD4 T helper cells | Plasticity | ThPOK | Lineage commitment | Functional reprogramming | Tumor | Runx3 | Protective immunity | Chronic viral infection | PRIMARY CYTOMEGALOVIRUS-INFECTION | BETA-CELLS | IMMUNOLOGY | TRANSCRIPTION FACTOR GATA-3 | FINGER PROTEIN MAZR | HELPER TYPE-1 CELLS | CD8 alpha beta cytotoxic T lymphocyte | EPITHELIAL-CELLS | COMPLEX CLASS-I | RUNX PROTEINS | T-CELL DEVELOPMENT | INTRAEPITHELIAL LYMPHOCYTES | T-Lymphocyte Subsets - immunology | T-Lymphocyte Subsets - cytology | Humans | Lymphoid Tissue - immunology | Autoimmune Diseases - genetics | CD4-Positive T-Lymphocytes - immunology | Inflammation - metabolism | Lymphocyte Activation - immunology | T-Lymphocytes, Helper-Inducer - immunology | T-Lymphocytes, Helper-Inducer - cytology | Transcription, Genetic | Thymus Gland - metabolism | Autoimmune Diseases - metabolism | T-Lymphocytes, Helper-Inducer - metabolism | CD4-Positive T-Lymphocytes - cytology | Autoimmune Diseases - immunology | CD4-Positive T-Lymphocytes - metabolism | Gene Expression Regulation | Lymphoid Tissue - metabolism | Inflammation - immunology | Transcription Factors - metabolism | Cell Differentiation - immunology | Animals | T-Lymphocyte Subsets - metabolism | Inflammation - genetics | Thymus Gland - immunology | Cell Lineage - immunology | Cytotoxicity, Immunologic | T cells | chronic viral infection | intestine | autoimmunity | tumor | plasticity | lineage commitment | functional reprogramming | CD8αβ Cytotoxic T lymphocyte | protective immunity
Journal Article
European Journal of Immunology, ISSN 0014-2980, 09/2015, Volume 45, Issue 9, pp. 2504 - 2516
The strong link between T‐cell metabolism and effector functions is well characterized in the murine system but hardly investigated in human T cells.... 
Human CD8 T cells | Mitochondrial inhibition | Glucose deprivation | Cytokines | 2‐deoxy‐glucose | Metabolism | ATP | Human CD4 T cells | 2-deoxy-glucose | MIGRATION | TARGET | IMMUNE CELLS | GLUTAMINE | LYMPHOCYTE ACTIVATION | 2-DEOXY-D-GLUCOSE | IMMUNOLOGY | GLYCOLYSIS | INHIBITION | MEMORY | REQUIRES | T-Lymphocyte Subsets - immunology | CD8-Positive T-Lymphocytes - cytology | T-Lymphocyte Subsets - cytology | Monocytes - cytology | Humans | Monocytes - metabolism | Mitochondria - immunology | Monocytes - immunology | Glycolysis - drug effects | CD4-Positive T-Lymphocytes - immunology | Oxidative Phosphorylation - drug effects | Interleukin-4 - biosynthesis | Interleukin-2 - immunology | T-Lymphocyte Subsets - drug effects | Deoxyglucose - pharmacology | Tumor Necrosis Factor-alpha - immunology | CD8-Positive T-Lymphocytes - metabolism | CD4-Positive T-Lymphocytes - cytology | CD4-Positive T-Lymphocytes - metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Monocytes - drug effects | Glucose - deficiency | Interleukin-4 - immunology | T-Lymphocyte Subsets - metabolism | CD8-Positive T-Lymphocytes - drug effects | Interferon-gamma - immunology | Interleukin-10 - biosynthesis | Cell Proliferation - drug effects | Primary Cell Culture | CD8-Positive T-Lymphocytes - immunology | Interleukin-2 - biosynthesis | Interleukin-10 - immunology | Tumor Necrosis Factor-alpha - biosynthesis | CD4-Positive T-Lymphocytes - drug effects | Interferon-gamma - biosynthesis | Glucose metabolism | Analysis | Singers | Glucose | T cells | Dextrose | T cell receptors | Respiration | Lymphocytes
Journal Article