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Molecular and Cellular Proteomics, ISSN 1535-9476, 03/2013, Volume 12, Issue 3, pp. 587 - 598
Journal Article
Journal of Immunology, ISSN 0022-1767, 01/2014, Volume 192, Issue 2, pp. 623 - 629
Chronic inflammation is known to promote metabolic dysregulation in obesity and type 2 diabetes. Although the precise origin of the unchecked inflammatory... 
IMMUNE-SYSTEM | INFLAMMATION | DISEASE | RESISTANCE | FAT | AKT | IMMUNOLOGY | DIET-INDUCED OBESITY | KEY PLAYERS | ADIPOSE-TISSUE | CUTTING EDGE | Tumor Necrosis Factor-alpha - metabolism | Antigens, CD - immunology | T-Lymphocytes, Regulatory - metabolism | Epithelial Cells - metabolism | TOR Serine-Threonine Kinases - metabolism | Obesity - immunology | Insulin - immunology | Interferon-gamma - metabolism | Antigens, CD - metabolism | T-Lymphocytes, Regulatory - immunology | Epithelium - immunology | Signal Transduction - immunology | Inflammation - metabolism | Tumor Necrosis Factor-alpha - immunology | Interleukin-10 - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Receptor, Insulin - immunology | Macrophages - immunology | Hyperinsulinism - metabolism | Intra-Abdominal Fat - immunology | Transforming Growth Factor beta - immunology | Epithelium - metabolism | Mice, Inbred C57BL | Apyrase - metabolism | Cells, Cultured | Apyrase - immunology | CTLA-4 Antigen - metabolism | Inflammation - immunology | CTLA-4 Antigen - immunology | Intra-Abdominal Fat - metabolism | Obesity - metabolism | TOR Serine-Threonine Kinases - immunology | Insulin - metabolism | Macrophages - metabolism | Animals | Hyperinsulinism - immunology | Proto-Oncogene Proteins c-akt - immunology | Epithelial Cells - immunology | Interferon-gamma - immunology | Interleukin-10 - antagonists & inhibitors | Receptor, Insulin - metabolism | Mice | Interleukin-10 - immunology | Transforming Growth Factor beta - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Nature, ISSN 0028-0836, 01/2012, Volume 481, Issue 7381, pp. 380 - 384
Acetyl coenzyme A (AcCoA) is the central biosynthetic precursor for fatty-acid synthesis and protein acetylation. In the conventional view of mammalian cell... 
FLUX ANALYSIS | DISTRIBUTIONS | FATTY-ACID SYNTHESIS | MULTIDISCIPLINARY SCIENCES | GROWTH | HYDROXYLATION | CELL-PROLIFERATION | SUPPRESSION | HIF-ALPHA | CANCER | DEHYDROGENASE | CD8-Positive T-Lymphocytes - cytology | Palmitic Acid - metabolism | Isocitrate Dehydrogenase - deficiency | Humans | Glutamine - metabolism | Kidney Neoplasms - metabolism | Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism | Oxygen - metabolism | Cell Hypoxia | Basic Helix-Loop-Helix Transcription Factors - metabolism | Acetyl Coenzyme A - biosynthesis | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Ketoglutaric Acids - metabolism | Lipogenesis | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Carbon - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Oxidation-Reduction | Carcinoma, Renal Cell - pathology | Cells, Cultured | Isocitrate Dehydrogenase - genetics | Acetyl Coenzyme A - metabolism | Citric Acid Cycle | Carcinoma, Renal Cell - metabolism | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Kidney Neoplasms - pathology | Physiological aspects | Hypoxia | Research | Lipid metabolism | Electron transport | Proteins | Confidence intervals | Metabolites | Lipids | Biosynthesis | Glucose | Experiments | Index Medicus
Journal Article
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 507, Issue 7490, pp. 118 - 123
The recognition events that mediate adaptive cellular immunity and regulate antibody responses depend on intercellular contacts between T cells and... 
SUPRAMOLECULAR ACTIVATION CLUSTER | ADHESION | COMPLEX | PROTEIN | MULTIDISCIPLINARY SCIENCES | DYNAMICS | PROLIFERATION | MICROSCOPY | CLASS-II | ELECTRON TOMOGRAPHY | MOLECULES | Cell Polarity | Virus Release | Antigen-Presenting Cells - cytology | Vesicular Transport Proteins - metabolism | Humans | Secretory Vesicles - metabolism | Male | Receptors, Antigen, T-Cell - ultrastructure | Immunological Synapses - metabolism | CD4-Positive T-Lymphocytes - immunology | DNA-Binding Proteins - metabolism | Histocompatibility Antigens Class I - metabolism | gag Gene Products, Human Immunodeficiency Virus - metabolism | Female | HIV - metabolism | Receptors, Antigen, T-Cell - immunology | CD4-Positive T-Lymphocytes - virology | B-Lymphocytes - metabolism | Antigen-Presenting Cells - metabolism | B-Lymphocytes - cytology | Immunological Synapses - ultrastructure | Receptors, Antigen, T-Cell - metabolism | Signal Transduction | Lymphocyte Activation | CD4-Positive T-Lymphocytes - metabolism | Endosomal Sorting Complexes Required for Transport - metabolism | Histocompatibility Antigens Class I - immunology | Immunological Synapses - secretion | Antigen-Presenting Cells - immunology | Protein Transport | Transcription Factors - metabolism | Secretory Vesicles - secretion | Intercellular Adhesion Molecule-1 - metabolism | Animals | B-Lymphocytes - immunology | CD4-Positive T-Lymphocytes - secretion | Protein Binding | Mice | Medicine | Plasma | Medical imaging | Microscopy | Lymphocytes | Rheumatology | Tomography | T cell receptors | Biology | Cytoplasm | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 03/2011, Volume 471, Issue 7340, pp. 637 - 641
Journal Article
Journal of Immunology, ISSN 0022-1767, 05/2013, Volume 190, Issue 9, pp. 4640 - 4649
Dendritic cells (DC) are professional APCs that regulate innate and adaptive immunity. The role of fatty-acid synthesis in DC development and function is... 
CANCER-CELLS | APOPTOSIS | KAPPA-B ACTIVATION | UNFOLDED PROTEIN RESPONSE | CYTOKINE PRODUCTION | SYNTHASE INHIBITION | ER STRESS | MAP KINASE | MACROPHAGES | ENDOPLASMIC-RETICULUM STRESS | IMMUNOLOGY | Fatty Acids - immunology | Leukocytes, Mononuclear - metabolism | Chemokine CCL2 - immunology | Dendritic Cells - immunology | Humans | Caspase 3 - metabolism | Male | Cyclin B1 - metabolism | Interferon-gamma - metabolism | PPAR gamma - metabolism | CD4-Positive T-Lymphocytes - immunology | Mitogen-Activated Protein Kinase Kinases - metabolism | Liver - immunology | CD8-Positive T-Lymphocytes - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Liver - metabolism | CD4-Positive T-Lymphocytes - metabolism | Interleukin-12 - metabolism | B7-2 Antigen - metabolism | Cell Differentiation - immunology | Intercellular Adhesion Molecule-1 - metabolism | Proto-Oncogene Proteins c-akt - immunology | T-Lymphocytes, Cytotoxic - metabolism | Endoplasmic Reticulum - immunology | Interleukin-12 - immunology | Mice | Killer Cells, Natural - metabolism | CD8-Positive T-Lymphocytes - immunology | bcl-X Protein - metabolism | Fatty Acids - biosynthesis | Mitogen-Activated Protein Kinase Kinases - immunology | Caspase 3 - immunology | Endoplasmic Reticulum - metabolism | Genes, MHC Class II - immunology | PPAR gamma - immunology | Cyclin B1 - immunology | Leukocytes, Mononuclear - immunology | bcl-X Protein - immunology | Killer Cells, Natural - immunology | Chemokine CCL2 - metabolism | B7-2 Antigen - immunology | Fatty Acids - metabolism | Dendritic Cells - metabolism | T-Lymphocytes, Cytotoxic - immunology | B7-1 Antigen - immunology | Intercellular Adhesion Molecule-1 - immunology | Mice, Inbred C57BL | B7-1 Antigen - metabolism | Animals | Apoptosis - immunology | Interferon-gamma - immunology | Dendritic Cells - cytology | Index Medicus | Abridged Index Medicus | Fatty-acid synthesis | ER stress | NK cells | T cells | Bone marrow dendritic cells
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2008, Volume 118, Issue 1, pp. 79 - 88
Despite great interest in cancer chemoprevention, effective agents are few. Here we show that chloroquine, a drug that activates the stress-responsive Atm-p53... 
MEDICINE, RESEARCH & EXPERIMENTAL | BCL-X-L | SIGNALING PATHWAYS | INDUCED APOPTOSIS | PHOSPHORYLATION | ATM | AUTOPHAGY | CYTOCHROME-C RELEASE | MYC-INDUCED LYMPHOMAGENESIS | TRANSGENIC MICE | P53 | Apoptosis - drug effects | Humans | Apoptosis - genetics | Male | Autophagy - drug effects | Burkitt Lymphoma - pathology | Neoplasms, Experimental - pathology | Chloroquine - pharmacology | Cell Transformation, Neoplastic - genetics | Autophagy - genetics | B-Lymphocytes - pathology | B-Lymphocytes - metabolism | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Tumor Suppressor Proteins - metabolism | Embryo, Mammalian - pathology | Cell Cycle Proteins - metabolism | Neoplasms, Experimental - prevention & control | bcl-2-Associated X Protein - metabolism | Ataxia Telangiectasia Mutated Proteins | Fibroblasts - pathology | Ataxia Telangiectasia - pathology | Ataxia Telangiectasia - genetics | Mice | Proto-Oncogene Proteins c-myc - genetics | Neoplasms, Experimental - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Embryo, Mammalian - metabolism | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Caspases - metabolism | Lysosomes - metabolism | Burkitt Lymphoma - prevention & control | Mice, Mutant Strains | Tumor Suppressor Proteins - genetics | Neoplasms, Experimental - genetics | Burkitt Lymphoma - genetics | Cell Cycle Proteins - genetics | Female | Lysosomes - pathology | Antirheumatic Agents - pharmacology | bcl-2-Associated X Protein - genetics | Antirheumatic Agents - therapeutic use | Ataxia Telangiectasia - prevention & control | Caspases - genetics | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Burkitt Lymphoma - metabolism | Chloroquine - therapeutic use | Ataxia Telangiectasia - metabolism | DNA-Binding Proteins - genetics | Cell Transformation, Neoplastic - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Animals | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Cell Transformation, Neoplastic - pathology | Prevention | Chloroquine | Lysosomes | Dosage and administration | Research | Drug therapy | Health aspects | Cancer | Index Medicus | Abridged Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, pp. e0136822 - e0136822
Methionine metabolism plays a central role in methylation reactions, production of glutathione and methylarginines, and modulating homocysteine levels. The... 
AMINO-ACID-METABOLISM | OXIDATIVE STRESS | DNA METHYLATION | LIQUID-CHROMATOGRAPHY | NITRIC-OXIDE SYNTHASE | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | FOLLOW-UP | STEATOHEPATITIS | ONE-CARBON METABOLISM | MASS-SPECTROMETRY | Glycine N-Methyltransferase - metabolism | Blood Chemical Analysis | Homocysteine - metabolism | Glutathione - biosynthesis | Diet, High-Fat | Female | Metabolic Networks and Pathways - physiology | Cysteine - metabolism | Dipeptides - metabolism | Betaine-Homocysteine S-Methyltransferase - metabolism | Acyl Coenzyme A - metabolism | B-Lymphocytes - metabolism | Methionine - metabolism | Liver - metabolism | Mice, Inbred C57BL | Metabolome | Adenosylhomocysteinase - metabolism | Methionine Adenosyltransferase - metabolism | DNA Methylation - genetics | Non-alcoholic Fatty Liver Disease - metabolism | Cystathionine beta-Synthase - metabolism | Random Allocation | Animals | 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - metabolism | Mice | Fatty liver | Physiological aspects | Development and progression | Genetic aspects | Research | Homocysteine | Amino acid metabolism | Transcription factors | Adenosylmethionine | High cholesterol diet | Bcl-2 protein | Laboratories | Liver | Glycine | Caspase-3 | Proteins | Elevation | Arginine | Betaine | Rodents | DNA methylation | Deoxyribonucleic acid--DNA | Glutathione | Phosphatidylethanolamine | Liver diseases | Nutrition | 5-Methyltetrahydrofolate-homocysteine S-methyltransferase | Methionine | Glycine N-methyltransferase | c-Jun protein | Caspase | Betaine-homocysteine S-methyltransferase | Gene expression | Metabolism | Fatty acids | Lymphoma | Fatty-acid synthase | Cholesterol | Molecular chains | Substrates | Depletion | Lymphocytes B | Diet | Nitric oxide | Fibrosis | DNA methyltransferase | Methylation | Nuclear reactions | Polymethyl methacrylate | B-cell lymphoma | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2014, Volume 211, Issue 11, pp. 2265 - 2279
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2013, Volume 110, Issue 31, pp. 12655 - 12660
The positive transcription elongation factor b (P-TEFb) is involved in physiological and pathological events including inflammation, cancer, AIDS, and cardiac... 
T lymphocytes | Pathology | RNA | HEK293 cells | Genes | Cell lines | Antibodies | Small nuclear RNA | Gene expression regulation | HIV 1 | 7SK SNRNA | TRANSCRIPTION FACTOR BCL11B | ELONGATION | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | POLYMERASE | HIV-1 TAT | MICROGLIAL CELLS | T-CELL LINEAGE | BROMODOMAIN PROTEIN BRD4 | RNA-Binding Proteins - genetics | Humans | Myosin Heavy Chains - genetics | Cardiomegaly - pathology | Positive Transcriptional Elongation Factor B - metabolism | Positive Transcriptional Elongation Factor B - genetics | Myosin Heavy Chains - metabolism | RNA, Small Nuclear - genetics | Tumor Suppressor Proteins - genetics | HEK293 Cells | Cardiac Myosins - metabolism | Repressor Proteins - metabolism | Promoter Regions, Genetic | Tumor Suppressor Proteins - metabolism | Protein Structure, Secondary | Cyclin-Dependent Kinase 9 - genetics | Cardiac Myosins - genetics | Repressor Proteins - genetics | Transcription Factors - genetics | Transcription Factors - metabolism | Animals | Cyclin-Dependent Kinase 9 - metabolism | Mice | RNA, Small Nuclear - metabolism | Cardiomegaly - genetics | RNA-Binding Proteins - metabolism | Cardiomegaly - metabolism | Physiological aspects | Transcription factors | Genetic aspects | Heart enlargement | Health aspects | Myosin | Proteins | Heart | Acquired immune deficiency syndrome--AIDS | Ribonucleic acid--RNA | Cancer | Index Medicus | Life Sciences | Neurons and Cognition | Biological Sciences
Journal Article