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Blood, ISSN 0006-4971, 02/2015, Volume 125, Issue 9, pp. 1427 - 1434
The impairment of cytotoxic activity of lymphocytes disturbs immune surveillance and leads to the development of hemophagocytic lymphohistiocytic syndrome... 
ACTIVATION | DISRUPTION | GENE | SUSCEPTIBILITY | FAMILIAL HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS | PERFORIN | MUTATIONS | IDENTIFICATION | HEMATOLOGY | CD8(+) T-CELLS | EXHAUSTION | Lymphocytic choriomeningitis virus - immunology | Spleen - virology | T-Lymphocytes, Cytotoxic - immunology | Lymphocytic Choriomeningitis - virology | Lymphohistiocytosis, Hemophagocytic - pathology | Cell Proliferation | Spleen - immunology | Killer Cells, Natural - virology | Lymphocytic Choriomeningitis - pathology | Interferon-gamma - secretion | Mice, Inbred C57BL | Cells, Cultured | Killer Cells, Natural - pathology | Lymphocytic Choriomeningitis - immunology | Viral Load | Lymphohistiocytosis, Hemophagocytic - virology | Animals | Killer Cells, Natural - immunology | Mice | Cytotoxicity, Immunologic - immunology | Spleen - pathology | Lymphohistiocytosis, Hemophagocytic - immunology | Killer Cells, Natural/immunology | Lymphocytic Choriomeningitis/pathology | Lymphohistiocytosis, Hemophagocytic/virology | Lymphocytic Choriomeningitis/immunology | Innate immunity | Lymphohistiocytosis, Hemophagocytic/immunology | Killer Cells, Natural/pathology | Spleen/pathology | Life Sciences | Immunology | Lymphocytic Choriomeningitis/virology | Spleen/virology | Lymphocytic choriomeningitis virus/immunology | Spleen/immunology | Killer Cells, Natural/virology | Lymphohistiocytosis, Hemophagocytic/pathology | Cytotoxicity, Immunologic/immunology | T-Lymphocytes, Cytotoxic/immunology | Interferon-gamma/secretion
Journal Article
Immunity, ISSN 1074-7613, 10/2013, Volume 39, Issue 4, pp. 687 - 696
Journal Article
Journal of Virology, ISSN 0022-538X, 11/2017, Volume 91, Issue 22
Journal Article
Immunity, ISSN 1074-7613, 07/2013, Volume 39, Issue 1, pp. 111 - 122
Immune cells sense microbial products through Toll-like receptors (TLR), which trigger host defense responses including type 1 interferons (IFNs) secretion. A... 
TUMOR-NECROSIS-FACTOR | ACTIVATION | I INTERFERONS | CHORIOMENINGITIS VIRUS | PROTEIN-TYROSINE PHOSPHATASES | HOST-DEFENSE | MURINE LUPUS | INFLAMMATORY ARTHRITIS | IMMUNOLOGY | NF-KAPPA-B | T-CELLS | Lymphocytic choriomeningitis virus - immunology | Colitis - genetics | Humans | Autoimmunity - genetics | Immunoblotting | Arthritis - genetics | Interferon Type I - immunology | Lymphocytic Choriomeningitis - immunology | Host-Pathogen Interactions - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - immunology | Autoimmunity - immunology | Myeloid Cells - immunology | TNF Receptor-Associated Factor 3 - genetics | Colitis - chemically induced | HEK293 Cells | Arthritis - immunology | Interferon Type I - metabolism | Lymphocytic choriomeningitis virus - physiology | Toll-Like Receptors - metabolism | Colitis - immunology | Lymphocytic Choriomeningitis - genetics | Cell Line | Lymphocytic Choriomeningitis - virology | Mice, Inbred C57BL | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - metabolism | Toll-Like Receptors - immunology | Cells, Cultured | Immunity - immunology | Mice, Transgenic | TNF Receptor-Associated Factor 3 - metabolism | Ubiquitination - immunology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Animals | Dextran Sulfate - immunology | TNF Receptor-Associated Factor 3 - immunology | Toll-Like Receptors - genetics | Interferon Type I - genetics | Myeloid Cells - metabolism | Mice | Immunity - genetics | Ubiquitin | Autoimmunity | Interferon | Biological response modifiers
Journal Article
Nature, ISSN 0028-0836, 2016, Volume 537, Issue 7620, pp. 412 - 416
Journal Article
Nature Immunology, ISSN 1529-2908, 06/2013, Volume 14, Issue 6, pp. 574 - 583
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2017, Volume 114, Issue 19, pp. 4987 - 4992
The presence of the endogenous Leishmania RNA virus 1 (LRV1) replicating stably within some parasite species has been associated with the development of more... 
Trypanosomatid protozoan parasite | Arboviruses | Leishmania subgenus viannia | Totiviridae | Leishmania RNA virus 1 | trypanosomatid protozoan parasite | AMERICAN CUTANEOUS LEISHMANIASIS | IFN-GAMMA | MULTIDISCIPLINARY SCIENCES | INNATE IMMUNE-RESPONSE | LYMPHOCYTIC CHORIOMENINGITIS VIRUS | PROTOZOAN PARASITE | RNA VIRUS 1 | BETA | Leishmania subgenus Viannia | arboviruses | INFANTUM | T-CELLS | TOSCANA VIRUS | Lymphocytic choriomeningitis virus - immunology | Leishmania guyanensis - immunology | Leishmaniasis, Mucocutaneous - immunology | Coinfection | Lymphocytic Choriomeningitis - pathology | Leishmaniasis, Mucocutaneous - pathology | Leishmaniasis, Mucocutaneous - genetics | Leishmaniavirus - immunology | Interferon Type I - immunology | Lymphocytic Choriomeningitis - immunology | Phlebotomus Fever - immunology | Mice, Knockout | Sandfly fever Naples virus - immunology | Animals | Leishmania guyanensis - virology | Phlebotomus Fever - genetics | Interferon Type I - genetics | Mice | Phlebotomus Fever - pathology | Lymphocytic Choriomeningitis - genetics | Care and treatment | Luciferase | Interferon | Research | Leishmaniasis | T cells | Macrophages | Viruses | Activation | Infections | Parasites | Synergism | Risk factors | Metastases | Genotype & phenotype | Replicating | Rodents | Down-regulation | Immune system | Vector-borne diseases | Pathogens | RNA viruses | Immune response | Double-stranded RNA | Ribonucleic acid--RNA | Pathogenicity | Pathology | Viral infections | Biological Sciences
Journal Article
Nature Immunology, ISSN 1529-2908, 07/2015, Volume 16, Issue 8, pp. 871 - 879
Journal Article
Journal Article
Nature Immunology, ISSN 1529-2908, 06/2013, Volume 14, Issue 6, pp. 603 - 610
Journal Article
Journal Article