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Nature Immunology, ISSN 1529-2908, 03/2019, Volume 20, Issue 3, pp. 326 - 336
T cell dysfunction is a hallmark of many cancers, but the basis for T cell dysfunction and the mechanisms by which antibody blockade of the inhibitory receptor... 
ANALYSIS REVEALS | PATHWAYS | SURVIVAL | APOPTOSIS | CHROMATIN | PERSISTENCE | INFECTION | DYSFUNCTION | IMMUNOLOGY | PD-1 | EXPRESSION | Lymphocytic choriomeningitis virus - immunology | Humans | Lymphocytic choriomeningitis virus - drug effects | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antibodies, Blocking - pharmacology | Lymphocytes, Tumor-Infiltrating - virology | Lymphocyte Subsets - virology | Lymphocytic Choriomeningitis - immunology | Lymphocyte Subsets - immunology | Melanoma, Experimental - prevention & control | Melanoma, Experimental - immunology | Female | Lymphocytic choriomeningitis virus - physiology | Melanoma, Experimental - virology | Lymphocytic Choriomeningitis - virology | Lymphocyte Subsets - drug effects | Mice, Inbred C57BL | Programmed Cell Death 1 Receptor - metabolism | Lymphocytes, Tumor-Infiltrating - drug effects | Animals | Lymphocytic Choriomeningitis - prevention & control | CD8-Positive T-Lymphocytes - virology | CD8-Positive T-Lymphocytes - drug effects | Antibodies, Blocking - immunology | Cell Line, Tumor | Mice, Congenic | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | Lymphocytes, Tumor-Infiltrating - immunology | Therapy | Stability | Transcription | Tumor-infiltrating lymphocytes | PD-1 protein | CD8 antigen | Melanoma | Chronic infection | Lymphocytes T | Immune checkpoint | Lymphocytes | Exhaustion | Tumors
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2012, Volume 109, Issue 8, pp. 3012 - 3017
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 04/2013, Volume 20, Issue 4, pp. 649 - 658
Journal Article
PLoS Neglected Tropical Diseases, ISSN 1935-2727, 04/2018, Volume 12, Issue 4, p. e0006398
Background Lymphocytic choriomeningitis virus (LCMV) causes a variety of diseases, including asymptomatic infections, meningitis, and congenital infections in... 
IMMUNE-RESPONSE | IMMUNIZATION | RECOMBINANT VACCINIA VIRUS | LASSA VIRUS | NUCLEOPROTEIN | VACCINATION | INFECTION | GUINEA-PIGS | NEUTRALIZING EPITOPE | PARASITOLOGY | TROPICAL MEDICINE | FEVER | Lymphocytic choriomeningitis virus - immunology | Humans | Viral Vaccines - genetics | Viral Proteins - immunology | Lymphocytic Choriomeningitis - immunology | Female | Viral Proteins - administration & dosage | Glycoproteins - genetics | Gene Expression | Lymphocytic Choriomeningitis - virology | Rabies virus - physiology | Mice, Inbred C57BL | Genetic Vectors - metabolism | Viral Proteins - genetics | Genetic Vectors - genetics | Glycoproteins - administration & dosage | Viral Vaccines - administration & dosage | Glycoproteins - immunology | Rabies virus - genetics | Animals | Lymphocytic Choriomeningitis - prevention & control | Virus Replication | Lymphocytic choriomeningitis virus - genetics | Mice | Viral Vaccines - immunology | Viral meningitis | Prevention | Rabies vaccines | Research | Virus research | Immunological research | Laboratories | CD8 antigen | Funding | Genes | Foetus | Viruses | Lymphocytes T | Genomes | Infections | Vaccines | Veterinary medicine | Immunity | Immunity (cell-mediated) | Suckling behavior | Proteins | Ebola virus | Lymphocytes | Meningitis | Deoxyribonucleic acid--DNA | Recombinant | Antigens | Cell survival | Fetuses | Glycoprotein | Glycoproteins | RNA polymerase | Disease control | Survival | Fever | Cells | P protein | Virology | Infectious diseases | Rabies | Adenoviruses | Replication | Recombinants | Symptoms | Viral infections | Deoxyribonucleic acid | DNA
Journal Article
Journal of Virology, ISSN 0022-538X, 06/2013, Volume 87, Issue 11, pp. 6283 - 6295
Journal Article
PLoS Pathogens, ISSN 1553-7366, 09/2012, Volume 8, Issue 9, p. e1002913
During acute viral infections, clearance of the pathogen is followed by the contraction of the anti-viral T cell compartment. In contrast, T cell responses... 
MICROBIOLOGY | TNFR FAMILY | CHRONIC VIRAL-INFECTION | LYMPHOCYTIC CHORIOMENINGITIS VIRUS | CD8 T-CELLS | RESPONSES | VIROLOGY | IMMUNOTHERAPY | CD27 | COSTIMULATION | MICE | EXPRESSION | PARASITOLOGY | Germinal Center - physiology | Lymphocytic choriomeningitis virus - immunology | Receptors, OX40 - physiology | Receptors, OX40 - genetics | Cercopithecus aethiops | Lymphocytic Choriomeningitis - immunology | Virus Latency - physiology | Adaptive Immunity - genetics | CD4-Positive T-Lymphocytes - immunology | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Receptors, OX40 - metabolism | CD8-Positive T-Lymphocytes - metabolism | Lymphocytic choriomeningitis virus - physiology | Virus Diseases - genetics | Vero Cells | Lymphocytic Choriomeningitis - genetics | Acute Disease | Virus Diseases - immunology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Mice, Knockout | Animals | Germinal Center - metabolism | Lymphocytic Choriomeningitis - prevention & control | Mice | CD8-Positive T-Lymphocytes - immunology | Virus Latency - immunology | Virus Diseases - prevention & control | Virus diseases | Physiological aspects | Development and progression | Virulence (Microbiology) | Research | T cells | Health aspects | Infections | T cell receptors | Immunology | Viral infections | Immune system
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2013, Volume 210, Issue 10, pp. 2087 - 2103
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2014, Volume 193, Issue 2, pp. 757 - 763
Direct mammalian target of rapamycin (Rapa) complex 1 inhibition by short-term low-dose Rapa treatment has recently been shown to improve CD8 T cell... 
MAMMALIAN TARGET | LIFE-SPAN | RESPONSES | CAPACITY | METABOLISM | NILE-VIRUS-INFECTION | DIFFERENTIATION | IMMUNOLOGY | T-CELLS | MTOR | CUTTING EDGE
Journal Article
Immunology, ISSN 0019-2805, 07/2017, Volume 151, Issue 3, pp. 340 - 348
Summary T regulatory (Treg) cells are critical for preventing autoimmunity and suppressing immune responses during cancer and chronic infection. However, the... 
simian immunodeficiency virus | interleukin‐2 | interferon‐γ | lymphocytic choriomeningitis virus | Tregs | tumour necrosis factor‐α | tumour necrosis factor-α | interferon-γ | interleukin-2 | PERSISTENCE | CHRONIC LCMV INFECTION | IMMUNOLOGY | interferon | VIRAL-INFECTION | EFFECTOR | BET | MEMORY | tumour necrosis factor | MICE | DIFFERENTIATION | TRANSCRIPTION FACTOR | EXPRESSION | Diphtheria Toxin - administration & dosage | Lymphocytic choriomeningitis virus - immunology | Antigens, Viral - administration & dosage | Cercopithecus aethiops | Lymphocytic choriomeningitis virus - drug effects | Immunologic Memory - drug effects | Lymphocytic Choriomeningitis - immunology | Antibodies, Viral - blood | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Time Factors | Female | Vero Cells | Disease Models, Animal | Simian Immunodeficiency Virus - immunology | Lymphocytic Choriomeningitis - virology | Mice, Transgenic | Diphtheria Toxin - immunology | Viral Vaccines - administration & dosage | Antigens, Viral - immunology | Adaptive Immunity - drug effects | Animals | Lymphocytic Choriomeningitis - prevention & control | Lymphocyte Activation - drug effects | CD8-Positive T-Lymphocytes - drug effects | Cell Proliferation - drug effects | CD8-Positive T-Lymphocytes - immunology | Viral Vaccines - immunology | CD4-Positive T-Lymphocytes - drug effects | Autoimmunity | Interferon | Vaccines | Biological response modifiers | T cells | Health aspects | CD8 antigen | Impairment | Differentiation (biology) | Chronic infection | Effector cells | Viruses | Lymphocytes T | Infections | Control | Lymphocytes | Recall | Expansion | Retarding | Pathogens | Immunological memory | Memory cells | Immune response | Immunoregulation | Markers | T cell receptors | Maintenance | Cell differentiation | CD4 antigen | Depletion | Mice | Intracellular | Cancer | Original
Journal Article