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Journal of Molecular Biology, ISSN 0022-2836, 2002, Volume 316, Issue 3, pp. 769 - 787
Vascular endothelial growth factor (VEGF) is a potent endothelial cell-specific mediator of angiogenesis and vasculogenesis. VEGF is involved pathologically in... 
protein structure | NMR | angiogenesis | vascular endothelial growth factor | peptide antagonist | Angiogenesis | Peptide antagonist | Protein structure | Vascular endothelial growth factor | MOLECULAR-DYNAMICS | TRIPLE-RESONANCE EXPERIMENTS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-STRUCTURE DETERMINATION | RECEPTOR-BINDING DOMAIN | BIOACTIVE CONFORMATION | ANGSTROM RESOLUTION | DE-NOVO DESIGN | IMPROVED SENSITIVITY | INTERPROTON DISTANCE RESTRAINTS | Disulfides - metabolism | Receptors, Vascular Endothelial Growth Factor | Vascular Endothelial Growth Factor A | Endothelial Growth Factors - metabolism | Vascular Endothelial Growth Factors | Humans | Molecular Sequence Data | Receptors, Growth Factor - antagonists & inhibitors | Crystallography, X-Ray | Endothelial Growth Factors - chemistry | Proto-Oncogene Proteins - chemistry | Vascular Endothelial Growth Factor Receptor-1 | Lymphokines - genetics | Peptides - chemical synthesis | Peptides - metabolism | Alanine - genetics | Solutions | Lymphokines - antagonists & inhibitors | Protein Structure, Quaternary | Lymphokines - metabolism | Nuclear Magnetic Resonance, Biomolecular | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Binding Sites | Dimerization | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Proto-Oncogene Proteins - antagonists & inhibitors | Bacteriophages - chemistry | Peptides - chemistry | Protein Structure, Secondary | Models, Molecular | Alanine - metabolism | Mutation - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Receptors, Growth Factor - chemistry | Peptides - pharmacology | Endothelial Growth Factors - antagonists & inhibitors | Lymphokines - chemistry | Endothelial Growth Factors - genetics | Hydrophobic and Hydrophilic Interactions | Receptor Protein-Tyrosine Kinases - chemistry | Receptors, Growth Factor - metabolism
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2001, Volume 276, Issue 10, pp. 7614 - 7620
Vascular endothelial growth factor (VEGF) induces adhesion molecules on endothelial cells during inflammation. Here we examined the mechanisms underlying... 
PROTEIN-KINASE-C | CYTOKINES | ANGIOGENESIS | PHOSPHORYLATION | PATHWAY | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | RECEPTOR | AKT | FLK-1/KDR ACTIVATION | Vascular Endothelial Growth Factor A | Vascular Endothelial Growth Factors | Humans | Nitric Oxide Synthase - antagonists & inhibitors | NF-kappa B - metabolism | RNA, Messenger - metabolism | MAP Kinase Kinase 2 | Type C Phospholipases - antagonists & inhibitors | MAP Kinase Kinase 1 | Ribonucleases - metabolism | Flow Cytometry | Time Factors | Intercellular Adhesion Molecule-1 - biosynthesis | E-Selectin - biosynthesis | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lymphokines - biosynthesis | Umbilical Veins - cytology | Protein Structure, Tertiary | Recombinant Proteins - metabolism | NF-kappa B - antagonists & inhibitors | Signal Transduction | Cells, Cultured | Enzyme Inhibitors - pharmacology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Endothelial Growth Factors - biosynthesis | Protein Kinase C - antagonists & inhibitors | Cell Adhesion | Blotting, Western | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Androstadienes - pharmacology | Endothelium, Vascular - metabolism | Models, Biological | Vascular Cell Adhesion Molecule-1 - biosynthesis | Nitric Oxide Synthase - metabolism | Enzyme Activation | DNA, Complementary - metabolism | Leukocytes - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Expert Opinion on Biological Therapy, ISSN 1471-2598, 07/2001, Volume 1, Issue 4, pp. 703 - 718
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 05/2002, Volume 62, Issue 9, pp. 2554 - 2560
Epidermal growth factor receptor (EGFR) tyrosine kinase is a potential target for anticancer therapy. ZD1839 (Iressa) is a selective inhibitor of EGFR tyrosine... 
BREAST-CANCER CELLS | TUMOR-NECROSIS-FACTOR | PLASMINOGEN-ACTIVATOR | ONCOLOGY | MOUSE BALB/3T3 CELLS | HUMAN PANCREATIC-CARCINOMA | MIDDLE T-ANTIGEN | TUBULAR MORPHOGENESIS | MICROVASCULAR ENDOTHELIAL-CELLS | HUMAN GLIOMA-CELLS | FACTOR-ALPHA | Endothelium, Vascular - cytology | Neovascularization, Physiologic - drug effects | Vascular Endothelial Growth Factor A | Vascular Endothelial Growth Factors | Carcinoma, Squamous Cell - metabolism | Humans | Endothelium, Vascular - drug effects | Male | Endothelium, Vascular - enzymology | Mitogen-Activated Protein Kinase Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Cornea - blood supply | Vulvar Neoplasms - enzymology | Lymphokines - antagonists & inhibitors | Vulvar Neoplasms - metabolism | Female | Lymphokines - biosynthesis | Tumor Cells, Cultured | Carcinoma, Squamous Cell - enzymology | Interleukin-8 - biosynthesis | Vulvar Neoplasms - drug therapy | Cells, Cultured | Enzyme Inhibitors - pharmacology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Angiogenesis Inhibitors - pharmacology | Endothelial Growth Factors - biosynthesis | Interleukin-8 - antagonists & inhibitors | Enzyme Activation - drug effects | Endothelial Growth Factors - antagonists & inhibitors | Cell Movement - drug effects | Animals | Carcinoma, Squamous Cell - drug therapy | Epidermal Growth Factor - antagonists & inhibitors | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Quinazolines - pharmacology
Journal Article
Science, ISSN 0036-8075, 7/1997, Volume 277, Issue 5322, pp. 55 - 60
Angiogenesis is thought to depend on a precise balance of positive and negative regulation. Angiopoietin-1 (Ang1) is an angiogenic factor that signals through... 
Receptors | Messenger RNA | Complementary DNA | Transgenic animals | Cell lines | Blood vessels | Adults | Research Articles | Physiological regulation | Embryos | Endothelial cells | PROTEIN | INHIBITION | VASCULOGENESIS | MULTIDISCIPLINARY SCIENCES | GENES | PATTERNS | K RO MULTIDISCIPLINARY SCIENCES | MOLECULAR-CLONING | TEK | EXPRESSION | RECEPTOR TYROSINE KINASE | ENDOTHELIAL GROWTH-FACTOR | Endothelium, Vascular - cytology | Vascular Endothelial Growth Factor A | Endothelial Growth Factors - metabolism | Phosphorylation | Membrane Glycoproteins - metabolism | Receptor, TIE-2 | Vascular Endothelial Growth Factors | Blood Vessels - metabolism | Humans | Angiopoietin-1 | Molecular Sequence Data | Angiopoietin-2 | Recombinant Fusion Proteins - metabolism | Embryo, Mammalian - metabolism | Blood Vessels - embryology | Lymphokines - genetics | Membrane Glycoproteins - antagonists & inhibitors | Cloning, Molecular | Lymphokines - metabolism | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Amino Acid Sequence | Signal Transduction | Cells, Cultured | Rats | Mice, Transgenic | Receptor Protein-Tyrosine Kinases - metabolism | Rats, Sprague-Dawley | Animals | Proteins - metabolism | Endothelium, Vascular - metabolism | Endothelial Growth Factors - genetics | Ligands | Mice | Proteins - chemistry | Neovascularization, Physiologic | Rodents | Circulatory system
Journal Article
Nature, ISSN 0028-0836, 06/2002, Volume 417, Issue 6892, pp. 954 - 958
Vascular endothelial growth factor (VEGF) is a principal regulator of blood vessel formation and haematopoiesis, but the mechanisms by which VEGF... 
INACTIVATION | HEMATOPOIETIC PROGENITOR CELLS | GENE | MULTIDISCIPLINARY SCIENCES | KINASE INHIBITORS | MICE | PROLIFERATION | ACUTE MYELOID-LEUKEMIA | EXPRESSION | PRECURSORS | ENDOTHELIAL GROWTH-FACTOR | Endothelium, Vascular - cytology | Clone Cells - cytology | Receptors, Vascular Endothelial Growth Factor | Vascular Endothelial Growth Factor A | Endothelial Growth Factors - metabolism | Clone Cells - drug effects | Vascular Endothelial Growth Factors | Humans | Cell Membrane Permeability | Receptors, Growth Factor - antagonists & inhibitors | Endothelium, Vascular - drug effects | Autocrine Communication - drug effects | RNA, Messenger - metabolism | Hematopoiesis - drug effects | Vascular Endothelial Growth Factor Receptor-1 | Flow Cytometry | Lymphokines - genetics | Gene Deletion | Lymphokines - antagonists & inhibitors | Proto-Oncogene Proteins - agonists | Lymphokines - metabolism | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Hematopoietic Stem Cells - drug effects | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - pharmacology | Cell Survival - drug effects | Proto-Oncogene Proteins - antagonists & inhibitors | Transduction, Genetic | Paracrine Communication | RNA, Messenger - genetics | Receptor Protein-Tyrosine Kinases - pharmacology | Cells, Cultured | Solubility | Hematopoietic Stem Cells - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Clone Cells - metabolism | Cell Division - drug effects | Mice, Knockout | Endothelial Growth Factors - antagonists & inhibitors | Receptors, Growth Factor - agonists | Animals | Endothelium, Vascular - metabolism | Endothelial Growth Factors - genetics | Hematopoietic Stem Cells - cytology | Mice | Receptors, Growth Factor - metabolism | Blood vessels | Genes | Rodents | Stem cells
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2007, Volume 117, Issue 12, pp. 3786 - 3799
The molecular mechanisms of acute lung injury resulting in inflammation and fibrosis are not well established. Here we investigate the roles of the IL-1... 
MONOSODIUM URATE CRYSTALS | MEDICINE, RESEARCH & EXPERIMENTAL | INTERLEUKIN-1 RECEPTOR ANTAGONIST | INDUCED CYTOKINE | INDUCED LUNG INJURY | AIRWAY INFLAMMATION | BLEOMYCIN-INDUCED PNEUMONOPATHY | DEFICIENT MICE | ONSET STILLS-DISEASE | NF-KAPPA-B | CUTTING EDGE | Respiratory Distress Syndrome, Adult - pathology | Interleukin-8 - genetics | Sialoglycoproteins - genetics | Interleukin-1beta - pharmacology | Antibiotics, Antineoplastic - toxicity | Humans | Sialoglycoproteins - metabolism | Pneumonia - pathology | Respiratory Distress Syndrome, Adult - metabolism | Receptors, Interleukin-1 Type I - metabolism | Receptors, Interleukin-1 Type I - antagonists & inhibitors | Respiratory Distress Syndrome, Adult - genetics | Lymphokines - genetics | Pneumonia - chemically induced | Bone Marrow Transplantation | Lymphokines - metabolism | Pulmonary Fibrosis - metabolism | Interleukin 1 Receptor Antagonist Protein - pharmacology | Interleukin-8 - metabolism | Bleomycin - toxicity | Disease Models, Animal | Pneumonia - genetics | Receptors, Interleukin-1 Type I - agonists | Respiratory Distress Syndrome, Adult - chemically induced | Myeloid Differentiation Factor 88 - genetics | Pulmonary Fibrosis - pathology | Signal Transduction - genetics | Recombinant Proteins - pharmacology | Mice, Knockout | Transplantation Chimera - genetics | Transplantation Chimera - metabolism | Animals | Signal Transduction - drug effects | Receptors, Interleukin-1 Type I - genetics | Pulmonary Fibrosis - chemically induced | Mice | Pneumonia - metabolism | Chronic Disease | Myeloid Differentiation Factor 88 - metabolism | Complications and side effects | Bleomycin | Pulmonary fibrosis | Dosage and administration | Research | Health aspects | Risk factors | Apoptosis | Pneumonia | Respiratory Distress Syndrome, Adult | Signal Transduction | Interleukin-1beta | Antibiotics, Antineoplastic | Myeloid Differentiation Factor 88 | Recombinant Proteins | Transplantation Chimera | Interleukin-8 | Lymphokines | Life Sciences | Sialoglycoproteins | Immunology | Pulmonary Fibrosis | Interleukin 1 Receptor Antagonist Protein | Receptors, Interleukin-1 Type I
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2002, Volume 99, Issue 17, pp. 11393 - 11398
Vascular endothelial growth factor (VEGF) plays a critical role during normal embryonic angiogenesis and also in the pathological angiogenesis that occurs in a... 
Angiogenesis | Biological Sciences | Receptors | Humans | Antibodies | Monoclonal antibodies | Animal traps | Pharmacokinetics | Dosage | Tumors | Cancer | REGRESSION | INHIBITION | METASTASIS | ANGIOPOIETINS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MONOCLONAL-ANTIBODY | TUMOR ANGIOGENESIS | NEOVASCULARIZATION | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | Vascular Endothelial Growth Factor A | Phosphorylation | Vascular Endothelial Growth Factors | Melanoma, Experimental - drug therapy | Antineoplastic Agents - therapeutic use | Endothelial Growth Factors - pharmacology | Endothelial Growth Factors - immunology | Endothelium, Vascular - physiology | Vascular Endothelial Growth Factor Receptor-1 | Immunoglobulin Constant Regions - genetics | Rhabdomyosarcoma - blood supply | Bone Neoplasms - blood supply | Cell Division | Extracellular Matrix - physiology | Lymphokines - antagonists & inhibitors | Drug Design | Protein Engineering | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Rhabdomyosarcoma - drug therapy | Antineoplastic Agents - pharmacology | Bone Neoplasms - drug therapy | Lymphokines - pharmacology | Proto-Oncogene Proteins - antagonists & inhibitors | Melanoma, Experimental - blood supply | Umbilical Veins | Endothelial Growth Factors - antagonists & inhibitors | Animals | Immunoglobulin G - genetics | Lymphokines - immunology | Mice | Mice, Inbred BALB C | 3T3 Cells | Growth | Physiological aspects | Causes of | Neovascularization | Vascular endothelial growth factor | Diseases
Journal Article
Cancer Research, ISSN 0008-5472, 08/2002, Volume 62, Issue 15, pp. 4316 - 4324
Hypoxia-inducible factor I (HIF-1) is a master regulator of the transcriptional response to oxygen deprivation. HIF-1 has been implicated in the regulation of... 
FACTOR 1-ALPHA | ONCOLOGY | GENE-EXPRESSION | OXIDE SYNTHASE PROMOTER | DOUBLE-STRAND BREAKS | TUMOR ANGIOGENESIS | DNA TOPOISOMERASE-I | NF-KAPPA-B | HIF-ALPHA | RESPONSIVE ELEMENT | ENDOTHELIAL GROWTH-FACTOR | Vascular Endothelial Growth Factor A | Gene Expression - drug effects | DNA, Neoplasm - metabolism | Vascular Endothelial Growth Factors | Humans | Transcriptional Activation - drug effects | Promoter Regions, Genetic - drug effects | Promoter Regions, Genetic - genetics | Hypoxia-Inducible Factor 1, alpha Subunit | Glioma - metabolism | Luciferases - genetics | DNA-Binding Proteins - metabolism | Glioma - genetics | RNA, Messenger - biosynthesis | Lymphokines - genetics | Transfection | Lymphokines - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Response Elements - genetics | Lymphokines - biosynthesis | Tumor Cells, Cultured | Nuclear Proteins - genetics | Camptothecin - analogs & derivatives | DNA-Binding Proteins - physiology | DNA-Binding Proteins - antagonists & inhibitors | Topotecan - pharmacology | Hypoxia-Inducible Factor 1 | RNA, Messenger - genetics | Enzyme Inhibitors - pharmacology | Nuclear Proteins - metabolism | Endothelial Growth Factors - biosynthesis | DNA-Binding Proteins - genetics | Endothelial Growth Factors - antagonists & inhibitors | Response Elements - drug effects | Endothelial Growth Factors - genetics | Nuclear Proteins - antagonists & inhibitors | Luciferases - antagonists & inhibitors | Nuclear Proteins - physiology | Transcription Factors | Transcriptional Activation - physiology | Glioma - drug therapy | Luciferases - biosynthesis | Drug Screening Assays, Antitumor
Journal Article