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British Journal of Pharmacology, ISSN 0007-1188, 12/2002, Volume 137, Issue 7, pp. 1021 - 1030
The mechanism(s) by which vascular endothelial growth factor (VEGF) induces endothelial nitric oxide synthase (eNOS) activation remain(s) unclear up to a... 
eNOS | PAF | PI3K | VEGF | PLC | PLA2 | PKC | PLA | PROTEIN-KINASE-C | ANGIOGENESIS | PERMEABILITY | PHOSPHORYLATION | NITRIC-OXIDE SYNTHASE | CALMODULIN | CALCIUM | PAF SYNTHESIS | PHARMACOLOGY & PHARMACY | PLATELET-ACTIVATING-FACTOR | GROWTH-FACTOR | Endothelium, Vascular - cytology | Vascular Endothelial Growth Factors | Platelet Activating Factor - pharmacology | Protein-Serine-Threonine Kinases | Type C Phospholipases - metabolism | Endothelium, Vascular - drug effects | Endothelial Growth Factors - pharmacology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Receptors, Cell Surface - antagonists & inhibitors | Lactones - pharmacology | Platelet Membrane Glycoproteins - antagonists & inhibitors | Calcium - antagonists & inhibitors | Time Factors | Cattle | Protein Kinase C - metabolism | Phosphorylation - drug effects | Chromones - pharmacology | Enzyme Inhibitors - pharmacology | Nitric Oxide Synthase Type III | Receptors, G-Protein-Coupled | Chelating Agents - pharmacology | Serine - metabolism | 1-Methyl-3-isobutylxanthine - pharmacology | Ginkgolides | Platelet Activating Factor - metabolism | Cyclic GMP - metabolism | Endothelium, Vascular - metabolism | Intercellular Signaling Peptides and Proteins - pharmacology | Nitric Oxide Synthase - metabolism | Vascular Endothelial Growth Factor A | Maleimides - pharmacology | Nitric Oxide Synthase - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - metabolism | Nitroprusside - pharmacology | Type C Phospholipases - antagonists & inhibitors | Dose-Response Relationship, Drug | Egtazic Acid - analogs & derivatives | Indoles - pharmacology | Lymphokines - pharmacology | Nitric Oxide Donors - pharmacology | Ionophores - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Proto-Oncogene Proteins - metabolism | Cells, Cultured | Morpholines - pharmacology | Protein Kinase C - antagonists & inhibitors | Calcimycin - pharmacology | Proto-Oncogene Proteins c-akt | Animals | Egtazic Acid - pharmacology | Androstadienes - pharmacology | Diterpenes | Signal Transduction - physiology | Nitric Oxide - metabolism | Papers
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2015, Volume 125, Issue 5, pp. 1901 - 1912
Reversal of HIV-1 latency by small molecules is a potential cure strategy. This approach will likely require effective drug combinations to achieve high levels... 
SUPPRESSIVE ANTIRETROVIRAL THERAPY | MEDICINE, RESEARCH & EXPERIMENTAL | VIRUS REACTIVATION | ACTIVATION | RESERVOIR | IN-VIVO | GENE-EXPRESSION | CD4(+) T-CELLS | HISTONE DEACETYLASE INHIBITORS | NF-KAPPA-B | LIFELONG PERSISTENCE | Anti-HIV Agents - pharmacology | Transcription, Genetic - drug effects | Lymphokines - secretion | Humans | Middle Aged | RNA, Messenger - analysis | Male | Virus Latency - drug effects | Anti-HIV Agents - administration & dosage | HIV-1 - physiology | Phorbol Esters - pharmacology | Adult | Anti-HIV Agents - therapeutic use | Female | CD4-Positive T-Lymphocytes - virology | Drug Evaluation, Preclinical | Bryostatins - pharmacology | HIV-1 - drug effects | Lymphocyte Activation | HIV Infections - virology | Protein Kinase C - drug effects | Cells, Cultured | RNA, Viral - analysis | Virion - metabolism | Azepines - pharmacology | Drug Synergism | Triazoles - pharmacology | CD4-Positive T-Lymphocytes - secretion | HIV Infections - drug therapy | Histone Deacetylase Inhibitors - pharmacology | Disulfiram - pharmacology | CD4-Positive T-Lymphocytes - drug effects | Physiological aspects | Research | RNA | T cells | Drug therapy | HIV infection | Studies | Statistical analysis | Cytokines | Acquired immune deficiency syndrome--AIDS | Lymphocytes | T cell receptors | Mathematical models | Gene expression | HIV | Infectious disease | AIDS
Journal Article
Circulation, ISSN 0009-7322, 1998, Volume 97, Issue 1, pp. 99 - 107
Background-Vascular endothelial growth factor (VEGF), an endothelial cell mitogen that promotes angiogenesis, was initially identified as a vascular... 
Growth substances | Prostaglandins | Permeability | Nitric oxide | Endothelium | endothelium | nitric oxide | CARDIAC & CARDIOVASCULAR SYSTEMS | ANGIOGENESIS | TYROSINE KINASE | VEGF | permeability | FLT-1 | FACTOR RECEPTOR | MICROVASCULAR PERMEABILITY | LIMB | growth substances | BLOOD-VESSELS | prostaglandins | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | EXPRESSION | SMOOTH-MUSCLE CELLS | Endothelium, Vascular - cytology | Capillary Permeability - physiology | Vascular Endothelial Growth Factor A | Vascular Endothelial Growth Factors | Platelet Activating Factor - pharmacology | Rifabutin - analogs & derivatives | Capillary Permeability - drug effects | Nitrites - metabolism | Platelet Activating Factor - antagonists & inhibitors | Male | Endothelial Growth Factors - pharmacology | Microcirculation - drug effects | Epoprostenol - physiology | Lactams, Macrocyclic | Phenylephrine - pharmacology | Cattle | Histamine H1 Antagonists - pharmacology | Blood Pressure - drug effects | Lymphokines - pharmacology | Bradykinin - pharmacology | Quinones - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Guinea Pigs | Histamine - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Nitric Oxide - physiology | Fibroblast Growth Factors - pharmacology | Benzoquinones | Pyridinium Compounds - pharmacology | Animals | Genistein - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Acta Oncologica, ISSN 0284-186X, 2003, Volume 42, Issue 4, pp. 294 - 303
Dose-response effects of fluorouracil, paclitaxel, doxorubicin, cisplatin, methotrexate, cyclophosphamide and etoposide on VEGF(165/164)-mediated angiogenesis... 
PHARMACOKINETICS | CISPLATIN | ONCOLOGY | ENDOTHELIUM | GUIDELINES | NOVO MAMMALIAN ANGIOGENESIS | RATS | TUMOR ANGIOGENESIS | GROWTH-FACTOR | CANCER | PACLITAXEL | Methotrexate - pharmacology | Neovascularization, Physiologic - drug effects | Vascular Endothelial Growth Factor A | Cyclophosphamide - administration & dosage | Injections, Intravenous | Paclitaxel - pharmacology | Vascular Endothelial Growth Factors | Humans | Male | Endothelial Growth Factors - pharmacology | Antineoplastic Agents - administration & dosage | Cisplatin - administration & dosage | Dose-Response Relationship, Drug | Fluorouracil - administration & dosage | Mesentery - drug effects | Weight Gain - drug effects | Antineoplastic Agents - pharmacology | Lymphokines - pharmacology | Paclitaxel - administration & dosage | Doxorubicin - administration & dosage | Etoposide - pharmacology | Rats | Etoposide - administration & dosage | Cisplatin - pharmacology | Rats, Sprague-Dawley | Mesentery - blood supply | Animals | Intercellular Signaling Peptides and Proteins - pharmacology | Cyclophosphamide - pharmacology | Methotrexate - administration & dosage | Fluorouracil - pharmacology | Doxorubicin - pharmacology | Cisplatin/administration & dosage/pharmacology | Doxorubicin/administration & dosage/pharmacology | Methotrexate/administration & dosage/pharmacology | Intercellular Signaling Peptides and Proteins/pharmacology | Sprague-Dawley | Antineoplastic Agents/administration & dosage/pharmacology | Neovascularization | Physiologic/drug effects | Mesentery/blood supply/drug effects | Cyclophosphamide/administration & dosage/pharmacology | Drug | Endothelial Growth Factors/pharmacology | Etoposide/administration & dosage/pharmacology | Intravenous | Lymphokines/pharmacology | Paclitaxel/administration & dosage/pharmacology | Fluorouracil/administration & dosage/pharmacology | Injections | Weight Gain/drug effects | Dose-Response Relationship | Cancer and Oncology | Cancer och onkologi
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 01/1997, Volume 185, Issue 1, pp. 171 - 175
Journal Article
Oncogene, ISSN 0950-9232, 04/1999, Volume 18, Issue 13, pp. 2221 - 2230
KDR/Flk-1 tyrosine kinase, one of the two VEGF receptors induces mitogenesis and differentiation of vascular endothelial cells. We have previously reported... 
Signal transduction | Protein kinase C | MAP kinase cascade | Tyrosine kinase receptor | Vascular endothelial growth factor | ANGIOGENESIS | signal transduction | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | tyrosine kinase receptor | PLC-GAMMA | CELL BIOLOGY | SIGNAL-TRANSDUCTION | HEMATOPOIETIC-CELLS | ONCOLOGY | GROWTH-FACTOR VEGF | vascular endothelial growth factor | GENETICS & HEREDITY | VASCULAR-PERMEABILITY FACTOR | PC12 CELLS | EXPRESSION | protein kinase C | RECEPTOR TYROSINE KINASE | Endothelium, Vascular - cytology | Receptors, Vascular Endothelial Growth Factor | Vascular Endothelial Growth Factor A | Tetradecanoylphorbol Acetate - pharmacology | DNA Replication - drug effects | Vascular Endothelial Growth Factors | Receptor Protein-Tyrosine Kinases - physiology | Maleimides - pharmacology | Endothelium, Vascular - drug effects | Endothelial Growth Factors - pharmacology | Proto-Oncogene Proteins p21(ras) - physiology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-raf - physiology | Transfection | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Adenoviridae - genetics | Indoles - pharmacology | Flavonoids - pharmacology | Lymphokines - pharmacology | Chromones - pharmacology | Calcium-Calmodulin-Dependent Protein Kinases - physiology | Protein Kinase C - physiology | Protein-Serine-Threonine Kinases - physiology | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Adenoviridae - physiology | 3T3 Cells - drug effects | Genetic Vectors - genetics | Protein Isoforms - physiology | Receptors, Growth Factor - physiology | Animals | Androstadienes - pharmacology | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Phosphatidylinositol 3-Kinases - physiology | Genetic Vectors - physiology | Mice | Enzyme Activation | Carbazoles - pharmacology | Genes, ras | MAP Kinase Kinase Kinase 1
Journal Article
Laboratory Investigation, ISSN 0023-6837, 2002, Volume 82, Issue 6, pp. 747 - 756
Although accumulating lines of evidence indicate the proangiogenic role of angiotensin II (Ang II), little is known about the molecular mechanisms associated... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | ACTIVATION | RECEPTOR SUBTYPES | INHIBITION | NITRIC-OXIDE | FACTOR EXPRESSION | PROLIFERATION | PATHOLOGY | IDENTIFICATION | BINDING | CONVERTING-ENZYME | Laminin - pharmacology | Receptor, Angiotensin, Type 1 | Receptors, Angiotensin - metabolism | Vascular Endothelial Growth Factor A | Endothelial Growth Factors - metabolism | Tetrazoles - pharmacology | Angiotensin Receptor Antagonists | Vascular Endothelial Growth Factors | Cyclooxygenase 2 | Nitric Oxide Synthase Type II | Endothelial Growth Factors - immunology | Isoenzymes - metabolism | Lymphokines - metabolism | Female | Collagen - pharmacology | Drug Therapy, Combination | Angiotensin II - therapeutic use | Disease Models, Animal | NG-Nitroarginine Methyl Ester - pharmacology | Angiotensin II - metabolism | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | Nitric Oxide Synthase Type III | Imidazoles - pharmacology | Neovascularization, Pathologic - chemically induced | Sulfonamides - pharmacology | Mice, Knockout | Animals | Nitric Oxide Synthase - deficiency | Proteoglycans - pharmacology | Neovascularization, Pathologic - drug therapy | Prostaglandin-Endoperoxide Synthases - metabolism | Lymphokines - immunology | Benzimidazoles - pharmacology | Macrophages - drug effects | Mice | Nitric Oxide Synthase - metabolism | Pyridines - pharmacology | Drug Combinations
Journal Article
CELL, ISSN 0092-8674, 05/2002, Volume 109, Issue 5, pp. 625 - 637
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 03/2001, Volume 193, Issue 5, pp. 607 - 620
Cyclosporin A (CsA) is an immunosuppressive drug that inhibits the activity of transcription factors of the nuclear factor of activated T cells (NFAT) family,... 
Angiogenesis | Cyclooxygenase | Cyclosporin A | VEGF | NFAT | DIABETIC-RETINOPATHY | MEDICINE, RESEARCH & EXPERIMENTAL | angiogenesis | SYNTHASE GENE | cyclosporin A | cyclooxygenase | KAPPA-B | IMMUNOLOGY | RESPONSE ELEMENT | COLON-CANCER | NF-ATC | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | GENE-EXPRESSION | TRANSCRIPTION FACTOR | UP-REGULATION | Endothelium, Vascular - cytology | Neovascularization, Physiologic - drug effects | Vascular Endothelial Growth Factor A | Endothelial Growth Factors - metabolism | Cyclosporine - pharmacology | Vascular Endothelial Growth Factors | Cyclooxygenase 2 | Humans | Endothelium, Vascular - drug effects | Endothelial Growth Factors - pharmacology | Nitrobenzenes - pharmacology | Cell Migration Inhibition | DNA-Binding Proteins - metabolism | Cornea - blood supply | Cornea - drug effects | Transfection | Isoenzymes - metabolism | Lymphokines - antagonists & inhibitors | Lymphokines - metabolism | Lymphokines - pharmacology | Genes, Reporter | Prostaglandin-Endoperoxide Synthases - genetics | Dinoprostone - pharmacology | Promoter Regions, Genetic | Mutagenesis, Site-Directed | Isoenzymes - genetics | Mice, Inbred C57BL | Cells, Cultured | Angiogenesis Inhibitors - pharmacology | NFATC Transcription Factors | Sulfonamides - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Nuclear Proteins | Endothelial Growth Factors - antagonists & inhibitors | Gene Expression Regulation - drug effects | Membrane Proteins | Transcription Factors - metabolism | Cell Movement - drug effects | Animals | Cyclooxygenase 2 Inhibitors | Endothelium, Vascular - metabolism | Prostaglandin-Endoperoxide Synthases - metabolism | Mice | Isoenzymes - antagonists & inhibitors | Original
Journal Article
Blood, ISSN 0006-4971, 03/2003, Volume 101, Issue 5, pp. 1810 - 1817
Adult angiogenesis, associated with pathologic conditions, is often accompanied by the formation of a fibrinous exudate. This temporary matrix consists mainly... 
1-MATRIX METALLOPROTEINASE | STROMELYSIN-1 MMP-3 | BLOOD-VESSELS | MICROVASCULAR ENDOTHELIAL-CELLS | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | TISSUE INHIBITOR | UROKINASE RECEPTOR | GROWTH-FACTOR | TNF-ALPHA | HEMATOLOGY | MICE LACKING | Endothelium, Vascular - cytology | Vascular Endothelial Growth Factor A | Phenylalanine - analogs & derivatives | Phenylalanine - pharmacology | Vascular Endothelial Growth Factors | Cells, Cultured - cytology | Humans | Fibroblast Growth Factor 2 - pharmacology | Matrix Metalloproteinase 2 - physiology | Endothelium, Vascular - drug effects | Matrix Metalloproteinase 1 - physiology | Endothelial Growth Factors - pharmacology | Neovascularization, Pathologic - enzymology | Protease Inhibitors - pharmacology | Matrix Metalloproteinases, Membrane-Associated | Aprotinin - pharmacology | Adenoviridae - genetics | Neovascularization, Pathologic - physiopathology | Lymphokines - pharmacology | Tissue Inhibitor of Metalloproteinase-3 - genetics | Cells, Cultured - drug effects | Tissue Inhibitor of Metalloproteinase-1 - physiology | Transduction, Genetic | Defective Viruses - genetics | Thiophenes - pharmacology | Tissue Inhibitor of Metalloproteinase-3 - physiology | Genetic Vectors - genetics | Drug Synergism | Fibrin | Neovascularization, Physiologic - physiology | Thrombosis - pathology | Tissue Inhibitor of Metalloproteinase-1 - genetics | Tumor Necrosis Factor-alpha - pharmacology | Intercellular Signaling Peptides and Proteins - pharmacology | Collagen | Culture Media - pharmacology | Metalloendopeptidases - physiology | Heart Diseases - pathology
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 11/2002, Volume 87, Issue 11, pp. 5290 - 5296
Angiogenesis and vascular remodeling are crucial processes in tumor invasion and metastasis as well as in embryo implantation and normal development of the... 
LUTEINIZING-HORMONE RECEPTOR | FIRST-TRIMESTER | CYTOTROPHOBLASTIC JEG-3 CELLS | PROTEIN-KINASE-C | IN-VITRO | GRANULOSA-CELLS | REPRODUCTIVE-TRACT | ENDOCRINOLOGY & METABOLISM | MICROVASCULAR ENDOTHELIAL-CELLS | VITRONECTIN RECEPTOR | HUMAN ENDOMETRIAL | Endothelium, Vascular - cytology | Neovascularization, Physiologic - drug effects | Vascular Endothelial Growth Factor A | Tetradecanoylphorbol Acetate - pharmacology | Vascular Endothelial Growth Factors | Coculture Techniques | Humans | Capillaries - drug effects | Endothelium, Vascular - drug effects | Endothelial Growth Factors - pharmacology | Chorionic Gonadotropin - immunology | Endometrial Neoplasms | Microcirculation - drug effects | Chorionic Gonadotropin - pharmacology | Endothelium, Vascular - physiology | Choriocarcinoma | Microcirculation - physiology | Protein Kinase C - metabolism | Female | Allantois - blood supply | Lymphokines - pharmacology | Ovarian Neoplasms | Tumor Cells, Cultured | Uterus - blood supply | Pertussis Toxin - pharmacology | Chorion - blood supply | Enzyme Activation - drug effects | Cell Division - drug effects | Antibodies - pharmacology | Cell Movement - drug effects | Animals | Chorionic Gonadotropin - administration & dosage | Intercellular Signaling Peptides and Proteins - pharmacology | Chickens | Bucladesine - pharmacology | Integrins - antagonists & inhibitors
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/1997, Volume 272, Issue 23, pp. 14713 - 14720
The syndecan family of transmembrane heparan sulfate proteoglycans is abundant on the surface of all adherent mammalian cells. Syndecans bind and modify the... 
FINE-STRUCTURE | CLEAVAGE SITE | FACTOR-ALPHA PRECURSOR | WOUND FLUID | K CQ BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTHELIAL-CELLS | MOLECULAR-CLONING | HEPARAN-SULFATE PROTEOGLYCANS | CELL-SURFACE PROTEOGLYCAN | IL-6 RECEPTOR | MAMMARY EPITHELIAL-CELLS | Membrane Glycoproteins - analysis | Vascular Endothelial Growth Factor A | Tetradecanoylphorbol Acetate - pharmacology | Membrane Glycoproteins - metabolism | Protein-Tyrosine Kinases - metabolism | Vascular Endothelial Growth Factors | Humans | Membrane Glycoproteins - chemistry | Antibodies | Endothelial Growth Factors - pharmacology | Amphiregulin | Glycoproteins - pharmacology | Skin - injuries | Proteoglycans - chemistry | Endothelium, Vascular - physiology | Thrombin - pharmacology | EGF Family of Proteins | Peptide Fragments - immunology | Cell Membrane - metabolism | Lymphokines - pharmacology | Transforming Growth Factor alpha - pharmacology | Amino Acid Sequence | Syndecans | Intercellular Signaling Peptides and Proteins | Cells, Cultured | Proteoglycans - metabolism | Proteoglycans - analysis | Epitopes | Platelet-Derived Growth Factor - pharmacology | Recombinant Proteins - pharmacology | Wounds and Injuries - physiopathology | ErbB Receptors - physiology | Heparin-binding EGF-like Growth Factor | Tumor Necrosis Factor-alpha - pharmacology | Peptide Fragments - chemistry | Receptors, Growth Factor - physiology | Growth Substances - pharmacology | Syndecan-1 | Receptors, Thrombin - physiology | Epidermal Growth Factor - pharmacology | Syndecan-4 | GTP-Binding Proteins - metabolism
Journal Article