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Cell metabolism, ISSN 1550-4131, 09/2019, Volume 30, Issue 3, pp. 539 - 555.e11
Epstein-Barr virus (EBV) causes Burkitt, Hodgkin, and post-transplant B cell lymphomas. How EBV remodels metabolic pathways to support rapid B cell outgrowth... 
Enzymes | Viral proteins | Microbiology | Analysis | Physiological aspects | Lymphomas | B cells | Health aspects | Folic acid | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 01/2010, Volume 463, Issue 7277, pp. 88 - 92
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 4, pp. 1404 - 1409
Journal Article
Blood, ISSN 0006-4971, 09/2012, Volume 120, Issue 11, pp. 2240 - 2248
Germinal centers (GCs) are sites of B-cell clonal expansion, hypermutation, and selection. GCs are polarized into dark (DZ) and light zones (LZ), a distinction... 
CHROMOSOMAL TRANSLOCATIONS | HUMAN TONSIL | SOMATIC HYPERMUTATION | GENE | AFFINITY MATURATION | BURKITTS-LYMPHOMA | CLASS DISCOVERY | HEMATOLOGY | EXPRESSION | MICROARRAY DATA | REVEALS | Leukocytes, Mononuclear - metabolism | Membrane Glycoproteins - metabolism | Oligonucleotide Array Sequence Analysis | Species Specificity | Germinal Center - immunology | Humans | Gene Expression Regulation, Neoplastic | Male | Gene Expression Profiling | Immunoglobulins - genetics | Antigens, CD - genetics | Palatine Tonsil - immunology | Antigens, CD - metabolism | Burkitt Lymphoma - pathology | Immunoglobulins - metabolism | Burkitt Lymphoma - immunology | Leukocytes, Mononuclear - immunology | Palatine Tonsil - metabolism | Lymphoma, B-Cell - immunology | Female | Receptors, CXCR4 - genetics | Child | Lymphoma, B-Cell - metabolism | Mice, Inbred C57BL | Cells, Cultured | Lymph Nodes - metabolism | Burkitt Lymphoma - metabolism | Germinal Center - pathology | Lymph Nodes - immunology | Lymph Nodes - cytology | Membrane Glycoproteins - genetics | Receptors, CXCR4 - metabolism | Leukocytes, Mononuclear - pathology | Palatine Tonsil - pathology | Animals | Germinal Center - metabolism | Lymphoma, B-Cell - pathology | Leukocytes, Mononuclear - cytology | Mice | Index Medicus | Abridged Index Medicus | Lymphoid Neoplasia | Immunobiology
Journal Article
Journal Article
Blood, ISSN 0006-4971, 01/2017, Volume 129, Issue 4, pp. 473 - 483
Follicular lymphoma(FL) is the most common form of indolent non-Hodgkin lymphoma, yet it remains only partially characterized at the genomic level. To improve... 
POINT MUTATIONS | CHRONIC LYMPHOCYTIC-LEUKEMIA | NON-HODGKIN-LYMPHOMA | MARGINAL ZONE LYMPHOMA | GATED PROTON CHANNEL | SEQUENCING DATA | HEMATOLOGY | CODING VARIANTS | MALT LYMPHOMA | INACTIVATING MUTATIONS | HISTONE GENES | Vacuolar Proton-Translocating ATPases - genetics | Protein-Tyrosine Kinases - metabolism | Receptors, Notch - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Lymphoma, Follicular - diagnosis | Ion Channels - genetics | Male | Receptors, Notch - genetics | Gene Expression Profiling | Receptors, Antigen, B-Cell - metabolism | Vacuolar Proton-Translocating ATPases - metabolism | CREB-Binding Protein - genetics | CREB-Binding Protein - metabolism | Protein-Tyrosine Kinases - genetics | Lymphoma, Follicular - genetics | Early Growth Response Protein 1 - genetics | Trans-Activators - genetics | Aged, 80 and over | Adult | Female | Receptors, CXCR4 - genetics | Repressor Proteins - metabolism | Lymphoma, Follicular - pathology | Lymphoma, Follicular - mortality | Repressor Proteins - genetics | Signal Transduction - genetics | Receptors, CXCR4 - metabolism | Disease-Free Survival | Histones - genetics | Ion Channels - metabolism | Receptors, Antigen, B-Cell - genetics | Trans-Activators - metabolism | Aged | Histones - metabolism | Mutation | Early Growth Response Protein 1 - metabolism | Index Medicus | Abridged Index Medicus | Lymphoid Neoplasia
Journal Article
Blood, ISSN 0006-4971, 02/2017, Volume 129, Issue 6, pp. 759 - 770
Kinases downstream of B-cell antigen receptor (BCR) represent attractive targets for therapy in non-Hodgkin lymphoma (NHL). As clinical responses vary,... 
SURFACE IGM | BCR | CHRONIC-LYMPHOCYTIC-LEUKEMIA | BRUTONS TYROSINE KINASE | HUMAN FOLLICULAR LYMPHOMA | GENE-EXPRESSION | KINASE INHIBITOR IBRUTINIB | MUTATIONS | TARGETING BTK | HEMATOLOGY | NF-KAPPA-B | Lymphoma, Follicular - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Lymphoma, Mantle-Cell - pathology | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Receptors, Antigen, B-Cell - metabolism | STAT1 Transcription Factor - metabolism | Lymphoma, Follicular - genetics | Mitogen-Activated Protein Kinase 1 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Single-Cell Analysis | Immunoglobulin M - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | STAT1 Transcription Factor - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Lymphoma, Large B-Cell, Diffuse - diagnosis | Mitogen-Activated Protein Kinase 3 - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Receptors, Antigen, B-Cell - genetics | CD79 Antigens - genetics | src-Family Kinases - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Phosphorylation | Gene Expression Regulation, Neoplastic | Lymphoma, Follicular - diagnosis | Lymphoma, Large B-Cell, Diffuse - metabolism | Phosphoproteins - metabolism | Proto-Oncogene Proteins c-akt - genetics | Lymphoma, Mantle-Cell - diagnosis | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Protein-Tyrosine Kinases - genetics | Flow Cytometry | Syk Kinase - genetics | Phospholipase C gamma - genetics | src-Family Kinases - metabolism | Lymphoma, Mantle-Cell - genetics | Lymphoma, Mantle-Cell - metabolism | Diagnosis, Differential | Phospholipase C gamma - metabolism | Lymphoma, Large B-Cell, Diffuse - pathology | Lymphoma, Follicular - pathology | p38 Mitogen-Activated Protein Kinases - genetics | Phosphoproteins - genetics | CD79 Antigens - metabolism | Syk Kinase - metabolism | Lymphoma, Large B-Cell, Diffuse - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis | Index Medicus | Abridged Index Medicus | Life Sciences | Human health and pathology | Hematology | Cancer | Lymphoid Neoplasia
Journal Article
Cancer Cell, ISSN 1535-6108, 06/2017, Volume 31, Issue 6, pp. 833 - 843.e5
Primary CNS lymphoma (PCNSL) harbors mutations that reinforce B cell receptor (BCR) signaling. Ibrutinib, a Bruton's tyrosine kinase (BTK) inhibitor, targets... 
ibrutinib | B cell receptor signaling | BTK | macrophage | ABC DLBCL | Aspergillus fumigatus | primary CNS lymphoma | SYSTEM | PEGYLATED LIPOSOMAL DOXORUBICIN | BRUTONS TYROSINE KINASE | ASPERGILLUS-FUMIGATUS | ACTIVATION | ONCOLOGY | IMMUNE-RESPONSES | ONCOGENIC MYD88 | CD79B MUTATIONS | ALVEOLAR MACROPHAGES | HIGH PREVALENCE | CELL BIOLOGY | Pyrazoles - therapeutic use | Humans | Middle Aged | Male | Receptors, Antigen, B-Cell - metabolism | Aspergillosis - epidemiology | Brain Neoplasms - metabolism | Protein-Tyrosine Kinases - immunology | Lymphoma - metabolism | Lymphoma - drug therapy | Protein-Tyrosine Kinases - genetics | Enzyme Inhibitors - pharmacokinetics | Aged, 80 and over | Female | Drug Therapy, Combination | Pyrazoles - pharmacokinetics | Pyrazoles - adverse effects | Enzyme Inhibitors - adverse effects | Myeloid Differentiation Factor 88 - genetics | Brain Neoplasms - drug therapy | Gene Knockout Techniques | Enzyme Inhibitors - therapeutic use | Mice, Knockout | Animals | Signal Transduction - drug effects | Pyrimidines - therapeutic use | Pyrimidines - adverse effects | Pyrimidines - pharmacokinetics | Aged | Mice | CD79 Antigens - genetics | Aspergillosis - immunology | Protein-Tyrosine Kinases - antagonists & inhibitors | Tyrosine | Mycoses | Chemotherapy | Lymphomas | Cancer | Antifungal agents | Macrophages | Diseases | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 09/2010, Volume 467, Issue 7311, pp. 86 - 90
Journal Article
Cancer Cell, ISSN 1535-6108, 04/2016, Volume 29, Issue 4, pp. 494 - 507
Chronic active B cell receptor (BCR) signaling, a hallmark of the activated B cell-like (ABC) subtype of diffuse large B cell lymphoma (DLBCL), engages the... 
ANTAGONISTS INDUCE | APOPTOSIS | ACTIVATION | ONCOLOGY | CODING GENOME | CARD11 MUTATIONS | CHAIN ASSEMBLY COMPLEX | IKK COMPLEX | NF-KAPPA-B | SOMATIC MUTATIONS | SIGNALING COMPLEX | CELL BIOLOGY | Inhibitor of Apoptosis Proteins - genetics | Humans | NF-kappa B - metabolism | Neoplasm Proteins - antagonists & inhibitors | Gene Expression Profiling | Receptors, Antigen, B-Cell - metabolism | Ubiquitin-Protein Ligases - physiology | Inhibitor of Apoptosis Proteins - physiology | Multiprotein Complexes - metabolism | CARD Signaling Adaptor Proteins - metabolism | Ubiquitination - drug effects | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Neoplasm Proteins - genetics | B-Lymphocytes - metabolism | Triazoles - therapeutic use | NF-kappa B - antagonists & inhibitors | Dipeptides - therapeutic use | Lymphoma, Large B-Cell, Diffuse - drug therapy | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Mitochondrial Proteins - chemistry | Cell Line, Tumor | Indoles - therapeutic use | Mice, Inbred NOD | Mice | Enzyme Activation | Ubiquitin-Protein Ligases - genetics | Neoplasm Proteins - physiology | Ubiquitin-Protein Ligases - antagonists & inhibitors | Baculoviral IAP Repeat-Containing 3 Protein | Lymphoma, Large B-Cell, Diffuse - metabolism | Neoplasm Proteins - metabolism | Caspases - metabolism | I-kappa B Kinase - metabolism | Protein Processing, Post-Translational - drug effects | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Indoles - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Dipeptides - pharmacology | Guanylate Cyclase - metabolism | Gene Dosage | Mice, SCID | Triazoles - pharmacology | Xenograft Model Antitumor Assays | B-Lymphocytes - drug effects | Animals | Intracellular Signaling Peptides and Proteins - chemistry | B-Cell CLL-Lymphoma 10 Protein | Lymphoma, Large B-Cell, Diffuse - classification | CRISPR-Cas Systems | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin | Care and treatment | Lymphomas | Ligases | Index Medicus
Journal Article