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Blood, ISSN 0006-4971, 08/2014, Volume 124, Issue 9, pp. 1473 - 1480
Journal Article
Leukemia, ISSN 0887-6924, 12/2011, Volume 25, Issue 12, pp. 1882 - 1890
The anaplastic lymphoma kinase (ALK), tyrosine kinase oncogene is implicated in a wide variety of cancers. In this study we used conditional onco-ALK (NPM-ALK... 
lymphomas | microRNA | VEGF | onco-ALK | ALK | ANGIOGENESIS | MICRORNAS | TRANSLATION | CHILDHOOD | INHIBITION | THERAPY | HEPATITIS-C VIRUS | ONCOLOGY | RESISTANCE | HEMATOLOGY | CHILDRENS-CANCER | Humans | Gene Expression Regulation, Neoplastic | Neovascularization, Pathologic | MicroRNAs - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Case-Control Studies | Embryo, Mammalian - metabolism | Immunoenzyme Techniques | Hypoxia - metabolism | DNA Methylation | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Female | Real-Time Polymerase Chain Reaction | Lymphoma, Large-Cell, Anaplastic - metabolism | Fibroblasts - metabolism | Lymphoma, Large-Cell, Anaplastic - genetics | Enzyme-Linked Immunosorbent Assay | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Down-Regulation | RNA, Messenger - genetics | Cells, Cultured | Receptor Protein-Tyrosine Kinases - metabolism | Cell Adhesion | Blotting, Western | Blotting, Northern | Hypoxia - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Embryo, Mammalian - cytology | Hypoxia - pathology | Mice, Nude | Fibroblasts - cytology | Lymphoma, Large-Cell, Anaplastic - pathology | Mice | Mice, Inbred BALB C | MicroRNAs - genetics | Cell Movement | Physiological aspects | Lymphomas | Genetic aspects | Research | Neovascularization | Gene expression | Phosphotransferases | Carcinogenesis | Life Sciences | Biochemistry, Molecular Biology
Journal Article
Clinical & Experimental Immunology, ISSN 0009-9104, 10/2016, Volume 186, Issue 1, pp. 96 - 105
Journal Article
Blood, ISSN 0006-4971, 2013, Volume 122, Issue 12, pp. 2083 - 2092
Journal Article
The Journal of Pathology, ISSN 0022-3417, 08/2015, Volume 236, Issue 4, pp. 445 - 456
Anaplastic large cell lymphoma (ALCL) is a rare, aggressive, non‐Hodgkin's lymphoma that is characterized by CD30 expression and disease onset in young... 
IL‐22 | IL‐21 | IL‐10 | ALK kinase | ALCL | cytokines | miR‐155 | miR-155 | IL-22 | IL-10 | IL-21 | NPM-ALK | TYROSINE KINASE | PATHOLOGY | IDENTIFICATION | MICRORNA-155 | PATHOGENESIS | ONCOLOGY | GENE-EXPRESSION | HODGKIN LYMPHOMA | LEUKEMIA | PROMOTER | TRANSGENIC MICE | Translocation, Genetic | Humans | Caspase 3 - metabolism | Gene Expression Regulation, Neoplastic | Suppressor of Cytokine Signaling 1 Protein | MicroRNAs - metabolism | Case-Control Studies | Chromosomes, Human, Pair 2 | DNA Methylation | Transfection | Anaplastic Lymphoma Kinase | Lymphoma, Large-Cell, Anaplastic - metabolism | STAT3 Transcription Factor - metabolism | Lymphoma, Large-Cell, Anaplastic - genetics | Promoter Regions, Genetic | Argonaute Proteins - metabolism | Lymphoma, Large-Cell, Anaplastic - therapy | Receptor Protein-Tyrosine Kinases - deficiency | Argonaute Proteins - genetics | Signal Transduction | CCAAT-Enhancer-Binding Protein-beta - genetics | Suppressor of Cytokine Signaling Proteins - genetics | Mice, SCID | CCAAT-Enhancer-Binding Protein-beta - metabolism | Chromosomes, Human, Pair 5 | Xenograft Model Antitumor Assays | Animals | Receptor Protein-Tyrosine Kinases - genetics | Cell Line, Tumor | Mice, Inbred NOD | Lymphoma, Large-Cell, Anaplastic - pathology | MicroRNAs - genetics | Suppressor of Cytokine Signaling Proteins - metabolism | Genetic Therapy - methods | Original Papers
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2009, Volume 420, Issue 3, pp. 345 - 361
RTKs (receptor tyrosine kinases) play important roles in cellular proliferation and different liation. In addition, RTKs reveal oncogenic potential when their... 
Extracellular-signal-regulated kinase (ERK) | Pleiotrophin | Anaplastic large cell lymphoma (ALCL) | Neuroblastoma | Non-small cell lung cancer (NSLCL) | Midkine | Anaplastic lymphoma kinase (ALK) | Inflammatory myofibroblastic tumour (IMT) | inflammatory myofibroblastic tumour (IMT) | GROWTH-FACTOR PLEIOTROPHIN | non-small cell lung cancer (NSLCL) | BIOCHEMISTRY & MOLECULAR BIOLOGY | anaplastic lymphoma kinase (ALK) | EML4-ALK FUSION GENE | neuroblastoma | LARGE-CELL LYMPHOMA | HUMAN BREAST-CANCER | extracellular-signal-regulated kinase (ERK) | TFG-ALK TRANSLOCATIONS | pleiotrophin | NEUROTROPHIC FACTOR HBNF | INFLAMMATORY MYOFIBROBLASTIC TUMOR | NON-HODGKINS-LYMPHOMA | midkine | anaplastic large cell lymphoma (ALCL) | GASTROINTESTINAL STROMAL TUMORS | RECEPTOR TYROSINE KINASE | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Oncogene Proteins, Fusion - metabolism | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Lung Neoplasms - metabolism | Neuroblastoma - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Lung Neoplasms - pathology | Nuclear Proteins - metabolism | Receptor Protein-Tyrosine Kinases | Protein-Tyrosine Kinases - genetics | Models, Biological | Oncogene Proteins, Fusion - genetics | Lymphoma, Large-Cell, Anaplastic - pathology | Neuroblastoma - metabolism | Nuclear Proteins - genetics | Lymphoma, Large-Cell, Anaplastic - metabolism | Neuroblastoma - pathology | Lymphoma, Large-Cell, Anaplastic - genetics | ALK, anaplastic lymphoma kinase | LTK, leucocyte tyrosine kinase | MUC-1, mucin-1 | IRS-1, IR substrate-1 | PTN, pleiotrophin | TGFβ, transforming growth factor β | ERK, extracellular-signal-regulated kinase | PKB, protein kinase B | Shc, Src homology and collagen homology | TPM, tropomyosin | IMP cyclohydrolase | MK, midkine | MYH9, non-muscle myosin heavy chain | MAM, meprin, A5 protein and receptor protein tyrosine phosphatase mu | NPM, nucleophosmin | mTOR, mammalian target of rapamycin | NIPA, nuclear interacting partner of ALK | RPTP, receptor protein tyrosine phosphatase | DLBCL, diffuse large B-cell lymphoma | FOXO3a, forkhead box O 3a | NF-κB, nuclear factor κB | Shp1, SH2 domain-containing phosphatase 1 | RANBP2, Ran-binding protein 2 | ALCL, anaplastic large cell lymphoma | Dpp, decapentaplegic | FRS2, fibroblast growth factor receptor substrate 2 | LDLa, low-density lipoprotein class A | EGFR, epidermal growth factor receptor | SEC31L1, SEC31 homologue A | GIST, gastrointestinal stromal tumour | RTK, receptor tyrosine kinase | SH2, Src homology 2 | TFG, TRK-fused gene | ATIC, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase | CLTC, clathrin heavy chain | MAPK, mitogen-activated protein kinase | Hen-1, hesitation-1 | MEK, MAPK | PI3K, phosphoinositide 3-kinase | HEK, human embryonic kidney | SCD-2, suppressor of constitutive dauer 2 | Review | EBPβ, CCAAT | CARS, cysteinyl-tRNA synthetase | JNK, c-Jun N-terminal kinase | ERK kinase | Grb2, growthfactor-receptor-bound protein 2 | SCC, squamous cell carcinoma | EML4, echinoderm microtubule-associated protein like 4 | SHH, sonic hedghog | BCR-Abl, breakpoint cluster region-Abl | IR, insulin receptor | ALO17, ALK lymphoma oligomerization partner on chromosome 17 | enhancer-binding protein β | PLCγ, phospholipase Cγ | NSCLC, non-small cell lung cancer | UCN-01, unco-ordinated 1 | Cdc42, cell division cycle 42 | STAT, signal transducer and activator of transcription | DRG, dorsal root ganglia | MSN, moesin | dALK, Drosophila ALK | IL-3, interleukin-3 | CNS, central nervous system | JAK, Janus kinase | CML, chronic myeloid leukaemia | Jeb, jelly belly | IMT, inflammatory myofibroblastic tumour | Medical and Health Sciences | Medicin och hälsovetenskap | MEDICIN | MEDICINE
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2017, Volume 114, Issue 15, pp. 3975 - 3980
Activating Janus kinase (JAK) and signal transducer and activator of transcription (STAT) mutations have been discovered in many T-cell malignancies, including... 
ALK− ALCL | Mutations | STAT | JAK | Cytokine receptor | STAT3 MUTATIONS | cytokine receptor | GRANULAR LYMPHOCYTIC-LEUKEMIA | MULTIDISCIPLINARY SCIENCES | KINASE | PROLIFERATION | T-CELL | PATHOGENESIS | mutations | THERAPY | NK CELLS | TARGETS | LYMPHOPROLIFERATIVE DISORDERS | ALK- ALCL | Phosphorylation | Cytokine Receptor gp130 - genetics | Humans | Janus Kinase 1 - metabolism | Piperidines - pharmacology | Janus Kinase 1 - genetics | Receptors, Cytokine - metabolism | Cytokines - genetics | Receptors, Cytokine - genetics | Lymphoma, Large-Cell, Anaplastic - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Lymphoma, Large-Cell, Anaplastic - genetics | Pyrazoles - pharmacology | Cytokine Receptor gp130 - metabolism | Cytokines - metabolism | Cell Survival | Pyrimidines - pharmacology | Janus Kinase 1 - antagonists & inhibitors | Receptor Protein-Tyrosine Kinases - metabolism | Xenograft Model Antitumor Assays | Pyrroles - pharmacology | Animals | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Lymphoma, Large-Cell, Anaplastic - drug therapy | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Cytokine receptors | Genetic aspects | Lymphomas | Health aspects | Phosphotransferases | STAT proteins | Biological Sciences
Journal Article