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Nature, ISSN 0028-0836, 08/2011, Volume 476, Issue 7360, pp. 298 - 303
Journal Article
Blood, ISSN 0006-4971, 04/2010, Volume 115, Issue 13, pp. 2578 - 2585
Certain malignant B cells rely on B-cell receptor (BCR)-mediated survival signals. Spleen tyrosine kinase (Syk) initiates and amplifies the BCR signal. In in... 
RHEUMATOID-ARTHRITIS | BCR | B-CELL LYMPHOMA | RESPONSE CRITERIA | R-CHOP | THERAPEUTIC TARGET | PHASE-III | TYROSINE KINASE INHIBITOR | FOLLICULAR LYMPHOMA | HEMATOLOGY | EXPRESSION | Humans | Middle Aged | Neoplasm Proteins - physiology | Salvage Therapy | Male | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Lymphoma, Non-Hodgkin - enzymology | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Diarrhea - chemically induced | Protein-Tyrosine Kinases - physiology | Pyridines - adverse effects | Antineoplastic Agents - adverse effects | Hypertension - chemically induced | Aged, 80 and over | Adult | Female | Antineoplastic Agents - pharmacology | Oxazines - administration & dosage | Syk Kinase | Lymphoma, Non-Hodgkin - drug therapy | Oxazines - pharmacology | Pyridines - therapeutic use | Hematologic Diseases - chemically induced | Pyridines - administration & dosage | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Treatment Outcome | Oxazines - adverse effects | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | Oxazines - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Aged | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Intracellular Signaling Peptides and Proteins - physiology | Cohort Studies | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus | Abridged Index Medicus | Clinical Trials and Observations
Journal Article
British Journal of Haematology, ISSN 0007-1048, 02/2008, Volume 140, Issue 3, pp. 287 - 294
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2013, Volume 8, Issue 9, pp. e74853 - e74853
Journal Article
Blood, ISSN 0006-4971, 05/2016, Volume 127, Issue 20, pp. 2411 - 2415
Journal Article
Annals of oncology : official journal of the European Society for Medical Oncology, ISSN 0923-7534, 2016, Volume 27, Issue 10, pp. 1928 - 1940
Journal Article
Cancer Letters, ISSN 0304-3835, 2016, Volume 383, Issue 2, pp. 309 - 317
Abstract In previous studies we demonstrated that targeting the nuclear exporter protein exportin-1 (CRM1/XPO1) by a selective inhibitor of nuclear export... 
Hematology, Oncology and Palliative Medicine | NHL | XPO1 | Selective inhibitors of nuclear export | SINE | CRM1 | Exportin-1 | SURVIVAL | DRUG-RESISTANCE | MODEL | CANCER | STRATEGIES | ONCOLOGY | LINE | CHOP | PROTEINS | Vincristine - pharmacology | TOR Serine-Threonine Kinases - metabolism | Transcription Factor RelA - antagonists & inhibitors | Apoptosis - drug effects | Humans | Lymphoma, Non-Hodgkin - enzymology | Lymphoma, Non-Hodgkin - pathology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | TOR Serine-Threonine Kinases - antagonists & inhibitors | Dexamethasone - pharmacology | Time Factors | Oxadiazoles - pharmacology | Acrylamides - pharmacology | Lymphoma, Non-Hodgkin - drug therapy | Cell Survival - drug effects | Hydrazines - pharmacology | Everolimus - pharmacology | Mice, SCID | Mice, Inbred ICR | Drug Synergism | Triazoles - pharmacology | Xenograft Model Antitumor Assays | Animals | Karyopherins - metabolism | Signal Transduction - drug effects | Transcription Factor RelA - metabolism | Tumor Burden - drug effects | Active Transport, Cell Nucleus - drug effects | Cyclophosphamide - pharmacology | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Cell Line, Tumor | Prednisone - pharmacology | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Karyopherins - antagonists & inhibitors | Doxorubicin - pharmacology | Receptors, Cytoplasmic and Nuclear - metabolism | International trade | Cyclophosphamide | Care and treatment | Dexamethasone | Analysis | Lymphomas | Prednisone | Exports | Steroids | Cancer | Drugs | TOR protein | Animal models | Laboratories | Toxicity | Xenotransplantation | Clinical trials | Cytotoxicity | Kinases | Experiments | Anticancer properties | Proteins | Cell growth | Antitumor agents | Cell cycle | Xenografts | Biocompatibility | Localization | Drug dosages | NF-κB protein | Chronic lymphatic leukemia | Hematology | Pharmacology | Chemical compounds | Patients | Lymphoma | Nuclear transport | Studies | Inhibitors | Response rates | In vivo methods and tests | Apoptosis | Index Medicus
Journal Article
International Journal of Hematology, ISSN 0925-5710, 9/2015, Volume 102, Issue 3, pp. 327 - 334
Indoleamine 2,3-dioxygenase (IDO) catalyzes the rate-limiting step in the metabolism of tryptophan along the kynurenine pathway. In tumors, increased IDO... 
Non-Hodgkin lymphoma | 1-methyl-tryptophan | Cyclophosphamide | Medicine & Public Health | Hematology | Oncology | Indoleamine 2,3-dioxygenase | Regulatory T cells | DENDRITIC CELLS | INCREASED POPULATIONS | PERIPHERAL-BLOOD | PROLIFERATION | CANCER | TRYPTOPHAN CATABOLISM | IMMUNOTHERAPY | HEMATOLOGICAL MALIGNANCIES | REGULATORY T-CELLS | HEMATOLOGY | Indoleamine-Pyrrole 2,3,-Dioxygenase - biosynthesis | Gene Expression Regulation, Enzymologic - drug effects | Neoplasm Proteins - biosynthesis | Enzyme Inhibitors - pharmacology | Neoplasms, Experimental - enzymology | Neoplasm Proteins - antagonists & inhibitors | Lymphoma, Non-Hodgkin - enzymology | T-Lymphocytes, Regulatory - pathology | Tryptophan - pharmacokinetics | Animals | Enzyme Inhibitors - pharmacokinetics | Tryptophan - analogs & derivatives | Cyclophosphamide - pharmacology | Female | Cyclophosphamide - pharmacokinetics | Mice | Mice, Inbred BALB C | Tryptophan - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Neoplasms, Experimental - drug therapy | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | T-Lymphocytes, Regulatory - enzymology | Lymphoma, Non-Hodgkin - drug therapy | Medical colleges | RNA | Analysis | Physiological aspects | Tryptophan | Lymphomas | T cells | High performance liquid chromatography | Index Medicus
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 2014, Volume 106, Issue 2, pp. djt378 - djt378
Journal Article