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Journal of Experimental Medicine, ISSN 0022-1007, 2014, Volume 211, Issue 13, pp. 2537 - 2547
Journal Article
International Archives of Allergy and Immunology, ISSN 1018-2438, 06/2012, Volume 158, Issue 4, pp. 418 - 422
IL-2-inducible T-cell kinase (ITK) deficiency is a rare inherited immunodeficiency disease characterized by homozygous mutations in the ITK gene and the... 
Novel Insights from Clinical Practice | Epstein-Barr virus-positive lymphoproliferative disorder | Rituximab | Lung involvement | IL-2-inducible T-cell kinase deficiency | LINKED LYMPHOPROLIFERATIVE SYNDROME | ITK | CYTOKINE PRODUCTION | ALLERGY | IMMUNOLOGY | MATURATION | Cough - drug therapy | Humans | Pneumonia, Viral - drug therapy | Cough - diagnosis | DNA, Viral - analysis | Tomography, X-Ray Computed | Lung - diagnostic imaging | Cough - enzymology | Lymphoproliferative Disorders - diagnostic imaging | Lung - enzymology | Lung - virology | Lymphocyte Activation - genetics | Protein-Tyrosine Kinases - genetics | Lymphoproliferative Disorders - enzymology | B-Lymphocytes - virology | Female | B-Lymphocytes - pathology | Fever - pathology | Lung - pathology | Cough - virology | Bronchoalveolar Lavage Fluid - virology | Epstein-Barr Virus Infections - enzymology | Lymphoproliferative Disorders - virology | Pneumonia, Viral - pathology | Fever - diagnosis | Epstein-Barr Virus Infections - drug therapy | Fever - virology | Lymphoproliferative Disorders - pathology | Epstein-Barr Virus Infections - pathology | B-Lymphocytes - drug effects | Point Mutation | Fever - enzymology | Cough - pathology | Lymphocyte Activation - drug effects | Lung - drug effects | Adolescent | Pneumonia, Viral - enzymology | Lymphoproliferative Disorders - drug therapy | Fever - drug therapy | Antibodies, Monoclonal, Murine-Derived - therapeutic use | Immunologic Factors - therapeutic use | Monoclonal antibodies | Viruses | Mutation | Drug therapy | Genes
Journal Article
Cancer Cell, ISSN 1535-6108, 2008, Volume 13, Issue 6, pp. 496 - 506
The mammalian genome contains several hundred microRNAs that regulate gene expression through modulation of target mRNAs. Here, we report a fragile chromosomal... 
CELLCYCLE | CHRONIC MYELOGENOUS LEUKEMIA | ONCOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | BCR-ABL | MOUSE | DOWN-REGULATION | CHRONIC LYMPHOCYTIC-LEUKEMIA | HUMAN CANCER-CELLS | CHRONIC MYELOID-LEUKEMIA | TARGET PREDICTIONS | TRANS-INTERACTION | CELL BIOLOGY | Up-Regulation | Whole-Body Irradiation | DNA Modification Methylases - antagonists & inhibitors | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | MicroRNAs - metabolism | Gene Expression Profiling | Loss of Heterozygosity | Lymphoma, T-Cell - metabolism | Lymphoproliferative Disorders - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | DNA Methylation | Lymphoproliferative Disorders - enzymology | Transfection | Time Factors | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Phenylbutyrates - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | 3' Untranslated Regions | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Philadelphia Chromosome | Promoter Regions, Genetic | DNA Modification Methylases - metabolism | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Gene Silencing | Lymphoproliferative Disorders - genetics | Gene Expression Regulation, Leukemic | Lymphoma, T-Cell - genetics | Lymphoproliferative Disorders - pathology | Chromosomes, Mammalian | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Azacitidine - pharmacology | Animals | Lymphoma, T-Cell - pathology | Cell Line, Tumor | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Proto-Oncogene Proteins c-abl - metabolism | Chromosomes, Human, Pair 14 | Cell Proliferation - drug effects | Mice | MicroRNAs - genetics | Fusion Proteins, bcr-abl - metabolism | Animal genetics | Cytogenetics | Genetic aspects | Genetic engineering | Gene expression | Leukemia
Journal Article
Journal Article
Journal Article
Journal Article
American Journal of Transplantation, ISSN 1600-6135, 04/2013, Volume 13, Issue 4, pp. 883 - 890
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2007, Volume 282, Issue 21, pp. 15833 - 15842
The clinical immunosuppressant FTY720 is a sphingosine analogue that, once phosphorylated by sphingosine kinase 2 (Sphk2), is an agonist of multiple receptor... 
1-PHOSPHATE RECEPTOR AGONIST | KINASE TYPE-2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | IMMUNOSUPPRESSIVE AGENT | ENDOPLASMIC-RETICULUM | LYMPHOCYTE EGRESS | SACCHAROMYCES-CEREVISIAE | TUMOR-GROWTH | MRL-LPR/LPR-MICE | IMMUNOMODULATORY DRUG FTY720 | Organ Specificity - drug effects | Receptors, Lysosphingolipid - antagonists & inhibitors | Apoptosis - drug effects | Humans | Apoptosis - genetics | Protein Transport - drug effects | Thymus Gland - enzymology | Cell Membrane Permeability - genetics | Autoimmune Diseases - genetics | Mitochondria | Caspases - metabolism | Lymphoproliferative Disorders - enzymology | Spleen - enzymology | Phosphorylation - drug effects | Immunosuppressive Agents - pharmacology | Autoimmune Diseases - drug therapy | Endoplasmic Reticulum - enzymology | Propylene Glycols - pharmacology | Autoimmune Diseases - enzymology | Sphingolipids - pharmacology | Jurkat Cells | bcl-2-Associated X Protein - metabolism | Fingolimod Hydrochloride | Sphingolipids - metabolism | Lymphoproliferative Disorders - genetics | Protein Transport - genetics | Mice, Knockout | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Sphingosine - pharmacology | Sphingosine - analogs & derivatives | Animals | Mutagenesis | Calcium Signaling - drug effects | Cell Membrane Permeability - drug effects | Lymphoproliferative Disorders - drug therapy | Mice | HeLa Cells | Calcium Signaling - genetics | Drug Resistance, Neoplasm - drug effects
Journal Article
Cell, ISSN 0092-8674, 1999, Volume 98, Issue 1, pp. 47 - 58
Caspases are cysteine proteases that mediate programmed cell death in phylogenetically diverse multicellular organisms. We report here two kindreds with... 
TNF RECEPTOR | TUMOR-NECROSIS-FACTOR | INTERLEUKIN-1-BETA-CONVERTING ENZYME | LIGAND TRAIL | APO-2 LIGAND | FADD-DEPENDENT APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MATURE T-CELLS | IN-VIVO | FAS GENE-MUTATIONS | NF-KAPPA-B | CELL BIOLOGY | Humans | Dendritic Cells - pathology | Dendritic Cells - physiology | Homeostasis | Lymphoproliferative Disorders - immunology | Mutation, Missense | Breast Neoplasms | Autoimmune Diseases - genetics | Lymphocytes - physiology | Membrane Glycoproteins - physiology | Lymphoproliferative Disorders - enzymology | TNF-Related Apoptosis-Inducing Ligand | Transfection | Caspase 10 | Female | fas Receptor - physiology | Child | Carrier Proteins - physiology | Recombinant Proteins - metabolism | Autoimmune Diseases - enzymology | Caspases - genetics | Autoimmune Diseases - immunology | Cells, Cultured | Fas-Associated Death Domain Protein | Lymphoproliferative Disorders - genetics | DNA Primers | Reverse Transcriptase Polymerase Chain Reaction | Fas Ligand Protein | Adaptor Proteins, Signal Transducing | Lymphocytes - pathology | Apoptosis Regulatory Proteins | Tumor Necrosis Factor-alpha - physiology | HeLa Cells | Amino Acid Substitution | Apoptosis | Autoimmunity | Allergy | Cysteine | Dendritic cells | Lymphocytes | Proteases | Genetic research | Genetic aspects | Allergic reaction | Cysteine proteinases | Lymphoproliferative disorders | Research | T cells | Cell death
Journal Article
Journal Article