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Blood, ISSN 0006-4971, 2013, Volume 121, Issue 11, pp. 2051 - 2058
Journal Article
Blood, ISSN 0006-4971, 01/2015, Volume 125, Issue 4, pp. 591 - 599
Journal Article
Blood, ISSN 0006-4971, 10/2012, Volume 120, Issue 15, pp. 3048 - 3057
Journal Article
Blood, ISSN 0006-4971, 03/2013, Volume 121, Issue 13, pp. 2522 - 2528
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 03/2012, Volume 18, Issue 6, pp. 1611 - 1618
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 01/2007, Volume 204, Issue 1, pp. 57 - 63
Journal Article
Science, ISSN 0036-8075, 12/1999, Volume 286, Issue 5446, pp. 1957 - 1959
Journal Article
Cancer Cell, ISSN 1535-6108, 2008, Volume 13, Issue 6, pp. 496 - 506
The mammalian genome contains several hundred microRNAs that regulate gene expression through modulation of target mRNAs. Here, we report a fragile chromosomal... 
CELLCYCLE | CHRONIC MYELOGENOUS LEUKEMIA | ONCOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | BCR-ABL | MOUSE | DOWN-REGULATION | CHRONIC LYMPHOCYTIC-LEUKEMIA | HUMAN CANCER-CELLS | CHRONIC MYELOID-LEUKEMIA | TARGET PREDICTIONS | TRANS-INTERACTION | CELL BIOLOGY | Up-Regulation | Whole-Body Irradiation | DNA Modification Methylases - antagonists & inhibitors | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | MicroRNAs - metabolism | Gene Expression Profiling | Loss of Heterozygosity | Lymphoma, T-Cell - metabolism | Lymphoproliferative Disorders - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | DNA Methylation | Lymphoproliferative Disorders - enzymology | Transfection | Time Factors | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Phenylbutyrates - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | 3' Untranslated Regions | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Philadelphia Chromosome | Promoter Regions, Genetic | DNA Modification Methylases - metabolism | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Gene Silencing | Lymphoproliferative Disorders - genetics | Gene Expression Regulation, Leukemic | Lymphoma, T-Cell - genetics | Lymphoproliferative Disorders - pathology | Chromosomes, Mammalian | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Azacitidine - pharmacology | Animals | Lymphoma, T-Cell - pathology | Cell Line, Tumor | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Proto-Oncogene Proteins c-abl - metabolism | Chromosomes, Human, Pair 14 | Cell Proliferation - drug effects | Mice | MicroRNAs - genetics | Fusion Proteins, bcr-abl - metabolism | Animal genetics | Cytogenetics | Genetic aspects | Genetic engineering | Gene expression | Leukemia | Index Medicus
Journal Article
by Coulter, Tanya I., MRCPI and Chandra, Anita, PhD, FRCPath and Bacon, Chris M., PhD, FRCPath and Babar, Judith, MRCP, FRCR and Curtis, James, PhD and Screaton, Nick, FRCP, FRCR and Goodlad, John R., MD, FRCPath and Farmer, George, MD and Steele, Cathal Laurence, MB and Leahy, Timothy Ronan, MRCPI and Doffinger, Rainer, PhD, FRCPath and Baxendale, Helen, PhD, FRCPath and Bernatoniene, Jolanta, PhD and Edgar, J. David M., FRCP, FRCPath and Longhurst, Hilary J., PhD, FRCPath and Ehl, Stephan, MD, PhD and Speckmann, Carsten, MD and Grimbacher, Bodo, MD, PhD and Sediva, Anna, MD, PhD and Milota, Tomas, MD and Faust, Saul N., PhD, FRCPCH and Williams, Anthony P., PhD, FRCPath and Hayman, Grant, FRCP, FRCPath and Kucuk, Zeynep Yesim, MD and Hague, Rosie, MRCP, FRCPH and French, Paul, MD, MRCS, DipFMS, FRCPath and Brooker, Richard, FRCPCH and Forsyth, Peter, FRCPath and Herriot, Richard, FRCP, FRCPath and Cancrini, Caterina, MD, PhD and Palma, Paolo, MD, PhD and Ariganello, Paola, MD and Conlon, Niall, PhD, FRCPath and Feighery, Conleth, PhD, FRCPath and Gavin, Patrick J., MD and Jones, Alison, PhD, FRCPCH and Imai, Kohsuke, MD, PhD and Ibrahim, Mohammad A.A., PhD, FRCP, FRCPath and Markelj, Gašper, MD and Abinun, Mario, MD, PhD and Rieux-Laucat, Frédéric, PhD and Latour, Sylvain, PhD and Pellier, Isabelle, MD, PhD and Fischer, Alain, MD, PhD and Touzot, Fabien, MD, PhD and Casanova, Jean-Laurent, MD, PhD and Durandy, Anne, MD, PhD and Burns, Siobhan O., MD, PhD and Savic, Sinisa, PhD, FRCPath and Kumararatne, D.S., FRCPath, DPhil (Oxon) and Moshous, Despina, MD, PhD and Kracker, Sven, PhD and Vanhaesebroeck, Bart, PhD, FMedSci and Okkenhaug, Klaus, PhD and Picard, Capucine, MD, PhD and Nejentsev, Sergey, MD, PhD and Condliffe, Alison M., PhD, FRCP and Cant, Andrew James, MD, FRCP, FRCPH
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 2, pp. 597 - 606.e4
Background Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described combined immunodeficiency resulting from gain-of-function mutations in... 
Allergy and Immunology | Activated phosphoinositide 3-kinase δ syndrome | hematopoietic stem cell transplantation | phosphoinositide 3-kinase δ | immunodeficiency | phosphoinositide 3-kinase inhibitor | PIK3CD gene | bronchiectasis | p110δ-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency | Activated phosphoinositide 3-kinase delta syndrome | IMMUNOLOGICAL FEATURES | HYPER-IGM SYNDROME | p110 delta-activating mutation causing senescent T cells | hematopoietic stem cell | COMMON VARIABLE IMMUNODEFICIENCY | PIK3CD | IMMUNOLOGY | lymphadenopathy | REFERENCE VALUES | P110-DELTA | phosphoinositide 3-kinase delta | P110 DELTA | B-CELL | ALLERGY | transplantation | MUTATIONS | Recurrence | Class I Phosphatidylinositol 3-Kinases - genetics | Herpesviridae Infections - mortality | Humans | Middle Aged | Child, Preschool | Infant | Male | Antibiotic Prophylaxis | Respiratory Tract Infections - genetics | Lymphoproliferative Disorders - therapy | Young Adult | Respiratory Tract Infections - mortality | Respiratory Tract Infections - therapy | Immunologic Deficiency Syndromes - mortality | Adult | Female | Surveys and Questionnaires | Herpesviridae Infections - genetics | Child | Immunologic Deficiency Syndromes - therapy | Hematopoietic Stem Cell Transplantation | International Cooperation | Lymphoproliferative Disorders - genetics | Mutation - genetics | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Lymphoproliferative Disorders - mortality | Animals | Herpesviridae Infections - therapy | Immunoglobulins, Intravenous - therapeutic use | Adolescent | Survival Analysis | Immunologic Deficiency Syndromes - genetics | Mice | Cohort Studies | Index Medicus | Abridged Index Medicus | Immune Deficiencies, Infection, and Systemic Immune Disorders | HSCT, Hematopoietic stem cell transplantation | BALF, Bronchoalveolar lavage fluid | CT, Computed tomography | APDS, Activated phosphoinositide-3 kinase δ syndrome | GOF, Gain of function | PI3K, Phosphoinositide 3-kinase | HSV, Herpes simplex virus | CMV, Cytomegalovirus | OR, Odds ratio | PPV, Pneumococcal polysaccharide vaccine | CNS, Central nervous system
Journal Article
PLoS Pathogens, ISSN 1553-7366, 01/2012, Volume 8, Issue 1, pp. e1002484 - e1002484
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV... 
III PROGRAM | RNA | PAR-CLIP | C-MYC | HUMAN B-CELLS | MICROBIOLOGY | KAPPA-B | ENCODED MICRORNAS | VIROLOGY | HUMAN GAMMA-HERPESVIRUSES | PROTEIN EXPRESSION | EPSTEIN-BARR-VIRUS | PARASITOLOGY | Herpesvirus 4, Human - physiology | Humans | Lymphoproliferative Disorders - virology | 3' Untranslated Regions - genetics |