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1. Full Text The Histomorphology of Lynch Syndrome–associated Ovarian Carcinomas: Toward a Subtype-specific Screening Strategy
by Chui, Michael Herman and Ryan, Paul and Radigan, Jordan and Ferguson, Sarah E and Pollett, Aaron and Aronson, Melyssa and Semotiuk, Kara and Holter, Spring and Sy, Keiyan and Kwon, Janice S and Soma, Anita and Singh, Naveena and Gallinger, Steven and Shaw, Patricia and Arseneau, Jocelyne and Foulkes, William D and Gilks, C Blake and Clarke, Blaise A
The American Journal of Surgical Pathology, ISSN 0147-5185, 09/2014, Volume 38, Issue 9, pp. 1173 - 1181
Women with Lynch syndrome (LS) are at increased risk for the development of epithelial ovarian cancer (OC). Analogous to previous studies on BRCA1/2 mutation... 
ovarian cancer | mismatch repair | Lynch syndrome | CELL-TYPE | SURGERY | RISKS | SYNCHRONOUS PRIMARY CANCERS | ENDOMETRIAL CARCINOMA | BRCA1 | PATHOLOGY | WOMEN | FREQUENCY | GENES | GYNECOLOGIC CANCERS | MUTATIONS | Colorectal Neoplasms, Hereditary Nonpolyposis - classification | Immunohistochemistry | Predictive Value of Tests | Microsatellite Instability | Carcinoma, Endometrioid - classification | Genetic Testing | Early Detection of Cancer - methods | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Middle Aged | Ovarian Neoplasms - pathology | Ovarian Neoplasms - genetics | Ovarian Neoplasms - classification | Carcinoma, Endometrioid - chemistry | Neoplasm Grading | DNA Mutational Analysis | DNA Mismatch Repair | Germ-Line Mutation | Adult | Female | Registries | Carcinoma, Endometrioid - genetics | Genetic Predisposition to Disease | Ovarian Neoplasms - chemistry | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Heredity | BRCA1 Protein - genetics | Canada | Phenotype | Lymphocytes, Tumor-Infiltrating - pathology | Biopsy | Pedigree | Aged | Colorectal Neoplasms, Hereditary Nonpolyposis - chemistry | BRCA2 Protein - genetics | Carcinoma, Endometrioid - pathology | Index Medicus
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2. Full Text Immunohistochemistry versus Microsatellite Instability Testing For Screening Colorectal Cancer Patients at Risk For Hereditary Nonpolyposis Colorectal Cancer Syndrome: Part I. The Utility of Immunohistochemistry
by Shia, Jinru
Journal of Molecular Diagnostics, ISSN 1525-1578, 07/2008, Volume 10, Issue 4, pp. 293 - 300
The utility of immunohistochemical detection of DNA mismatch repair (MMR) protein in screening colorectal tumors for hereditary nonpolyposis colorectal cancer... 
COLON-CANCER | GENE-MUTATIONS | LYNCH-SYNDROME | HMSH2 | EXPRESSION ANALYSIS | MSH2 | REVISED BETHESDA GUIDELINES | TUMOR-CELLS | DNA MISMATCH-REPAIR | PATHOLOGY | IDENTIFICATION | Microsatellite Instability | Humans | Risk Factors | Mass Screening - methods | Colorectal Neoplasms - diagnosis | Syndrome | Colorectal Neoplasms, Hereditary Nonpolyposis - prevention & control | Immunohistochemistry - methods | Colorectal Neoplasms, Hereditary Nonpolyposis - metabolism | Sensitivity and Specificity | Colorectal Neoplasms - complications | Colorectal Neoplasms, Hereditary Nonpolyposis - etiology | Colorectal Neoplasms - metabolism | Index Medicus | Counterpoint | Point
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3. Full Text Lynch Syndrome: An Review
by Sehgal, R and Sheahan, K and O'Connell, PR and Hanly, AM and Martin, ST and Winter, DC
GENES, ISSN 2073-4425, 09/2014, Volume 5, Issue 3, pp. 497 - 507
Lynch syndrome is one of the most common cancer susceptibility syndromes. Individuals with Lynch syndrome have a 50%-70% lifetime risk of colorectal cancer,... 
screening | NONPOLYPOSIS COLORECTAL-CANCER | MICROSATELLITE INSTABILITY | ENDOMETRIAL CANCERS | history | FAMILY-G | LYNCH SYNDROME-I | BETHESDA GUIDELINES | genetics | GENETIC TESTING STRATEGIES | GENETICS & HEREDITY | MISMATCH-REPAIR GENES | CRC clinic | INSTITUTE WORKSHOP | Lynch syndrome | ADENOMATOUS POLYPOSIS
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4. Full Text The risk of extra‐colonic, extra‐endometrial cancer in the Lynch syndrome
by Watson, Patrice and Vasen, Hans F.A and Mecklin, Jukka‐Pekka and Bernstein, Inge and Aarnio, Markku and Järvinen, Heikki J and Myrhøj, Torben and Sunde, Lone and Wijnen, Juul T and Lynch, Henry T
International Journal of Cancer, ISSN 0020-7136, 07/2008, Volume 123, Issue 2, pp. 444 - 449
Persons with the Lynch syndrome (LS) are at high risk for cancer, including cancers of the small bowel, stomach, upper urologic tract (renal pelvis and... 
cancer risk | MSH2 | MLH1 | Lynch syndrome | Cancer risk | BREAST-CANCER | ONCOLOGY | NONPOLYPOSIS COLORECTAL-CANCER | MUTATION CARRIERS | MISMATCH-REPAIR GENES | SURVEILLANCE | TUMORS | Multivariate Analysis | MutL Protein Homolog 1 | United States - epidemiology | Urologic Neoplasms - epidemiology | Age Distribution | Age Factors | Humans | Middle Aged | Netherlands - epidemiology | Male | Incidence | Ovarian Neoplasms - genetics | Urologic Neoplasms - genetics | Neoplasms - genetics | DNA Mismatch Repair | Aged, 80 and over | Adult | Female | Registries | Nuclear Proteins - genetics | Odds Ratio | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Kaplan-Meier Estimate | Proportional Hazards Models | MutS Homolog 2 Protein - genetics | Ovarian Neoplasms - epidemiology | Confounding Factors (Epidemiology) | Adaptor Proteins, Signal Transducing - genetics | Denmark - epidemiology | Aged | Mutation | Finland - epidemiology | Neoplasms - epidemiology | Index Medicus
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5. Full Text Differentiating Lynch-Like From Lynch Syndrome
by Carethers, John M
Gastroenterology, ISSN 0016-5085, 2014, Volume 146, Issue 3, pp. 602 - 604
Gastroenterology and Hepatology | INACTIVATION | METHYLATION | HYPERMETHYLATION | MSH2 | MISMATCH REPAIR-DEFICIENCY | COLORECTAL-CANCER | HMLH1 | MLH1 | GASTROENTEROLOGY & HEPATOLOGY | MutL Protein Homolog 1 | Colorectal Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Humans | Adaptor Proteins, Signal Transducing - genetics | Brain Neoplasms - genetics | MutS Homolog 2 Protein - genetics | Neoplastic Syndromes, Hereditary - genetics | Germ-Line Mutation - genetics | Nuclear Proteins - genetics | Index Medicus | Abridged Index Medicus | microsatellite instability | colorectal cancer | Lynch-like syndrome | Lynch syndrome
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6. Full Text Discordant mismatch repair protein immunoreactivity in lynch syndrome-associated neoplasms: A recommendation for screening synchronous/metachronous neoplasms
by Roth, Rachel M and Haraldsdottir, Sigurdis and Hampel, Heather and Arnold, Christina A and Frankel, Wendy L
American Journal of Clinical Pathology, ISSN 0002-9173, 07/2016, Volume 146, Issue 1, pp. 50 - 56
Objectives: Lynch syndrome (LS) predisposes individuals to developing synchronous and metachronous LS-associated neoplasms (LSANs). Mismatch repair protein... 
Metachronous cancer | Mismatch repair proteins | Synchronous cancer | Cancer screening | Lynch syndrome | NONPOLYPOSIS COLORECTAL-CANCER | CARCINOMAS | RISK | PATHOLOGY | NATURAL-HISTORY | DEFICIENCY | ENDOMETRIAL CANCER | Immunohistochemistry | Early Detection of Cancer - methods | Biomarkers, Tumor - analysis | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Humans | Middle Aged | Male | DNA Mismatch Repair - genetics | DNA Repair Enzymes - analysis | Young Adult | Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis | Adolescent | Aged, 80 and over | Adult | Female | Aged | Retrospective Studies | Index Medicus | Abridged Index Medicus
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7. Full Text Ureteroscopic management of upper tract urothelial carcinoma (UTUC) in patients with Lynch Syndrome (hereditary nonpolyposis colorectal cancer syndrome)
by Hubosky, Scott G and Boman, Bruce M and Charles, Sarah and Bibbo, Marluce and Bagley, Demetrius H
BJU International, ISSN 1464-4096, 10/2013, Volume 112, Issue 6, pp. 813 - 819
Objectives To report our experience with ureteroscopic laser ablation of upper tract urothelial carcinoma (UTUC) in patients with Lynch Syndrome (LS), as... 
yndrome | ynch | kidney neoplasms | ureteroscopy | ureteric neoplasms | hereditary nonpolyposis colorectal cancer | Lynch Syndrome | UPPER URINARY-TRACT | BIOPSY | BLADDER-TUMORS | RISK | NEPHROURETERECTOMY | CLASSIFICATION | TRANSITIONAL-CELL CARCINOMA | UROLOGY & NEPHROLOGY | EXPERIENCE | KIDNEY | United States - epidemiology | Kidney Neoplasms - genetics | Follow-Up Studies | Humans | Middle Aged | Ureteral Neoplasms - pathology | Male | Neoplasms, Multiple Primary | Kidney Neoplasms - surgery | Colorectal Neoplasms, Hereditary Nonpolyposis - mortality | Neoplasm Grading | Nephrectomy | DNA Mutational Analysis | Adult | Female | Retrospective Studies | Ureteroscopy - methods | Carcinoma, Transitional Cell - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - surgery | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Treatment Outcome | MutS Homolog 2 Protein - genetics | Carcinoma, Transitional Cell - pathology | Ureteral Neoplasms - complications | Kidney Neoplasms - pathology | Aged | Carcinoma, Transitional Cell - surgery | DNA, Neoplasm - genetics | Mutation | Ureteral Neoplasms - surgery | Rare earth metals | Care and treatment | Ablation (Surgery) | Carcinoma | Gene mutations | Colorectal cancer | Medical genetics | Genetic aspects | Intermedin | Cancer | Lasers in medicine | Lasers | Tumors | Index Medicus
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8. Full Text Biallelic MUTYH mutations can mimic Lynch syndrome
by Morak, Monika and Heidenreich, Barbara and Keller, Gisela and Hampel, Heather and Laner, Andreas and De La Chapelle, Albert and Holinski-Feder, Elke
European Journal of Human Genetics, ISSN 1018-4813, 11/2014, Volume 22, Issue 11, pp. 1334 - 1337
The hallmarks of Lynch syndrome (LS) include a positive family history of colorectal cancer (CRC), germline mutations in the DNA mismatch repair (MMR) genes,... 
somatic mutations | base excision repair | immunohistochemistry | DNA mismatch repair | Lynch syndrome | MUTYH | NONPOLYPOSIS COLORECTAL-CANCER | BIOCHEMISTRY & MOLECULAR BIOLOGY | POLYPOSIS MAP | RISK | MLH1 | MSH6 | 10-MB PARACENTRIC INVERSION | GENETICS & HEREDITY | EARLY-ONSET | CARCINOMAS | ADENOMA | MYH | Immunohistochemistry | Microsatellite Instability | Exons | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Humans | Middle Aged | DNA Glycosylases - genetics | Male | DNA Repair - genetics | DNA Mismatch Repair - genetics | Homozygote | DNA Mutational Analysis | Pedigree | Alleles | Germ-Line Mutation | Adult | Female | DNA Glycosylases - metabolism | Genomics | Genes | Colorectal carcinoma | Colorectal cancer | Family medical history | Microsatellite instability | DNA repair | Sebaceous gland | Mimicry | K-Ras protein | Proteins | MSH6 protein | Histopathology | MMR protein | Mismatch repair | Gastroenterology | DNA methylation | Tumorigenesis | Urothelial carcinoma | Age | Deoxyribonucleic acid--DNA | Phenotypes | MSH2 protein | Transversion | Breast cancer | Polyposis | Patients | Adenomatous polyposis coli | Protein expression | Mutation | Tumors | Index Medicus | Short Report
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9. Full Text Characteristics of Lynch syndrome associated ovarian cancer
by Woolderink, J.M and De Bock, G.H and de Hullu, J.A and Hollema, H and Zweemer, R.P and Slangen, B.F.M and Gaarenstroom, K.N and van Beurden, M and van Doorn, H.C and Sijmons, R.H and Vasen, H.F.A and Mourits, M.J.E
Gynecologic Oncology, ISSN 0090-8258, 08/2018, Volume 150, Issue 2, pp. 324 - 330
To describe clinical characteristics of Lynch syndrome associated ovarian cancer and the efficacy of surveillance in the early detection of these ovarian... 
Surveillance | Survival | Lynch syndrome | Ovarian cancer | BRCA1/2 MUTATION CARRIERS | MSH2 MUTATION | GERMLINE | NONPOLYPOSIS COLORECTAL-CANCER | RISK | RANDOMIZED CONTROLLED-TRIAL | CLINICAL-FEATURES | ENDOMETRIAL CANCER | OBSTETRICS & GYNECOLOGY | ONCOLOGY | EARLY-ONSET | GYNECOLOGIC CANCERS | Diagnosis | Cancer | Index Medicus
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10. Full Text Papillary thyroid carcinoma (PTC) in Lynch syndrome: Report of two cases and discussion on Lynch syndrome behaviour and genetics
by Pelizzo, M.R and Pennelli, G and Zane, M and Galuppini, F and Colletti, P.M and Merante Boschin, I and Rubello, D
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 2015, Volume 74, pp. 9 - 16
Abstract We present here two cases of papillary thyroid carcinoma (PTC) in patients affected by Lynch syndrome (LS). The first case is a 47-year-old woman with... 
Internal Medicine | Medical Education | Clinical and genetic characteristics | Papillary thyroid carcinoma | Lynch syndrome | CRITERIA | MEDICINE, RESEARCH & EXPERIMENTAL | MSH2 MUTATION | NONPOLYPOSIS COLORECTAL-CANCER | GERM-LINE | MICROSATELLITE INSTABILITY | RISK | LYNCH SYNDROME-I | SOMATIC MUTATIONS | MISMATCH-REPAIR GENES | PHARMACOLOGY & PHARMACY | INSTITUTE WORKSHOP | Lymph Node Excision | MutL Protein Homolog 1 | Thyroid Neoplasms - surgery | Carcinoma - surgery | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Humans | Middle Aged | Thyroid Neoplasms - etiology | Male | Lymphatic Metastasis | MutS Homolog 2 Protein - genetics | Carcinoma - etiology | Thyroidectomy | Thyroid Cancer, Papillary | Thyroid Neoplasms - genetics | Carcinoma, Papillary | Adaptor Proteins, Signal Transducing - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - complications | Germ-Line Mutation | Adult | Carcinoma - genetics | Female | Mutation | Nuclear Proteins - genetics | Colon cancer | Carcinoma | Molecular genetics | Analysis | Thyroid diseases | Glycine | Ovarian cancer | Cancer | Index Medicus
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11. Full Text Targeted gene sequencing of Lynch syndrome–related and sporadic endometrial carcinomas
by Libera, Laura and Craparotta, Ilaria and Sahnane, Nora and Chiaravalli, Anna Maria and Mannarino, Laura and Cerutti, Roberta and Riva, Cristina and Marchini, Sergio and Furlan, Daniela
Human Pathology, ISSN 0046-8177, 11/2018, Volume 81, pp. 235 - 244
About one-third of endometrial carcinomas (ECs), mainly of endometrioid histology, harbor the mismatch repair (MMR) defects and microsatellite instability... 
MLH1 silencing | MMR defect | Endometrial cancer | Targeted sequencing | ARID1A | Lynch syndrome | ARID 1A | MLH 1 silencing | MUTATIONS | PATHOLOGY | CANCER | EXPRESSION | DEFICIENCY | Genetic research | Genetic aspects | Gene mutations | Analysis | Genes | Cancer | Polymerase chain reaction | DNA methylation | Genomes | Mutation | Deoxyribonucleic acid--DNA | Tumors
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12. Full Text Hereditary colorectal cancer syndromes: American society of clinical oncology clinical practice guideline endorsement of familial risk-colorectal cancer: European Society for medical oncology clinical practice guidelines
by Stoffel, Elena M and Mangu, Pamela B and Gruber, Stephen B and Hamilton, Stanley R and Kalady, Matthew F and Lau, Michelle Wan Yee and Lu, Karen H and Roach, Nancy and Limburg, Paul J and European Society of Clinical Oncology and American Society of Clinical Oncology
Journal of Clinical Oncology, ISSN 0732-183X, 10/2015, Volume 33, Issue 2, pp. 209 - 217
Purpose To provide recommendations on prevention, screening, genetics, treatment, and management for people at risk for hereditary colorectal cancer (CRC)... 
LYNCH-SYNDROME | MULTICENTER | MANAGEMENT | ONCOLOGY | PHENOTYPE | REVISED BETHESDA GUIDELINES | IDENTIFICATION | MLH1 | MSH2 MUTATION CARRIERS | ADENOMATOUS POLYPOSIS | ENDOMETRIAL CANCER | Medical History Taking | Microsatellite Instability | Genetic Testing | Sigmoidoscopy | Early Detection of Cancer - methods | Adenomatous Polyposis Coli - prevention & control | Humans | Genetic Counseling | Colorectal Neoplasms, Hereditary Nonpolyposis - prevention & control | Colorectal Neoplasms, Hereditary Nonpolyposis - therapy | Anticarcinogenic Agents - administration & dosage | Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis | Colonoscopy | DNA Mismatch Repair | Germ-Line Mutation | Adenomatous Polyposis Coli - therapy | Adenomatous Polyposis Coli - genetics | Population Surveillance - methods | Adenomatous Polyposis Coli Protein - genetics | Genetic Predisposition to Disease | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | DNA Glycosylases - genetics | Heterozygote | Adenomatous Polyposis Coli - diagnosis | Chemoprevention - methods | Index Medicus | Gic2 | To4 | ASCO Special | Gic1 | To8 | Gdln1
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13. Full Text Lynch syndrome and cervical cancer
by Antill, Yoland C and Dowty, James G and Win, Aung Ko and Thompson, Tina and Walsh, Michael D and Cummings, Margaret C and Gallinger, Steven and Lindor, Noralane M and Le Marchand, Loïc and Hopper, John L and Newcomb, Polly A and Haile, Robert W and Church, James and Tucker, Katherine M and Buchanan, Daniel D and Young, Joanne P and Winship, Ingrid M and Jenkins, Mark A
International Journal of Cancer, ISSN 0020-7136, 12/2015, Volume 137, Issue 11, pp. 2757 - 2761
Carriers of germline mutations in DNA mismatch repair (MMR) genes are at increased risk of several cancers including colorectal and gynecologic cancers (Lynch... 
mismatch repair | cervical cancer | Lynch syndrome | RISKS | NONPOLYPOSIS COLORECTAL-CANCER | MUTATION CARRIERS | LOWER UTERINE SEGMENT | MLH1 | MSH2 | ONCOLOGY | FAMILIES | CARCINOMAS | PATIENT | REGISTRY | United States | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Humans | Middle Aged | Risk Factors | Risk | DNA Mismatch Repair - genetics | Mutation - genetics | Uterine Cervical Neoplasms - genetics | Incidence | New Zealand | Young Adult | Canada | Adolescent | Adult | Female | Registries | Aged | Australia | Analysis | Cervical cancer | Mutation | Population genetics | DNA repair | Risk factors | Index Medicus
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14. Full Text Clinicopathological comparison of colorectal and endometrial carcinomas in patients with Lynch-like syndrome versus patients with Lynch syndrome
by Mas-Moya, Jenny, MD and Dudley, Beth, MS and Brand, Randall E., MD and Thull, Darcy, MS and Bahary, Nathan, MD, PhD and Nikiforova, Marina N., MD and Pai, Reetesh K., MD
Human Pathology, ISSN 0046-8177, 2015, Volume 46, Issue 11, pp. 1616 - 1625
Summary Screening for DNA mismatch repair (MMR) deficiency in colorectal and endometrial carcinomas identifies patients at risk for Lynch syndrome. Some... 
Pathology | MSI | Endometrial carcinoma | Lynch-like syndrome | Colorectal carcinoma | Mismatch repair protein | Lynch syndrome | MISMATCH-REPAIR DEFICIENCY | POPULATION | GERMLINE | MICROSATELLITE INSTABILITY | IMPLEMENTATION | PATHOLOGY | CANCER | ACADEMIC-MEDICAL-CENTER | FREQUENT CAUSE | MUTATIONS | IMMUNOHISTOCHEMISTRY | MutL Protein Homolog 1 | Promoter Regions, Genetic | Microsatellite Instability | Colorectal Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Middle Aged | Male | Young Adult | Endometrial Neoplasms - genetics | Proto-Oncogene Proteins B-raf - genetics | DNA Mismatch Repair | Adaptor Proteins, Signal Transducing - genetics | Germ-Line Mutation | Adult | Endometrial Neoplasms - pathology | Female | Aged | Colorectal Neoplasms - pathology | Nuclear Proteins - genetics | Care and treatment | Gene mutations | Comparative analysis | Colorectal cancer | Proteins | Polymerase chain reaction | Genetic counseling | Lymphocytes | Cloning | Mortality | Colleges & universities | Protein expression | Mutation | Deoxyribonucleic acid--DNA | Tumors | Index Medicus
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